7 research outputs found
Ramucirumab plus docetaxel versus placebo plus docetaxel in patients with locally advanced or metastatic urothelial carcinoma after platinum-based therapy (RANGE): a randomised, double-blind, phase 3 trial
- Author
- Agarwal
- Akira Yokomizo
- Alejo Rodriguez-Vida
- Alejo RodrĂguez-Vida
- Alexandra Drakaki
- Alexandra Drakaki
- Alina Amalia Herzal
- Andrea Necchi
- Andrea Necchi
- Andrey Semenov
- Andrey Semenov
- Anghel Adrian Udrea
- Annamaria H Zimmermann
- Annemie Rutten
- Apolo
- Aristotelis Bamias
- Aristotelis Bamias
- Astra M Liepa
- Aude Flechon
- Aude Fléchon
- Avivit Peer
- Avivit Peer
- Balar
- Bellmunt
- Bellmunt
- Bellmunt
- Bellmunt
- Benjamin Herms
- Boris Alekseev
- Boris Alekseev
- Bozena Sikora-Kupis
- Brigitte Laguerre
- Camidge
- Catherine Becht
- Chia-Chi Lin
- Chien-Liang Lin
- Chikara Ohyama
- Chong Xian Pan
- Choueiri
- Christos Papandreou
- Claudia Lorena Urzua Flores
- Constance Thibault
- Cora N Sternberg
- Cora N Sternberg
- Crew
- Cristiano Ferrario
- Daniel Castellano
- Daniel Castellano Gauna
- Daniel Kejzman
- Daniel P Petrylak
- Daniel Petrylak
- David Sarid
- Devlin
- Dickinson
- Dimitrios Mavroudis
- Eli Rosenbaum
- Elizabeth Jane Hovey
- Enrique Grande Pulido
- Evan Y Yu
- F Xavier GarcĂa Del Muro
- Florence Joly
- Francesco Massari
- Fransiscus L G Erdkamp
- Fredrik Laestadius
- Fredrik Laestadius
- Fumimasa Fukuta
- Georgios Gakis
- Giampaolo Tortora
- Giampaolo Tortora
- Giorgio Vittorio Scagliotti
- Golan
- GĂŒnter Niegisch
- Hahn
- Hakan Harputluoglu
- Hakan Harputluoglu
- Haralambos Kalofonos
- Hasan Senol Coskun
- Hasan Senol Coskun
- Herbst
- Herlinde Dumez
- Hiroyuki Nishiyama
- Hiroyuki Tsunemori
- Hyo Jin Lee
- Igor Bondarenko
- Inoue
- Inoue
- Irfan Cicin
- Irfan Ăiçin
- Isabel Syndikus
- Ivan Sinielnikov
- Ivor J Percent
- Ivor Percent
- Jae-Lyun Lee
- Jae-Lyun Lee
- Jaeger
- James Schwarz
- Janos Révész
- Jean-Pascal Machiels
- Jeanny Aragon-Ching
- Jennifer Cultrera
- Joanna Wojcik-Tomaszewska
- John Hainsworth
- Juan Ignacio Delgado Mignorance
- Junichi Inokuchi
- Junji Yonese
- Katherine M Bell-McGuinn
- Katsuyoshi Hashine
- Kazuo Nishimura
- Kim N Chi
- Kim Nguyen Chi
- Koji Kawai
- Lajos Geczi
- Lajos GĂ©czi
- Langer
- Leticia Vazquez Cortés
- Lisa Sengeloev
- Loehrer
- Marc-Oliver Grimm
- Marcello Tucci
- Masafumi Oyama
- Masayoshi Nagata
- Masuda
- Maureen J B Aarts
- McCaffrey
- Michael Schenker
- Michael Stöckle
- Michiel S van der Heijden
- Michiel S van der Heijden
- Miriam Hegemann
- Motohide Uemura
- Mustafa Erman
- Mutsushi Kawakita
- Naoto Miyajima
- Naveed Sarwar
- Necchi
