6 research outputs found
Canagliflozin and renal outcomes in type 2 diabetes and nephropathy
- Author
- A Kaldun Nossuli
- Aamir Jamal
- Adalbert Schiller
- Adam Cheifetz
- Adarsh Daswani
- Adeera Levin
- Adline Ghazi
- Adrian Guinsburg
- Adriana Cif
- Adriana Gabriela Onaca
- Adriana Ilavska
- Adriana Villarino
- Agarwal R.
- Agnieszka Starzec
- Ahmed Arif
- Ahmed Awad
- Aiping Yin
- Akimichi Asano
- Alan Jackson
- Alan McMahon
- Alan Perlman
- Alberto Di Carlo
- Alberto Esquenazi
- Alejandra Oviedo
- Alejandro Valdes Depeda
- Aleksandra Kendereski
- Alex Valenzuela
- Alexander Dreval
- Alexander Gonzalez
- Alexander Shinkov
- Alexander Turchin
- Alexandre Klein
- Alfonso Soto Gonzalez
- Alfred Penfornis
- Alfredo Chew Wong
- Alfredo Wassermann
- Ali Torshizi
- Alicia Chilito
- Alina Agafyina
- Alison Dawson
- Alva Hansraj
- Amer Al-Karadsheh
- Amorin Remus Popa
- Amrendra Kumar
- Amy Sprague
- Ana Limos
- Ana Maria Cusumano
- Ana Maria Elosegui
- Anabella Amigo
- Anatoliy Kazmirchuk
- Andrea Phillips
- Andrea Stella
- Andreas Maddux
- Andrej Dzupina
- Andres Alvarisqueta
- Andrew Johnson
- Andrew O'Shaughnessy
- Andrew Steele
- Andrian Yakov
- Andrzej Januszewicz
- Andrzej Madej
- Angelina Angelova
- Anibal Gastaldi
- Anil Gupta
- Anita Bhajan Manocha
- Anjanette Tan
- Anna Kaminska
- Anna Maria Veronelli
- Anna Strzelecka
- Anna Zateyshchikova
- Anselmo Bordonava
- Antanas Navickas
- Anthony Gunstone
- Anthony Roberts
- Antonio Ceriello
- Antonio Galan Serrano
- Antonio Scafuto Scotton
- Antonio Terrelonge
- Antônio Roberto Chacra
- Anupama Gowda
- Arjun D Sinha
- Armando Perez
- Ashot Mkrtumyan
- Atanas Koundurdjiev
- Augusto Vallejos
- Aurelian-Emil Ranetti
- Ayim Akyea-Djamson
- Aysha Badat
- Bakris G.
- Baldev Singh
- Barbara Greco
- Barbara Kaczmarek
- Barbara Rewerska
- Barry M Brenner
- Belia Martin Del Camp Blanco
- Bernard Zinman
- Bertrand Cariou
- Bertrand Dussol
- Bhasker Mehta
- Bhimavarapu Sudhakar
- Björn Paschen
- Bompoint S.
- Borys Mankovskyy
- Botond Csiky
- Boyan Nonchev
- Brenner B. M.
- Brett Kissela
- Brian Nichol
- Bruce Neal
- Bruce Trippe
- Bruno Geloneze Neto
- Bull S.
- Byung-Wan Lee
- C B Keshavamurthy
- Cannon C. P.
- Capuano G.
- Carlo Giorda
- Carlos Alberto Cuneo
- Carlos Arauz-Pacheco
- Carlos Barrera
- Carlos Perez
- Carmel Hawley
- Carmen Crisan
- Carol Pollock
- Carolyn Droste
- Caroucel Chuateco
- Caryl David
- Cecilia Garcia Ballesteros
- Cecilia Jimeno
- Celso Amodeo
- Cesar Javier Zaidman
- Cesar Yoiti Hayashida
- Chamberlain Obialo
- Chang-Hsun Hsieh
- Charles Cook
- Charles Kaupke
- Charytan D. M.
- Chek Loong Loh
- Chen Leia
- Cheol-Young Park
- Chih-Ching Lin
- Christopher P Cannon
- Christy Yao
- Chu P. -L.
