Precision of maxillo-mandibular registration with intraoral scanners in vitro

Purpose: To compare the precision of maxillo-mandibular registration and resulting full arch occlusion produced by three intraoral scanners in vitro. Methods: Six dental models (groups A–F) were scanned five times with intraoral scanners (CEREC, TRIOS, PLANMECA), producing both full arch and two buccal maxillo-mandibular scans. Total surface area of contact points (defined as regions within 0.1 mm and all mesh penetrations) was measured, and the distances between four pairs of key points were compared, each two in the posterior and anterior. Results: Total surface area of contact points varied significantly among scanners across all groups. CEREC produced the smallest contact surface areas (5.7–25.3 mm2), while PLANMECA tended to produce the largest areas in each group (22.2–60.2 mm2). Precision of scanners, as measured by the 95% CI range, varied from 0.1–0.9 mm for posterior key points. For anterior key points the 95% CI range was smaller, particularly when multiple posterior teeth were still present (0.04–0.42 mm). With progressive loss of posterior units (groups D–F), differences in the anterior occlusion among scanners became significant in five out of six groups (D–F left canines and D, F right canines, p < 0.05). Conclusions: Maxillo-mandibular registrations from three intraoral scanners created significantly different surface areas of occlusal contact. Posterior occlusions revealed lower precision for all scanners than anterior. CEREC tended towards incorrect posterior open bites, whilst TRIOS was most consistent in reproducing occluding units

Female visibility/representation in Saudi Arabia : a critical multimodal/discourse analysis of the 2013 IKEA catalogue and press discourses on Saudi Arabia

PhD ThesisThis study examines gender representation in Saudi Arabia using combined approaches of Multimodal Social Semiotics (MSS) and Critical Discourse Studies (CDS). The thesis conducts a critical analysis of both advertisements and media discourses. The former focuses on verbal and visual analysis of the 2013 IKEA catalogue (in Arabic and English), and the latter pertains to the verbal and visual discourse of ‘Western’ newspapers’ portrayal of Saudi Arabia in their coverage of this particular catalogue issue, i.e. removal of female images from the Saudi version. The aim of this study is to investigate both the discursive practices in the catalogue and in the press coverage so as to deconstruct the issue of female visibility in Saudi Arabia and how publication of the catalogue would provide a suitable discursive opportunity for stereotypical representation of Saudi Arabia as the ‘Other’. Two overarching questions guide the analysis in the thesis: (1) how were females represented in the 2013 Arabic IKEA catalogue, which was distributed in Saudi Arabia? (2) How do the examined newspapers discursively represent the social actors when reporting the exclusion of females? In light of these questions, the thesis undertakes a twofold analysis. The first is a verbal linguistic analysis of both the catalogue in Arabic and the news reports covering the issue. The subject of analysis for the linguistic representation of males and females in the Arabic version of the catalogue mainly examines the masculine and feminine forms in morphosyntactic categories, in order to determine the audience in the language used by the catalogue. A qualitative data analysis software tool, MAXQDA, is used to obtain accurate results that describe the frequencies of the examined variables. In terms of media discourse, approaches from CDS are utilized to analyze the discursive representation of the social groups involved. Following CDS notions of Self and Other representation (KhosraviNik 2015), the subject matter of this research involves examining how stereotypes of Self and Other, in terms of gender equality in Saudi Arabia, may have been applied by IKEA and in subsequent coverage of the perceived problem. Analytical tools from the Discourse Historical approach, Sociocognitive approach and Socio-semantic approach are incorporated in the analytical design to answer the research questions. The second part of the twofold analysis for this study is a visual analysis of the UK and Saudi editions of the 2013 IKEA catalogue as well as the images accompanying the news reports, based on the Multimodal Social Semiotic approach, mainly drawing on Kress and van Leeuwen’s Visual Grammar (1996, 2006). More specifically, the visual representation of social ii actors in the IKEA catalogues is examined in terms of how the social actors are positioned in the visual representation as well as the ways they would be related to the prospective viewer. Therefore, CDS tools are utilized to study lexical and grammatical choices in language while the visual characteristics are deconstructed through Multimodal tools. The findings reveal a sharp contrast between the textual and visual representations of females in the catalogues. Females are linguistically visible within the Saudi edition but are visually excluded, which revealed IKEA’s linguistic sexism. Conversely, linguistic and visual representations in the newspapers complement each other and reveal the ways in which news sources construct Saudi Arabia in the context of women’s rights, as certain negative themes associated with Saudi Arabia emerge, e.g. ‘backwardness’ and ‘the oppression of women’s rights’. The analysis further reveals that women’s rights is a common discourse in this context, with a tendency to be accompanied by discourses that perpetuate stereotypes of Saudi women being ‘oppressed’ and ‘invisible’. Such representations are inherently linked to a wider critique of Orientalism and negative Other representation of Islam in the mainstream ‘Western’ discourses on Saudi Arabia

