64 research outputs found
Is there consensus in defining childhood cerebral visual impairment? A systematic review of terminology and definitions
The childhood condition of visual difficulties caused by brain damage, commonly termed cortical or cerebral visual impairment (CVI), is well established but has no internationally accepted definition. Clarification of its core features is required to advance research and clinical practice. This systematic review aimed to identify the definitions of childhood CVI in the original scientific literature to describe and critically appraise a consensual definition of the condition. MEDLINE, EMBASE, PsychINFO, CINAHL and AMED databases were searched in January 2017. Studies were included if they (1) were published original research, (2) contained a childhood CVI sample, (3) contained a definition of CVI and (4) described their CVI identification/diagnostic method. Thematic analysis identified concepts within definitions and narrative synthesis was conducted. Of 1150 articles, 51 met inclusion criteria. Definitions were subdivided according to detail (descriptive definition, description not reaching definition status and diagnostic/operationalising criteria). Three themes concerning visual deficits, eye health and brain integrity were identified (each containing subthemes) and analysed individually across definitions. The most common themes were âvisual impairmentâ (n=20), âretrochiasmatic pathway damageâ(n=13) and ânormal/near normal eye healthâ (n=15). The most consensual definition identified here may not be the best quality for advancing our understanding of CVI. We argue for the alternative definition: CVI is a verifiable visual dysfunction which cannot be attributed to disorders of the anterior visual pathways or any potentially co-occurring ocular impairment. We propose reporting guidelines to permit comparison across studies and increase the evidence base for more reliable clinical assessment and diagnosis
Motherâinfant interactions with infants with congenital visual impairment and associations with longitudinal outcomes in cognition and language
Background:
This study investigated motherâinfant interactions, including maternal maintaining of infant attentional focus and sensitivity, with infants with congenital severe and profound visual impairment (VI) and the association with developmental trajectories from one to three years.
Method:
Fiftyâfive infants and mothers were videoârecorded playing together with a standard set of toys at Time 1 (T1) mean age 12.95 months (8.13â17.05 months). Maintain was categorized as the mother following and maintaining the childâs focus, and Sensitivity, the motherâs responsiveness and contingency to infant behaviour. Vision level was measured using the Near Detection Scale. Cognition and language were measured at T1, 12 months later (T2) and 24 months later (T3) using the ReynellâZinkin Scales.
Results:
Crossâsectional analyses showed that mothers of infants with severe VI (basic form vision) produced higher rates of Maintain compared to those with children with profound VI (light perception at best). Linear mixedâeffects models examining developmental progression from T1 to T3 (controlling for vision level) showed an average increase of 5 DQ points (CI 95%: 1.03â9.08) in verbal comprehension for higher Sensitivity. No significant findings were found for Maintain.
Conclusions:
The findings suggest that motherâinfant interactions (maternal Maintain) are associated with level of vision at infancy, but only maternal Sensitivity has a longâterm positive association with advances in verbal comprehension from infancy to about three years. They highlight the need for incorporating strategies related to parentâinfant interactions, including increased sensitivity, into early intervention for children with visual impairment
Perceptions of the appropriate response to norm violation in 57 societies
Norm enforcement may be important for resolving conflicts and promoting cooperation. However, little is known about how preferred responses to norm violations vary across cultures and across domains. In a preregistered study of 57 countries (using convenience samples of 22,863 students and non-students), we measured perceptions of the appropriateness of various responses to a violation of a cooperative norm and to atypical social behaviors. Our findings highlight both cultural universals and cultural variation. We find a universal negative relation between appropriateness ratings of norm violations and appropriateness ratings of responses in the form of confrontation, social ostracism and gossip. Moreover, we find the country variation in the appropriateness of sanctions to be consistent across different norm violations but not across different sanctions. Specifically, in those countries where use of physical confrontation and social ostracism is rated as less appropriate, gossip is rated as more appropriate.info:eu-repo/semantics/publishedVersio
