284 research outputs found
Spin Evolution of Supermassive Black Holes and Galactic Nuclei
The spin angular momentum S of a supermassive black hole (SBH) precesses due
to torques from orbiting stars, and the stellar orbits precess due to dragging
of inertial frames by the spinning hole. We solve the coupled post-Newtonian
equations describing the joint evolution of S and the stellar angular momenta
Lj, j = 1...N in spherical, rotating nuclear star clusters. In the absence of
gravitational interactions between the stars, two evolutionary modes are found:
(1) nearly uniform precession of S about the total angular momentum vector of
the system; (2) damped precession, leading, in less than one precessional
period, to alignment of S with the angular momentum of the rotating cluster.
Beyond a certain distance from the SBH, the time scale for angular momentum
changes due to gravitational encounters between the stars is shorter than
spin-orbit precession times. We present a model, based on the
Ornstein-Uhlenbeck equation, for the stochastic evolution of star clusters due
to gravitational encounters and use it to evaluate the evolution of S in nuclei
where changes in the Lj are due to frame dragging close to the SBH and to
encounters farther out. Long-term evolution in this case is well described as
uniform precession of the SBH about the cluster's rotational axis, with an
increasingly important stochastic contribution when SBH masses are small. Spin
precessional periods are predicted to be strongly dependent on nuclear
properties, but typical values are 10-100 Myr for low-mass SBHs in dense
nuclei, 100 Myr - 10 Gyr for intermediate mass SBHs, and > 10 Gyr for the most
massive SBHs. We compare the evolution of SBH spins in stellar nuclei to the
case of torquing by an inclined, gaseous accretion disk.Comment: 25 page
Effectiveness of Personal Protective Measures to Prevent Lyme Disease
Use of protective clothing and tick repellents on the skin or clothing while outdoors is 40% and 20% effective, respectively
Role of Human Polyomaviruses in Respiratory Tract Disease in Young Children
KI virus was detected in respiratory secretions of 8/367 (2.2%) symptomatic and 0/96 asymptomatic children (p = 0.215). WU virus was detected in 26/367 (7.1%) symptomatic and 6/96 (6.3%) asymptomatic children (p = 1.00). These human polyomaviruses may not independently cause respiratory tract disease in young children
The Zel'dovich effect and evolution of atomic Rydberg spectra along the Periodic Table
In 1959 Ya. B. Zel'dovich predicted that the bound-state spectrum of the
non-relativistic Coulomb problem distorted at small distances by a short-range
potential undergoes a peculiar reconstruction whenever this potential alone
supports a low-energy scattering resonance. However documented experimental
evidence of this effect has been lacking. Previous theoretical studies of this
phenomenon were confined to the regime where the range of the short-ranged
potential is much smaller than Bohr's radius of the Coulomb field. We go beyond
this limitation by restricting ourselves to highly-excited s states. This
allows us to demonstrate that along the Periodic Table of elements the
Zel'dovich effect manifests itself as systematic periodic variation of the
Rydberg spectra with a period proportional to the cubic root of the atomic
number. This dependence, which is supported by analysis of experimental and
numerical data, has its origin in the binding properties of the ionic core of
the atom.Comment: 17 pages, 12 figure
Iron loading and disease surveillance.
Iron is an oxidant as well as a nutrient for invading microbial and neoplastic cells. Excessive iron in specific tissues and cells (iron loading) promotes development of infection, neoplasia, cardiomyopathy, arthropathy, and various endocrine and possibly neurodegenerative disorders. To contain and detoxify the metal, hosts have evolved an iron withholding defense system, but the system can be compromised by numerous factors. An array of behavioral, medical, and immunologic methods are in place or in development to strengthen iron withholding. Routine screening for iron loading could provide valuable information in epidemiologic, diagnostic, prophylactic, and therapeutic studies of emerging infectious diseases
Oligoclonal bands increase the specificity of MRI criteria to predict multiple sclerosis in children with radiologically isolated syndrome
Background: Steps towards the development of diagnostic criteria are needed for children with the radiologically isolated syndrome to identify children at risk of clinical demyelination. Objectives: To evaluate the 2005 and 2016 MAGNIMS magnetic resonance imaging criteria for dissemination in space for multiple sclerosis, both alone and with oligoclonal bands in cerebrospinal fluid added, as predictors of a first clinical event consistent with central nervous system demyelination in children with radiologically isolated syndrome. Methods: We analysed an international historical cohort of 61 children with radiologically isolated syndrome (18 years), defined using the 2010 magnetic resonance imaging dissemination in space criteria (Ped-RIS) who were followed longitudinally (mean 4.2 4.7 years). All index scans also met the 2017 magnetic resonance imaging dissemination in space criteria. Results: Diagnostic indices (95% confidence intervals) for the 2005 dissemination in space criteria, with and without oligoclonal bands, were: sensitivity 66.7% (38.4\u201388.2%) versus 72.7% (49.8\u201389.3%); specificity 83.3% (58.6\u201396.4%) versus 53.9% (37.2\u201369.9%). For the 2016 MAGNIMS dissemination in space criteria diagnostic indices were: sensitivity 76.5% (50.1\u201393.2%) versus 100% (84.6\u2013100%); specificity 72.7% (49.8\u201389.3%) versus 25.6% (13.0\u201342.1%). Conclusions: Oligoclonal bands increased the specificity of magnetic resonance imaging criteria in children with Ped-RIS. Clinicians should consider testing cerebrospinal fluid to improve diagnostic certainty. There is rationale to include cerebrospinal fluid analysis for biomarkers including oligoclonal bands in planned prospective studies to develop optimal diagnostic criteria for radiologically isolated syndrome in children
Global circulation patterns of seasonal influenza viruses vary with antigenic drift.
