The TransLectures-UPV Toolkit

The final publication is available at Springer via http://dx.doi.org/10.1007/978-3-319-13623-3_28Over the past few years, online multimedia educational repositories have increased in number and popularity. The main aim of the transLectures project is to develop cost-effective solutions for producing accurate transcriptions and translations for large video lecture repositories, such as VideoLectures.NET or the Universitat Politècnica de València s repository, poliMedia. In this paper, we present the transLectures-UPV toolkit (TLK), which has been specifically designed to meet the requirements of the transLectures project, but can also be used as a conventional ASR toolkit. The main features of the current release include HMM training and decoding with speaker adaptation techniques (fCMLLR). TLK has been tested on the VideoLectures.NET and poliMedia repositories, yielding very competitive results. TLK has been released under the permissive open source Apache License v2.0 and can be directly downloaded from the transLectures website.The research leading to these results has received funding from the European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement no 287755 (transLectures) and ICT Policy Support Programme (ICT PSP/2007-2013) as part of the Competitiveness and InnovationFramework Programme (CIP) under grant agreement no 621030 (EMMA), andthe Spanish MINECO Active2Trans (TIN2012-31723) research project.Del Agua Teba, MA.; Giménez Pastor, A.; Serrano Martinez Santos, N.; Andrés Ferrer, J.; Civera Saiz, J.; Sanchis Navarro, JA.; Juan Císcar, A. (2014). The TransLectures-UPV Toolkit. En Advances in Speech and Language Technologies for Iberian Languages: Second International Conference, IberSPEECH 2014, Las Palmas de Gran Canaria, Spain, November 19-21, 2014. Proceedings. Springer International Publishing. 269-278. https://doi.org/10.1007/978-3-319-13623-3_28S269278Final report on massive adaptation (M36). To be delivered on October 2014 (2014)First report on massive adaptation (M12), https://www.translectures.eu/wp-content/uploads/2013/05/transLectures-D3.1.1-18Nov2012.pdfOpencast Matterhorn, http://opencast.org/matterhorn/sclite - Score speech recognition system output, http://www1.icsi.berkeley.edu/Speech/docs/sctk-1.2/sclite.htmSecond report on massive adaptation (M24), https://www.translectures.eu//wp-content/uploads/2014/01/transLectures-D3.1.2-15Nov2013.pdfTLK: The transLectures-UPV Toolkit, https://www.translectures.eu/tlk/Baum, L.E., Petrie, T., Soules, G., Weiss, N.: A Maximization Technique Occurring in the Statistical Analysis of Probabilistic Functions of Markov Chains. The Annals of Mathematical Statistics 41(1), 164–171 (1970)Dahl, G.E., Yu, D., Deng, L., Acero, A.: Context-Dependent Pre-Trained Deep Neural Networks for Large-Vocabulary Speech Recognition. IEEE Transactions on Audio, Speech, and Language Processing 20(1), 30–42 (2012)Digalakis, V., Rtischev, D., Neumeyer, L., Sa, E.: Speaker Adaptation Using Constrained Estimation of Gaussian Mixtures. IEEE Transactions on Speech and Audio Processing 3, 357–366 (1995)Huang, J.T., Li, J., Yu, D., Deng, L., Gong, Y.: Cross-language knowledge transfer using multilingual deep neural network with shared hidden layers. In: Proc. of ICASSP (2013)Munteanu, C., Baecker, R., Penn, G., Toms, E., James, D.: The Effect of Speech Recognition Accuracy Rates on the Usefulness and Usability of Webcast Archives. In: Proc. of CHI, pp. 493–502 (2006)Ney, H., Ortmanns, S.: Progress in dynamic programming search for LVCSR. Proceedings of the IEEE 88(8), 1224–1240 (2000)Ortmanns, S., Ney, H., Eiden, A.: Language-model look-ahead for large vocabulary speech recognition. In: Proc. of ICSLP, vol. 4, pp. 2095–2098 (1996)Ortmanns, S., Ney, H., Aubert, X.: A word graph algorithm for large vocabulary continuous speech recognition. Computer Speech and Language 11(1), 43–72 (1997)Povey, D., et al.: The Kaldi Speech Recognition Toolkit. In: Proc. of ASRU (2011)Rumelhart, D., Hintont, G., Williams, R.: Learning representations by back-propagating errors. Nature 323(6088), 533–536 (1986)Rybach, D., et al.: The RWTH Aachen University Open Source Speech Recognition System. In: Proc. Interspeech, pp. 2111–2114 (2009)Seide, F., Li, G., Chen, X., Yu, D.: Feature engineering in Context-Dependent Deep Neural Networks for conversational speech transcription. In: Proc. of ASRU, pp. 24–29 (2011)Viterbi, A.: Error bounds for convolutional codes and an asymptotically optimum decoding algorithm. IEEE Transactions on Information Theory 13(2), 260–269 (1967)Young, S., et al.: The HTK Book. Cambridge University Engineering Department (1995)Young, S.J., Odell, J.J., Woodland, P.C.: Tree-based state tying for high accuracy acoustic modelling. In: Proc. of HLT, pp. 307–312 (1994

