33 research outputs found

    Comparision of two anesthetic protocols for ovariohisterectomy in healthy female dogs

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    ABSTRACT: To determine the hemodynamic and physiologic changes and the characteristics of the recuperation phase in two anesthetic protocols to be used in healthy female dogs for elective ovary ohisterectomy, two groups of animals were used in order to test two protocols: Group I was given fentanyl + ethomidato and group II fentanyl + thiopental. For maintenance isofluorane was used in both groups. The following variables were measured at five minute intervals during the surgical procedure: cardiac frequency, breathing frequency, temperature, expired carbon dioxide, non- invasive blood pressure and oxygen saturation. Statistically, temperature and capnography were the only ones yielding significant results: temperature presented an average of 37.7 ± 1.4, in protocol I and 38.0 ± 1.2 in protocol II (p < 0.05); for capnography the average was of 50.9 ± 19.1 for protocol I and 51.9 ± 7.9 for protocol II (p < 0.01), the other variables did not present statistical differences between the tested protocols and maintained themselves within physiological parameters. For recuperation the fallowing variables were measured: time to gag reflex, esternal position, time of liquid ingestion and time of ingestion of solids. In summary, in spite of the significant differences in temperature and capnography, the values were always within physiological parameters therefore in practical terms the protocols behaved in a similar manner. It corresponds to the clinician to define which of the two protocols is more suitable depending of variables and circumstances other than those analyzed in this study such as costs and availability.RESUMEN: Para determinar los cambios hemodinámicos, y fisiológicos y la recuperación en dos protocolos anestésicos, en hembras caninas sanas durante ovariohisterectomia (OVH) electiva, se utilizaron dos grupos de animales, a cada uno de los cuales se les asignó un protocolo anestésico: Grupo I (fentanil + etomidato), grupo II (fentanil + tiopental). En ambos grupos el mantenimiento se hizo con isoflurano. Cada cinco minutos durante el procedimiento quirúrgico se midieron las siguientes variables: frecuencia cardíaca, frecuencia respiratoria, temperatura, dióxido de carbono expirado, presión arterial no invasiva, saturación de oxígeno. Las variables que presentaron significancia, desde el punto de vista estadístico, fueron: temperatura, con una media en el protocolo I de 37.7 ± 1.4, y de 38.0 ± 1.2 en el protocolo II (p < 0.05); y la variable capnografía con una media para el protocolo I de 50.9 ± 19.1 (p < 0.05) y en el protocolo II de 51.9 ± 7.9. Las demás variables se comportaron dentro de los parámetros normales, sin cambios significativos entre los protocolos. Durante el tiempo de recuperación se midieron las siguientes variables: tiempo de presentación del reflejo deglutorio, posición esternal, primera ingesta de líquidos y primera ingesta de alimentos. En resumen, desde el punto de vista estadístico los dos protocolos se comportaron de manera similar a pesar de las diferencias significativas de las variables temperatura y capnografía, por tanto corresponde al criterio clínico definir cuál de los dos protocolos utilizar, dependiendo de variables y circunstancias distintas a las analizadas en este estudio, como son la disponibilidad y el precio de los medicamentos, entre otros

    Assessment of graphitized coal ash char concentrates as a potential synthetic graphite source

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    Coal ash char concentrates from four countries (Portugal, Poland, Romania, and South Africa) were prepared, characterised, and graphitized under the scope of the Charphite project (Third ERA-MIN Joint Call (2015) on the Sustainable Supply of Raw Materials in Europe). Coal ash chars may be a secondary raw material to produce synthetic graphite and could be an alternative to natural graphite, which is a commodity with a high supply risk. The char concentrates and the graphitized material derived from the char concentrates were characterised using proximate analysis, X-ray fluorescence, X-ray diffraction (structural), Raman microspectroscopy, solid-state nuclear magnetic resonance, scanning electron microscopy, and petrographic analyses to determine if the graphitization of the char was successful, and which char properties enhanced or hindered graphitization. Char concentrates with a lower proportion of anisotropic particles and a higher proportion of mixed porous particles showed greater degrees of graphitization. It is curious to see that embedded Al2O3 minerals, such as glass and clay, influenced graphitization, as they most likely acted as catalysts for crystal growth in the basal direction. However, the graphitized samples, as a whole, do not compare well against a reference natural graphite sample despite some particles in select char concentrates appearing to be graphitized following graphitization.Fil: Badenhorst, Charlotte. University Of Johannesburg; SudáfricaFil: Santos, Cláudia. Universidad de Porto; PortugalFil: Lazaro Martinez, Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; ArgentinaFil: Bialecka, Barbara. Central Mining Institute; PoloniaFil: Cruceru, Mihai. University Constantin Brancusi of Targu Jiu; RumaniaFil: Guedes, Alexandra. Universidad de Porto; PortugalFil: Guimarâes, Renato. Universidad de Porto; PortugalFil: Moreira, Karen. Universidad de Porto; PortugalFil: Predeanu, Georgeta. University Politehnica Of Bucharest; RumaniaFil: Suárez-Ruíz, Isabel. Consejo Superior de Investigaciones Científicas; EspañaFil: Cameán, Ignacio. Consejo Superior de Investigaciones Científicas; EspañaFil: Valentim, Bruno. Universidad de Porto; PortugalFil: Wagner, Nicola. University Of Johannesburg; Sudáfric

