THEORETICAL ANALYSIS OF QUASI-STATIC COMPRESSION OF HEXAGONAL RING

This paper presents a study on the load-compression and energy absorption characteristics of a laterally crushed across faces of hexagonal ring with constraints on expansion perpendicular to the loading axis. The theoretical analysis in compression across faces is developed using Equivalent Structure Technique. Experimental observations are compared with theoretical analyses and good agreements are seen

Comparison of equations for the calculation of LDL-cholesterol in hospitalized patients

BACKGROUND : The Friedewald equation is widely used to calculate LDL-C for cardiovascular risk prediction but is less accurate with comorbidities and extreme lipid values. Several novel formulae have been reported to outperform the Friedewald formula. METHODS : We examined 14,219 lipid profiles and evaluated four formulae (Friedewald, Chen, de Cordova, Hattori) and compared these to direct measurement of LDL-C across various triglyceride (TG), total cholesterol (TC) and HDL-cholesterol (HDL-C) ranges using Beckman reagents and instruments. Linear regression and ROC analysis were performed. RESULTS : The de Cordova formula showed a high correlation with directly measured LDL-C (r= 0.90, P b 0.001), comparable to the Friedewald calculated values for directly measured LDL-C (r = 0.95, P b 0.001). The de Cordova formula was favorable in some ranges of HDL, TC and the lowest TG range (r = 0.97, P b 0.001) but performed least well in comparison with the three other LDL-C calculations (AUC=0.8331), demonstrating inconsistent bias. The Chen formula performed better than Friedewald (AUC = 0.9049). The Hattori formula outperformed all formulae including Friedewald over various ranges of lipid values (AUC= 0.9097). CONCLUSIONS : We observe favorable correlations of the de Cordova formula with Friedewald at low TG values. However, the Hattori formula appears to be best for application in hospitalized patients, even at extreme lipid values.http://www.elsevier.com/locate/clinchim2016-04-30hb201

THE RELATIONSHIP OF SOPPENG WITH OTHER REGIONS BETWEEN 17TH AND 19TH CENTURIES BASED ON GRAVE DATA AT JERA LOMPOE

Jaringan budaya kerajaan Soppeng pra-Islam telah dibahas oleh beberapa peneliti sehingga kita memiliki gambaran yang luas tentang periode tersebut. Pada periode Islam, pemahaman kita tentang jaringan budaya kerajaan Soppeng masih terbatas, terutama dalam perspektif arkeologi. Artikel ini akan fokus pada diskusi tentang jaringan budaya kerajaan Soppeng berdasarkan data kubur Jera Lompoe, dengan titik berat analisis pada nisan kubur. Data sekunder berupa hasil kajian sejarah akan mendukung analisis arkeologi. Hasil penelitian menunjukan bahwa ada lima informasi tentang jaringan budaya kerajaan Soppeng abad ke-17 hingga abad ke-19, yaitu: (a) nisan Aceh tipe K, (b) nisan tipe hulu keris dan mahkota, (c) nisan tipe pedang, (d) makam duta kerajaan Sidenreng dan Pajung Luwu, dan (e) makam We Adang, istri salah seorang Raja Bone. Luasnya jaringan budaya kerajaan Soppeng pada abad ke-17 hingga ke-19 menjadi petunjuk tentang peran pentingnya dalam historiografi Sulawesi Selatan dan keikutsertaannya dalam trend penggunaan nisan kubur se-Nusantara.Hubungan Kerajaan Soppeng pra-Islam dengan wilayah lain telah dibahas oleh beberapa peneliti sehingga kita memiliki gambaran yang luas tentang periode tersebut. Pada periode Islam, pemahaman kita tentang hubungan budaya Kerajaan Soppeng masih terbatas, terutama dalam perspektif arkeologi. Artikel ini akan fokus pada diskusi tentang hubungan budaya Kerajaan Soppeng berdasarkan data kubur Jera Lompoe, dengan titik analisis pada nisan kubur. Metode yang digunakan adalah survei dan analisis tipe nisan. Data sekunder berupa hasil kajian sejarah akan menguatkan hasil analisis arkeologi. Hasil penelitian menunjukan bahwa ada lima informasi tentang hubungan budaya Kerajaan Soppeng abad ke-17 hingga abad ke-19 berdasarkan data kubur , yaitu: (a) nisan Aceh tipe K, (b) nisan tipe hulu keris dan mahkota, (c) nisan tipe pedang, (d) makam duta Kerajaan Sidenreng dan Pajung Luwu, dan (e) makam We Adang, istri salah seorang Raja Bone. Luasnya hubungan budaya Kerajaan Soppeng pada abad ke-17 hingga ke-19 menjadi petunjuk tentang peran pentingnya dalam historiografi Sulawesi Selatan dan keikutsertaannya dalam kecenderungan penggunaan nisan kubur se-Nusantara     The relationship of the pre-Islamic Soppeng Kingdom with other regions has been discussed by several researchers, adding new data to this period. In the Islamic period, the observations of the cultural relations Soppeng had previously had were highly limited, especially from an archaeological perspective. This article presents conclusion drawn from grave data analysis of Jera Lompoe, gravestone being the core of analyses. Primary data were gathered through gravestone surveys; while secondary data were taken from related studies. The study indicates 5 findings: (a) Aceh type K, (b) keris hilt and crown type, (c) sword-type, (d) the tomb of the ambassadors of the Kingdom of Sidenreng and Pajung Luwu, and (e) the grave of We Adang, the wife of one of the Kings of Bone. The influential roles of Soppeng were apparent in the 17th and19th centurie

