Bilateral ovarian teratoma complicated with carcinosarcoma in a 68 year old woman: a case report

<p>Abstract</p> <p>Background</p> <p>Composing of less than 1% of all ovarian cancers, immature teratoma is a malignancy that mainly affects the young, and they present with advanced disease. The treatment of immature teratoma is conservative primary surgery usually involving unilateral salpingo-oophorectomy followed by combination chemotherapy.</p> <p>Case presentation</p> <p>Here we present a case of a 68 year old woman with bilateral ovarian teratoma complicated with carcinosarcoma. The patient was diagnosed as FIGO stage IIIC. She underwent neoadjuvant chemotherapy and interval cytoreduction followed by optimal cytoreduction. The post operative management strategies and gynaecological follow up studies revealed no evidence of regional or distant metastasis.</p> <p>Conclusion</p> <p>Thus the choice of initial treatment should be decided in a selective fashion depending on various prognostic factors in order to increase the survival of the patients.</p

The Mitochondrial Ca(2+) Uniporter: Structure, Function, and Pharmacology.

Mitochondrial Ca(2+) uptake is crucial for an array of cellular functions while an imbalance can elicit cell death. In this chapter, we briefly reviewed the various modes of mitochondrial Ca(2+) uptake and our current understanding of mitochondrial Ca(2+) homeostasis in regards to cell physiology and pathophysiology. Further, this chapter focuses on the molecular identities, intracellular regulators as well as the pharmacology of mitochondrial Ca(2+) uniporter complex

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing on mechanistic and essential (as opposed to correlative and dispensable) aspects of the process. As we provide molecularly oriented definitions of terms including intrinsic apoptosis, extrinsic apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic cell death, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, immunogenic cell death, cellular senescence, and mitotic catastrophe, we discuss the utility of neologisms that refer to highly specialized instances of these processes. The mission of the NCCD is to provide a widely accepted nomenclature on cell death in support of the continued development of the field

FigureS3.pdf

<p>Fig. S3. Effect of different treatments on time to peak. Time to peak values were averaged over all cells/ex­periment and all independent experi­ments (n=4-10) for control (shear), Ca²⁺-free+La³⁺, U73122, U73343, FCCP (0.5), FCCP (2), antimycin A, oligomycin, CGP37157 (10), WT and MCU KD. *<i>P</i><0.05 vs. con­trol. ^†<i>P</i> < 0.05 vs. WT (MCU KD was only compared to WT).</p

FigureS2.pdf

<p>Fig. S2. Effect of the addition of different chemicals on normalized fluorescence during the preincubation period. Char­acteris­tic nor­mal­ized fluorescence signals vs. time are shown for ECs on a single field of view during the 20 min preincuba­tion period with either FCCP (2), antimycin A or CGP37157 (10).</p

FigureS3.pdf

<p>Fig. S3. Effect of different treatments on time to peak. Time to peak values were averaged over all cells/ex­periment and all independent experi­ments (n=4-10) for control (shear), Ca²⁺-free+La³⁺, U73122, U73343, FCCP (0.5), FCCP (2), antimycin A, oligomycin, CGP37157 (10), WT and MCU KD. *<i>P</i><0.05 vs. con­trol. ^†<i>P</i> < 0.05 vs. WT (MCU KD was only compared to WT).</p