    Aplicaciones móviles: arquitecturas, visualización, realidad aumentada, herramientas de medición, desarrollo híbrido

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    Se presenta el estado de avance de una investigación sobre sistemas móviles, iniciada en el año 2012 y que culminará en este año 2016 (fue prorrogado un año desde Diciembre de 2015). Las aplicaciones móviles poseen desventajas originadas en restricciones en el tamaño de pantalla, en la capacidad de procesamiento y en la disponibilidad de energía. Ante ello, este proyecto estudia e investiga acerca de métodos, técnicas y herramientas que permitan optimizar la calidad de los sistemas móviles, tomando como referencia el estándar de calidad de la norma ISO/IEC 25000 y la norma de procesos de ciclo de vida del software ISO/IEC 12207. Al inicio del proyecto, los investigadores pertenecían a diferentes universidades nacionales del NOA; sin embargo, en la actualidad, la mayoría pertenecen a la Universidad Nacional de Santiago del Estero. Las principales tecnologías que se estudian son: arquitecturas móviles alternativas, herramientas para el desarrollo híbrido de aplicaciones móviles, técnicas de visualización, realidad aumentada, nuevos métodos ágiles de desarrollo aplicables a sistemas móviles, herramientas para la medición de magnitudes físicas, sensibilidad al contexto. Las aplicaciones o prototipos que se desarrollan se aplican en los siguientes dominios: educación, turismo, ingeniería forestal, rehabilitación (salud).Eje: Ingeniería de SoftwareRed de Universidades con Carreras en Informática (RedUNCI

    Aplicaciones móviles: arquitecturas, visualización, realidad aumentada, herramientas de medición, desarrollo híbrido

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    Se presenta el estado de avance de una investigación sobre sistemas móviles, iniciada en el año 2012 y que culminará en este año 2016 (fue prorrogado un año desde Diciembre de 2015). Las aplicaciones móviles poseen desventajas originadas en restricciones en el tamaño de pantalla, en la capacidad de procesamiento y en la disponibilidad de energía. Ante ello, este proyecto estudia e investiga acerca de métodos, técnicas y herramientas que permitan optimizar la calidad de los sistemas móviles, tomando como referencia el estándar de calidad de la norma ISO/IEC 25000 y la norma de procesos de ciclo de vida del software ISO/IEC 12207. Al inicio del proyecto, los investigadores pertenecían a diferentes universidades nacionales del NOA; sin embargo, en la actualidad, la mayoría pertenecen a la Universidad Nacional de Santiago del Estero. Las principales tecnologías que se estudian son: arquitecturas móviles alternativas, herramientas para el desarrollo híbrido de aplicaciones móviles, técnicas de visualización, realidad aumentada, nuevos métodos ágiles de desarrollo aplicables a sistemas móviles, herramientas para la medición de magnitudes físicas, sensibilidad al contexto. Las aplicaciones o prototipos que se desarrollan se aplican en los siguientes dominios: educación, turismo, ingeniería forestal, rehabilitación (salud).Eje: Ingeniería de SoftwareRed de Universidades con Carreras en Informática (RedUNCI

    Aplicaciones móviles: arquitecturas, visualización, realidad aumentada, herramientas de medición, desarrollo híbrido

    Get PDF
    Se presenta el estado de avance de una investigación sobre sistemas móviles, iniciada en el año 2012 y que culminará en este año 2016 (fue prorrogado un año desde Diciembre de 2015). Las aplicaciones móviles poseen desventajas originadas en restricciones en el tamaño de pantalla, en la capacidad de procesamiento y en la disponibilidad de energía. Ante ello, este proyecto estudia e investiga acerca de métodos, técnicas y herramientas que permitan optimizar la calidad de los sistemas móviles, tomando como referencia el estándar de calidad de la norma ISO/IEC 25000 y la norma de procesos de ciclo de vida del software ISO/IEC 12207. Al inicio del proyecto, los investigadores pertenecían a diferentes universidades nacionales del NOA; sin embargo, en la actualidad, la mayoría pertenecen a la Universidad Nacional de Santiago del Estero. Las principales tecnologías que se estudian son: arquitecturas móviles alternativas, herramientas para el desarrollo híbrido de aplicaciones móviles, técnicas de visualización, realidad aumentada, nuevos métodos ágiles de desarrollo aplicables a sistemas móviles, herramientas para la medición de magnitudes físicas, sensibilidad al contexto. Las aplicaciones o prototipos que se desarrollan se aplican en los siguientes dominios: educación, turismo, ingeniería forestal, rehabilitación (salud).Eje: Ingeniería de SoftwareRed de Universidades con Carreras en Informática (RedUNCI

    COVID-19 outbreaks in a transmission control scenario: challenges posed by social and leisure activities, and for workers in vulnerable conditions, Spain, early summer 2020