- Chwen-Tzuei Chang
- Chye Lee Gan
- Clara Barrios
- Claude Galphin
- Claudia Goycoa
- Claudia Moreira de Brito
- Clodoaido Caringal
- Cristian Serafinceanu
- Cristina Toarba
- Cristobal Morales Portillo
- Csaba Kovesdy
- Cynthia Bowman-Stroud
- Cynthia Christiano
- Cynthia Mustieles Rocha
- Cyrus Desouza
- Cássio Slompo Ramos
- Dagmar Bartaskova
- Dale Crawford Allison
- Dalia Kozloviene
- Dan Scharfstein
- Dana Cosma
- Daniel Coyne
- Daniel Hiser
- Daniel Kolansky
- Daniel Panarotto
- Daniel Pella
- Daniel Weiner
- Daniil Chizhov
- Dariusz Sowinski
- Darren K McGuire
- Davesh Sennik
- David C Wheeler
- David Cherney 3rd
- David Gorson
- David Johnson
- David M Charytan
- David Packham
- David Scott
- David Wheeler
- De Zeeuw D.
- Debbie Cohen-Stein
- Debbie Mascaro
- Deepak Koppolu
- Dennis Levinson
- Derek Lewis
- Detian Li
- Devasmita Dev
- Devesh Patel
- Dewan Deepak
- Dick de Zeeuw
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- Dinesh Khullar
- Diogo Belo
- Dmitry Zateyshshikov
- Domenico Santoro
- Domingos d'Avila
- Donald Brandon
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- Dong-Wan Chae
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- Dorota Mlodawska-Choluj
- Doru Negru
- Edgar Arcos
- Edoardo Mannucci
- Eduardo Farias
- Edward Watson
- Edwards R.
- Egle Gaupsiene
- Egle Urbanaviciene
- Ekaterina Velichkova
- Elena Christofides
- Elena Grineva
- Elena Kolmakova
- Elena Shutemova
- Eleonora Harcsa
- Elizabeth Barranco
- Elizabeth Gelersztein
- Elizabeth Kern
- Elizete Keitel
- Eloisa Tellez Chavez
- Emanuela Orsi
- Emil Martinka
- Emyr Davies
- Enrique Gonzalez
- Eric Alamartine
- Eric Hernandez Triana
- Eric Thervet
- Erick Turcios Juarez
- Esteban Cercos
- Eugenia Galindo-Ramos
- Eva Peterfai
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- Evandro de Souza Portes
- Evgueniy Vazelov
- Fabian Otreras
- Fabiana Loss de Carvalho Contieri
- Fabio Malberti
- Fadi Saba
- Fadlo Fraige Filho
- Favio Edmundo Enriquez Sosa
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- Ferdinando Carlo Sasso
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- Fernando Thomé
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- Fracisco Javier Gonzalez Martinez
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- François Dubé
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- Freemu Varghese
- Gabriela Cecilia Coloma
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- Gabriele von Ingersleben
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- Graham Hillis
- Graziano Di Cianni
- Grazyna Orlowska-Kowalik
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- Greene T.
- Greg Fulcher
- Gregorio Obrador
- Gregorio Obrador Vera
- Grit Faulmann
- Guadalupe Morales Franco
- Guillermo Fragale
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- Gulam Latiff
- Gustavo Cristian Greloni
- Guy Chouinard
- Gyongyi Csecsei
- Gyorgy Paragh
- Halyna Tomashkevych
- Hans Prozesky
- Harpreet Bajaj
- Hasnain Khandwala
- Hector Rodriguez
- Heerspink H. J. L.
- Helena Oosthuizen
- Hendrik Nortje
- Henry Watson
- Hermann Haller
- Hernan Finkelstein
- Hernan Yupanqui
- Hiddo J L Heerspink
- Hiralal Maheshwari
- Hiroko Oishi
- Hiromi Aoki
- Hiromi Rodriguez Pattzi
- Hiroshi Kono
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- Holly Wang
- Hong Mao
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- Hongli Lin
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- Isabel Garcia
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- Jardine M. J.