A review on nanocellulosic fibres as new material for sustainable packaging: process an applications

The demand for exploring advanced and eco-friendly sustainable packaging materials with superior physical, mechanical and barrier properties is increasing. The materials that are currently used in packaging for food, beverage, medical and pharmaceutical products, as well as in industrial applications, are non-degradable, and thus, these materials are raising environmental pollution concerns. Numerous studies have been conducted on the utilization of bio-based materials in the pursuit of developing sustainable packaging materials. Although significant improvements have been achieved, a balance among environmental concerns, economic considerations and product packaging performance is still lacking. This is likely due to bio-based materials being used in product packaging applications without a proper design. The present review article intends to summarize the information regarding the potential applications of cellulosic nanofiber for the packaging. The importance of the design process, its principles and the challenges of design process for sustainable packaging are also summarized in this review. Overall it can be concluded that scientists, designers and engineers all are necessarily required to contribute towards research in order to commercially exploit cellulose nanofiber for sustainable packaging

Morphological segmentation analysis and texture-based support vector machines classification on mice liver fibrosis microscopic images

Background To reduce the intensity of the work of doctors, pre-classification work needs to be issued. In this paper, a novel and related liver microscopic image classification analysis method is proposed. Objective For quantitative analysis, segmentation is carried out to extract the quantitative information of special organisms in the image for further diagnosis, lesion localization, learning and treating anatomical abnormalities and computer-guided surgery. Methods in the current work, entropy based features of microscopic fibrosis mice’ liver images were analyzed using fuzzy c-cluster, k-means and watershed algorithms based on distance transformations and gradient. A morphological segmentation based on a local threshold was deployed to determine the fibrosis areas of images. Results the segmented target region using the proposed method achieved high effective microscopy fibrosis images segmenting of mice liver in terms of the running time, dice ratio and precision. The image classification experiments were conducted using Gray Level Co-occurrence Matrix (GLCM). The best classification model derived from the established characteristics was GLCM which performed the highest accuracy of classification using a developed Support Vector Machine (SVM). The training model using 11 features was found to be as accurate when only trained by 8 GLCMs. Conclusion The research illustrated the proposed method is a new feasible research approach for microscopy mice liver image segmentation and classification using intelligent image analysis techniques. It is also reported that the average computational time of the proposed approach was only 2.335 seconds, which outperformed other segmentation algorithms with 0.8125 dice ratio and 0.5253 precision

Spatial, temporal, and demographic patterns in prevalence of smoking tobacco use and attributable disease burden in 204 countries and territories, 1990-2019 : a systematic analysis from the Global Burden of Disease Study 2019

