59 research outputs found
Time Scales in Spectator Fragmentation
Proton-proton correlations and correlations of p-alpha, d-alpha, and t-alpha
from spectator decays following Au + Au collisions at 1000 AMeV have been
measured with an highly efficient detector hodoscope. The constructed
correlation functions indicate a moderate expansion and low breakup densities
similar to assumptions made in statistical multifragmentation models. In
agreement with a volume breakup rather short time scales were deduced employing
directional cuts in proton-proton correlations.
PACS numbers: 25.70.Pq, 21.65.+f, 25.70.MnComment: 8 pages, with 5 included figures; To appear in the proceedings of the
CRIS 2000 conference; Also available from
http://www-kp3.gsi.de/www/kp3/aladin_publications.htm
Breakup Density in Spectator Fragmentation
Proton-proton correlations and correlations of protons, deuterons and tritons
with alpha particles from spectator decays following 197Au + 197Au collisions
at 1000 MeV per nucleon have been measured with two highly efficient detector
hodoscopes. The constructed correlation functions, interpreted within the
approximation of a simultaneous volume decay, indicate a moderate expansion and
low breakup densities, similar to assumptions made in statistical
multifragmentation models.
PACS numbers: 25.70.Pq, 21.65.+f, 25.70.Mn, 25.75.GzComment: 11 pages, LaTeX with 3 included figures; Also available from
http://www-kp3.gsi.de/www/kp3/aladin_publications.htm
Thermal and Chemical Freeze-out in Spectator Fragmentation
Isotope temperatures from double ratios of hydrogen, helium, lithium,
beryllium, and carbon isotopic yields, and excited-state temperatures from
yield ratios of particle-unstable resonances in 4He, 5Li, and 8Be, were
determined for spectator fragmentation, following collisions of 197Au with
targets ranging from C to Au at incident energies of 600 and 1000 MeV per
nucleon. A deviation of the isotopic from the excited-state temperatures is
observed which coincides with the transition from residue formation to
multi-fragment production, suggesting a chemical freeze-out prior to thermal
freeze-out in bulk disintegrations.Comment: 14 pages, 10 figures, submitted to Phys. Rev. C, small changes as
suggested by the editors and referee
Temperatures of Exploding Nuclei
Breakup temperatures in central collisions of 197Au + 197Au at bombarding
energies E/A = 50 to 200 MeV were determined with two methods. Isotope
temperatures, deduced from double ratios of hydrogen, helium, and lithium
isotopic yields, increase monotonically with bombarding energy from 5 MeV to 12
MeV, in qualitative agreement with a scenario of chemical freeze-out after
adiabatic expansion. Excited-state temperatures, derived from yield ratios of
states in 4He, 5Li, 6Li, and 8Be, are about 5 MeV, independent of the
projectile energy, and seem to reflect the internal temperature of fragments at
their final separation from the system.
PACS numbers: 25.70.Mn, 25.70.Pq, 25.75.-qComment: 10 pages, RevTeX with 4 included figures; Also available from
http://www-kp3.gsi.de/www/kp3/aladin_publications.htm
Transient integral boundary layer method to calculate the translesional pressure drop and the fractional flow reserve in myocardial bridges
BACKGROUND: The pressure drop – flow relations in myocardial bridges and the assessment of vascular heart disease via fractional flow reserve (FFR) have motivated many researchers the last decades. The aim of this study is to simulate several clinical conditions present in myocardial bridges to determine the flow reserve and consequently the clinical relevance of the disease. From a fluid mechanical point of view the pathophysiological situation in myocardial bridges involves fluid flow in a time dependent flow geometry, caused by contracting cardiac muscles overlying an intramural segment of the coronary artery. These flows mostly involve flow separation and secondary motions, which are difficult to calculate and analyse. METHODS: Because a three dimensional simulation of the haemodynamic conditions in myocardial bridges in a network of coronary arteries is time-consuming, we present a boundary layer model for the calculation of the pressure drop and flow separation. The approach is based on the assumption that the flow can be sufficiently well described by the interaction of an inviscid core and a viscous boundary layer. Under the assumption that the idealised flow through a constriction is given by near-equilibrium velocity profiles of the Falkner-Skan-Cooke (FSC) family, the evolution of the boundary layer is obtained by the simultaneous solution of the Falkner-Skan equation and the transient von-Kármán integral momentum equation. RESULTS: The model was used to investigate the relative importance of several physical parameters present in myocardial bridges. Results have been obtained for steady and unsteady flow through vessels with 0 – 85% diameter stenosis. We compare two clinical relevant cases of a myocardial bridge in the middle segment of the left anterior descending coronary artery (LAD). The pressure derived FFR of fixed and dynamic lesions has shown that the flow is less affected in the dynamic case, because the distal pressure partially recovers during re-opening of the vessel in diastole. We have further calculated the wall shear stress (WSS) distributions in addition to the location and length of the flow reversal zones in dependence on the severity of the disease. CONCLUSION: The described boundary layer method can be used to simulate frictional forces and wall shear stresses in the entrance region of vessels. Earlier models are supplemented by the viscous effects in a quasi three-dimensional vessel geometry with a prescribed wall motion. The results indicate that the translesional pressure drop and the mean FFR compares favourably to clinical findings in the literature. We have further shown that the mean FFR under the assumption of Hagen-Poiseuille flow is overestimated in developing flow conditions
Breakup Temperature of Target Spectators in Au + Au Collisions at E/A = 1000 MeV
Breakup temperatures were deduced from double ratios of isotope yields for
target spectators produced in the reaction Au + Au at 1000 MeV per nucleon.
