Multi-wavelength lens construction of a Planck and Herschel-detected star-bursting galaxy

We present a source-plane reconstruction of a Herschel and Planck-detected gravitationally lensed dusty star-forming galaxy (DSFG) at z = 1.68 using Hubble, Submillimeter Array (SMA), and Keck observations. The background submillimeter galaxy (SMG) is strongly lensed by a foreground galaxy cluster at z = 0.997 and appears as an arc with a length of ∼15″ in the optical images. The continuum dust emission, as seen by SMA, is limited to a single knot within this arc. We present a lens model with source-plane reconstructions at several wavelengths to show the difference in magnification between the stars and dust, and highlight the importance of multi-wavelength lens models for studies involving lensed DSFGs. We estimate the physical properties of the galaxy by fitting the flux densities to model spectral energy distributions leading to a magnification-corrected starformation rate (SFR) of 390 ± 60 M yr−1 and a stellar mass of 1.1 ± 0.4 10 x 11 M. These values are consistent with high-redshift massive galaxies that have formed most of their stars already. The estimated gas-to-baryon fraction, molecular gas surface density, and SFR surface density have values of 0.43 ± 0.13, 350 ± 200 M pc−2, and ~ 12 7 M yr−1 kpc−2, respectively. The ratio of SFR surface density to molecular gas surface density puts this among the most star-forming systems, similar to other measured SMGs and local ULIRGs

Extremely Red Submillimeter Galaxies:New z ≳ 4-6 Candidates Discovered Using ALMA and Jansky VLA

We present the detailed characterization of two extremely red submillimeter galaxies (SMGs), ASXDF1100.053.1 and 231.1, with the Atacama Large Millimeter/submillimeter Array (ALMA) and the Jansky Very Large Array (VLA). These SMGs were selected originally using AzTEC at 1100 micron, and are observed by Herschel to be faint at 100--500 micron. Their (sub)millimeter colors are as red as -- or redder -- than known z>~5 SMGs; indeed, ASXDF1100.053.1 is redder than HFLS 3, which lies at z=6.3. They are also faint and red in the near-/mid-infrared: ~1 microJy at IRAC 4.5 micron and <0.2 microJy in the Ks filter. These SMGs are also faint in the radio waveband, where F_6GHz=4.5 microJy for ASXDF1100.053.1 and F_1.4GHz=28 microJy for ASXDF1100.231.1, suggestive of z=6.5^{+1.4}_{-1.1} and z=4.1^{+0.6}_{-0.7} for ASXDF1100.053.1 and 231.1, respectively. ASXDF1100.231.1 has a flux excess in the 3.6-micron filter, probably due to H$\alpha$ emission at z=4--5. Derived properties of ASXDF1100.053.1 for z=5.5--7.5 and 231.1 for z=3.5--5.5 are as follows: their infrared luminosities are [6.5-7.4]x10^{12} and [4.2-4.5]x10^{12} L_sun; their stellar masses are [0.9-2]x10^{11} and [0.4-3]x10^{10} M_sun; their circularized half-light radii in the ALMA maps are ~1 and <~0.2 kpc (~2--3 kpc for 90% of the total flux). Lastly, their surface infrared luminosity densities, Sigma_IR, are ~1x10^{12} and >~1.5x10^{13} L_sun kpc^{-2}, similar to values seen for local (U)LIRGs. These data suggest that ASXDF1100.053.1 and 231.1 are compact SMGs at z>~4 and can plausibly evolve into z>~3 compact quiescent galaxies.Comment: 16 pages, 14 figures, accepted to the Astrophysical Journal part

Multimodal decoding of human liver regeneration

The liver has a unique ability to regenerate1,2; however, in the setting of acute liver failure (ALF), this regenerative capacity is often overwhelmed, leaving emergency liver transplantation as the only curative option3-5. Here, to advance understanding of human liver regeneration, we use paired single-nucleus RNA sequencing combined with spatial profiling of healthy and ALF explant human livers to generate a single-cell, pan-lineage atlas of human liver regeneration. We uncover a novel ANXA2+ migratory hepatocyte subpopulation, which emerges during human liver regeneration, and a corollary subpopulation in a mouse model of acetaminophen (APAP)-induced liver regeneration. Interrogation of necrotic wound closure and hepatocyte proliferation across multiple timepoints following APAP-induced liver injury in mice demonstrates that wound closure precedes hepatocyte proliferation. Four-dimensional intravital imaging of APAP-induced mouse liver injury identifies motile hepatocytes at the edge of the necrotic area, enabling collective migration of the hepatocyte sheet to effect wound closure. Depletion of hepatocyte ANXA2 reduces hepatocyte growth factor-induced human and mouse hepatocyte migration in vitro, and abrogates necrotic wound closure following APAP-induced mouse liver injury. Together, our work dissects unanticipated aspects of liver regeneration, demonstrating an uncoupling of wound closure and hepatocyte proliferation and uncovering a novel migratory hepatocyte subpopulation that mediates wound closure following liver injury. Therapies designed to promote rapid reconstitution of normal hepatic microarchitecture and reparation of the gut-liver barrier may advance new areas of therapeutic discovery in regenerative medicine. </p

Lens models of <i>Herschel</i>-selected galaxies from high-resolution near-IR observations

We present Keck-Adaptive Optics and Hubble Space Telescope high resolution near-infrared (IR) imaging for 500 μm bright candidate lensing systems identified by the Herschel Multi-tiered Extragalactic Survey and Herschel Astrophysical Terahertz Large Area Survey. Out of 87 candidates with near-IR imaging, 15 (~17%) display clear near-IR lensing morphologies. We present near-IR lens models to reconstruct and recover basic rest-frame optical morphological properties of the background galaxies from 12 new systems. Sources with the largest near-IR magnification factors also tend to be the most compact, consistent with the size bias predicted from simulations and previous lensing models for submillimeter galaxies (SMGs). For four new sources that also have high-resolution submillimeter maps, we test for differential lensing between the stellar and dust components and find that the 880 μm magnification factor (μ880) is ~1.5 times higher than the near-IR magnification factor (μNIR), on average. We also find that the stellar emission is ~2 times more extended in size than dust. The rest-frame optical properties of our sample of Herschel-selected lensed SMGs are consistent with those of unlensed SMGs, which suggests that the two populations are similar