22 research outputs found
Infection prevention and control measures and tools for the prevention of entry of carbapenem-resistant Enterobacteriaceae into healthcare settings : guidance from the European Centre for Disease Prevention and Control
Background: Infections with carbapenem-resistant Enterobacteriaceae (CRE) are increasingly being reported from
patients in healthcare settings. They are associated with high patient morbidity, attributable mortality and hospital
costs. Patients who are âat-riskâ may be carriers of these multidrug-resistant Enterobacteriaceae (MDR-E).
The purpose of this guidance is to raise awareness and identify the âat-riskâ patient when admitted to a healthcare
setting and to outline effective infection prevention and control measures to halt the entry and spread of CRE.
Methods: The guidance was created by a group of experts who were functioning independently of their
organisations, during two meetings hosted by the European Centre for Disease Prevention and Control. A list of
epidemiological risk factors placing patients âat-riskâ for carriage with CRE was created by the experts. The
conclusions of a systematic review on the prevention of spread of CRE, with the addition of expert opinion, were
used to construct lists of core and supplemental infection prevention and control measures to be implemented for
âat-riskâ patients upon admission to healthcare settings.
Results: Individuals with the following profile are âat-riskâ for carriage of CRE: a) a history of an overnight stay in a
healthcare setting in the last 12 months, b) dialysis-dependent or cancer chemotherapy in the last 12 months, c)
known previous carriage of CRE in the last 12 months and d) epidemiological linkage to a known carrier of a CRE.
Core infection prevention and control measures that should be considered for all patients in healthcare settings
were compiled. Preliminary supplemental measures to be implemented for âat-riskâ patients on admission are: preemptive
isolation, active screening for CRE, and contact precautions. Patients who are confirmed positive for CRE
will need additional supplemental measures. Conclusions: Strengthening the microbiological capacity, surveillance and reporting of new cases of CRE in
healthcare settings and countries is necessary to monitor the epidemiological situation so that, if necessary, the
implemented CRE prevention strategies can be refined in a timely manner. Creating a large communication
network to exchange this information would be helpful to understand the extent of the CRE reservoir and to
prevent infections in healthcare settings, by applying the principles outlined here.
This guidance document offers suggestions for best practices, but is in no way prescriptive for all healthcare
settings and all countries. Successful implementation will result if there is local commitment and accountability. The
options for intervention can be adopted or adapted to local needs, depending on the availability of financial and
structural resources.peer-reviewe
Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: a population-level modelling analysis
Background: Infections due to antibiotic-resistant bacteria are threatening modern health care. However, estimating their incidence, complications, and attributable mortality is challenging. We aimed to estimate the burden of infections caused by antibiotic-resistant bacteria of public health concern in countries of the EU and European Economic Area (EEA) in 2015, measured in number of cases, attributable deaths, and disability-adjusted life-years (DALYs).
Methods: We estimated the incidence of infections with 16 antibiotic resistanceâbacterium combinations from European Antimicrobial Resistance Surveillance Network (EARS-Net) 2015 data that was country-corrected for population coverage. We multiplied the number of bloodstream infections (BSIs) by a conversion factor derived from the European Centre for Disease Prevention and Control point prevalence survey of health-care-associated infections in European acute care hospitals in 2011â12 to estimate the number of non-BSIs. We developed disease outcome models for five types of infection on the basis of systematic reviews of the literature.
Findings: From EARS-Net data collected between Jan 1, 2015, and Dec 31, 2015, we estimated 671â689 (95% uncertainty interval [UI] 583â148â763â966) infections with antibiotic-resistant bacteria, of which 63¡5% (426â277 of 671â689) were associated with health care. These infections accounted for an estimated 33â110 (28â480â38â430) attributable deaths and 874â541 (768â837â989â068) DALYs. The burden for the EU and EEA was highest in infants (aged <1 year) and people aged 65 years or older, had increased since 2007, and was highest in Italy and Greece.