Concentration-Dependent Protection by Ethanol Extract ofPropolis against γ-Ray-Induced Chromosome Damage in HumanBlood Lymphocytes

[EN] Radioprotection with natural products may be relevant to the mitigation of ionizing radiation-induced damage in mammalian systems; in this sense, propolis extracts have shown effects such as antioxidant, antitumoral, anti-inflammatory, and immunostimulant. We report for the first time a cytogenetic study to evaluate the radioprotective effect, in vitro, of propolis against radiation-induced chromosomal damage. Lymphocytes were cultured with increasing concentrations of ethanol extract of propolis (EEP), including 20, 40, 120, 250, 500, 750, 1000, and 2000 ¿g mL-1 and then exposed to 2 Gy ¿-rays. A significant and concentration-dependent decrease is observed in the frequency of chromosome aberrations in samples treated with EEP. The protection against the formation of dicentrics was concentration-dependent, with a maximum protection at 120 ¿g mL-1 of EEP. The observed frequency of dicentrics is described as negative exponential function, indicating that the maximum protectible fraction of dicentrics is approximately 44. Free radical scavenging and antioxidant activities are the mechanisms that these substances use to protect cells from ionizing radiation. Copyright © 2011 A. Montoro et al.This research was supported in part by the Company Dieteticos Intersa S.A., U.P.V., and Hospital Universitario La Fe of Valencia and Consejo de Seguridad Nuclear (2696/SRO). The authors express their appreciation to Dr. Pepe Perez (Hospital Universitario La Fe) and Dr. Alberto Yuste (U.P.V.).Montoro, A.; Barquinero, J.; Almonacid, M.; Montoro, A.; Sebastià, N.; Verdú Martín, GJ.; Sahuquillo, V.... (2011). Concentration-Dependent Protection by Ethanol Extract ofPropolis against γ-Ray-Induced Chromosome Damage in HumanBlood Lymphocytes. Evidence-based Complementary and Alternative Medicine. 1-7. doi:10.1155/2011/174853S1

White Paper 5: Brain, Mind & Behaviour

© CSICThe study of the brain will tell us what makes us humans and how our social behavior generates. Increasing our understanding of how the brain functions and interacts with the ecosystem to interpret the world will not only help to find effective means to treat and/or cure neurological and psychiatric disorders but will also change our vision on questions pertaining to philosophy and humanities and transform other fields such as economy and law. Neurosciences research at the CSIC is already valuable and should be intensified mainly focused on the eight major challenges described in this volume

Postlaunch evidence-generation studies for medical devices in Spain: the RedETS approach to integrate real-world evidence into decision making

The Monitoring Studies (MS) program, the approach developed by RedETS to generate postlaunch real-world evidence (RWE), is intended to complement and enhance the conventional health technology assessment process to support health policy decision making in Spain, besides informing other interested stakeholders, including clinicians and patients. The MS program is focused on specific uncertainties about the real effect, safety, costs, and routine use of new and insufficiently assessed relevant medical devices carefully selected to ensure the value of the additional research needed, by means of structured, controlled, participative, and transparent procedures. However, despite a clear political commitment and economic support from national and regional health authorities, several difficulties were identified along the development and implementation of the first wave of MS, delaying its execution and final reporting. Resolution of these difficulties at the regional and national levels and a greater collaborative impulse in the European Union, given the availability of an appropriate methodological framework already provided by EUnetHTA, might provide a faster and more efficient comparative RWE of improved quality and reliability at the national and international levels

Assessment of Pablo de Olavide University's Alignment with the 2030 Agenda. A Diagnosis from Seville, Spain

Document compiled by staff from Pablo de Olavide University of Seville (UPO), with technical assistance from Periferia Consultoría Social. This project has been funded with support from the European Commission.Versión española del documento en: https://dx.doi.org/10.46661/rio.20230630_1Recognizing the crucial role of universities in implementing the 2030 Agenda, the Pablo de Olavide University (UPO) has conducted a comprehensive assessment to evaluate its alignment and contribution towards achieving the Targets defined within the 17 Sustainable Development Goals (SDGs). The 2030 Agenda presents a dual mandate for universities. Firstly, they are tasked with integrating the SDGs into their educational and research programs. Secondly, they are expected to act as catalysts for societal transformation and promote a governance model in higher education that aligns with the Agenda's objectives. In light of these responsibilities, UPO has recognized the need to equip itself with the necessary tools to effectively assess the fulfillment of these mandates. This accountability is crucial for demonstrating UPO's commitment to the SDGs and for enhancing the effectiveness of its actions within the framework of the Agenda. This document provides a summary of the process undertaken by UPO, in collaboration with Periferia Social Consulting, between November 2022 and May 2023. The objective was to design a set of indicators that can measure UPO's contribution to the 2030 Agenda. The first section describes the methodology and various phases involved in the process. Following that, the document presents the system of indicators developed and provides information on UPO's contribution to the 2030 Agenda for the academic year 2021-2022. In the annexes, two posters are included, displaying the complete set of indicators and the measurements made for the 2021-2022 academic year.Universidad Pablo de Olavid