- Niels Viggo Jensen
- Nobuaki Matsubara
- Nobuaki Matsubara
- Nobuo Shinohara
- Oday Hamid
- Petr Karlov
- Petrylak
- Petrylak
- Petrylak
- Piotr Tomczak
- Raggi
- Raya Leibowitz-Amit
- Reinoud J B Blaisse
- Richard A Walgren
- Robert Huddart
- Roman Fomkin
- Ronald de Wit
- Ronald de Wit
- Rosenberg
- Ryan C Widau
- Santhanam Sundar
- Sato
- Satoshi Fukasawa
- Satoshi Nagamori
- Saxman
- Scott Tagawa
- Se Hoon Park
- Sergio Bracarda
- Sharma
- Shinichi Yamashita
- Simon Chowdhury
- Simon Crabb
- Siobhan Su Wan Ng
- Smith
- Sonpavde
- Spratlin
- Sternberg
- Stéphane Culine
- Su-Peng Yeh
- Suet-Lai Shirley Wong
- Sufia Safina
- Sufia Z Safina
- Sun Young Rha
- Susanna Yee-Shan Cheng
- Syed Hussain
- Takahiro Osawa
- Thean Hsiang Tan
- Thomas Flaig
- Thomas Lowe
- Thomas Powles
- Thomas Powles
- Timothy Dudley Clay
- Ulka Vaishampayan
- Vahdat
- Vasilis Karavasilis
- von der Maase
- Wataru Obara
- Wen-Pin Su
- Wen-Pin Su
- William Lawler
- Wolfgang Schultze-Seemann
- Xavier Garcia del Muro
- Xia
- Xia
- Yen-Chuan Ou
- Yen-Chuan Ou
- Yoshihiko Tomita
- Yu Jung Kim
- Yu-Li Su
- Yuksel Urun
- Yun-Gyoo Lee
- Yurii Golovko
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2017
- Field of study
Few treatments with a distinct mechanism of action are available for patients with platinum-refractory advanced or metastatic urothelial carcinoma. We assessed the efficacy and safety of treatment with docetaxel plus either ramucirumab-a human IgG1 VEGFR-2 antagonist-or placebo in this patient population
3. Kulinarische Zeichen im Habitus der römischen Gesellschaft
- Author
- Anth Gr.
- Anth Gr.
- Apic
- Apic
- Apic
- Apic
- Apul
- Apul
- Athen
- Athen
- Athen
- Cat
- Cat
- Cat
- Cat Cic
- Cic
- Cic
- Cic Pis
- Cic Pis
- Cic Pis
- Cic Verr
- der Ort
- Gary-Prieur
- Gastraum Garten
- Hadr
- Hedyph
- Hellegouarc'h Sall
- Hierzu Lex
- Hor
- Hor
- Hor
- Hor
- Hor
- Hor
- Hor
- Hor
- Hor
- Hor
- Hor
- Hor
- Hor
- Hor
- Hor
- Hor
- Hor
- Hor
- Hor
- Hor
- Hor
- Hor
- Hor
- Hor
- Hor
- Hor
- Hor
- Hor
- Hor
- Hor
- Hor Arist
- Hor Hor
- Hor O'
- Imperium Romanum
- In Petr
- Iuv
- Iuv
- Iuv
- Iuv
- Iuv
- Iuv
- Iuv
- Iuv Hor
- Iuv Suet
- Jh
- Jh
- Kirschen
- Liv
- Lucil
- Lucil
- Lucil
- Lucil
- Lucil
- Lucil
- Lucil
- Luxusfischen
- Macr Sat
- Macrob
- Macrob
- Mart
- Mart
- Mart
- Mart
- Mart
- Mart
- Mart
- Mart
- Mart
- Mart
- Mart
- Mart
- Mart
- Mart
- Mart
- Mart
- Mart
- Mart Lukian
- Mart Mart
- Mart Verg
- Mart Àsentierten
- Mrozek
- Ov
- Ov Met
- Patron
- Pers
- Pers
- Pers Cic
- Pers Sat
- Petr
- Petr
- Petr
- Petr
- Petr
- Petr
- Petr
- Petr
- Petr
- Petr
- Petr
- Petr Ov.