Interpretation: Our results present the health burden of five types of infection with antibiotic-resistant bacteria expressed, for the first time, in DALYs. The estimated burden of infections with antibiotic-resistant bacteria in the EU and EEA is substantial compared with that of other infectious diseases, and has increased since 2007. Our burden estimates provide useful information for public health decision-makers prioritising interventions for infectious diseases
SARS-CoV-2 antibody prevalence among homeless people and shelter workers in Denmark:a nationwide cross-sectional study
BACKGROUND: People experiencing homelessness (PEH) and associated shelter workers may be at higher risk of infection with âSevere acute respiratory syndrome coronavirus 2â (SARS-CoV-2). The aim of this study was to determine the prevalence of SARS-CoV-2 among PEH and shelter workers in Denmark. DESIGN AND METHODS: In November 2020, we conducted a nationwide cross-sectional seroprevalence study among PEH and shelter workers at 21 recruitment sites in Denmark. The assessment included a point-of-care test for antibodies against SARS-CoV-2, followed by a questionnaire. The seroprevalence was compared to that of geographically matched blood donors considered as a proxy for the background population, tested using a total Ig ELISA assay. RESULTS: We included 827 participants in the study, of whom 819 provided their SARS-CoV-2 antibody results. Of those, 628 were PEH (median age 50.8 (IQR 40.9â59.1) years, 35.5% female) and 191 were shelter workers (median age 46.6 (IQR 36.1â55.0) years and 74.5% female). The overall seroprevalence was 6.7% and was similar among PEH and shelter workers (6.8% vs 6.3%, pâ=â0.87); and 12.2% among all participants who engaged in sex work. The overall participant seroprevalence was significantly higher than that of the background population (2.9%, pâ<â0.001). When combining all participants who reported sex work or were recruited at designated safe havens, we found a significantly increased risk of seropositivity compared to other participants (OR 2.23, 95%CI 1.06â4.43, pâ=â0.02). Seropositive and seronegative participants reported a similar presence of at least one SARS-CoV-2 associated symptom (49% and 54%, respectively). INTERPRETATIONS: The prevalence of SARS-CoV-2 antibodies was more than twice as high among PEH and associated shelter workers, compared to the background population. These results could be taken into consideration when deciding in which phase PEH are eligible for a vaccine, as part of the Danish national SARS-CoV-2 vaccination program rollout. FUNDING: TrygFonden and HelseFonden. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12889-022-13642-7
Children with atopic dermatitis may have unacknowledged contact allergies contributing to their skin symptoms
Infection prevention and control measures and tools for the prevention of entry of carbapenem-resistant Enterobacteriaceae into healthcare settings: guidance from the European Centre for Disease Prevention and Control
Background: Infections with carbapenem-resistant Enterobacteriaceae (CRE) are increasingly being reported from patients in healthcare settings. They are associated with high patient morbidity, attributable mortality and hospital costs. Patients who are "at-risk" may be carriers of these multidrug-resistant Enterobacteriaceae (MDR-E).The purpose of this guidance is to raise awareness and identify the "at-risk" patient when admitted to a healthcare setting and to outline effective infection prevention and control measures to halt the entry and spread of CRE.
Methods: The guidance was created by a group of experts who were functioning independently of their organisations, during two meetings hosted by the European Centre for Disease Prevention and Control. A list of epidemiological risk factors placing patients "at-risk" for carriage with CRE was created by the experts. The conclusions of a systematic review on the prevention of spread of CRE, with the addition of expert opinion, were used to construct lists of core and supplemental infection prevention and control measures to be implemented for "at-risk" patients upon admission to healthcare settings.
Results: Individuals with the following profile are "at-risk" for carriage of CRE: a) a history of an overnight stay in a healthcare setting in the last 12 months, b) dialysis-dependent or cancer chemotherapy in the last 12 months, c) known previous carriage of CRE in the last 12 months and d) epidemiological linkage to a known carrier of a CRE.Core infection prevention and control measures that should be considered for all patients in healthcare settings were compiled. Preliminary supplemental measures to be implemented for "at-risk" patients on admission are: pre-emptive isolation, active screening for CRE, and contact precautions. Patients who are confirmed positive for CRE will need additional supplemental measures.
Conclusions: Strengthening the microbiological capacity, surveillance and reporting of new cases of CRE in healthcare settings and countries is necessary to monitor the epidemiological situation so that, if necessary, the implemented CRE prevention strategies can be refined in a timely manner. Creating a large communication network to exchange this information would be helpful to understand the extent of the CRE reservoir and to prevent infections in healthcare settings, by applying the principles outlined here.This guidance document offers suggestions for best practices, but is in no way prescriptive for all healthcare settings and all countries. Successful implementation will result if there is local commitment and accountability. The options for intervention can be adopted or adapted to local needs, depending on the availability of financial and structural resources.</p
Additional file 1: of Infection prevention and control measures and tools for the prevention of entry of carbapenem-resistant Enterobacteriaceae into healthcare settings: guidance from the European Centre for Disease Prevention and Control
Printable tables and material for frontline workers. (DOCX 1280 kb