Background Ending the global tobacco epidemic is a defining challenge in global health. Timely and comprehensive estimates of the prevalence of smoking tobacco use and attributable disease burden are needed to guide tobacco control efforts nationally and globally. Methods We estimated the prevalence of smoking tobacco use and attributable disease burden for 204 countries and territories, by age and sex, from 1990 to 2019 as part of the Global Burden of Diseases, Injuries, and Risk Factors Study. We modelled multiple smoking-related indicators from 3625 nationally representative surveys. We completed systematic reviews and did Bayesian meta-regressions for 36 causally linked health outcomes to estimate non-linear dose-response risk curves for current and former smokers. We used a direct estimation approach to estimate attributable burden, providing more comprehensive estimates of the health effects of smoking than previously available. Findings Globally in 2019, 1.14 billion (95% uncertainty interval 1.13-1.16) individuals were current smokers, who consumed 7.41 trillion (7.11-7.74) cigarette-equivalents of tobacco in 2019. Although prevalence of smoking had decreased significantly since 1990 among both males (27.5% [26. 5-28.5] reduction) and females (37.7% [35.4-39.9] reduction) aged 15 years and older, population growth has led to a significant increase in the total number of smokers from 0.99 billion (0.98-1.00) in 1990. Globally in 2019, smoking tobacco use accounted for 7.69 million (7.16-8.20) deaths and 200 million (185-214) disability-adjusted life-years, and was the leading risk factor for death among males (20.2% [19.3-21.1] of male deaths). 6.68 million [86.9%] of 7.69 million deaths attributable to smoking tobacco use were among current smokers. Interpretation In the absence of intervention, the annual toll of 7.69 million deaths and 200 million disability-adjusted life-years attributable to smoking will increase over the coming decades. Substantial progress in reducing the prevalence of smoking tobacco use has been observed in countries from all regions and at all stages of development, but a large implementation gap remains for tobacco control. Countries have a dear and urgent opportunity to pass strong, evidence-based policies to accelerate reductions in the prevalence of smoking and reap massive health benefits for their citizens. Copyright (C) 2021 The Author(s). Published by Elsevier Ltd.Peer reviewe

Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950–2019: a comprehensive demographic analysis for the Global Burden of Disease Study 2019

Background: Accurate and up-to-date assessment of demographic metrics is crucial for understanding a wide range of social, economic, and public health issues that affect populations worldwide. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 produced updated and comprehensive demographic assessments of the key indicators of fertility, mortality, migration, and population for 204 countries and territories and selected subnational locations from 1950 to 2019. Methods: 8078 country-years of vital registration and sample registration data, 938 surveys, 349 censuses, and 238 other sources were identified and used to estimate age-specific fertility. Spatiotemporal Gaussian process regression (ST-GPR) was used to generate age-specific fertility rates for 5-year age groups between ages 15 and 49 years. With extensions to age groups 10–14 and 50–54 years, the total fertility rate (TFR) was then aggregated using the estimated age-specific fertility between ages 10 and 54 years. 7417 sources were used for under-5 mortality estimation and 7355 for adult mortality. ST-GPR was used to synthesise data sources after correction for known biases. Adult mortality was measured as the probability of death between ages 15 and 60 years based on vital registration, sample registration, and sibling histories, and was also estimated using ST-GPR. HIV-free life tables were then estimated using estimates of under-5 and adult mortality rates using a relational model life table system created for GBD, which closely tracks observed age-specific mortality rates from complete vital registration when available. Independent estimates of HIV-specific mortality generated by an epidemiological analysis of HIV prevalence surveys and antenatal clinic serosurveillance and other sources were incorporated into the estimates in countries with large epidemics. Annual and single-year age estimates of net migration and population for each country and territory were generated using a Bayesian hierarchical cohort component model that analysed estimated age-specific fertility and mortality rates along with 1250 censuses and 747 population registry years. We classified location-years into seven categories on the basis of the natural rate of increase in population (calculated by subtracting the crude death rate from the crude birth rate) and the net migration rate. We computed healthy life expectancy (HALE) using years lived with disability (YLDs) per capita, life tables, and standard demographic methods. Uncertainty was propagated throughout the demographic estimation process, including fertility, mortality, and population, with 1000 draw-level estimates produced for each metric. Findings: The global TFR decreased from 2•72 (95% uncertainty interval [UI] 2•66–2•79) in 2000 to 2•31 (2•17–2•46) in 2019. Global annual livebirths increased from 134•5 million (131•5–137•8) in 2000 to a peak of 139•6 million (133•0–146•9) in 2016. Global livebirths then declined to 135•3 million (127•2–144•1) in 2019. Of the 204 countries and territories included in this study, in 2019, 102 had a TFR lower than 2•1, which is considered a good approximation of replacement-level fertility. All countries in sub-Saharan Africa had TFRs above replacement level in 2019 and accounted for 27•1% (95% UI 26•4–27•8) of global livebirths. Global life expectancy at birth increased from 67•2 years (95% UI 66•8–67•6) in 2000 to 73•5 years (72•8–74•3) in 2019. The total number of deaths increased from 50•7 million (49•5–51•9) in 2000 to 56•5 million (53•7–59•2) in 2019. Under-5 deaths declined from 9•6 million (9•1–10•3) in 2000 to 5•0 million (4•3–6•0) in 2019. Global population increased by 25•7%, from 6•2 billion (6•0–6•3) in 2000 to 7•7 billion (7•5–8•0) in 2019. In 2019, 34 countries had negative natural rates of increase; in 17 of these, the population declined because immigration was not sufficient to counteract the negative rate of decline. Globally, HALE increased from 58•6 years (56•1–60•8) in 2000 to 63•5 years (60•8–66•1) in 2019. HALE increased in 202 of 204 countries and territories between 2000 and 2019. Interpretation: Over the past 20 years, fertility rates have been dropping steadily and life expectancy has been increasing, with few exceptions. Much of this change follows historical patterns linking social and economic determinants, such as those captured by the GBD Socio-demographic Index, with demographic outcomes. More recently, several countries have experienced a combination of low fertility and stagnating improvement in mortality rates, pushing more populations into the late stages of the demographic transition. Tracking demographic change and the emergence of new patterns will be essential for global health monitoring. Funding: Bill & Melinda Gates Foundation. © 2020 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 licens