- Petr Sat
- Philosophen
- Plaut
- Plaut Aul
- Plaut Curc
- Plaut Pseud
- Plaut Rud
- Plin
- Plin
- Plin
- Plin
- Plin
- Plin
- Plin
- Plin
- Plin
- Plin
- Plin
- Plin
- Plin
- Plin Macrob
- Plin Mart
- Plin Plin
- Plin Varr
- Plin Vgl
- Plut
- Plut Ach
- Plut Cic
- Plut Cic
- Plut Mor
- Plut Varr
- Rolle
- Rom
- Sen
- Sen
- Sen
- Sen
- Sen
- Sen
- Sen Helv
- Sippel
- Stat Silv
- Stockton The Gracchi
- Suet
- Suet
- Suet Apul
- Suet Aug
- Suet Div
- Suet Dom
- Suet Gal
- Suet Petr
- Tac
- Tac Hist
- Tertull
- Tierarten
- v. Chr
- v. Chr Cic
- Val Max
- Val Max
- Varr
- Varr
- Varr
- Varr Hor
- Varr Men
- Varr Plin
- Verg
- Verg Catal
- Vermutung
- Verwandte
- Vgl
- Vgl
- Vgl
- Vgl
- Vgl
- Vgl
- Vgl
- Vgl
- Vgl
- Vgl
- Vgl Plaut
- Zum
- Ăen
- Àcherlich
- Àhnt
- Publication venue
- 'Vandenhoeck & Ruprecht GmbH & Co, KG'
- Publication date
- Field of study
5. Essen im Transgressionsdiskurs
- Author
- Aischyl Ag.
- Anm
- Apic Empfehlungen
- Apoll Rhod
- Apul
- Apul
- Apul
- Caes
- Caes Suet
- Cat
- Cat
- Cat
- Cat
- Cat
- Cat
- Cat
- Cat
- Cat Agr
- Cat Iuv
- Catul
- Cels Colum
- Cic
- Cic
- Cic
- Cic
- Cic
- den Nahrungsmittel
- des Thyestes
- Eine
- Enn
- Etwa Apic
- Fillia Futuristische KĂŒche
- Genuss
- Getreidebasis
- Hdt
- Hesiod Theog
- Hierzu Hor
- Hom Od.
- Hom Od.
- Hor
- Hor
- Hor
- Hor
- Hor
- Hor
- Hor
- Hor
- Hor
- Hor
- Hor O'
- In
- Iuv
- Iuv
- Iuv
- Iuv
- Iuv
- Iuv
- Iuv Bild
- Iuv Dagegen Hdt
- Kragelund Vatinius
- Linderski Jerzy
- Lucan
- Lucil
- Lucil
- Lucil
- Lucil
- Lucr Bechers
- Mart
- Mart
- Mart
- Mart
- Mart
- Mart
- Mart
- Mart Apul
- Mart Iuv
- Mart Àtzlichen
- Men
- Mus A.
- Muson
- MĂ€nnern
- Nach Cat
- Nach Paul Fest
- Nicht
- O'
- Osten
- Ov
- Ov
- Ov
- Ov
- Ov Met
- Pers
- Petr
- Petr
- Petr Sat
- Petr Sat
- Petron Sat
- Plaut Capt
- Plaut Cas
- Plaut Cur
- Plaut Men
- Plaut Poen
- Plaut Pseud
- Plaut Truc
- Plin
- Plin
- Plin
- Plin
- Plin
- Plin
- Plin
- Plin Pan
- Plut Caes
- Sall Cat
- Sen
- Sen
- Sen Helv
- Suet Aug
- Suet Aug
- Suet Claud
- Suet Tib
- Suet Vit
- Tac
- Tac Hist
- Ter Haut
- Verg
- Verg
- Verg
- Verg
- Verg
- Verg
- Verg
- Verg
- Verg Aen
- Verg Aen
- Verg Aen
- Verg Aen
- Verg Aen
- Verhalten
- Vgl
- Vgl
- Vgl
- Vgl
- Vgl
- Vgl
- Vgl
- Vgl
- Vgl B. Petr.
