Racing performance of the Quarter Horse: genetic parameters, trends and correlation for earnings, best time and time class

The aim of this study was to evaluate the sprint racing performance of Quarter Horses in Brazil. Estimating genetic parameters, trends and correlations were obtained by single- and two-trait analyses using Bayesian inference (earnings to 2 years of equestrian age, best time and time class at distances of 301 m and 402 m). The data comprised a period of 38 equestrian years (1978 to 2015) with 23,482 sprint race records from 5861 animals. The heritability estimates were of low to moderate magnitude, ranging from 0.10 to 0.37 (single-trait) and from 0.15 to 0.41 (two-traits), and the repeatability was 0.31 to 0.46. The additive, residual and phenotypic correlations between earnings to 2 years of equestrian age and the other traits (best time and time class in distances 301 m and 402 m) were high (−0.95, −0.96, 0.69 and 0.92), low (−0.29, −0.37, 0.26 and 0.27) and moderate (−0.41, −0.47, 0.37 and 0.47), respectively. There is a positive genetic trend for all traits considered. However, evaluation of the last 10 equestrian years (2006 to 2015) showed negative trends (genetic loss) and trends close to zero (genetic stagnation). The design of breeding programs using the earnings trait in conjunction with other racing performance traits can enhance changes in the genetic gains as a whole in speed-racing Quarter Horses. These findings suggest that the traits studied should be included in breeding selection programs for racing Quarter Horses.info:eu-repo/semantics/publishedVersio

Electrodeposited lead dioxide coatings

Lead dioxide coatings on inert substrates such as titanium and carbon now offer new opportunities for a material known for 150 years. It is now recognised that electrodeposition allows the preparation of stable coatings with different phase structures and a wide range of surface morphologies. In addition, substantial modification to the physical properties and catalytic activities of the coatings are possible through doping and the fabrication of nanostructured deposits or composites. In addition to applications as a cheap anode material in electrochemical technology, lead dioxide coatings provide unique possibilities for probing the dependence of catalytic activity on layer composition and structure (critical review, 256 references)

Stabilization of angiotensin-(1-7) by key substitution with a cyclic non-natural amino acid

Angiotensin-(1-7) [Ang-(1-7)], a heptapeptide hormone of the renin-angiotensin-aldosterone system (RAAS), is a promising candidate as a treatment for cancer that reflects its antiproliferative and anti-angiogenic properties. However, the peptide’s therapeutic potential is limited by the short half-life and low bioavailability resulting from rapid enzymatic metabolism by peptidases including angiotensin-converting enzyme (ACE) and dipeptidyl peptidase 3 (DPP 3). We report the facile assembly of three novel Ang-(1-7) analogues by solid-phase peptide synthesis which incorporates the cyclic non-natural δ-amino acid ACCA. The analogues containing the ACCA substitution at the site of ACE cleavage exhibit complete resistance to human ACE, while substitution at the DDP3 cleavage site provided stability against DPP 3 hydrolysis. Furthermore, the analogues retain the anti-proliferative properties of Ang-(1-7) against the 4T1 and HT-1080 cancer cell lines. These results suggest that ACCA-substituted Ang-(1-7) analogues which show resistance against proteolytic degradation by peptidases known to hydrolyze the native heptapeptide may be novel therapeutics in the treatment of cancer

Composição corporal e percepção de autoimagem em universitárias

Introduction: Body image is the way we perceive the body. To recognize it is to clearly state its existence and, from this perception, to see the body's capacity to be changeable, that is, it can be changed at any moment. Objective: Classify the level of distortion of body self-image of university students of the physical education course of a public university of Pauí (UFPI) and verify its relation with anthropometric parameters, since it is believed that these students tend to present a greater concern with their appearance. Methodology: Study is descriptive and quantitative having a sample of 105 students, enrolled between the year of 2011 and 2015 and representing 75% of the total student population, were selected to participate of this descriptive-quantitative study. The self-image distortion was evaluated through the Body Shape Questionnaire (BSQ) and a body control scale was used for the analysis of body weight, composition and metabolism. Results: The students were 21.5±1.8 years old, 58.3±2.0kg weight and 160.6±2.1cm height. Regarding the anthropometric evaluation, students presented body mass index of 22.4±0.6; waist circumference of 70.6±0.8cm and waist/hip ratio of 0.73±0.01cm - values considered normal for adult women. The value obtained from the QSB, 84.2±9.6 points, indicates a slight distortion in the self-body perception. This distortion is present in 53% of the total participants. In conclusion these findings are worrisome because they are a group of future professionals that will work on and promote health and body practices.Introdução: A imagem corporal é a forma como percebemos o corpo. Reconhecê-la é afirmar com clareza sua existência e, a partir dessa percepção, ver a capacidade do corpo ser mutável, ou seja, ele pode a cada momento ser alterado. Objetivo: Classificar o nível de distorção da autoimagem corporal de universitárias do curso de Educação Física de uma universidade pública do Piauí e verificar a relação com os parâmetros antropométricos, pois se acredita que essas estudantes tendem a apresentar uma preocupação maior com a aparência. Metodologia: Estudo é de carácter descritivo e quantitativo, tendo uma amostra de 105 universitárias com ingresso entre 2011 a 2015, as quais representam 75% do total da população. Para avaliar a distorção da autoimagem foi utilizado o questionário Body Shape Questionnaire (BSQ), e para a análise de peso, composição e metabolismo corporal, uma balança de controle corporal (Omron, modelo HBF-514C). Resultados: As estudantes apresentaram idade de 21,5±1,8 anos, peso 58,3±2,0 kg, estatura 160,6±2,1cm, Ãndice de Massa Corporal 22,4±0,6kg/m2; Circunferência da Cintura 70,6±0,8cm e Relação da Cintura/Quadril 0,73±0,01cm, sendo todos esses valores normais para mulheres adultas. Em relação à autoimagem corporal foi encontrado o valor de 84,2±9,6 pontos, que indica uma leve distorção. Essa alteração esteve presente em 53% das participantes. Conclusão: Desta forma, esses achados revelam-se preocupantes pelo fato de se tratar de um grupo de futuros profissionais, multiplicadores de conceitos, da área de saúde e orientadores de práticas corporais