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- Meg Jardine
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- Roberto Pecoits-Filho
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- Rodolfo Andres Ahuad Guerrero
- Rohana Abdul Ghani
- Rohit Pankhaniya
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- Ronald Harris
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- Ronaldo Arturo Gonzalez Orellana
- Ronan Roussel
- Ronnie Aronson
- Rosa Isela Luna Ceballos
- Rosângela Milagres
- Ruben Dario Vargas Alonso
- Rury Holman
- Russell Scott
- Sacha De Serres
- Sahay Manisha
- Saiful Shahrizal Bin Shudim
- Sailaja Ventrapragada
- Salah Abusnana
- Salvatore De Cosmo
- Sam Henein
- Sam Philip
- Samuel Cohen
- Samuel Mujica Trenche
- Samy Hadjadj
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- Sandor Vangel
- Sandra Berenice Saaveddra Sanchez
- Sanjeev Rastogi
- Sara Jaffer
- Sarah Olelewe
- Satoshi Ota
- Satu Pesickova
- Scott Kasner
- Secundino Cigarran Guldris
- Senan Sultan
- Serge Cournoyer
- Sergei Nedogoda
- Sergey Vorobyev
- Sergio Saul Irizar Santana
- Shahabul Arfeen
- Shahnaz Shahinfar
- Shang-Jyh Hwang
- Shelley Williams
- Shenaz Ramtoola
- Shenglian Gan
- Sherry Sussman
- Shizuo Kajiyama
- Shozo Miyauchi
- Silvia Ines Orio
- Silvia Nicolai
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- Simon Roger
- Simon Young
- Sin Gon Kim
- Singhan Krishnan
- Sini George
- Slobodan Antic
- Sohan Dua
- Sonia Hermida
- Soo Kun Lim
- Sophie Borot
- Souhila Ounadjela
- Sreedhar Mandayam
- Srikanth Bellary
- Stanislav Zemek
- Stanislaw Mazur
- Stefan Dimitrov
- Stephan Maxeiner
- Stephen Grubb
- Stephen Smith
- Steven Fishbane
- Stuart Handelsman
- Suely Keiko Kohara
- Sun Kim
- Sun-Hee Park
- Sunil Sheth
- Susumu Kashine
- Svetlana Goykhman
- Svitlana D Bilyk
- Swee Win Lam
- Sylvia Rosas
- Sylvia Shaw
- Szilard Vasas
- Sérgio Alberto Cunha Vêncio
- Sérgio Yamada
- Tadashi Iitsuka
- Takamoto Kodera
- Takashi Wada
- Takayuki Watanabe
- Tamara Malek Marin
- Tamas Oroszlan
- Tara Chang
- Tareq Nassar
- Tarissa Beatrice Zanata Petry
- Tatiana Koroleva
- Tatiana Morugova
- Tatiana Raskina
- Tatyana Zykova
- Te-Lin Hsia
- Terue Sakakibara
- Tetiana Zlova
- Tetsuji Niiya
- Tetyana Pertseva
- Tiago Schuch
- Timothy Hall
- Tom Christensen
- Tom Greene
- Tomas Drasnar
- Tomas Smith Casabella
- Tonatiu Diaz Escalante
- Toshihiko Yanase
- Toshio Kawada
- Vadym Vizir
- Vanassa Ratnasingam
- Venessa Tsang
- Venkata Behara
- Vera Klokocnikova
- Vera Krane
- Veronica Anghel
- Veselka Genadieva
- Vesna Popovic-Radinovic
- Viacheslav Marasaev
- Victor Commendatore
- Victor Saavedra Gajardo
- Vijayaraman Arutchelvam
- Viktor Margaritov
- Viktor Zaviriukha
- Viktoria Andreeva
- Vimladhevi Govender
- Vincent Pichette
- Vincent Woo
- Vira Tseluyko
- Virginia Esther Visco
- Vivek Sood
- Vivekan Jha
- Vladimir Dobronravov
- Vladimir Khirmanov
- Vladimir Tesar
- Vlado Perkovic
- Volker Burst
- Volodymyr Botsyurko
- Walter Guillermo Douthat
- Walter Pharr
- Wasim Hanif
- Wataru Yumita
- Wayne H-H Sheu
- Wayne Turner
- Wei Yen Kong
- Weihong Song
- Weiping Lu
- Wendy Lane
- Wenge Li
- Wheeler D. C.
- Wladmir Saporito
- Xuemei Li
- Xueqing Yu
- Yamil Canaan
- Yan Ren
- Yannick Le Meur
- Yaozhong Kong
- Yasuro Kumeda
- Yasushi Wakida
- Yavin Y.
- Yeong Hoon Kim
- Yevgeniya Svyshchenko
- Young Min Cho
- Yulia Samoylova
- Yung-Chuan Lu
- Yuriy Mostovoy
- Yuriy Shwartz
- Yvette Ethel Yap
- Zaynab Abejuela
- Zdravko Kamenov
- Zeid Khitan
- Zhang H.
- Zinman B.
