337 research outputs found
Failure Analysis of a Reactor after Explosion Accident
AbstractBurst of a reactor occurred in an explosion accident during the production of antistatic agent process. According to the results of site survey, the current regulations and standards as well as the requirements of the accident investigation group, the reason of burst was discussed by failure analysis of the shell and bolts. The shell strength was analyzed by visual inspection, thickness measurement, and strength verification as well as estimating of bursting pressure. It can be concluded that the tank strength met the requirements of design condition. The bolts of the reactor was broken in the accident, so the failure analysis of bolts was carried out in detail, including visual inspection, fracture examination, chemical composition analysis, mechanical testing and strength verification. According to the results of the measured mechanical properties, the strength of the bolts was verified. It can be concluded that the bolts could bear the proof pressure test safely. Fracture analysis shows that no obvious metallurgical defects were found, the bolts were broken due to extreme overload. According to the technical analysis of the shell and the bolts, it can be concluded that the reactor could service safely under normal operating conditions. The cause of the bursting was transient extreme overpressure
Investigation of bonded hydrogen defects in nanocrystalline diamond films grown with nitrogen/methane/hydrogen plasma at high power conditions
In this work, we investigate the influence of some growth parameters such as high microwave power ranging from 3.0 to 4.0 kW and N2 additive on the incorporation of bonded hydrogen defects in nanocrystalline diamond (NCD) films grown through a small amount of pure N2 addition into conventional 4% CH4/H2 plasma using a 5 kW microwave plasma CVD system. Incorporation form and content of hydrogen point defects in the NCD films produced with pure N2 addition was analyzed by employing Fourier-transform infrared (FTIR) spectroscopy for the first time. A large amount of hydrogen related defects was detected in all the produced NCD films with N2 additive ranging from 29 to 87 ”m thick with grain size from 47 nm to 31 nm. Furthermore, a specific new H related sharp absorption peak appears in all the NCD films grown with pure N2/CH4/H2 plasma at high powers and becomes stronger at powers higher than 3.0 kW and is even stronger than the 2920 cmâ1 peak, which is commonly found in CVD diamond films. Based on these experimental findings, the role of high power and pure nitrogen addition on the growth of NCD films including hydrogen defect formation is analyzed and discussed
proBDNF inhibits the proliferation and migration of OLN-93 oligodendrocytes
In contrast with mature brainâderived neurotrophic factor (mBDNF), proBDNF induces cell apoptosis. However, the function of proBDNF in oligodendrocytes remains unclear. In the present study, the OLNâ93 oligodendroglia cell line was utilized as an in vitro model to analyse the functions of proBDNF in oligodendroglia. p75NTR, sortilin and proBDNF were expressed in cultured OLNâ93 cells. It was indicated that proBDNF inhibited OLNâ93 cell proliferation in a doseâdependent manner as determined using the MTT assay and BrdU staining. Furthermore, proBDNF suppressed the migration of OLNâ93 cells as demonstrated using the scratch assay. proBDNF also decreased cell viability and promoted apoptosis as indicated by activated cysteineâaspartic acid proteaseâ3 (caspaseâ3) immunocytochemistry. Notably, antiâproBDNF treatment neutralized the effect of proBDNF and resulted in increased cell proliferation and migration and decreased apoptosis. However, these effects were not observed in the presence of recombinant p75NTR extracellular domainâhuman FC fusion protein and p75NTR antibody, indicating that proBDNF imparts its inhibitory effects on oligodendrocytes through the p75NTR signal pathway.Shen Liu, Wei Guo, Hengxing Zhou, Liang Tang, Shiqing Feng, Jin-Hua Zhong, and Xi- Fu Zho
Effects of Exogenous Cellulase Source on In Vitro Fermentation Characteristics and Methane Production of Crop Straws and Grasses
In vitro fermentation experiments were conducted to investigate the effects of 3 sources of
exogenous cellulase products (EC) at 4 dose rates (DR) (0, 12, 37 and 62 IU/g of DM) on degradation
of forage and methane production by mixed rumen micro-organisms of goats. The maximum gas
production (Vf) of grasses was higher (P<0.001) in Neocallimastix patriciarum (NP) group than those in
Trichoderma reesei (TR) and Trichoderma longibrachiatum (TL) groups. Quadratic increases in dry
matter degradation (DMD) of forage and neutral detergent fiber (NDFD) of straw were observed for all
EC, with optimum DR in the low range. Supplementation of EC originated from TR and NP increased
(P<0.001) DMD of forage compared to that from TL. Addition of EC originated from TR and NP also
decreased pH value, ammonia nitrogen (NH3-N) and methane (CH4) production compared to that from
TL. Quadratic decreases in pH value, NH3-N and CH4 of forage were noted for EC of TR and NP, and
with optimum DR in the low range. For short chain fatty acid, the EC of NP increased total volatile
fatty acid (TVFA) and acetate concentration and the ratio of acetate to propionate of forage compared
with EC of TL and TR, and with optimum DR in the low to medium range. It was concluded that the
