Sound event detection in the DCASE 2017 Challenge

International audienceEach edition of the challenge on Detection and Classification of Acoustic Scenes and Events (DCASE) contained several tasks involving sound event detection in different setups. DCASE 2017 presented participants with three such tasks, each having specific datasets and detection requirements: Task 2, in which target sound events were very rare in both training and testing data, Task 3 having overlapping events annotated in real-life audio, and Task 4, in which only weakly-labeled data was available for training. In this paper, we present the three tasks, including the datasets and baseline systems, and analyze the challenge entries for each task. We observe the popularity of methods using deep neural networks, and the still widely used mel frequency based representations, with only few approaches standing out as radically different. Analysis of the systems behavior reveals that task-specific optimization has a big role in producing good performance; however, often this optimization closely follows the ranking metric, and its maximization/minimization does not result in universally good performance. We also introduce the calculation of confidence intervals based on a jackknife resampling procedure, to perform statistical analysis of the challenge results. The analysis indicates that while the 95% confidence intervals for many systems overlap, there are significant difference in performance between the top systems and the baseline for all tasks

DCASE 2017 Challenge setup: Tasks, datasets and baseline system

International audienceDCASE 2017 Challenge consists of four tasks: acoustic scene classification , detection of rare sound events, sound event detection in real-life audio, and large-scale weakly supervised sound event detection for smart cars. This paper presents the setup of these tasks: task definition, dataset, experimental setup, and baseline system results on the development dataset. The baseline systems for all tasks rely on the same implementation using multilayer perceptron and log mel-energies, but differ in the structure of the output layer and the decision making process, as well as the evaluation of system output using task specific metrics

Adult Stromal Cells Derived from Human Adipose Tissue Provoke Pancreatic Cancer Cell Death both In Vitro and In Vivo

1932-6203 (Electronic) Journal Article Research Support, Non-U.S. Gov'tBACKGROUND: Normal tissue homeostasis is maintained by dynamic interactions between epithelial cells and their microenvironment. Disrupting this homeostasis can induce aberrant cell proliferation, adhesion, function and migration that might promote malignant behavior. Indeed, aberrant stromal-epithelial interactions contribute to pancreatic ductal adenocarcinoma (PDAC) spread and metastasis, and this raises the possibility that novel stroma-targeted therapies represent additional approaches for combating this malignant disease. The aim of the present study was to determine the effect of human stromal cells derived from adipose tissue (ADSC) on pancreatic tumor cell proliferation. PRINCIPAL FINDINGS: Co-culturing pancreatic tumor cells with ADSC and ADSC-conditioned medium sampled from different donors inhibited cancer cell viability and proliferation. ADSC-mediated inhibitory effect was further extended to other epithelial cancer-derived cell lines (liver, colon, prostate). ADSC conditioned medium induced cancer cell necrosis following G1-phase arrest, without evidence of apoptosis. In vivo, a single intra-tumoral injection of ADSC in a model of pancreatic adenocarcinoma induced a strong and long-lasting inhibition of tumor growth. CONCLUSION: These data indicate that ADSC strongly inhibit PDAC proliferation, both in vitro and in vivo and induce tumor cell death by altering cell cycle progression. Therefore, ADSC may constitute a potential cell-based therapeutic alternative for the treatment of PDAC for which no effective cure is available

Neural crest-related NXPH1/α-NRXN signaling opposes neuroblastoma malignancy by inhibiting organotropic metastasis