- Zishan Ali
- Zuzana Ochodnicka
- Ângela Regina Nazario Sabbag
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2019
- Field of study
BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to <90 ml per minute per 1.73 m2 of body-surface area and albuminuria (ratio of albumin [mg] to creatinine [g], >300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of <15 ml per minute per 1.73 m2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P<0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P<0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years
Stress-induced adaptive morphogenesis in bacteria
- Author
- Ali Azam
- Allan
- Ausmees
- Ausmees
- Azevedo
- Badrinarayanan
- Barreteau
- Bath
- Belas
- Belas
- Belas
- Belas
- Ben-Yehuda
- Ben-Yehuda
- Berkmen
- Bernal-Cabas
- Bernhardt
- Bharat
- Billings
- Bisson-Filho
- Boaretti
- Boccard
- Bos
- Brenzinger
- Briegel
- Briers
- Bylund
- Cabeen
- Caccamo
- Cambré
- Cao
- Cava
- Chaiyanan
- Chaput
- Chauhan
- Chen
- Cho
- Claessen
- Claessen
- Claessen
- Costa
- Cox
- Cserti
- Curtis
- Curtis
- Dajkovic
- Dalia
- Dame
- Dame
- Dame
- Dame
- Dame
- Daniels
- Darcan
- Day
- Delhaye
- Dell'Era
- den Blaauwen
- Deng
- Dillon
- Dominguez-Escobar
- Dorman
- Dorman
- Drlica
- Edwards
- Egan
- Emami
- Eriksson
- Erill
- Errington
- Errington
- Errington
- Ewert
- Fang
- Ferguson
- Flärdh
- Flärdh
- Fogel
- Foster
- Frenkiel-Krispin
- Gangaiah
- Ganji
- Garner
- Ghaffar
- Glaser
- Gonin
- Gordon
- Gould
- Gruber
- Gudas
- Hale
- Harshey
- Hassler
- Heidrich
- Helmann
- Henriques
- Henriques
- Hernando-Pérez
- Higgins
- Hirano
- Hoeniger
- Holmes
- Hong
- Horii
- Horvath
- Howery
- Huang
- Hunke
- Hussain
- Hyams
- Höltje
- Ishihama
- Jackson
- Janion
- Jensen
- Jensen
- Jiang
- Jones
- Jordan
- Jun
- Justice
- Justice
- Justice
- Karas
- Kawagishi
- Kawai
- Kawazura
- Kearns
- Kim
- Klančnik
- Klieneberger
- Koonin
- Krebs
- Kusumoto
- Kysela
- Lawler
- Le
- Le
- Leaver
- Leclercq
- Lenarcic
- Letek
- Lewis
- Lioy
- Little
- Little
- Little
- Lopez-Garrido
- Luijsterburg
- Luijsterburg
- Mahamid
- Marbouty
- Mazza
- McCarter
- Meeske
- Meeske
- Menetski
- Mercier
- Mercier
- Merker
- Meyer
- Mizoguchi
- Mohammadi
- Monahan
- Morlot
- Mukherjee
- Möker
- Möker
- Möker
- Möller
- Natale
- Nichols
- Nielsen
- Nilsson
- Noom
- Ojkic
- Oliver
- Onwuamaegbu
- Paradis-Bleau
- Partridge
- Perego
- Persat
- Pianetti
- Pichoff
- Pinto
- Pinto
- Popham
- Postow
- Prashar
- Prashar
- Priyadarshini
- Raetz
- Raivio
- Ramijan
- Rather
- Reyes-Lamothe
- Rodriguez
- Rojas
- Rosenberger
- Ross
- Ross
- Rowley
- Ruiz
- Sanchez-Puelles
- Sauvage
- Schlimpert
- Schmidt
- Setlow
- Sham
- Shinoda
- Signoretto
- Silhavy
- Skoko
- Slavchev
- Smits
- Stock
- Stovepoindexter
- Studer
- Sussman
- Swoboda
- Teleman
- Tendeng
- Thomas
- Tocheva
- Traag
- Trastoy
- Travers
- Trusca
- Trussart
- Tsang
- Typas
- Typas
- Ursell
- Val
- van der Meij
- van Noort
- van Teeffelen
- van Teeffelen
- van Teeffelen
- Verstraeten
- Vilhena
- Vollmer
- Vollmer
- Vollmer
- Wagner
- Wagner
- Walsby
- Wang
- Wang
- Wang
- Willemse
- Wolf
- Wolgemuth
- Wortinger
- Wu
- Wu
- Xu
- Yang
- Yang
- Yao
- Yen Shin
- Young
- Zhang
- Zhao
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2019
- Field of study
