Immediate Tight Sealing of Skin Incisions Using an Innovative Temperature-controlled Laser Soldering Device: In Vivo Study in Porcine Skin

A temperature-controlled laser soldering system (TCLS) was used for bonding skin incisions on the backs of pigs. The bonded incisions were evaluated mechanically and histologically. The immediate tight sealing of the wound by the TCLS contributed to high-quality, rapid wound healing in comparison to cyanoacrylate glues or standard suturing. TCLS carries several advantages and should be further evaluated on humans

Micro- and Nanostructured Biomaterials for Sutureless Tissue Repair

Sutureless procedures for wound repair and closure have recently integrated nanostructured devices to improve their effectiveness and clinical outcome. This review highlights the major advances in gecko-inspired bioadhesives that relies mostly on van der Waals bonding forces. These are challenged by the moist environment of surgical settings that weaken adherence to tissue. The incorporation of nanoparticles in biomatrices and their role in tissue repair and drug delivery is also reviewed with an emphasis on procedures involving adhesives that are laser-activated. Nanostructured adhesive devices have the advantage of being minimally invasive to tissue, can seal wounds, and deliver drugs in situ. All these tasks are very difficult to accomplish by sutures or staples that are invasive to host organs and often cause scarring