- Vgl Chr
- Vgl Hor
- Vgl Hor
- Zu Polyphem Liv Andr
- Zur
- Àhlen
- öglich
- Publication venue
- 'Vandenhoeck & Ruprecht GmbH & Co, KG'
- Publication date
- Field of study
The Social Structure of the Roman House
- Author
- Allroggen-Bedel
- Aristophanes
- AriĂšs
- AriĂšs
- Bagnani
- Barbet
- Barbet
- Barbet
- Barbet
- Barbet
- Barbet
- Barbet
- Barbet
- Barbet
- Barbet
- Barbet
- Barbet
- Barbet
- Bastet
- Bastet
- Becatti
- Bek
- Beyen
- Beyen
- Bieber
- Boersma
- Bourdieu
- Carandini
- Carandini
- Carandini
- Carandini
- Carandini
- Carandini
- Carandini
- Carandini
- Carandini
- Carandini
- Carandini
- Carettoni
- Carettoni
- Carettoni
- Carettoni
- Carettoni
- Castiglione
- Cato
- Cato
- Cic.
- Cic.
- Cicero
- Cicero
- Cicero
- Cicero
- Cicero.
- Coarelli
- Coarelli
- Coarelli
- Crook
- D'Arms
- Daunton
- de Vos
- de Vos
- Douglas
- Drack
- Drerup
- Drexel
- Dwyer
- Dwyer
- Eck
- Eck
- Elia
- Elia
- Elias
- Elias
- Engemann
- Eschebach
- Fittschen
- Fittschen
- Fittschen
- Franciscis
- FriedlÀnder
- FriedlÀnder
- Girouard
- Girouard
- Girouard
- Girouard
- Grimal
- Gros
- Gros
- Gros
- Hill
- Hoffmann
- Horace
- Jashemski
- Jones
- Jung
- Kettering
- Kroll
- Laidlaw
- Laidlaw
- Leach
- Leach
- Leach
- Lehmann
- Levi
- Ling
- Ling
- Maiuri
- Maiuri
- Maiuri
- Maiuri
- Maiuri
- Maiuri
- Maiuri
- Maiuri
- Maiuri
- Maiuri
- Maiuri
- Marquardt
- Mau
- Mau
- Mau-Kelsey
- McKay
- McKay
- McKay
- McKay
- McKay
- McKay
- Meiggs
- Mielsch
- Mylonas
- Nepos
- Nepos
- Nero
- Olynthos
- Olynthos
- Ovid.
- Packer
- Pape
- Pape
- Pape
- Pausanias
- Pergamum
- Petr.
- Petronius
- Petronius
- Petronius
- Platner-Ashby
- Plautus
- Pliny
- Pliny
- Pliny
- Pliny
- Pliny
- Pliny
- Pliny
- Pliny
- Pliny
- Pliny
- Pliny
- Pliny
- Pliny
- Pliny
- Pliny
- Pliny
- Pliny
- Pliny
- Pliny.
- Priene
- Rawson
- Rice
- Richardson
- Ridgeway
- Rizzo
- Rostovtzeff
- Schefold
- Schefold
- Seneca
- Seneca
- Seneca
- Sherwin-White
- Stat.
- Strocka
- Strocka
- Studnicza
- Suet.
- Suet.
- Suet.
- Suet.
- Suet.
- Suet.
- Sulze
- Tac.
- Tac.
- Tac.
- Tac.