Bacteria thrive in virtually all environments. Like all other living organisms, bacteria may encounter various types of stresses, to which cells need to adapt. In this chapter, we describe how cells cope with stressful conditions and how this may lead to dramatic morphological changes. These changes may not only allow harmless cells to withstand environmental insults but can also benefit pathogenic bacteria by enabling them to escape from the immune system and the activity of antibiotics. A better understanding of stress-induced morphogenesis will help us to develop new approaches to combat such harmful pathogens.Microbial Biotechnolog
Embodying and Disabling Antiwar Activism: Disrupting YouTube’s “Mother’s Day for Peace”
- Author
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
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- Gomez Olivert
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- Rendell Marc
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- Vizir Vadym
- Vlasenko Maryna
- Volker Burst Germany:
- Vorobyev Sergey
- Vukotic Goga
- Wada Takashi
- Wadud Khurram
- Wahba Mona
- Wakasugi Masakiyo
- Wakeling John
- Wakida Yasushi
- Walker Robert
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- Warren Mark
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- Watanabe Takayuki
- Watson Edward
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- Weiner Daniel
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- Williams Shelley
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- Winocour Peter
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- y Orozco Juan Alfredo Tamayo
- Yakov Andrian
- Yamada Masayo
- Yamada S\ue9rgio
- Yanagida Kazuhiro
- Yanase Toshihiko
- Yang Jinkui
- Yao Christy
- Yen Kong Wei
- Yin Aiping
- Yoiti Hayashida Cesar
- Young Simon
- Yu Xueqing
- Yuan Lee Li
- Yumita Wataru
- Yupanqui Hernan
- Zalunardo Nadia
- Zamarripa Escobedo Rolando
- Zaniewski-Singh Michelle
- Zanoli Luca
- Zaoui Philippe
- Zateyshchikova Anna
- Zateyshshikov Dmitry
- Zaynab Abejuela Philippines:
- Zealand: John Baker New
- Zemek Stanislav
- Zhao Minghui
- Zheng Hongguang
- Zlova Tetiana
- Zsom Marianna
- Zub Liliia
- Zykova Tatyana
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 01/01/2021
- Field of study
BACKGROUND AND PURPOSE: Chronic kidney disease with reduced estimated glomerular filtration rate or elevated albuminuria increases risk for ischemic and hemorrhagic stroke. This study assessed the effects of sodium glucose cotransporter 2 inhibitors (SGLT2i) on stroke and atrial fibrillation/flutter (AF/AFL) from CREDENCE (Canagliflozin and Renal Events in Diabetes With Established Nephropathy Clinical Evaluation) and a meta-analysis of large cardiovascular outcome trials (CVOTs) of SGLT2i in type 2 diabetes mellitus.METHODS: CREDENCE randomized 4401 participants with type 2 diabetes mellitus and chronic kidney disease to canagliflozin or placebo. Post hoc, we estimated effects on fatal or nonfatal stroke, stroke subtypes, and intermediate markers of stroke risk including AF/AFL. Stroke and AF/AFL data from 3 other completed large CVOTs and CREDENCE were pooled using random-effects meta-analysis.RESULTS: In CREDENCE, 142 participants experienced a stroke during follow-up (10.9/1000 patient-years with canagliflozin, 14.2/1000 patient-years with placebo; hazard ratio [HR], 0.77 [95% CI, 0.55-1.08]). Effects by stroke subtypes were: ischemic (HR, 0.88 [95% CI, 0.61-1.28]; n=111), hemorrhagic (HR, 0.50 [95% CI, 0.19-1.32]; n=18), and undetermined (HR, 0.54 [95% CI, 0.20-1.46]; n=17). There was no clear effect on AF/AFL (HR, 0.76 [95% CI, 0.53-1.10]; n=115). The overall effects in the 4 CVOTs combined were: total stroke (HRpooled, 0.96 [95% CI, 0.82-1.12]), ischemic stroke (HRpooled, 1.01 [95% CI, 0.89-1.14]), hemorrhagic