Understanding the spatiotemporal patterns of emergence and circulation of new human seasonal influenza virus variants is a key scientific and public health challenge. The global circulation patterns of influenza A/H3N2 viruses are well characterized, but the patterns of A/H1N1 and B viruses have remained largely unexplored. Here we show that the global circulation patterns of A/H1N1 (up to 2009), B/Victoria, and B/Yamagata viruses differ substantially from those of A/H3N2 viruses, on the basis of analyses of 9,604 haemagglutinin sequences of human seasonal influenza viruses from 2000 to 2012. Whereas genetic variants of A/H3N2 viruses did not persist locally between epidemics and were reseeded from East and Southeast Asia, genetic variants of A/H1N1 and B viruses persisted across several seasons and exhibited complex global dynamics with East and Southeast Asia playing a limited role in disseminating new variants. The less frequent global movement of influenza A/H1N1 and B viruses coincided with slower rates of antigenic evolution, lower ages of infection, and smaller, less frequent epidemics compared to A/H3N2 viruses. Detailed epidemic models support differences in age of infection, combined with the less frequent travel of children, as probable drivers of the differences in the patterns of global circulation, suggesting a complex interaction between virus evolution, epidemiology, and human behaviour.T.B.
was
supported
by
a
Newton
International
Fellowship
from
the
Royal
Society
and
through
NIH
U54
GM111274.
S.R.
was
supported
by
MRC
(UK,
Project
MR/J008761/1),
Wellcome
Trust
(UK,
Project
093488/Z/10/Z),
Fogarty
International
Centre
(USA,
R01
TW008246â01),
DHS
(USA,
RAPIDD
program),
NIGMS
(USA,
MIDAS
U01
GM110721â01)
and
NIHR
(UK,
Health
Protection
Research
Unit
funding).
The
Melbourne
WHO
Collaborating
Centre
for
Reference
and
Research
on
Influenza
was
supported
by
the
Australian
Government
Department
of
Health
and
thanks
N.
Komadina
and
Y.âM.
Deng.
The
Atlanta
WHO
Collaborating
Center
for
Surveillance,
Epidemiology
and
Control
of
Influenza
was
supported
by
the
U.S.
Department
of
13
Health
and
Human
Services.
NIV
thanks
A.C.
Mishra,
M.
ChawlaâSarkar,
A.M.
Abraham,
D.
Biswas,
S.
Shrikhande,
AnuKumar
B,
and
A.
Jain.
Influenza
surveillance
in
India
was
expanded,
in
part,
through
US
Cooperative
Agreements
(5U50C1024407
and
U51IP000333)
and
by
the
Indian
Council
of
Medical
Research.
M.A.S.
was
supported
through
NSF
DMS
1264153
and
NIH
R01
AI
107034.
Work
of
the
WHO
Collaborating
Centre
for
Reference
and
Research
on
Influenza
at
the
MRC
National
Institute
for
Medical
Research
was
supported
by
U117512723.
P.L.,
A.R.
&
M.A.S
were
supported
by
EU
Seventh
Framework
Programme
[FP7/2007â2013]
under
Grant
Agreement
no.
278433-ÂâPREDEMICS
and
ERC
Grant
agreement
no.
260864.
C.A.R.
was
supported
by
a
University
Research
Fellowship
from
the
Royal
Society.This is the author accepted manuscript. It is currently under infinite embargo pending publication of the final version
A Scalable System for Production of Functional Pancreatic Progenitors from Human Embryonic Stem Cells
Development of a human embryonic stem cell (hESC)-based therapy for type 1 diabetes will require the translation of proof-of-principle concepts into a scalable, controlled, and regulated cell manufacturing process. We have previously demonstrated that hESC can be directed to differentiate into pancreatic progenitors that mature into functional glucose-responsive, insulin-secreting cells in vivo. In this study we describe hESC expansion and banking methods and a suspension-based differentiation system, which together underpin an integrated scalable manufacturing process for producing pancreatic progenitors. This system has been optimized for the CyT49 cell line. Accordingly, qualified large-scale single-cell master and working cGMP cell banks of CyT49 have been generated to provide a virtually unlimited starting resource for manufacturing. Upon thaw from these banks, we expanded CyT49 for two weeks in an adherent culture format that achieves 50â100 fold expansion per week. Undifferentiated CyT49 were then aggregated into clusters in dynamic rotational suspension culture, followed by differentiation en masse for two weeks with a four-stage protocol. Numerous scaled differentiation runs generated reproducible and defined population compositions highly enriched for pancreatic cell lineages, as shown by examining mRNA expression at each stage of differentiation and flow cytometry of the final population. Islet-like tissue containing glucose-responsive, insulin-secreting cells was generated upon implantation into mice. By four- to five-months post-engraftment, mature neo-pancreatic tissue was sufficient to protect against streptozotocin (STZ)-induced hyperglycemia. In summary, we have developed a tractable manufacturing process for the generation of functional pancreatic progenitors from hESC on a scale amenable to clinical entry
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