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52 research outputs found

Typography| Its development and its use as a means of expression

Author: Swan Harold J.
Publication venue: University of Montana, Maureen and Mike Mansfield Library
Publication date: 01/01/1929
Field of study

Association of genetic variants of the histamine H1 and muscarinic M3 receptors with BMI and HbA1c values in patients on antipsychotic medication

Rationale: Antipsychotic affinity for the histamine H1 receptor and the muscarinic M3 receptor have been associated with the side effects weight gain, and development of diabetes, respectively. Objectives: We investigated polymorphisms of the histamine H1 (HRH1) and muscarinic acetylcholine receptor M3 (CHRM3) receptor genes for an association with body mass index (BMI) and glycated hemoglobin (HbA1c). Methods: We included 430 Caucasian patients with a non-affective psychotic disorder using antipsychotics for at least 3 months. Primary endpoints of the study were cross-sectionally measured BMI and HbA1c; secondary endpoints were obesity and hyperglycaemia. Two single-nucleotide polymorphisms (SNPs) in the HRH1 gene, rs346074 and rs346070, and one SNP in the CHRM3 gene, rs3738435, were genotyped. Our primary hypothesis in this study was an interaction between genotype on BMI and antipsychotic affinity for the H1 and M3 receptor. Results: A significant association of interaction between haplotype rs346074-rs346070 and BMI (p value 0.025) and obesity (p value 0.005) in patients using high-H1 affinity antipsychotics versus patients using low-H1 affinity antipsychotics was found. There was no association of CHRM3 gene variant rs3738435 with BMI, and we observed no association with HbA1c or hyperglycaemia in any of the variants. Conclusions: This study, for the first time, demonstrates a significant association between HRH1 variants and BMI in patients with a psychotic disorder using antipsychotics. In future, genotyping of HRH1 variants may help predicting weight gain in patients using antipsychotics

Crossref

Proceedings - University of Groningen

University of Groningen

Springer - Publisher Connector

ARTS repository - University of Groningen

PubMed Central

Erasmus University Digital Repository

Dissertations of the University of Groningen

Bioinorganic Chemistry of Alzheimer’s Disease

Author: Aagaard A.
Acharya M. R.
Adair J. C.
Adam-Vizi V.
Agaard A.
Agnati L. F.
Aisen P. S.
Al-Saleh I.
Alies B.
Alies B.
Altamura S.
Alzuet G.
Alzuet G.
Amaravadi R.
Ambjorn M.
Andrade L. G. M.
Andrews G. K.
Angeletti B.
Ankarcrona M.
Antonyuk S. V.
Apostolova M. D.
Arakawa M.
Arena G.
Armon C.
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Asmussen J. W.
Atamna H.
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Atamna H.
Atamna H.
Atamna H.
Atwood C. S.
Atwood C. S.
Atwood C. S.
Backstrom J. R.
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Badrick A. C.
Baillet A.
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Bao Q.
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Publication venue: 'American Chemical Society (ACS)'
Publication date: 01/01/2012
Field of study

Crossref

Online Research Database In Technology

New genetic loci link adipose and insulin biology to body fat distribution.