Genetic Evidence Supporting the Association of Protease and Protease Inhibitor Genes with Inflammatory Bowel Disease: A Systematic Review
As part of the European research consortium IBDase, we addressed the role of proteases and protease inhibitors (P/PIs) in inflammatory bowel disease (IBD), characterized by chronic mucosal inflammation of the gastrointestinal tract, which affects 2.2 million people in Europe and 1.4 million people in North America. We systematically reviewed all published genetic studies on populations of European ancestry (67 studies on Crohn's disease [CD] and 37 studies on ulcerative colitis [UC]) to identify critical genomic regions associated with IBD. We developed a computer algorithm to map the 807 P/PI genes with exact genomic locations listed in the MEROPS database of peptidases onto these critical regions and to rank P/PI genes according to the accumulated evidence for their association with CD and UC. 82 P/PI genes (75 coding for proteases and 7 coding for protease inhibitors) were retained for CD based on the accumulated evidence. The cylindromatosis/turban tumor syndrome gene (CYLD) on chromosome 16 ranked highest, followed by acylaminoacyl-peptidase (APEH), dystroglycan (DAG1), macrophage-stimulating protein (MST1) and ubiquitin-specific peptidase 4 (USP4), all located on chromosome 3. For UC, 18 P/PI genes were retained (14 proteases and 4protease inhibitors), with a considerably lower amount of accumulated evidence. The ranking of P/PI genes as established in this systematic review is currently used to guide validation studies of candidate P/PI genes, and their functional characterization in interdisciplinary mechanistic studies in vitro and in vivo as part of IBDase. The approach used here overcomes some of the problems encountered when subjectively selecting genes for further evaluation and could be applied to any complex disease and gene family
Perceptions of the appropriate response to norm violation in 57 societies
An Author Correction to this article: DOI: 10.1038/s41467-021-22955-x.Norm enforcement may be important for resolving conflicts and promoting cooperation. However, little is known about how preferred responses to norm violations vary across cultures and across domains. In a preregistered study of 57 countries (using convenience samples of 22,863 students and non-students), we measured perceptions of the appropriateness of various responses to a violation of a cooperative norm and to atypical social behaviors. Our findings highlight both cultural universals and cultural variation. We find a universal negative relation between appropriateness ratings of norm violations and appropriateness ratings of responses in the form of confrontation, social ostracism and gossip. Moreover, we find the country variation in the appropriateness of sanctions to be consistent across different norm violations but not across different sanctions. Specifically, in those countries where use of physical confrontation and social ostracism is rated as less appropriate, gossip is rated as more appropriate.Peer reviewe
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Changes in social norms during the early stages of the COVID-19 pandemic across 43 countries
Data availability:
The data generated in this study have been deposited in the Open Science Framework (https://doi.org/10.17605/OSF.IO/STKFR). Non-experimental data included in our datasets (i.e., intensity of government response to COVID-19 is the Stringency Index, COVID-19 deaths and cases per million) are taken from the Oxford COVIDâ19 Government Response Tracker [22 Hale, T. et al. A global panel database of pandemic policies (Oxford COVIDâ19 Government Response Tracker). Nat. Human Behav. https://doi.org/10.1038/s41562-021-01079-8 (2021).] and Our World in Data [38 Ritchie, H. et al. Coronavirus Pandemic (COVID-19). Our World in Data. https://ourworldindata.org/coronavirus (2020).] (downloaded November 2020). Wave 0 data are from [3 Gelfand, M. J. et al. Differences between tight and loose cultures: a 33-nation study. Science 332, 1100â1104 (2011).[ and Wave 1 data are from [5 Eriksson, K. et al. Perceptions of the appropriate response to norm violation in 57 societies. Nat. Commun. 12, 1481 (2021).].Code availability:
The survey and analysis code are available at the Open Science Framework (https://doi.org/10.17605/OSF.IO/STKFR).Supplementary information is available online at: https://www.nature.com/articles/s41467-024-44999-5#Sec40 .The emergence of COVID-19 dramatically changed social behavior across societies and contexts. Here we study whether social norms also changed. Specifically, we study this question for cultural tightness (the degree to which societies generally have strong norms), specific social norms (e.g. stealing, hand washing), and norms about enforcement, using survey data from 30,431 respondents in 43 countries recorded before and in the early stages following the emergence of COVID-19. Using variation in disease intensity, we shed light on the mechanisms predicting changes in social norm measures. We find evidence that, after the emergence of the COVID-19 pandemic, hand washing norms increased while tightness and punishing frequency slightly decreased but observe no evidence for a robust change in most other norms. Thus, at least in the short term, our findings suggest that cultures are largely stable to pandemic threats except in those norms, hand washing in this case, that are perceived to be directly relevant to dealing with the collective threat.Knut and Wallenberg Grant âHow do human norms form and change?â 2016.0167. (G.An.). The Swedish Research Council grant âNorms & Risk: Do social norms help dealing with collective threatsâ 2021-06271 (G.An.). Ministero dellâIstruzione dellâUniversitĂ e della Ricerca, PRIN 2017, prot. 20178TRM3F (D.B.). Universidad de Los Andes, Fondo VicerrectorĂa de Investigaciones (J.-C.C.). Ministry of Innovation and Technology of Hungary, National Research, Development and Innovation Fund NKFIH-OTKA K135963 (M.F.). Grant 23-061770âS of the Czech Science Foundation (M.H. and S.G.). RVO: 68081740 of the Institute of Psychology, Czech Academy of Sciences (M.H. and S.G.). RA Science Committee, research project N.20TTSH-070 (A.Gr. and N.Khac.). Open University of Israel, 511687 (R.N.). HSE University Basic Research Program (E.O.). Project BASIC (PID2022-141802NB-I00) funded by MCIN/AEI/10.13039/501100011033 and by âERDF A way of making Europeâ (A.SĂĄ.). US Army Research Office Grant W911NF-19-1-910281 (B.S.). Netherlands Organisation for Scientific Research, 019.183SG.001 (E.S.). Netherlands Organisation for Scientific Research, VI.Veni.201âG.013 (E.S.). European Commission, Horizon 2020-ID 870827 (E.S.). UKRI Grant âSecret Powerâ No. EP/X02170X/1 awarded under the European Commissionâs âEuropean Research Council - STGâ Scheme (G.A.T.)
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Anger and disgust shape judgments of social sanctions across cultures, especially in high individual autonomy societies
Data availability;
The datasets analyzed during the current study are available in the Center for Open Science repository, https://osf.io/djnfg/.Supplementary Information is available online at: https://link.springer.com/article/10.1038/s41598-024-55815-x#Sec17 .When someone violates a social norm, others may think that some sanction would be appropriate. We examine how the experience of emotions like anger and disgust relate to the judged appropriateness of sanctions, in a pre-registered analysis of data from a large-scale study in 56 societies. Across the world, we find that individuals who experience anger and disgust over a norm violation are more likely to endorse confrontation, ostracism and, to a smaller extent, gossip. Moreover, we find that the experience of anger is consistently the strongest predictor of judgments of confrontation, compared to other emotions. Although the link between state-based emotions and judgments may seem universal, its strength varies across countries. Aligned with theoretical predictions, this link is stronger in societies, and among individuals, that place higher value on individual autonomy. Thus, autonomy values may increase the role that emotions play in guiding judgments of social sanctions.This research was funded by the Swedish Foundation for Humanities and Social Sciences (Riksbankens Jubileumsfond) [P17-0030:1]. The contribution of J.W was supported by CAS Youth Innovation Promotion Association and fundings from the Institute of Psychology, Chinese Academy of Sciences (Y5CX052003 and E2CX3315CX). The contributions of M.H and S.G. for the Czech part of research was supported by a Grant 23-061770S of the Czech Science Foundation and by RVO: 68081740 of the Institute of Psychology, Czech Academy of Sciences. Open access funding provided by Linköping University
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