Cell-Instructive Surface Gradients of Photoresponsive Amyloid-like Fibrils

[Image: see text] Gradients of bioactive molecules play a crucial role in various biological processes like vascularization, tissue regeneration, or cell migration. To study these complex biological systems, it is necessary to control the concentration of bioactive molecules on their substrates. Here, we created a photochemical strategy to generate gradients using amyloid-like fibrils as scaffolds functionalized with a model epitope, that is, the integrin-binding peptide RGD, to modulate cell adhesion. The self-assembling β-sheet forming peptide (CKFKFQF) was connected to the RGD epitope via a photosensitive nitrobenzyl linker and assembled into photoresponsive nanofibrils. The fibrils were spray-coated on glass substrates and macroscopic gradients were generated by UV-light over a centimeter-scale. We confirmed the gradient formation using matrix-assisted laser desorption ionization mass spectroscopy imaging (MALDI-MSI), which directly visualizes the molecular species on the surface. The RGD gradient was used to instruct cells. In consequence, A549 adapted their adhesion properties in dependence of the RGD-epitope density

Concept of a Self-Learning Workplace Cell for Worker Assistance While Collaboration with a Robot Within the Self-Adapting-Production-Planning-System

For some time, the focus of past research on industrial workplace designs has been the optimization of processes from the technological point of view. Since human workers have to work within this environment the design process must regard Human Factor needs. The operators are under additional stress due to the range of high dynamic processes and due to the integration of robots and autonomous operating machines. There have been few studies on how Human Factors influence the design of workplaces for Human-Robot Collaboration (HRC). Furthermore, a comprehensive, systematic and human-centred design solution for industrial workplaces particularly considering Human Factor needs within HRC is widely uncertain and a specific application with reference to production workplaces is missing. The research findings described in this paper aim the optimization of workplaces for manual production and maintenance processes with respect to the workers within HRC. In order to increase the acceptance of integration of human-robot teams, the concept of the Assisting-Industrial-Workplace-System (AIWS) was developed. As a flexible hybrid cell for HRC integrated into a Self-Adapting-Production-Planning-System (SAPPS) assists the worker while interaction

High Temperature Dynamic Pressure Measurements Using Silicon Carbide Pressure Sensors

Un-cooled, MEMS-based silicon carbide (SiC) static pressure sensors were used for the first time to measure pressure perturbations at temperatures as high as 600 C during laboratory characterization, and subsequently evaluated in a combustor rig operated under various engine conditions to extract the frequencies that are associated with thermoacoustic instabilities. One SiC sensor was placed directly in the flow stream of the combustor rig while a benchmark commercial water-cooled piezoceramic dynamic pressure transducer was co-located axially but kept some distance away from the hot flow stream. In the combustor rig test, the SiC sensor detected thermoacoustic instabilities across a range of engine operating conditions, amplitude magnitude as low as 0.5 psi at 585 C, in good agreement with the benchmark piezoceramic sensor. The SiC sensor experienced low signal to noise ratio at higher temperature, primarily due to the fact that it was a static sensor with low sensitivity

