110 research outputs found
Copper(I)-Mediated Regio- and Stereoselective Allylic Substitutions and Their Applications to Natural Product Syntheses
This work focused on the copper(I)-mediated stereoselective anti-allylic substitution reactions using organozinc reagents and chiral cyclic phosphates or pentafluorobenzoates. The applications of this method to the preparation of natural products were also reported
Recent Progress in Steroid Synthesis Triggered by the Emergence of New Catalytic Methods
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154510/1/ejoc201901466_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/154510/2/ejoc201901466.pd
SN2' alkylation of chiral allylic cyanohydrin o-phosphates with organocuprates
Enantiomerically enriched cyanohydrin O-phosphates, prepared
by enantioselective cyanophosphorylation of α,β-unsaturated
aldehydes, react regioselectively at the γ-position
with organocuprates derived from alkyl Grignard reagents
and CuCN to afford chiral γ-alkyl-substituted α,β-unsaturated
nitriles. The configuration of the new C–C double bond
is mainly (E) when the reaction is performed at –78 °C and
(Z) when it is carried out at higher temperatures (0 °C). A
high level of transfer of the chirality in the new stereocentre,
corresponding to a stereospecific anti attack onto the cyanophosphate, is observed. Enantiomerically enriched (E)-γ-alkylated
α,β-unsaturated esters are prepared after subsequent
methanolysis in a three-step sequence from the corresponding
α,β-unsaturated aldehydes. In addition, the synthesis of
(R)-4-methylnonan-1-ol, also known as the sex pheromone of
the yellow mealworm Tenebrio molitor L, and its (S) enantiomer
have been carried out in a four-step route from (E)-oct-2-enal.This work has been supported by the DGES of the Spanish Ministerio
de Educación y Ciencia (MEC) (CTQ2004-00808/BQU), the
Generalitat Valenciana (CTIOIB/2002/320, GRUPOS03/134 and
GV05/144) and the University of Alicante
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