Author: Aalto Ville
Aasarød Knut
Abecasis Goncalo R
Abecasis Gonçalo
Absher Devin
Adair Linda S
Adam Martin
Adeyemo Adebowale
Ahlqvist Emma
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Ahola Aila
Ainali Chrysanthi
Akylbekova Ermeg
Ala-Korpela Mika
Alavere Helen
Albagha Omar M E
Albrecht Eva
Alen Markku
Alexander Myriam
Alhenc-Gelas François
Alizadeh Behrooz Z
Allison Matthew A
Alonso Nerea
Altshuler David
Ambite Jose Luis
Amin Najaf
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Artigas Maria Soler
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Barroso Ines
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Bataille Veronique
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Bonnet Fabrice
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Borecki Ingrid
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Bouatia-Naji Nabila
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Castano-Betancourt Martha
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Cavalieri Margherita
Cazier Jean-Baptiste
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Chakravarti Aravinda
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Chang Hsing-Yi
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Charchar Fadi J
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Chaturvedi Nish
Chen Constance
Chen Han
Chen Ida
Chen Jin
Chen Ming-Huei
Chen Wei
Chen Yii-Der Ida
Cheng Iona
Cheng Sulin
Chines Peter S
Cho Yoon Shin
Choi Murim
Chouraki Vincent
Christiansen Claus
Chu Audrey Y
Cimponeriu Dan
Ciullo Marina
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Clarke Robert
Claudi-Boehm Simone
Coassin Stefan
Cochran Barbara
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Collins Rory
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Cooper Cyrus
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Cooper Richard S
Coresh Josef
Cornelis Marilyn C
Corre Tanguy
Corsi Anna Maria
Couper David
Cousminer Diana L
Coviello Andrea D
Cox David
Crawford Dana
Crisponi Laura
Croteau-Chonka Damien C
Cucca Francesco
Cummings Steven R
Cupples Adrienne L
Cupples L Adrienne
Curhan Gary
d'Adamo Pio
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Dailiana Zoe
Danesh John
Danoy Patrick
Dastani Zari
Davies Gail
Daw E Warwick
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de Faire Ulf
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Deelen Joris
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Demirkan Ayse
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Dermitzakis Emmanouil T
Deshmukh Harshal
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Diemert Patrick
Dimas Antigone S
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Ding Jingzhong
Do Ron
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Doney Alex
Dong Yanbin
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Doumatey Ayo
Dreisbach Albert W
Drong Alexander W
Duggan David
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Durda Peter
Döring Angela
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Ebrahim Shah
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Egan Josephine
Ehret Georg
Eiriksdottir Gudny
Eisman John A
Eklund Niina
El Mokhtari NourEddine
Elks Cathy E
Ellinghaus David
Elliott Paul
Elosua Roberto
Emilsson Valur
Endlich Karlhans
Epstein Stephen E
Erbel Raimund
Erdmann Jeanette
Erdos Michael R
Eriksson Joel
Eriksson Johan
Eriksson Niclas
Eriksson Per
Ernst Florian
Esko Tonu
Esko Tõnu
Esko Tönu
Estrada Karol
Eury Elodie
Evangelou Evangelos
Evans Alun
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Eyheramendy Susana
Eyjolfsson Gudmundur Ingi
Fagerholm Emma
Falhammar Henrik
Fall Tove
Farrall Martin
Fauser Bart C J M
Fava Cristiano
Feenstra Bjarke
Fehrmann Rudolf
Feitosa Mary
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Ferrannini Ele
Ferrario Marco M
Ferreira Teresa
Ferreli Liana
Ferrières Jean
Ferrucci Luigi
Fischer Krista
Florez Jose C
Folkersen Lasse
Folsom Aaron R
Fontanillas Pierre
Ford Ian
Fornage Myriam
Foroud Tatiana
Forouhi Nita G
Forrester Terrence
Forsblom Carol
Foster Meredith C
Fowke Jay
Fowkes F Gerald R
Fowkes Gerard R
Fox Caroline S
Fox Ervin R
Franceschini Nora
Franco Oscar H
Franco-Cereceda Anders
Franke Andre
Franke Lude
Franks Paul W
Frants Rune