- Tacitus
- Tacitus
- Tamm
- Tamm
- Tamm
- Tamm
- Tamm
- Tamm
- Thébert
- Tiberius
- van Buren
- Varro
- Varro
- Varro
- Varro
- Varro
- Veblen
- Verg.
- Virgil
- Walker
- Weinstock
- Wiegand
- Wiseman
- Wiseman
- Zanker
- Zanker
- Publication venue
- 'Cambridge University Press (CUP)'
- Publication date
- Field of study
Demography, Geography and the Sources of Roman Slaves
- Author
- Alföldy
- Aubert
- Bagnall
- Bankole
- Beckles
- BieĆșuĆska-Malowist
- Boer
- Braudel
- Brett
- Caesar
- Cascio
- Chorley
- Coale
- Coarelli
- Craton
- Criscuolo
- Crook
- D'Arms
- De Martino
- de Ste. Croix
- Duncan-Jones
- Eltis
- Engelmann
- Finley
- Fogel
- Frier
- Garnsey
- Gutman
- Harris
- Heather
- Herrmann
- Herrmann-Otto
- Higman
- Hopkins
- Hopkins
- John
- Klein
- Lamur
- Marinovich
- Mattingly
- Mitchell
- Newell
- Papinian
- Parkin
- Patterson
- Petr.
- Pleket
- Ramin
- Rathbone
- Riddle
- Sablayrolles
- Scheidel
- Scheidel
- Scheidel
- Shaw
- Shaw
- Shryock
- Shtaerman
- Shtaerman
- Suet.
- Thomas
- Treggiari
- Treggiari
- Ulpian
- Ulpian
- Varro
- Veyne
- W. V. Harris
- Weaver
- Publication venue
- 'JSTOR'
- Publication date
- Field of study
Ramucirumab plus docetaxel versus placebo plus docetaxel in patients with locally advanced or metastatic urothelial carcinoma after platinum-based therapy (RANGE): overall survival and updated results of a randomised, double-blind, phase 3 trial
- Author
- Aarts Maureen J. B.
- Acs Peter Istvan
- Alekseev Boris
- Aragon-Ching Jeanny B.
- Bamias Aristotelis
- Becht Catherine
- Bedke Jens
- Bell-McGuinn Katherine M.
- Blaisse Reinoud J. B.
- Bondarenko Igor
- Bracarda Sergio
- Castellano Daniel
- Cheng Susanna Yee-Shan
- Chi Kim N.
- Chowdhury Simon
- Cicin Irfan
- Clay Timothy Dudley
- Coskun Hasan Senol
- Crabb Simon J.
- Culine Stéphane
- Cultrera Jennifer Lyn
- de Wit Ronald
- Delgado Mignorance Juan Ignacio
- Drakaki Alexandra
- Dumez Herlinde
- Erdkamp Fransiscus L. G.
- Erman Mustafa
- Ferrario Cristiano
- Flaig Thomas W.
- Fléchon Aude
- Fomkin Roman
- Fukasawa Satoshi
- Fukuta Fumimasa
- Gajate Borau Pablo
- Gakis Georgios
- Garcia del Muro Xavier
- Golovko Yuriy
- Grande Enrique
- Grimm Marc-Oliver
- GĂ©czi Lajos
- Hainsworth John D.
- Hamid Oday
- Harputluoglu Hakan
- Hashine Katsuyoshi
- Herms Benjamin T.
- Herzal Alina Amalia
- Hovey Elizabeth Jane
- Hozak Rebecca R.
- Huddart Robert
- Hussain Syed A.
- Inokuchi Junichi
- Jensen Niels Viggo
- Joly Florence
- Kalofonos Haralambos
- Karavasilis Vasilis
- Karlov Petr
- Kawai Koji
- Kawakita Mutsushi
- Kejzman Daniel
- Kim Yu Jung
- Laestadius Fredrik
- Laguerre Brigitte
- Lawler William Eyre
- Lee Hyo Jin
- Lee Jae-Lyun
- Lee Yun-Gyoo
- Leibowitz-Amit Raya
- Li Jian-Ri
- Liepa Astra M.