Diagnóstico sobre alineamiento de la Universidad Pablo de Olavide de Sevilla con la Agenda 2030

Documento elaborado por el Grupo Interno de la UPO, con la asistencia técnica de Periferia Consultoría Social, y la financiación de la Agencia Andaluza de Cooperación Internacional.Versión inglesa del documento en: https://dx.doi.org/10.46661/rio.20230718_1Consciente del papel clave que juegan la universidades en la implementación de la Agenda 2030, la Universidad Pablo de Olavide (UPO) plantea realizar un diagnóstico para conocer el grado de alineamiento y contribución a la consecución de las metas englobadas en los 17 ODS que conforman dicha Agenda. La Agenda 2030 marca un doble mandato a las Universidades; por un lado, incorporar los ODS en el ámbito de la formación y la investigación y por otro, como agente transformador de la sociedad y modelo de gobernanza en Educación Superior. En este sentido, la UPO necesita dotarse de las herramientas necesarias con las que poder determinar cómo se están cumpliendo efectivamente estos mandatos, con la finalidad tanto de rendir cuentas sobre su contribución al cumplimiento de los ODS y de mejorar la eficacia de sus actuaciones en el marco de dicha Agenda. Este documento es un resumen del proceso que desde la UPO con el apoyo de Periferia Consultoría Social se ha llevado a cabo entre los meses de noviembre 2022 y mayo 2023 para la construcción de un Sistema de Indicadores que permite medir la contribución de la UPO a la Agenda 2030. En un primer apartado, se describe la metodología y distintas fases llevadas a cabo; a continuación, se presenta el sistema de indicadores construido y la información sobre la contribución de la UPO a la Agenda 2030 para el curso 2021-2022. En anexos, se pueden encontrar las fichas metodológicas de cada uno de los indicadores que conforman el sistema; así como, dos poster donde visualizar el conjunto de indicadores y la medición realizada para el curso 2021-2022.Universidad Pablo de Olavid

Libro Blanco Volumen 5: Cerebro, mente y comportamiento

Llegar a entender cómo funciona el cerebro y cómo este interacciona con el ecosistema para interpretar el mundo que nos rodea sin duda facilitará el desarrollo de estrategias más eficaces para tratar o curar los trastornos neurológicos y psiquiátricos. Además, la comprensión de los principios fundamentales que controlan el funcionamiento del sistema nervioso transformará nuestra visión sobre muchas cuestiones que han sido tradicionalmente enmarcadas en el campo de la filosofía, repercutiendo en áreas como la economía o el derecho. Las neurociencias nos ayudarán, en definitiva, a entender qué nos hace humanos. Este es un campo en el que los investigadores del CSIC destacan internacionalmente y así debe seguir siendo en los próximos años. Para lograrlo, deberíamos potenciar y reforzar nuestras investigaciones en los ocho desafíos que describimos en este volumen.Peer reviewe

TransLectures

transLectures (Transcription and Translation of Video Lectures) is an EU STREP project in which advanced automatic speech recognition and machine translation techniques are being tested on large video lecture repositories. The project began in November 2011 and will run for three years. This paper will outline the project¿s main motivation and objectives, and give a brief description of the two main repositories being considered: VideoLectures.NET and poliMedia. The first results obtained by the UPV group for the poliMedia repository will also be provided.The research leading to these results has received funding from the European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement no. 287755. Funding was also provided by the Spanish Government (iTrans2 project, TIN2009-14511; FPI scholarship BES-2010-033005; FPU scholarship AP2010-4349)Silvestre Cerdà, JA.; Del Agua Teba, MA.; Garcés Díaz-Munío, GV.; Gascó Mora, G.; Giménez Pastor, A.; Martínez-Villaronga, AA.; Pérez González De Martos, AM.... (2012). TransLectures. IberSPEECH 2012. 345-351. http://hdl.handle.net/10251/3729034535

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio

The Mosaic Brain: Sex/Gender and the Neurosciences

Brain function is influenced by internal inputs from many parts of the body, including chemicals in the blood and bacteria in the gut. The gut microbiota is a fundamental component of the body that can be transferred across generations and contribute to the unique features of the human phenotype influencing both health and disease. Deciphering the controlling mechanisms of microbiome-bodybrain interactions may help in identifying new molecular targets to prevent and/or treat a range of psychiatric and neurologic disorders as well as their physical comorbidities. Here we provide an update on the functioning of the gut microbiome-body-brain axis and outline open scientific challenges and future research directions