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Frayling Timothy M
Freedman Barry I
Freimer Nelson B
Freitag Daniel F
Friedrich Nele
Froguel Philippe
Frost Morten
Fuchsberger Christian
Galan Pilar
Ganesh Santhi K
Ganna Andrea
Gansevoort Ron T
Gao Xiaoyi
Garcia Melissa
Garcia-Giralt Natàlia
Garnaas Maija
Gasparini Paolo
Gauguier Dominique
Gaunt Tom R
Gautvik Kaare M
Geller Frank
Gharavi Ali G
Giedraitis Vilmantas
Gieger Christian
Gierman Hinco J
Gigante Bruna
Gill Geoffrey V
Giroux Sylvie
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Glazer Nicole
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Glenn Kim
Glorioso Nicola
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Go Min Jin
Godson Catherine
Goel Anuj
Goessling Wolfram
Golay Alain
Goldstein Benjamin A
Goltzman David
Gong Jian
González-Macías Jesús
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Goodarzi Mark O
Goodloe Robert
Gordin Daniel
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Gorski Mathias
Grabe Hans-Jörgen
Graff Misa
Grallert Harald
Grammer Tanja B
Gravito Martha L
Greenwood Celia M T
Grewal Jagvir
Grimsby Jonna
Grobbee Diederick E
Groop Leif
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Gross Myron
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Grundberg Elin
Grässler Jürgen
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Gu Tianwei
Guarrera Simonetta
Gudbjartsson Daniel F
Gudnason Villi
Gudnason Vilmundur
Guiducci Candace
Guo Qun
Guo Xiuqing
Gurdasani Deepti
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Gyllensten Ulf
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Hadjadj Samy
Hadley David
Haessler Jeff
Hager Jörg
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Haines Jonathan
Hall Alistair S
Hall Per
Hallan Stein
Haller Toomas
Hallmans Goran
Hallmans Göran
Hamsten Anders
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Hanson Robert L
Hardy Rebecca
Haritunians Talin
Harjutsalo Valma
Harris Tamara
Hartikainen Anna-Liisa
Hartman Catharina A
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Hassinen Maija
Hastie Nicholas D
Hastie Nick
Hattersley Andrew T
Haun Margot
Havulinna Aki S
Hayward Caroline
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He Bing
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Hedblad Bo
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Heikkilä Kauko
Heikkilä Outi
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Heliövaara Markku
Helmer Catherine
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Henderson Brian
Hengstenberg Christian
Henneman Peter
Hercberg Serge
Herder Christian
Hernandez Dena
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Herrera Lizbeth
Herzig Karl-Heinz
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Hietala Kustaa
Higashio Julia
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Hingorani Aroon
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Hivert Marie-France
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Hoffmann Wolfgang
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Homuth Georg
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Horikoshi Momoko
Hosseini Mohsen
Hottenga Jouke-Jan
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Howard Philip
Hsiung Chao Agnes
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Huang Jinyan
Hui Jennie
Humphries Steve E
Hundertmark Claudia
Hung Yi-Jen
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Hunt Steven C
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Hveem Kristian
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Igl Wilmar
Ikram M Arfan
Illig Thomas
Imboden Medea
Ingelsson Erik
Ingle Catherine
Ingvarsson Thorvaldur
Ioannidis John P A
Iribarren Carlos
Isaacs Aaron
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Islam Muhammad
Ittermann Till
Iwai Naoharu
Jackson Anne U
Jackson Rebecca
Jacobs Gunnar
Jafar Tazeen H
James Alan L
Jameson Karen A
Jang Yangsoo
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Jansen Hanneke
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Jarvelin Marjo-Riitta
Jeff Janina
Jenny Nancy
Johannsdottir Hrefna
Johansen Berit
Johansson Ingegerd
Johansson Åsa
Johnson Andrew
Johnson Louise
Johnson Paul C D
Johnson Toby
Jones Graeme
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Jousilahti Pekka