Neuroblastoma is a pediatric cancer that can present as low- or high-risk tumors (LR-NBs and HR-NBs), the latter group showing poor prognosis due to metastasis and strong resistance to current therapy. Whether LR-NBs and HR-NBs differ in the way they exploit the transcriptional program underlying their neural crest, sympatho-adrenal origin remains unclear. Here, we identified the transcriptional signature distinguishing LR-NBs from HR-NBs, which consists mainly of genes that belong to the core sympatho-adrenal developmental program and are associated with favorable patient prognosis and with diminished disease progression. Gain- and loss-of-function experiments revealed that the top candidate gene of this signature, Neurexophilin-1 (NXPH1), has a dual impact on NB cell behavior in vivo: whereas NXPH1 and its receptor α-NRXN1 promote NB tumor growth by stimulating cell proliferation, they conversely inhibit organotropic colonization and metastasis. As suggested by RNA-seq analyses, these effects might result from the ability of NXPH1/α-NRXN signalling to restrain the conversion of NB cells from an adrenergic state to a mesenchymal one. Our findings thus uncover a transcriptional module of the sympatho-adrenal program that opposes neuroblastoma malignancy by impeding metastasis, and pinpoint NXPH1/α-NRXN signaling as a promising target to treat HR-NBs.This work was supported by grants from the Ministerio de Ciencia e Innovacion, Gobierno de España (MCINN; BFU2016-81887-REDT and BFU2016-77498-P) and the Asociación Española Contra el Cancer (AECC CI_2016) to EM, from the Fondo de Investigación en Salud (FIS) - Instituto de salud Carlos III (PI14/00038) and the NEN association (Association of Families and Friends of Patients with Neuroblastoma) to CL, from the Instituto de Salud Carlos III-FSE (MS17/00037; PI18/00014; PI21/00020) to TC-T, from Instituto de Salud Carlos III (CP22/00127, co-funded by European Social Fund “Investing in your future”) to BMJ, from the Agence Nationale pour la Recherche (ANR-17-CE14-0023-01, ANR-17-CE14-0009-02) and the city of Paris (Emergence program) to ELG, from ISCIII-FEDER (CP13/00189 and CPII18/00009) to AMC. LF received a PhD fellowship from the Spanish Ministry of Science, Education and Universities (FPU AP2012-2222). LT-D was funded by a FPI Fellowship (PRE2019-088005). GLD was supported by the Asociación Española Contra el Cancer (AECC #AIO14142105LED)

Emergence of Zaire Ebola Virus Disease in Guinea - Preliminary Report

In March 2014, the World Health Organization was notified of an outbreak of a communicable disease characterized by fever, severe diarrhea, vomiting, and a high fatality rate in Guinea. Virologic investigation identified Zaire ebolavirus (EBOV) as the causative agent. Full-length genome sequencing and phylogenetic analysis showed that EBOV from Guinea forms a separate clade in relationship to the known EBOV strains from the Democratic Republic of Congo and Gabon. Epidemiologic investigation linked the laboratory-confirmed cases with the presumed first fatality of the outbreak in December 2013. This study demonstrates the emergence of a new EBOV strain in Guinea

The equilibrium shape of (65) Cybele: primordial or relic of a large impact?

Context. Cybele asteroids constitute an appealing reservoir of primitive material genetically linked to the outer Solar System, and the physical properties (size and shape) of the largest members can be readily accessed by large (8m class) telescopes. Aims. We took advantage of the bright apparition of the most iconic member of the Cybele population, (65) Cybele, in July and August 2021 to acquire high-angular-resolution images and optical light curves of the asteroid with which we aim to analyse its shape and bulk properties. Methods. Eight series of images were acquired with VLT/SPHERE+ZIMPOL, seven of which were combined with optical light curves to reconstruct the shape of the asteroid using the ADAM, MPCD, and SAGE algorithms. The origin of the shape was investigated by means of N-body simulations. Results. Cybele has a volume-equivalent diameter of 263±3 km and a bulk density of 1.55 ± 0.19 g cm−3. Notably, its shape and rotation state are closely compatible with those of a Maclaurin equilibrium figure. The lack of a collisional family associated with Cybele and the higher bulk density of that body with respect to other large P-type asteroids suggest that it never experienced any large disruptive impact followed by rapid re-accumulation. This would imply that its present-day shape represents the original one. However, numerical integration of the long-term dynamical evolution of a hypothetical family of Cybele shows that it is dispersed by gravitational perturbations and chaotic diffusion over gigayears of evolution. Conclusions. The very close match between Cybele and an equilibrium figure opens up the possibility that D ≥ 260 km (M ≥ 1.5 × 1019 kg) small bodies from the outer Solar System all formed at equilibrium. However, we cannot currently rule out an old impact as the origin of the equilibrium shape of Cybele. Cybele itself is found to be dynamically unstable, implying that it was ‘recently’ (<1 Gyr ago) placed on its current orbit either through slow diffusion from a relatively stable orbit in the Cybele region or, less likely, from an unstable, Jupiter-family-comet orbit in the planet-crossing region.This work has been supported by the Czech Science Foundation through grants 20-08218S (J. Hanuš) and 21-11058S (M. Brož), as well as by the National Science Foundation under Grant No. 1743015 (F. Marchis). T. Santana-Ros acknowledges funding from the NEO-MAPP project (H2020-EU-2-1-6/870377). In addition, this work was partially funded by the Spanish MICIN/AEI/10.13039/501100011033 and by “ERDF A way of making Europe” by the “European Union” through grant RTI2018-095076-B-C21, and the Institute of Cosmos Sciences University of Barcelona (ICCUB, Unidad de Excelencia ‘María de Maeztu’) through grant CEX2019-000918-M. This research has made use of the Asteroid Families Portal maintained at the Department of Astronomy, University of Belgrade. TRAPPIST is a project funded by the Belgian Fonds (National) de la Recherche Scientifique (F.R.S.-FNRS) under grant PDR T.0120.21. TRAPPIST-North is a project funded by the University of Liège, in collaboration with the Cadi Ayyad University of Marrakech (Morocco). E. Jehin is F.R.S.-FNRS Senior Research Associate