- Lin Chia-Chi
- Lin Chien-Liang
- Lorena Urzua Flores Claudia
- Lowe Thomas Eugene
- Machiels Jean-Pascal
- Massari Francesco
- Matsubara Nobuaki
- Mavroudis Dimitrios
- Miyajima Naoto
- Nagamori Satoshi
- Nagata Masayoshi
- Necchi Andrea
- Niegisch G. nter
- Nishimura Kazuo
- Nishiyama Hiroyuki
- Obara Wataru
- Ohyama Chikara
- Osawa Takahiro
- Ou Yen-Chuan
- Oyama Masafumi
- Pan Chong Xian
- Papandreou Christos
- Park Se Hoon
- Peer Avivit
- Percent Ivor J.
- Petrylak Daniel P.
- Powles Thomas
- Rha Sun Young
- Rodriguez-Vida Alejo
- Rosenbaum Eli
- Russo Francesca
- Rutten Annemie
- Révész Janos
- Safina Sufia
- Sarid David
- Sarwar Naveed
- Scagliotti Giorgio Vittorio
- Schenker Michael
- Schultze-Seemann Wolfgang
- Schwarz James K.
- Schwentner Christina A.
- Semenov Andrey
- Sengeloev Lisa
- Shinohara Nobuo
- Sikora-Kupis Bozena
- Sinielnikov Ivan
- Sternberg Cora N.
- Stöckle Michael
- Su Wen-Pin
- Su Yu-Li
- Sundar Santhanam
- Syndikus Isabel
- Tagawa Scott T.
- Tan Thean Hsiang
- Thibault Constance
- Tomczak Piotr
- Tomita Yoshihiko
- Tortora Giampaolo
- Tsunemori Hiroyuki
- Tucci Marcello
- Udrea Anghel Adrian
- Uemura Motohide
- Urun Yuksel
- Vaishampayan Ulka
- van der Heijden Michiel S.
- Vazquez Cortés Leticia
- Walgren Richard A.
- Wan Ng Siobhan Su
- Wijayawardana Sameera
- Wojcik-Tomaszewska Joanna
- Wong Suet-Lai Shirley
- Yamashita Shinichi
- Yeh Su-Peng
- Yokomizo Akira
- Yonese Junji
- Yu Evan Y.
- Zimmermann Annamaria H.
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2020
- Field of study
Background: Ramucirumabâan IgG1 vascular endothelial growth factor receptor 2 antagonistâplus docetaxel was previously reported to improve progression-free survival in platinum-refractory, advanced urothelial carcinoma. Here, we report the secondary endpoint of overall survival results for the RANGE trial. Methods: We did a randomised, double-blind, phase 3 trial in patients with advanced or metastatic urothelial carcinoma who progressed during or after platinum-based chemotherapy. Patients were enrolled from 124 investigative sites (hospitals, clinics, and academic centres) in 23 countries. Previous treatment with one immune checkpoint inhibitor was permitted. Patients were randomly assigned (1:1) using an interactive web response system to receive intravenous ramucirumab 10 mg/kg or placebo 10 mg/kg volume equivalent followed by intravenous docetaxel 75 mg/m2 (60 mg/m2 in Korea, Taiwan, and Japan) on day 1 of a 21-day cycle. Treatment continued until disease progression, unacceptable toxicity, or other discontinuation criteria were met. Randomisation was stratified by geographical region, Eastern Cooperative Oncology Group performance status at baseline, and visceral metastasis. Progression-free survival (the primary endpoint) and overall survival (a key secondary endpoint) were assessed in the intention-to-treat population. The study is registered with ClinicalTrials.gov, NCT02426125; patient enrolment is complete and the last patient on treatment is being followed up for safety issues. Findings: Between July 20, 2015, and April 4, 2017, 530 patients were randomly allocated to ramucirumab plus docetaxel (n=263) or placebo plus docetaxel (n=267) and comprised the intention-to-treat population. At database lock (March 21, 2018) for the final overall survival analysis, median follow-up was 7·4 months (IQR 3·5â13·9). In our sensitivity analysis of