stroke (HRpooled, 0.50 [95% CI, 0.30-0.83]), undetermined stroke (HRpooled, 0.86 [95% CI, 0.49-1.51]), and AF/AFL (HRpooled, 0.81 [95% CI, 0.71-0.93]). There was evidence that SGLT2i effects on total stroke varied by baseline estimated glomerular filtration rate (P=0.01), with protection in the lowest estimated glomerular filtration rate (<45 mL/min/1.73 m2]) subgroup (HRpooled, 0.50 [95% CI, 0.31-0.79]).CONCLUSIONS: Although we found no clear effect of SGLT2i on total stroke in CREDENCE or across trials combined, there was some evidence of benefit in preventing hemorrhagic stroke and AF/AFL, as well as total stroke for those with lowest estimated glomerular filtration rate. Future research should focus on confirming these data and exploring potential mechanisms. Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT02065791
Kidney and Cardiovascular Effects of Canagliflozin According to Age and Sex: A Post Hoc Analysis of the CREDENCE Randomized Clinical Trial
- Author
- Abdallah Joseph
- Abdul Ghani Rohana
- Abdullah Raied
- Abejuela Zaynab
- Abouglila Kamal
- Abraham Oomman
- Abraira Munoz Luis David
- Abramowitz Matthew
- Abusnana Salah
- Acosta Idalia
- Agafyina Alina
- Agarwal Rajiv
- Agarwal Rajiv
- Aggarwal Naresh
- Agra Jeimeen
- Ahmad Nik Nur Fatnoon Nik
- Ahmed Fayzal
- Aiello Joseph
- Ainsworth Paul
- Aizenberg Diego
- Aizenberg Diego
- Akiyama Hitoshi
- Akright Laura
- Akyea-Djamson Ayim
- Al-Karadsheh Amer
- Alamartine Eric
- Alappan Rajendran
- Albisu Juan Pablo
- Alexandra Terront Lozano Monica
- Ali Norsiah
- Ali Zishan
- Alicic Radica
- Allison Dale Crawford
- Alvarisqueta Andres
- Amodeo Celso
- Andreeva Viktoria
- Angelescu Liliana Monica
- Angelova Angelina
- Anghel Veronica
- Antic Slobodan
- Aoki Hiromi
- Aquitania Grace
- Arauz-Pacheco Carlos
- Arcos Edgar
- Arfeen Shahabul
- Arif Ahmed
- Arnott Clare
- Aronson Ronnie
- Arutchelvam Vijayaraman
- Arvind Moogali
- Asano Akimichi
- Atray Naveen
- Avendano Jorge
- Avram Rodica-Ioana
- Awad Ahmed
- Babikova Jana
- Badat Aysha
- Bajaj Harpreet
- Baker John
- Bakris George
- Bakris George
- Bakris George
- Ballesteros Cecilia Garcia
- Barbarash Olga
- Barna Olga
- Barnard Maria
- Barnhill Peggy
- Baron Paul Frenk
- Barranco Elizabeth
- Barrera Carlos
- Barrios Clara
- Bartaskova Dagmar
- Bartolacci Ines
- Barton Petr
- Barysheva Olga
- Beacom Matthew
- Behara Venkata
- Bellary Srikanth
- Belo Diogo
- Belobradkova Jana
- Bentley-Lewis Rhonda
- Benusova Olga
- Berenguer Ramon
- Berli Mario Alberto
- Bermudez Lidia
- Bernardo Marializa
- Bhushan Raju Sree
- Bijata-Bronisz Renata
- Bilyk Svitlana D.
- Biscoveanu Mihaela
- Bonadonna Riccardo
- Bordonava Anselmo
- Borges João Lindolfo Cunha
- Borot Sophie
- Botsyurko Volodymyr
- Bowman-Stroud Cynthia
- Brandon Donald
- Breedt Johannes
- Bregman Rachel
- Brenner Barry M.
- Brusco Osvaldo
- Buganova Ingrid
- Burst Volker
- Busch Robert
- Busegeanu Mihaela-Magdalena
- Calcaneo Juan Peralta
- Calella Pedro
- Canaan Yamil
- Canani Luis Henrique
- Cannon Christopher P.
- Cannon Christopher P.
- Canonge Rafael Simo
- Cantero Maria Cecilia
- Cardoza Kathryn
- Caringal Clodoaido
- Cariou Bertrand
- Carrillo Luis Venegas
- Cartasegna Luis Rodolfo
- Casabella Tomas Smith
- Castellanos Ricardo Orozco
- Castellino Pietro
- Castro Fernando Cereto
- Cepeda Alejandro Valdes
- Cercos Esteban
- Ceriello Antonio
- Chacra Antônio Roberto
- Chae Dong-Wan
- Chae Dong-Wan
- Chandra Vyasam Ramesh
- Chang Chwen-Tzuei
- Chang Tara
- Charytan David M.
- Charytan David M.
- Charytan David M.