European guidelines on structure and qualification of general thoracic surgery

OBJECTIVE To update the recommendations for the structural characteristics of general thoracic surgery (GTS) in Europe in order to provide a document that can be used as a guide for harmonizing the general thoracic surgical practice in Europe. METHODS A task force was created to set the structural, procedural and qualification characteristics of a European GTS unit. These criteria were endorsed by the Executive Committee of the European Society of Thoracic Surgeons and by the Thoracic Domain of the European Association for Cardio-Thoracic Surgery and were validated by the European Board of Thoracic Surgery at European Union of Medical Specialists. RESULTS Criteria regarding definition and scope of GTS, structure and qualification of GTS unit, training and education and recommendations for subjects of particular interest (lung transplant, oesophageal surgery, minimally invasive thoracic surgery, quality surveillance) were developed. CONCLUSIONS This document will hopefully represent the first step of a process of revision of the modern thoracic surgeons' curricula, which need to be qualitatively rethought in the setting of the qualification process. The structural criteria highlighted in the present document are meant to help and tackle the challenge of cultural and language barriers as well as of widely varying national training programme

Asteroid (16) Psyche’s primordial shape: A possible Jacobi ellipsoid

Context. Asteroid (16) Psyche is the largest M-type asteroid in the main belt and the target of the NASA Psyche mission. It is also the only asteroid of this size (D >  200 km) known to be metal rich. Although various hypotheses have been proposed to explain the rather unique physical properties of this asteroid, a perfect understanding of its formation and bulk composition is still missing. Aims. We aim to refine the shape and bulk density of (16) Psyche and to perform a thorough analysis of its shape to better constrain possible formation scenarios and the structure of its interior. Methods. We obtained disk-resolved VLT/SPHERE/ZIMPOL images acquired within our ESO large program (ID 199.C-0074), which complement similar data obtained in 2018. Both data sets offer a complete coverage of Psyche’s surface. These images were used to reconstruct the three-dimensional (3D) shape of Psyche with two independent shape modeling algorithms (MPCD and ADAM). A shape analysis was subsequently performed, including a comparison with equilibrium figures and the identification of mass deficit regions. Results. Our 3D shape along with existing mass estimates imply a density of 4.20  ±  0.60 g cm−3, which is so far the highest for a solar system object following the four telluric planets. Furthermore, the shape of Psyche presents small deviations from an ellipsoid, that is, prominently three large depressions along its equator. The flatness and density of Psyche are compatible with a formation at hydrostatic equilibrium as a Jacobi ellipsoid with a shorter rotation period of ∼3h. Later impacts may have slowed down Psyche’s rotation, which is currently ∼4.2 h, while also creating the imaged depressions. Conclusions. Our results open the possibility that Psyche acquired its primordial shape either after a giant impact while its interior was already frozen or while its interior was still molten owing to the decay of the short-lived radionuclide 26Al.Based on observations collected at the European Organisation for Astronomical Research in the Southern Hemisphere under ESO programme 199.C-0074 (principal investigator: P. Vernazza). P. Vernazza, A. Drouard, M. Ferrais and B. Carry were supported by CNRS/INSU/PNP. J.H. and J.D. were supported by grant 18-09470S of the Czech Science Foundation and by the Charles University Research Programme no. UNCE/SCI/023. E.J. is F.R.S.-FNRS Senior Research Associate. The work of TSR was carried out through grant APOSTD/2019/046 by Generalitat Valenciana (Spain). This work was supported by the MINECO (Spanish Ministry of Economy) through grant RTI2018-095076-B-C21 (MINECO/FEDER, UE)