investigator-assessed progression-free survival at the overall survival database lock, median progression-free survival remained significantly improved with ramucirumab compared with placebo (4·1 months [95% CI 3·3â4·8] vs 2·8 months [2·6â2·9]; HR 0·696 [95% CI 0·573â0·845]; p=0·0002). Median overall survival was 9·4 months (95% CI 7·9â11·4) in the ramucirumab group versus 7·9 months (7·0â9·3) in the placebo group (stratified HR 0·887 [95% CI 0·724â1·086]; p=0·25). Grade 3 or worse treatment-related treatment-emergent adverse events in 5% or more of patients and with an incidence more than 2% higher with ramucirumab than with placebo were febrile neutropenia (24 [9%] of 258 patients in the ramucirumab group vs 16 [6%] of 265 patients in the placebo group) and neutropenia (17 [7%] of 258 vs six [2%] of 265). Serious adverse events were similar between groups (112 [43%] of 258 patients in the ramucirumab group vs 107 [40%] of 265 patients in the placebo group). Adverse events related to study treatment and leading to death occurred in eight (3%) patients in the ramucirumab group versus five (2%) patients in the placebo group. Interpretation: Additional follow-up supports that ramucirumab plus docetaxel significantly improves progression-free survival, without a significant improvement in overall survival, for patients with platinum-refractory advanced urothelial carcinoma. Clinically meaningful benefit might be restricted in an unselected population. Funding: Eli Lilly and Company
Evaluation of a quality improvement intervention to reduce anastomotic leak following right colectomy (EAGLE): pragmatic, batched stepped-wedge, cluster-randomized trial in 64 countries
- Author
- Aarts Frits
- Ababneh Hazim
- Abad-Motos Ane
- Abaidalla Ahmed
- Abbakar Malaz
- Abd El Aal Ahmed
- Abd-Errazik Mohammad Ahmad
- Abdalradiy Abdalrahmman G
- Abdelkhalek Mohamed
- Abdelkhalek Mostafa
- Abdellatif Ahmed
- Abdellatif Mohamed
- Abdelsaid Kirolas
- Abdou Khaled
- Abdulfatah Mustapha
- Abdullah Mohammad Amer
- Abdullahi Mustapha Miko Mohammed
- AbellĂĄn Antonio Melero
- Abeysinghe Nayana
- Abiyere Henry
- Achimas-Cadariu Patriciu Andrei
- Adakaya Sıla
- Adam Nicolas
- Adams Benita
- Adams Ferdinand
- Adegboye Kazeem
- Adeyeye Ademola
- Adra Lama
- Adu-Poku Patricia
- Afuwape Oludolapo
- Afzal Ameer
- Afzal Muhammad Farooq
- Agapov Mihail
- Agara Daniel
- Aggarwal Manisha
- Agger Erika
- Aghadi Ifeanyi Kene
- Ahmed Amjed Yassir
- Ahmed Haleemasahdia
- Ahmed Khalil
- Ahmed Manar
- Ahmed Masood
- Ahmed Safia
- Ahn Hong Min
- Aibe Raquel
- Aigner Felix
- Aissat Abdenour
- Aitbaeva Arai
- Akay Omer
- Akbar Ali
- Akbas Ahmet
- Akere Abidemi
- Akesen Selcan
- Akgun Erhan
- Akhtar Naseem
- Akın Emrah
- Akova Elif
- Aktas Serhat
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- de Andrés-Asenjo Beatriz
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- Feiss Anna
- Felix Michael Shalzim
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- Fernandes Andre
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- Garcia-FlĂłrez Luis Joaquin
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- Hamdan Alaa
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- Hamed Hosam
- Hameed Malika
- Hamid Hytham K S
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- Hamza Amr
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- Hill Charlotte
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- Hoetzel Alexander