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    Severe acute respiratory syndrome coronavirus 2 community-wide transmission declined in Spain by early May 2020, being replaced by outbreaks and sporadic cases. From mid-June to 2 August, excluding single household outbreaks, 673 outbreaks were notified nationally, 551 active (>6,200 cases) at the time. More than half of these outbreaks and cases coincided with: (i) social (family/friends’ gatherings or leisure venues) and (ii) occupational (mainly involving workers in vulnerable conditions) settings. Control measures were accordingly applied

    MixInYeast: A Multicenter Study on Mixed Yeast Infections

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    Invasive candidiasis remains one of the most prevalent systemic mycoses, and several studies have documented the presence of mixed yeast (MY) infections. Here, we describe the epidemiology, clinical, and microbiological characteristics of MY infections causing invasive candidiasis in a multicenter prospective study. Thirty-four centers from 14 countries participated. Samples were collected in each center between April to September 2018, and they were sent to a reference center to confirm identification by sequencing methods and to perform antifungal susceptibility testing, according to the European Committee on Antimicrobial Susceptibility Testing (EUCAST). A total of 6895 yeast cultures were identified and MY occurred in 150 cases (2.2%). Europe accounted for the highest number of centers, with an overall MY rate of 4.2% (118 out of 2840 yeast cultures). Of 122 MY cases, the most frequent combinations were Candida albicans/C. glabrata (42, 34.4%), C. albicans/C. parapsilosis (17, 14%), and C. glabrata/C. tropicalis (8, 6.5%). All Candida isolates were susceptible to amphotericin B, 6.4% were fluconazole-resistant, and two isolates (1.6%) were echinocandin-resistant. Accurate identification of the species involved in MY infections is essential to guide treatment decisions

    Predictors of clinically significant quality of life impairment in Parkinson’s disease

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    COPPADIS Study Group.Quality of life (QOL) plays an important role in independent living in Parkinson’s disease (PD) patients, being crucial to know what factors impact QoL throughout the course of the disease. Here we identified predictors of QoL impairment in PD patients from a Spanish cohort. PD patients recruited from 35 centers of Spain from the COPPADIS cohort from January 2016, to November 2017, were followed up during 2 years. Health-related QoL (HRQoL) and global QoL (GQoL) were assessed with the 39-item Parkinson’s disease Questionnaire (PDQ-39) and the EUROHIS-QOL 8-item index (EUROHIS-QOL8), respectively, at baseline (V0) and at 24 months ± 1 month (V2). Clinically significant QoL impairment was defined as presenting an increase (PDQ-39SI) or decrement (EUROHIS-QOL8) at V2 ≥ 10% of the score at baseline (V0). A comparison with a control group was conducted for GQoL. GQoL did not change significantly in PD patients (N = 507; p = 0.686) or in the control group (N = 119; p = 0.192). The mean PDQ-39SI was significantly increased in PD patients (62.7 ± 8.5 years old; 58.8% males; N = 500) by 21.6% (from 16.7 ± 13 to 20.3 ± 16.4; p < 0.0001) at V2. Ninety-three patients (18.6%) presented a clinically significant HRQoL impairment at V2. To be younger (OR = 0.896; 95% CI 0.829–0.968; p = 0.006), to be a female (OR = 4.181; 95% CI 1.422–12.290; p = 0.009), and to have a greater increase in BDI-II (Beck Depression Inventory-II) (OR = 1.139; 95% CI 1.053–1.231; p = 0.001) and NMSS (Non-Motor Symptoms Scale) (OR = 1.052; 95% CI 1.027–1.113; p < 0.0001) total scores from V0 to V2 were associated with clinically significant HRQoL impairment at the 2-year follow-up (Hosmer–Lemeshow test, p = 0.665; R 2 = 0.655). An increase in ≥5 and ≥10 points of BDI-II and NMSS total score at V2 multiplied the probability of presenting clinically significant HRQoL impairment by 5 (OR = 5.453; 95% CI 1.663–17.876; p = 0.005) and 8 (OR = 8.217; 95% CI, 2.975–22.696; p = 0.002), respectively. In conclusion, age, gender, mood, and non-motor impairment were associated with clinically significant HRQoL impairment after the 2-year follow-up in PD patients.Mir P. has received honoraria from AbbVie, Abbott, Allergan, Bial, Merz, UCB and Zambon and have received grants from the Spanish Ministry of Economy and Competitiveness [PI16/01575] co-founded by ISCIII (Subdirección General de Evaluación y Fomento de la Investigación) and by Fondo Europeo de Desarrollo Regional (FEDER), the Consejería de Economía, Innovación, Ciencia y Empleo de la Junta de Andalucía [CVI-02526, CTS-7685], the Consejería de Salud y Bienestar Social de la Junta de Andalucía [PI-0437-2012, PI-0471-2013], the Sociedad Andaluza de Neurología, the Jacques and Gloria Gossweiler Foundation, the Fundación Alicia Koplowitz, the Fundación Mutua Madrileña.Peer reviewe

    Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

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    Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio
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