Global burden of 87 risk factors in 204 countries and territories, 1990�2019: a systematic analysis for the Global Burden of Disease Study 2019

Background: Rigorous analysis of levels and trends in exposure to leading risk factors and quantification of their effect on human health are important to identify where public health is making progress and in which cases current efforts are inadequate. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 provides a standardised and comprehensive assessment of the magnitude of risk factor exposure, relative risk, and attributable burden of disease. Methods: GBD 2019 estimated attributable mortality, years of life lost (YLLs), years of life lived with disability (YLDs), and disability-adjusted life-years (DALYs) for 87 risk factors and combinations of risk factors, at the global level, regionally, and for 204 countries and territories. GBD uses a hierarchical list of risk factors so that specific risk factors (eg, sodium intake), and related aggregates (eg, diet quality), are both evaluated. This method has six analytical steps. (1) We included 560 risk�outcome pairs that met criteria for convincing or probable evidence on the basis of research studies. 12 risk�outcome pairs included in GBD 2017 no longer met inclusion criteria and 47 risk�outcome pairs for risks already included in GBD 2017 were added based on new evidence. (2) Relative risks were estimated as a function of exposure based on published systematic reviews, 81 systematic reviews done for GBD 2019, and meta-regression. (3) Levels of exposure in each age-sex-location-year included in the study were estimated based on all available data sources using spatiotemporal Gaussian process regression, DisMod-MR 2.1, a Bayesian meta-regression method, or alternative methods. (4) We determined, from published trials or cohort studies, the level of exposure associated with minimum risk, called the theoretical minimum risk exposure level. (5) Attributable deaths, YLLs, YLDs, and DALYs were computed by multiplying population attributable fractions (PAFs) by the relevant outcome quantity for each age-sex-location-year. (6) PAFs and attributable burden for combinations of risk factors were estimated taking into account mediation of different risk factors through other risk factors. Across all six analytical steps, 30 652 distinct data sources were used in the analysis. Uncertainty in each step of the analysis was propagated into the final estimates of attributable burden. Exposure levels for dichotomous, polytomous, and continuous risk factors were summarised with use of the summary exposure value to facilitate comparisons over time, across location, and across risks. Because the entire time series from 1990 to 2019 has been re-estimated with use of consistent data and methods, these results supersede previously published GBD estimates of attributable burden. Findings: The largest declines in risk exposure from 2010 to 2019 were among a set of risks that are strongly linked to social and economic development, including household air pollution; unsafe water, sanitation, and handwashing; and child growth failure. Global declines also occurred for tobacco smoking and lead exposure. The largest increases in risk exposure were for ambient particulate matter pollution, drug use, high fasting plasma glucose, and high body-mass index. In 2019, the leading Level 2 risk factor globally for attributable deaths was high systolic blood pressure, which accounted for 10·8 million (95 uncertainty interval UI 9·51�12·1) deaths (19·2% 16·9�21·3 of all deaths in 2019), followed by tobacco (smoked, second-hand, and chewing), which accounted for 8·71 million (8·12�9·31) deaths (15·4% 14·6�16·2 of all deaths in 2019). The leading Level 2 risk factor for attributable DALYs globally in 2019 was child and maternal malnutrition, which largely affects health in the youngest age groups and accounted for 295 million (253�350) DALYs (11·6% 10·3�13·1 of all global DALYs that year). The risk factor burden varied considerably in 2019 between age groups and locations. Among children aged 0�9 years, the three leading detailed risk factors for attributable DALYs were all related to malnutrition. Iron deficiency was the leading risk factor for those aged 10�24 years, alcohol use for those aged 25�49 years, and high systolic blood pressure for those aged 50�74 years and 75 years and older. Interpretation: Overall, the record for reducing exposure to harmful risks over the past three decades is poor. Success with reducing smoking and lead exposure through regulatory policy might point the way for a stronger role for public policy on other risks in addition to continued efforts to provide information on risk factor harm to the general public. Funding: Bill & Melinda Gates Foundation. © 2020 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 licens