Ju Sung Yun
Jukema J Wouter
Jula Antti
Juliusdottir Thorhildur
Justice Anne E
Järvelin Marjo-Riitta
Jöckel Karl-Heinz
Kaakinen Marika
Kahali Bratati
Kalafati Ioanna-Panagiota
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Kaprio Jaakko
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Karjalainen Juha
Karlsson Magnus
Karpe Fredrik
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Kennedy Stephen H
Kessler Thorsten
Kestenbaum Bryan
Kesäniemi Antero
Ketkar Shamika
Kettunen Johannes
Keyzer Jules
Khaw Kay-Tee
Khusainova Rita
Khusnutdinova Elza
Kiel Douglas P
Kiess Wieland
Kilpeläinen Tuomas O
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Kim Ghi Su
Kim Hyo-Soo
Kim Hyung-Lae
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Kinnunen Leena
Kinra Sanjay
Kiryluk Krzysztof
Kita Yoshikuni
Kivimaki Mika
Kizer Jorge R
Klaric Irena Martinovic
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Klopp Norman
Kloppenburg Margreet
Knowles David
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Kocarnik Jonathan
Koenig Wolfgang
Koh Jung-Min
Kolcic Ivana
Koller Daniel L
Kollerits Barbara
Kollia Panagoula
Kolonel Laurence
Kolovou Genovefa
Komulainen Pirjo
Kong Augustine
Kooner Ishminder K
Kooner Jaspal
Kooperberg Charles
Koromila Theodora
Koudstaal Peter J
Kovacs Peter
Kraft Peter
Kraja Aldi T
Kramer Holly
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Krauss Ronald M
Krestyaninova Maria
Kretzler Matthias
Kristiansson Kati
Kroemer Heyo K
Kronenberg Florian
Kruk Marcin
Krämer Bernhard K
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Kulkarni Smita R
Kuller Lew
Kumar M J Kranthi
Kumari Meena
Kung Annie Wai Chee
Kutalik Zoltan
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Kuulasmaa Kari
Kuusisto Johanna
Kuznetsova Tatiana
Kwan Tony
Kytö Janne
Kyvik Kirsten O
Kähönen Mika
König Inke R
Körner Antje
Köttgen Anna
Laakso Markku
Laaksonen Marika
Laaksonen Reijo
Laan Maris
LaCroix Andrea
Lacroix Andrea Z
Ladenvall Claes
Ladouceur Martin
Lagou Vasiliki
Lahermo Päivi
Lahti Jari
Lai Sandra
Laisk Triin
Laitinen Jaana
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Lakka Timo A
Lambert Ann
Lamina Claudia
Langdahl Bente Lomholt
Langefeld Carl D
Langenberg Claudia
Langford Cordelia
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Lathrop Mark
Lauc Lovorka Barac
Launer Lenore
Laven Joop S E
Lawlor Debbie A
Lawrence Robert W
Le Marchand Loic
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Leander Karin
Lecoeur Cecile
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Lehtimäki Terho
Lehto Markku
Leo Paul J
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Leung Ping C
Levy Daniel
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Li Guo
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Li Xiaohui
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Lindström Jaana
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Ljunggren Östen
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Longstreth W T
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Lorentzon Mattias
Louwers Yvonne V
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Luan Jian'an
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Ludwig Barbara
Lumley Thomas
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Lundmark Per
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Lyssenko Valeriya
Lyytikainen Leo-Pekka
Lyytikäinen Leo-Pekka
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Macgregor Stuart
Mach François
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Maestroni Anna
Maestroni Silvia
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Mahajan Anubha
Malinowski Jennifer
Mangino Massimo
Mani K Radha
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Marongiu Mara
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Marullo Letizia
Masciullo Corrado
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Matise Tara
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Medina-Gómez Carolina
Medland Sarah E
Meduri Eshwar
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Meisinger Christa
Meitinger Thomas
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Melbye Mads
Mellström Dan
Melzer David
Mencej-Bedrac Simona
Meneton Pierre
Menni Cristina
Merger Sigrun
Meschia James F