Binary asteroid (31) Euphrosyne: ice-rich and nearly spherical

Aims. Asteroid (31) Euphrosyne is one of the biggest objects in the asteroid main belt and it is also the largest member of its namesake family. The Euphrosyne family occupies a highly inclined region in the outer main belt and contains a remarkably large number of members, which is interpreted as an outcome of a disruptive cratering event. Methods. The goals of this adaptive-optics imaging study are threefold: to characterize the shape of Euphrosyne, to constrain its density, and to search for the large craters that may be associated with the family formation event. Results. We obtained disk-resolved images of Euphrosyne using SPHERE/ZIMPOL at the ESO 8.2 m VLT as part of our large program (ID: 199.C-0074, PI: Vernazza). We reconstructed its 3D shape via the ADAM shape modeling algorithm based on the SPHERE images and the available light curves of this asteroid. We analyzed the dynamics of the satellite with the Genoid meta-heuristic algorithm. Finally, we studied the shape of Euphrosyne using hydrostatic equilibrium models. Conclusions. Our SPHERE observations show that Euphrosyne has a nearly spherical shape with the sphericity index of 0.9888 and its surface lacks large impact craters. Euphrosyne’s diameter is 268 ± 6 km, making it one of the top ten largest main belt asteroids. We detected a satellite of Euphrosyne – S/2019 (31) 1 – that is about 4 km across, on a circular orbit. The mass determined from the orbit of the satellite together with the volume computed from the shape model imply a density of 1665 ± 242 kg m−3, suggesting that Euphrosyne probably contains a large fraction of water ice in its interior. We find that the spherical shape of Euphrosyne is a result of the reaccumulation process following the impact, as in the case of (10) Hygiea. However, our shape analysis reveals that, contrary to Hygiea, the axis ratios of Euphrosyne significantly differ from those suggested by fluid hydrostatic equilibrium following reaccumulation.This work has been supported by the Czech Science Foundation through grant 18-09470S (J. Hanuš, O. Chrenko, P. Ševeček) and by the Charles University Research program No. UNCE/SCI/023. M.B. was supported by the Czech Science Foundation grant 18-04514J. Computational resources were supplied by the Ministry of Education, Youth and Sports of the Czech Republic under the projects CESNET (LM2015042) and IT4Innovations National Supercomputing Centre (LM2015070). P. Vernazza, A. Drouard, M. Ferrais and B. Carry were supported by CNRS/INSU/PNP. M.M. was supported by the National Aeronautics and Space Administration under grant No. 80NSSC18K0849 issued through the Planetary Astronomy Program. The work of TSR was carried out through grant APOSTD/2019/046 by Generalitat Valenciana (Spain). This work was supported by the MINECO (Spanish Ministry of Economy) through grant RTI2018-095076-B-C21 (MINECO/FEDER, UE). The research leading to these results has received funding from the ARC grant for Concerted Research Actions, financed by the Wallonia-Brussels Federation. TRAPPIST is a project funded by the Belgian Fonds (National) de la Recherche Scientifique (F.R.S.-FNRS) under grant FRFC 2.5.594.09.F. TRAPPIST-North is a project funded by the Université de Liège, and performed in collaboration with Cadi Ayyad University of Marrakesh. E. Jehin is a FNRS Senior Research Associate