Arthropod diversity in pure oak forests of coppice origin in northern Thrace (Turkey)

Oak (Quercus spp.) forests are among the most important forest types in Turkey. In the past, oak forests were managed through coppice clear-cutting, but in recent decades they have mostly been converted to high forest. This study was aimed at explaining how arthropod diversity is affected during conversion from coppice to high oak forest and during the early stages of coppice succession. We tested the hypothesis that arthropod richness, abundance and diversity in coppice oak sites varied according to stand age and a number of other forest characteristics. Arthropod communities were sampled in 50 plots using four different methods: pitfall traps, sweep nets, sticky cards and cloth shaking. A total of 13 084 individuals were collected and classified into 193 Recognizable Taxonomic Units (RTUs), with the most RTUs and the greatest number of specimens captured by sweep netting. We identified 17 taxa within RTU’s with more than 1% of the captured arthropods, which constituted 75% of the total specimens. The number of RTUs varied significantly according to trap type. Arthropod richness and Shannon-Wiener biodiversity index (H′) increased with elevation and precipitation. In young (1-40 yrs-old) and middle-aged (41-80 yrs) stands, arthropod biodiversity was not significantly affected by stand type, but slightly increased with diameter at breast height and tree height. Forest characteristics, such as the litter layer, understory and crown diameter, weakly influenced arthropod richness and abundance. Cluster analysis revealed that stand types and trap types differed taxonomically. Principal component analysis showed that stand types were clearly separated by the stand parameters measured. Insect families (Formicidae, Thripidae, Lygaeidae, Dolichopodidae, Luaxanidae, Cicadellidae and Ichneumonidae) could potentially be used as indicators of coppice oak conditions. As the coppice oak changes to mature forest, further studies are needed to better assess the relation between arthropods, forest types and structural characteristics of stands

Erratum to: ‘Early prediction of acute kidney injury after transapical and transaortic aortic valve implantation with urinary G1 cell cycle arrest biomarkers’

Background: Acute kidney injury (AKI) is a common complication following transcatheter aortic valve implantation (TAVI) leading to increased mortality and morbidity. Urinary G1 cell cycle arrest proteins TIMP-2 and IGFBP7 have recently been suggested as sensitive biomarkers for early detection of AKI in critically ill patients. However, the precise role of urinary TIMP-2 and IGFBP7 in patients undergoing TAVI is unknown. Methods: In a prospective observational trial, 40 patients undergoing TAVI (either transaortic or transapical) were enrolled. Serial measurements of TIMP-2 and IGFBP7 were performed in the early post interventional course. The primary clinical endpoint was the occurrence of AKI stage 2/3 according to the KDIGO classification. Results: Now we show, that ROC analyses of [TIMP-2]*[IGFBP7] on day one after TAVI reveals a sensitivity of 100 % and a specificity of 90 % for predicting AKI 2/3 (AUC 0.971, 95 % CI 0.914-1.0, SE 0.0299, p = 0.001, cut-off 1.03). In contrast, preoperative and postoperative serum creatinine levels as well as glomerular filtration rate (GFR) and perioperative change in GFR did not show any association with the development of AKI. Furthermore, [TIMP2]*[IGFBP7] remained stable in patients with AKI = 1, but its levels increased significantly as early as 24 h after TAVI in patients who developed AKI 2/3 in the further course (4.77 +/- 3.21 vs. 0.48 +/- 0.68, p = 0.022). Mean patients age was 81.2 +/- 5.6 years, 16 patients were male (40.0 %). 35 patients underwent transapical and five patients transaortic TAVI. 15 patients (37.5 %) developed any kind of AKI;eight patients (20 %) met the primary endpoint and seven patients required renal replacement therapy (RRT) within 72 h after surgery. Conclusion: Early elevation of urinary cell cycle arrest biomarkers after TAVI is associated with the development of postoperative AKI. [TIMP-2]*[ IGFBP7] provides an excellent diagnostic accuracy in the prediction of AKI that is superior to that of serum creatinine

Point-of-care testing for disasters: needs assessment, strategic planning, and future design.