source of EC differed in fiber degradation and methane emission, and with optimum DR of TR in the
low range (from 12 to 37 U/g DM) in improving fiber degradation and decreasing methane emission
Array-based sequencing of filaggrin gene for comprehensive detection of disease-associated variants
The filaggrin gene (FLG) is essential for skin differentiation and epidermal barrier formation. FLG loss-of-function (LoF) variants are associated with ichthyosis vulgaris and the major genetic risk factor for developing atopic dermatitis (AD).1, 2, 3 Genetic stratification of patients with AD according to FLG LoF risk is a common practice for both research and clinical studies; however, few studies comprehensively sequence the entire FLG coding region. Most studies that include FLG genotyping have screened for common predominant LoF variants to report allele frequencies after full Sanger sequencing of a smaller batch of test patient samples or previously published data. This strategy potentially results in underreporting of the genetic contribution especially in ethnicities where FLG LoF variants are highly diverse.4 Distinct LoF variants have been reported for most ethnicities studied to date. For example, 2 predominant sequence variants (p.R501X and c.2282del4) make up approximately 80% of the mutation burden in northern Europeans,5 whereas in East Asian ethnicities, a larger FLG LoF mutation spectrum is found with fewer predominating variants.6, 7 However, routinely Sanger sequencing the entire FLG coding region for large cohorts is not always feasible, although desirable as it is essential to correctly stratify patients. To address this, we developed a robust and cost-effective high-throughput PCR-based method for analyzing the entire coding region of FLG using Fluidigm microfluidics technology and next-generation sequencing (NGS). We have applied this method to fully resequence cohorts of Chinese, Malay, and Indian patients with AD from the Singaporean population.ASTAR (Agency for Sci., Tech. and Research, Sâpore)Published versio
Spin injection into a ballistic semiconductor microstructure
A theory of spin injection across a ballistic
ferromagnet-semiconductor-ferromagnet junction is developed for the Boltzmann
regime. Spin injection coefficient is suppressed by the Sharvin
resistance of the semiconductor , where is the
Fermi-surface cross-section. It competes with the diffusion resistances of the
ferromagnets , and in the absence of contact
barriers. Efficient spin injection can be ensured by contact barriers. Explicit
formulae for the junction resistance and the spin-valve effect are presented.Comment: 5 pages, 2 column REVTeX. Explicit prescription relating the results
of the ballistic and diffusive theories of spin injection is added. To this
end, some notations are changed. Three references added, typos correcte
On a free boundary problem for a two-species weak competition system
[[abstract]]We study a LotkaâVolterra type weak competition model with a free boundary in a one-dimensional habitat. The main objective is to understand the asymptotic behavior of two competing species spreading via a free boundary. We also provide some sufficient conditions for spreading success and spreading failure, respectively. Finally, when spreading successfully, we provide an estimate to show that the spreading speed (if exists) cannot be faster than the minimal speed of traveling wavefront solutions for the competition model on the whole real line without a free boundary.[[incitationindex]]SCI[[booktype]]çŽæŹ[[booktype]]é»ć
Partial Wave Analysis of
BES data on are presented. The
contribution peaks strongly near threshold. It is fitted with a
broad resonance with mass MeV, width MeV. A broad resonance peaking at 2020 MeV is also required
with width MeV. There is further evidence for a component
peaking at 2.55 GeV. The non- contribution is close to phase
space; it peaks at 2.6 GeV and is very different from .Comment: 15 pages, 6 figures, 1 table, Submitted to PL
Body-centered-cubic Ni and its magnetic properties
The body-centered-cubic (bec) phase of Ni, which does not exist in nature, has been achieved as a thin film on GaAs(001) at 170 K via molecular beam epitaxy. The bec Ni is ferromagnetic with a Curie temperature of 456 K and possesses a magnetic moment of 0.52 \uc2\ub1 0.08 \uce\ubcB/atom. The cubic magneto-crystalline anisotropy of bec Ni is determined to be +4.0 \uc3\u97 105 ergs \uc2\ub7 cm-3, as opposed to -5.7 \uc3\u97 10 4 ergs \uc2\ub7 cm-3 for the naturally occurring face-centered-cubic (fcc) Ni. This sharp contrast in the magnetic anisotropy is attributed to the different electronic band structures between bec Ni and fcc Ni, which are determined using angle-resolved photoemission with synchrotron radiation
Measurement of the Atmospheric Muon Spectrum from 20 to 3000 GeV
The absolute muon flux between 20 GeV and 3000 GeV is measured with the L3
magnetic muon spectrometer for zenith angles ranging from 0 degree to 58
degree. Due to the large exposure of about 150 m2 sr d, and the excellent
momentum resolution of the L3 muon chambers, a precision of 2.3 % at 150 GeV in
the vertical direction is achieved.
The ratio of positive to negative muons is studied between 20 GeV and 500
GeV, and the average vertical muon charge ratio is found to be 1.285 +- 0.003
(stat.) +- 0.019 (syst.).Comment: Total 32 pages, 9Figure
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