Metspalu Andres
Metzger Marie
Meulenbelt Ingrid
Mihai Ioana
Mihailov Evelin
Miki Tetsuro
Milaneschi Yuri
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Miljkovic Iva
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Minelli Cosetta
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Murgia Federico
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Mägi Reedik
Mäkinen Ville-Petteri
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Müller-Nurasyid Martina
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Najjar Samer
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Nuotio Marja-Liisa
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O'Rahilly Stephen
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Oei Ling
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Ogihara Toshio
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Olafsson Isleifur
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Papamarkou Theodore
Parish Sarah
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Parkkonen Maija
Parsa Afshin
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Paré Guillaume
Pasko Dorota
Pastinen Tomi
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Peacock Munro
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Pennell Craig E
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Peralta Carmen A
Perola Markus
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Peters Ulrike
Petersen Ann-Kristin
Pettersson-Kymmer Ulrika
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Pihur Vasyl
Pirastu Mario
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Pols Huibert A P
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Porcu Eleonora
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Postma Dirkje S
Potter Simon
Pouta Anneli
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Prabhakaran Dorairajan
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Prior Sarah
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Prokopenko Inga
Province Michael
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Rayner Nigel W
Redline Susan
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Rehnberg Emil
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Renstrom Frida
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Rosengård-Bärlund Milla
Rosinger Silke
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Rotter Jerome I
Rousseau François
Roussel Ronan
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Räikkönen Katri
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Saraheimo Markku
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Sekowska Magdalena
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Sengupta Sebanti
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Seshadri Sudha
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Sharma Pankaj
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Shungin Dmitry
Sidore Carlo
Siegbahn Agneta
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Sinisalo Juha
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Sitlani Colleen M
Sivananthan Mohan
Sjögren Marketa
Skorpen Frank
Slaets Joris P
Slagboom P Eline
Small Kerrin
Small Kerrin S
Smit Johannes H
Smith Albert
Smith Erin N
Smith George Davey
Smith Jennifer A
Smith Nicholas L
Snider Harold
Snieder Harold
Soininen Pasi
Song Ci
Song Kijoung
Soranzo Nicole
Sorice Rossella
Soro-Paavonen Aino
Sovio Ulla
Spector Tim D
Spector Timothy D
Speliotes Elizabeth K
Spencer Kylee
Srinivasan Sathanur R
St Pourcain Beate
Stacey Simon N
Staessen Jan A
Stanèáková Alena
Stančáková Alena
Stark Klaus
Starr John M
Stathopoulou Maria G
Stavarachi Monica
Stefansson Kari
Steinle Nanette I
Steinthorsdottir Valgerdur
Stewart Alexandre F R
Stirrups Kathleen
Stolk Lisette
Stolk Ronald P
Strachan David P
Stracke Sylvia
Stram Daniel
Strauch Konstantin
Strawbridge Rona J
Streeten Elizabeth A
Stringham Heather M
Struchalin Maksim
Stumvoll Michael
Styrkarsdottir Unnur
Sulem Patrick
Sun Yan V
Sundström Johan
Surakka Ida
Surdulescu Gabriela
Svensson Olle
Swan Elizabeth J
Swertz Morris A
Swift Amy J
Syreeni Anna
Syvänen Ann-Christine
Sõber Siim
Söderlund Jenny
Tabara Yasuharu
Tai E Shyong
Taliun Daniel
Talmud Philippa J
Tammesoo Mar-Liis
Tan Sian-Tsung
Tanaka Toshiko
Tang Nelson L S
Tarnow Lise