Sistem maklumat geografi (GIS) dan sektor kesihatan awam: kajian demam denggi di Bandar Baru Bangi dan Kajang

Sektor Kesihatan Awam dikenalpasti pada peringkat antarabangsa sebagai salah satu aplikasi baru dalam teknologi geografi. GIS dilihat sebagai memiliki keupayaan untuk memperbaiki kesihatan penduduk dan menyumbang kepada pembangunan polisi, pelaksanaan, dan kajian dalam kesihatan awam. Pertubuhan Kesihatan Sedunia (WHO) menyatakan bahawa GIS adalah amat bernilai di dalam mengumpulkan (compilation) dan mempersembahkan data pada peringkat kebangsaan dan wilayah, terutamanya data alam sekitar dan data yang berkaitan dengan kesan penggunaan perkhidmatan kesihatan. Sistem Maklumat Geografi (GIS) secara umumnya berperanan di dalam mengumpul, menyimpan, menganalisis, memanipulasi, dan memaparkan semula maklumat mengikut kehendak pengguna berdasarkan kepada tujuan dan objektif data dan maklumat itu dibentuk. Artikel ini adalah untuk melihat keupayaan GIS dalam Sektor Kesihatan Awam melalui kajian penyakit demam denggi di Bandar Baru Bangi dan Kajang. Analisis reruang (spatial) yang berkaitan dengan penyakit ini terutamanya dari sudut demografi dan persekitaran digunakan. Hasil analisis reruang ini mendapati bahawa tiada perbezaan taburan kes denggi antara tahun 1999 dan 2000, lokaliti denggi dapat dikenalpasti dengan tepat, hubungan antara satu kes dengan kes lain dapat divisualisasi dengan mudah dan penentuan kawasan berisiko tinggi untuk kes denggi bagi tujuan kawalan jangkamasa panjang dapat ditentukan

Sediment control interventions and river flow dynamics: impact on sediment entry into the large canals

At Marala barrage, two canals, i.e. Marala Ravi Link Canal (MRLC) and Upper Chenab Canal (UCC) off-take from left side of the River Chenab. MRLC has a very old history of experiencing sedimentation issues. Several attempts have been made to counterfoil or minimize this problem in the recent past. Two remarkable measures are the remodeling of MRLC in 2000-2001 (in-tervention-1) and the shifting of the confluence point of a heavily sediment-laden upstream tributary of the Chenab River by construction of a spur dike in 2004 (intervention-2). This paper investigates the effectiveness of these structural interventions as sedimentation control measures. The baseline period is selected from 1997 to 2000 and the impact is analyzed for two post-intervention time steps, i.e. evaluation period-1 ranging from 2001 to 2004 and evaluation period-2 from 2005 to 2011. Results obtained from double mass analysis revealed that sediment load increased by 33 and 8 % due to intervention-1, while decreased by 12 and 22 % due to intervention-2 in MRLC and UCC, respectively. The results suggest that monsoon floods are mainly responsible for sediment loading in the canals (66 % for UCC and 73 % for MRLC), supported by the finding that effective discharge (1900 m3 s-1) is almost twice the mean annual river discharge. The discharge classes between 900 and 2900 m3 s- 1 are mainly responsible for major proportion (89 % in MRLC and 86 % in UCC) of the total sediment load over the 15-year study period. The intervention-1 could not minimize the sediment entry into the canals; rather it aggravated the situation. The intervention-2, however, proved a useful structural measure in this regard