Pairs of He and Li isotopes and pairs of He and H
isotopes (p, d and d, t) yield consistent temperatures after feeding
corrections, based on the quantum statistical model, are applied. The
temperatures rise with decreasing impact parameter from 4 MeV for peripheral to
about 10 MeV for the most central collisions.
The good agreement with the breakup temperatures measured previously for
projectile spectators at an incident energy of 600 MeV per nucleon confirms the
observed universality of the spectator decay at relativistic bombarding
energies. The measured temperatures also agree with the breakup temperatures
predicted by the statistical multifragmentation model. For these calculations a
relation between the initial excitation energy and mass was derived which gives
good simultaneous agreement for the fragment charge correlations.
The energy spectra of light charged particles, measured at =
150, exhibit Maxwellian shapes with inverse slope parameters much
higher than the breakup temperatures. The statistical multifragmentation model,
because Coulomb repulsion and sequential decay processes are included, yields
light-particle spectra with inverse slope parameters higher than the breakup
temperatures but considerably below the measured values. The systematic
behavior of the differences suggests that they are caused by
light-charged-particle emission prior to the final breakup stage.
PACS numbers: 25.70.Mn, 25.70.Pq, 25.75.-qComment: 29 pages, TeX with 11 included figures; Revised version accepted for
publication in Z. Phys. A Two additional figure
Could increased axial wall stress be responsible for the development of atheroma in the proximal segment of myocardial bridges?
<p>Abstract</p> <p>Background</p> <p>A recent model describing the mechanical interaction between a stenosis and the vessel wall has shown that axial wall stress can considerably increase in the region immediately proximal to the stenosis during the (forward) flow phases, so that abnormal biological processes and wall damages are likely to be induced in that region. Our objective was to examine what this model predicts when applied to myocardial bridges.</p> <p>Method</p> <p>The model was adapted to the hemodynamic particularities of myocardial bridges and used to estimate by means of a numerical example the cyclic increase in axial wall stress in the vessel segment proximal to the bridge. The consistence of the results with reported observations on the presence of atheroma in the proximal, tunneled, and distal vessel segments of bridged coronary arteries was also examined.</p> <p>Results</p> <p>1) Axial wall stress can markedly increase in the entrance region of the bridge during the cardiac cycle. 2) This is consistent with reported observations showing that this region is particularly prone to atherosclerosis.</p> <p>Conclusion</p> <p>The proposed mechanical explanation of atherosclerosis in bridged coronary arteries indicates that angioplasty and other similar interventions will not stop the development of atherosclerosis at the bridge entrance and in the proximal epicardial segment if the decrease of the lumen of the tunneled segment during systole is not considerably reduced.</p
Coronary artery calcium screening: current status and recommendations from the European Society of Cardiac Radiology and North American Society for Cardiovascular Imaging
Current guidelines and literature on screening for coronary artery calcium for cardiac risk assessment are reviewed for both general and special populations. It is shown that for both general and special populations a zero score excludes most clinically relevant coronary artery disease. The importance of standardization of coronary artery calcium measurements by multi-detector CT is discussed
New genetic loci link adipose and insulin biology to body fat distribution.
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms
- …