- Holzner Philipp
- Hooper Richard
- Hooper Richard L
- Horiguchi Akihiko
- HorvĂĄth Ăva
- Houdin Anabella
- Hoyos-Torres Alejandro
- Hsieh Yi Chien
- Hu Felicia Su-Min
- Hubley Shelley
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- Yew Chor Kuan
- Yılmaz GĂŒlseren
- Yilmazlar Tuncay
- YiÄit Direnç
- Yoldas Tayfun
- Yonekura Hiroshi
- Yorkmui Liu
- Yoshino Kenji
- Younes Lina
- Young Trudi
- Yule Michael
- Yusoff Zakiah Mohd
- Zaari Fatimazahraa
- Zabiyaka Mikhail
- ZadroĆŒna Monika
- Zafar Madiha
- Zagaynov Eugeny
- Zaidi Syed-Nadeem
- Zaimis Tilemachos
- Zain Wan Zainira Wan
- Zainy Rhendra Hardy Mohamad
- Zakaria Andee Dzulkarnaen
- Zakaria Maheen
- Zakaria Zaidi
- Zamudio-Bautista Jorge Luis
- Zanc Loredana
- Zanoni Andrea
- Zanus Giacomo
- Zapparoli Alessandro
- Zappone Anna
- Zarzava Eirini
- Zatari Dirar
- Zawadzki Marek
- Zayakov Georgi
- Zaycev Andrey
- Zazo Aya
- Zazo Rama
- Zdravkovic Maja
- Zengin Abdullah KaÄan
- Zeringa Georgia
- Zimmerman David D E
- Zuhdy Mohammad
- Zvirych Vitalii
- Zywicka Ewa
- Ălvarez-Llano Laura
- Ăngelo Miguel Duarte
- ĂSullivan Sara Nuñez
- Ăzçelik Mehmet Faik
- Äoza Ivo
- Ćanlı Ahmet Necati
- Publication venue
- Publication date
- 01/01/2023
- Field of study
Background
Anastomotic leak affects 8 per cent of patients after right colectomy with a 10-fold increased risk of postoperative death. The EAGLE study aimed to develop and test whether an international, standardized quality improvement intervention could reduce anastomotic leaks.
Methods
The internationally intended protocol, iteratively co-developed by a multistage Delphi process, comprised an online educational module introducing risk stratification, an intraoperative checklist, and harmonized surgical techniques. Clusters (hospital teams) were randomized to one of three arms with varied sequences of intervention/data collection by a derived stepped-wedge batch design (at least 18 hospital teams per batch). Patients were blinded to the study allocation. Low- and middle-income country enrolment was encouraged. The primary outcome (assessed by intention to treat) was anastomotic leak rate, and subgroup analyses by module completion (at least 80 per cent of surgeons, high engagement; less than 50 per cent, low engagement) were preplanned.
Results
A total 355 hospital teams registered, with 332 from 64 countries (39.2 per cent low and middle income) included in the final analysis. The online modules were completed by half of the surgeons (2143 of 4411). The primary analysis included 3039 of the 3268 patients recruited (206 patients had no anastomosis and 23 were lost to follow-up), with anastomotic leaks arising before and after the intervention in 10.1 and 9.6 per cent respectively (adjusted OR 0.87, 95 per cent c.i. 0.59 to 1.30; P = 0.498). The proportion of surgeons completing the educational modules was an influence: the leak rate decreased from 12.2 per cent (61 of 500) before intervention to 5.1 per cent (24 of 473) after intervention in high-engagement centres (adjusted OR 0.36, 0.20 to 0.64; P < 0.001), but this was not observed in low-engagement hospitals (8.3 per cent (59 of 714) and 13.8 per cent (61 of 443) respectively; adjusted OR 2.09, 1.31 to 3.31).
Conclusion
Completion of globally available digital training by engaged teams can alter anastomotic leak rates. Registration number: NCT04270721 (http://www.clinicaltrials.gov)