Objective evidence-based national surveys serve as a first step in identifying suitable point-of-care device designs, effective test clusters, and environmental operating conditions. Preliminary survey results show the need for point-of-care testing (POCT) devices using test clusters that specifically detect pathogens found in disaster scenarios. Hurricane Katrina, the tsunami in southeast Asia, and the current influenza pandemic (H1N1, "swine flu") vividly illustrate lack of national and global preparedness. Gap analysis of current POCT devices versus survey results reveals how POCT needs can be fulfilled. Future thinking will help avoid the worst consequences of disasters on the horizon, such as extensively drug-resistant tuberculosis and pandemic influenzas. A global effort must be made to improve POC technologies to rapidly diagnose and treat patients to improve triaging, on-site decision making, and, ultimately, economic and medical outcomes

Multi-objective topology optimisation for acoustic porous materials using gradient-based, gradient-free, and hybrid strategies

When designing passive sound-attenuation structures, one of the challenging problems that arise is optimally distributing acoustic porous materials within a design region so as to maximise sound absorption while minimising material usage. To identify efficient optimisation strategies for this multi-objective problem, several gradient, non-gradient, and hybrid topology optimisation strategies are compared. For gradient approaches, the solid-isotropic-material-with-penalisation method and a gradient-based constructive heuristic are considered. For gradient-free approaches, hill climbing with a weighted-sum scalarisation and a non-dominated sorting genetic algorithm-II are considered. Optimisation trials are conducted on seven benchmark problems involving rectangular design domains in impedance tubes subject to normal-incidence sound loads. The results indicate that while gradient methods can provide quick convergence with high-quality solutions, often gradient-free strategies are able to find improvements in specific regions of the Pareto front. Two hybrid approaches are proposed, combining a gradient method for initiation and a non-gradient method for local improvements. An effective Pareto-slope-based weighted-sum hill climbing is introduced for local improvement. Results reveal that for a given computational budget, the hybrid methods can consistently outperform the parent gradient or non-gradient method

Marginal adaptation of ceramic and composite inlays in minimally invasive mod cavities

Objectives: This study aims to evaluate the effect of a minimally invasive mesial-occlusal-distal (mod) preparation on the marginal adaptation of ceramic and composite inlays with the aim of saving sound dental substance. Materials and methods: Class II mod cavities were prepared in 50 extracted human molars and randomly allocated to five groups (n = 10). In all groups, the mesial-proximal box margins were located in the dentin, 1mm below the cementoenamel junction (CEJ), while the distal box margins were 1mm above the CEJ. In groups A and B, conventional standard preparations with a divergent angle of α = 6° were prepared. In groups C, D, and E, minimally invasive standard preparations with a convergent angle of α = 10° were prepared. In groups A and D, composite inlays and, in groups B and C, ceramic inlays were fabricated (chairside economical restoration of esthetic ceramics (CEREC)) and adhesively inserted. In group E, a direct composite filling using the incremental technique was placed. Replicas were taken before and after thermomechanical loading (1,200,000cycles, 50/5°C, max. load 49N). Marginal integrity (tooth-luting composite, luting composite-inlay) was evaluated by scanning electron microscopy (×200). The percentage of continuous margins in the different locations was compared between and within groups before and after cycling, using ANOVA and Scheffé post hoc test. Results: After the thermomechanical loading, no significant differences were observed between the different groups with respect to the interface of luting composite-inlay. At the interface of tooth-luting composite for preparations involving the dentin, groups A and B behaved significantly better compared to the control group E, which in turn were not different to groups C and D. Conclusion: Composite and ceramic inlays inserted in minimally invasive prepared mod cavities result in margins not different from those of inlays placed in conventional mod preparations. Direct composite filling margins, however, were inferior to those attained by conventional indirect restorations. Clinical relevance: Minimally invasive preparations for mod inlays with undercuts show marginal adaptation equal to that of conventional inlay preparation design