- Chavez Eloisa Tellez
- Che Yusof Mohd Daud
- Chen Nan
- Chen Qinkai
- Cherney David
- Cherney David
- Chertow Glenn
- Cheung Ngai Wah
- Chilito Alicia
- Chiovato Luca
- Chizhov Daniil
- Cho Young Min
- Chouinard Guy
- Christensen Tom
- Christiano Cynthia
- Christofides Elena
- Chuang Lee-Ming
- Chuateco Caroucel
- Cif Adriana
- Cohen Kenneth
- Cohen Robert
- Cohen-Stein Debbie
- Colaso Patricia del Carmen Gonzalez
- Coloma Gabriela Cecilia
- Colombo Hugo
- Cometa Luis Valderrama
- Comia Rhea Severina
- Commendatore Victor
- Contieri Fabiana Loss de Carvalho
- Conway James
- Cook Charles
- Correa Rotter Jose Ricardo
- Cosma Dana
- Costa Fernando Augusto Alves da
- Cournoyer Serge
- Coyne Daniel
- Crisan Carmen
- Cruz Juan Baas
- Csecsei Gyongyi
- Csiky Botond
- Cuadrado Jesus
- Culak Jan
- Cuneo Carlos Alberto
- Cusumano Ana Maria
- Daboul Nizar
- Danos Peter
- DaRoza Gerald
- Darwish Riad
- Daswani Adarsh
- David null
- Davies Emyr
- Davies Mark
- Davies Simon
- Dawson Alison
- de Almeida Roberto Simões
- de Brito Claudia Moreira
- De Cosmo Salvatore
- De Nicola Luca
- De Nicola Luca
- de Salazar Dora Inés Molina
- De Serres Sacha
- de Souza Pedro
- de Zeeuw Dick
- de Zeeuw Dick
- Deak Laszlo
- Deboni Luciane Mônica
- Deck Kenneth
- Deepak Dewan
- del Campo Blanco Belia Martin
- Demian Luiza Despina
- Derosa Giuseppe
- Desouza Cyrus
- Dev Devasmita
- Dhillon Monika
- Di Carlo Alberto
- Di Cianni Graziano
- Di Tanna Gian Luca
- Diaz Ruiz Jorge Ernesto Andres
- Dimitrov Stefan
- Distiller Larry
- Distiller Lawrence
- Djordjevic Miodrag
- Dobronravov Vladimir
- Dohnalova Lenka
- Douthat Walter Guillermo
- Dran Ricardo Dario
- Drasnar Tomas
- Dreval Alexander
- Dreval Alexander
- Droste Carolyn
- Dua Sohan
- Dubé François
- Dudar Iryna
- Dudas Mihaly
- Dussol Bertrand
- Dzupina Andrej
- Dzuponova Jana
- d’Avila Domingos
- Eder Frank
- Edwin Fernando M.
- Egido de los Rios Jesus
- El Kossi Mohsen
- El-Shahawy Mohamed
- Elosegui Ana Maria
- English Patrick
- Enriquez Sosa Favio Edmundo
- Ervin John
- Escalante Tonatiu Diaz
- Escobedo Rolando Zamarripa
- Esquenazi Alberto
- Evans John
- Faghih Markus
- Farias Eduardo
- Fariña Marcelo Medina
- Faulmann Grit
- Fauvel Jean-Pierre
- Felício João Soares
- Ferariu Ioana Emilia
- Ferkl Richard
- Fernandez Maria Florencia
- Filho Roberto Pecoits
- Finkelstein Hernan
- Fishbane Steven
- Flores Fernando Jimenez
- Flota Cervera Luis Fernando
- Fragale Guillermo
- Fraige Filho Fadlo
- Franco Guadalupe Morales
- Franco Roberto Jorge da Silva
- Frascà Giovanni
- Fraser Donald
- Fraser Ian
- Fresnedo Gema Fernandez
- Fretes Jose Osvaldo
- Frias Juan
- Fuiano Giorgio
- Fulop Peter
- Fushtey Ivan
- Gajardo Victor Saavedra
- Galindo-Ramos Eugenia
- Galphin Claude
- Gambaro Giovanni
- Gan Chye Lee
- Gan Shenglian
- Garcia Isabel
- Garcia Nestor Horacio
- Garcia Pere Alvarez
- Garibotto Giacomo
- Gastaldi Anibal
- Gaupsiene Egle
- Gelersztein Elizabeth
- Genadieva Veselka
- Genova-Hristova Gabriela
- Ghazi Adline
- Giorda Carlo
- Glenny Jorge Archibaldo
- Glinkina Irina
- Gnudi Luigi
- Godlevska Olga
- Goldenberg Ronald
- Golovchenko Oleksandr
- Gomes Marcus
- Gomez Rangel Jose David
- Gomez Olivert
- Gonzalez Martinez Francisco Javier
- Gonzalez Orellana Ronaldo Arturo
- Gonzalez Alexander
- Gonzalez Alfonso Soto
- Gonzalez Enrique
- Gonzalez Joaquin Pablo
- Gonzalo Godoy Jorquera Juan
- Gopalakrishnan Natarajan
- Gorson David
- Gourdy Pierre
- Govender Ravendran
- Govender Vimladhevi
- Gowda Anupama
- Goycoa Claudia
- Górriz Jose L.