Taylor Andrew
Taylor Kira
Tayo Bamidele
Tenesa Albert
Terzic Janos
Teslovich Tanya M
Teumer Alexander
Thelle Dag S
Thompson John R
Thorand Barbara
Thorgeirsson Gudmundur
Thorleifsson Gudmar
Thorn Lena M
Thornton-Wells Tricia
Thorsteinsdottir Unnur
Thun Gian-Andri
Tiirikainen Maarit
Tikkanen Emmi
Tikkanen Heikki
Timpson Nicholas
Timpson Nicholas J
Tin Adrienne
Tiret Laurence
Tobin Martin
Tobin Martin D
Toenjes Anke
Tolonen Nina
Tomaschitz Andreas
Tomaszewski Maciej
Toniolo Daniela
Townsend Raymond R
Tracy Russell P
Travers Mary E
Tregouet David-Alexandre
Treloar Susan A
Tremblay Angelo
Tremoli Elena
Tripathy Vikal
Troffa Chiara
Trompet Stella
Trummer Olivia
Tryggvadottir Laufey
Tryggvason Karl
Trégouët David-Alexandre
Tsaprouni Loukia
Tsoka Sophia
Tsui Kim
Tukiainen Taru
Tuomilehto Jaakko
Turner Stephen T
Tylavsky Frances A
Tyrer Jonathon
Tzoulaki Ioanna
Tönjes Anke
Uda Manuela
Ueshima Hirotsugu
Uh Hae-Won
Uiterwaal Cuno S P M
Uitterlinden Andre G
Uitterlinden André G
Ulivi Sheila
Ulivi Shelia
Umans Jason
Umemura Satoshi
Urreizti Roser
Uusitupa Matti
Vallejo Edgar E
van Dam Rob M
Van den Herik Evita G
van der Harst Pim
van der Klauw Melanie M
van der Schoot C Ellen
van der Schouw Yvonne T
van Duijn Cornelia
Van Duijn Cornelia
van Gils Carla H
van Gilst Wiek H
van Heemst Diana
Van Hul Wim
van Meurs Joyce B J
van Meurs Joyve B J
van Nierop Peter
van Oort Floor V A
van Pelt L Joost
van Schoor Natasja M
Van Vliet-Ostaptchouk Jana V
van Wingerden Sophie
van Wingerden Sophie W
Van Zuydam Natalie
Vandenput Liesbeth
Varga Tibor V
Vartiainen Erkki
Vasan Ramachandran S
Vedantam Sailaja
Veldre Gudrun
Verlaan Dominique
Vernon Smith Albert
Veronesi Giovanni
Verweij Niek
Verwoert Germaine
Verwoert Germaine C
Viigimaa Margus
Viikari Jorma
Vinay D G
Vineis Paolo
Vink Jacqueline M
Virtamo Jarmo
Visscher Peter M
Visser Jenny A
Vitart Veronique
Vohl Marie-Claude
Voight Benjamin F
Volcik Kelly A
Vollenweider Peter
Vonk Judith M
Voorhuis Marlies
Völker Uwe
Völzke Henry
Wadén Johan
Waeber Gerard
Waeber Gérard
Wagenknecht Lynne E
Waggott Daryl
Wagner Peter J
Wain Louise V
Wainwright Nicholas
Waite Lindsay L
Walker Mark
Wallace Leanne
Wallaschofski Henri
Wallentin Lars
Wang Hansong
Wang Jie Jin
Wang Thomas J
Wang Xiaoling
Wareham Nicholas
Wareham Nick J
Warrington Nicole M
Watanabe Richard M
Waterworth Dawn
Watkins Hugh
Weder Alan B
Weedon Michael N
Welch Ryan P
Wells George A
Wennauer Roman
Westra Harm-Jan
Wheeler Eleanor
Wheeler Heather E
Whincup Peter H
Whitfield John B
Wichmann H Erich
Wichmann H-Erich
Widen Elisabeth
Wiggins Kerri L
Wijmenga Cisca
Wijnands-van Gent Colette J M
Wild Philipp S
Wild Sarah H
Wilk Alicja
Wilkens Lynne
Willems Sara M
Willemsen Gonneke
Willemsvan-vanDijk Ko
Willenborg Christina
Willer Cristen J
Williams Frances M K
Williams Rasheeda
Williams Winfred W
Willner Dana
Wilsgaard Tom
Wilson James F
Wilson James G
Wilson Sarah
Wilson Scott G
Winkler Thomas
Witteman Jacqueline C
Witteman Jacqueline C M
Wojczynski Mary K
Wolffenbuttel Bruce H R
Wong Andrew
Wong Tien Y
Woo Jean
Wood Andrew R
Wood Andy
Workalemahu Tsegaselassie
Wright Alan F
Wu Chunyuan
Wu Joseph M W
Wu Ying
Würtz Peter
Xiao Su-Mei
Yajnik Chittaranjan S
Yang Jian
Yang Qiong
Yang Tsun-Po
Yao Jie
Yengo Loïc
Yerges-Armstrong Laura M
Young Alicia
Young Elizabeth H
Young J H
Young Lauren
Yuan Xin
Zaboli Ghazal
Zalloua Pierre A
Zarrabeitia María T
Zelenika Diana
Zemunik Tatijana
Zerbini Gianpaolo
Zgaga Lina
Zhai Guangju
Zhang Feng
Zhang Qunyuan
Zhang Weihua
Zhao Jing Hua
Zhao Wei
Zheng Hou-Feng
Zheng Wei
Zhou Yanhua
Zhu Haidong
Zhu Kun
Zhu Xiaofeng
Zhuang Wei V
Zhuang Wei Vivian
Ziegler Andreas
Zillikens M Carola
Zimmermann Martina E
Zitting Paavo
Zondervan Krina T
Zukowska-Szczechowska Ewa
Zygmunt Marek
Ärnlöv Johan
Österholm Anne-May
Publication venue: 'Springer Science and Business Media LLC'
Publication date: 01/01/2015
Field of study

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms

University of Groningen

HAL-Université de Bretagne Occidentale

Carolina Digital Repository

UNSWorks

White Rose Research Online

Online Research Database In Technology

University of Newcastle's Digital Repository

RD&E Research Repository

Proceedings - University of Groningen

Harvard University - DASH

PubMed Central

Cronfa at Swansea University