- Gracious Noble
- Greco Barbara
- Greene Tom
- Greloni Gustavo Cristian
- Grineva Elena
- Grubb Stephen
- Guerrero Rodolfo Andres Ahuad
- Guinsburg Adrian
- Gulati Rakesh
- Guldris Secundino Cigarran
- Gunstone Anthony
- Gupta Anil
- Gupta Milan
- Guzman Juan Rosas
- Gyrina Olga
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- Wheeler David C.
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- Yamada Sérgio
- Yanagida Kazuhiro
- Yanase Toshihiko
- Yang Jinkui
- Yao Christy
- Yap Yvette Ethel
- Yi Tae Won
- Yin Aiping
- Yoon Kun Ho
- Young Simon
- Yu Xueqing
- Yumita Wataru
- Yupanqui Hernan
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- Zalunardo Nadia
- Zanella Maria Teresa
- Zaniewski-Singh Michelle
- Zanoli Luca
- Zaoui Philippe
- Zateyshchikova Anna
- Zateyshshikov Dmitry
- Zemek Stanislav
- Zhang Hong
- Zhang Hong
- Zhang Hong
- Zhao Minghui
- Zheng Hongguang
- Zinman Bernard
- Zinman Bernard
- Zlova Tetiana
- Zsom Marianna
- Zub Liliia
- Zykova Tatyana
- Publication venue
- Publication date
- 01/01/2023
- Field of study
Rationale & Objective: It is unclear whether the effect of canagliflozin on adverse kidney and cardiovascular events in those with diabetic kid-ney disease varies by age and sex. We assessed the effects of canagliflozin among age group categories and between sexes in the Canagli-flozin and Renal Endpoints in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) study.Study Design: Secondary analysis of a random-ized controlled trial. Setting & Participants: Participants in the CREDENCE trial. Intervention: Participants were randomly assigned to receive canagliflozin 100 mg/d or placebo.Outcomes: Primary composite outcome of kid-ney failure, doubling of serum creatinine con-centration, or death due to kidney or cardiovascular disease. Prespecified secondary and safety outcomes were also analyzed. Out-comes were evaluated by age at baseline (<60, 60-69, and >_70 years) and sex in the intention-to-treat population using Cox regression models.Results: The mean age of the cohort was 63.0 & PLUSMN; 9.2 years, and 34% were female. Older age and female sex were independently associ-ated with a lower risk of the composite of adverse kidney outcomes. There was no evidence that the effect of canagliflozin on the primary outcome (acomposite of kidney failure, a doubling of serum creatinine concentration, or death from kidney or cardiovascular causes) differed between age groups (HRs, 0.67 [95% CI, 0.52-0.87], 0.63 [0.4 8-0.82], and 0.89 [0.61-1.29] for ages <60, 60-69, and >_70 years, respectively; P = 0.3 for interaction) or sexes (HRs, 0.71 [95% CI, 0.5 4-0.95] and 0.69 [0.56-0.8 4] in women and men, respectively; P = 0.8 for interaction). No differences in safety outcomes by age group or sex were observed.Limitations: This was a post hoc analysis with multiple comparisons.Conclusions: Canagliflozin consistently reduced the relative risk of kidney events in people with diabetic kidney disease in both sexes and across age subgroups. As a result of greater background risk, the absolute reduction in adverse kidney outcomes was greater in younger participants.Funding: This post hoc analysis of the CREDENCE trial was not funded. The CREDENCE study was sponsored by Janssen Research and Development and was conducted collaboratively by the sponsor, an academic-led steering committee, and an academic research organization, George Clinical.Trial Registration: The original CREDENCE trial was registered at ClinicalTrials.gov with study number NCT02065791