Key Experiment and Quantum Reasoning

For around five decades, physicists have been experimenting with single quanta such as single photons. Insofar as the practised ensemble reasoning has become obsolete for the interpretation of these experiments, the non-classical intrinsic probabilistic nature of quantum theory has gained increased importance. One of the most important exclusive features of quantum physics is the undeniable existence of the superposition of states, even for single quantum objects. One known example of this effect is entanglement. In this paper, two classically contradictory phenomena are combined to one single experiment. This experiment incontestably shows that a single photon incident on an optical beam splitter can either be reflected or transmitted. The almost complete absence of coincident clicks of two photodetectors demonstrates that these two output states are incompatible. However, when combining these states using two mirrors, we can observe interference patterns in the counting rate of the single photon detector. The only explanation for this is that the two incompatible output states are prepared and kept simultaneously—a typical consequence of a quantum superposition of states. (Semi-)classical physical concepts fail here, and a full quantum concept is predestined to explain the complementary experimental outcomes for the quantum optical “non-waves” called single photons. In this paper, we intend to demonstrate that a true quantum physical key experiment (“true” in the sense that it cannot be explained by any classical physical concept), when combined with full quantum reasoning (probability, superposition and interference), influences students’ readiness to use quantum elements for interpretation

The genetic architecture of the human cerebral cortex

The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder

Key Experiment and Quantum Reasoning

For around five decades, physicists have been experimenting with single quanta such as single photons. Insofar as the practised ensemble reasoning has become obsolete for the interpretation of these experiments, the non-classical intrinsic probabilistic nature of quantum theory has gained increased importance. One of the most important exclusive features of quantum physics is the undeniable existence of the superposition of states, even for single quantum objects. One known example of this effect is entanglement. In this paper, two classically contradictory phenomena are combined to one single experiment. This experiment incontestably shows that a single photon incident on an optical beam splitter can either be reflected or transmitted. The almost complete absence of coincident clicks of two photodetectors demonstrates that these two output states are incompatible. However, when combining these states using two mirrors, we can observe interference patterns in the counting rate of the single photon detector. The only explanation for this is that the two incompatible output states are prepared and kept simultaneously—a typical consequence of a quantum superposition of states. (Semi-)classical physical concepts fail here, and a full quantum concept is predestined to explain the complementary experimental outcomes for the quantum optical “non-waves” called single photons. In this paper, we intend to demonstrate that a true quantum physical key experiment (“true” in the sense that it cannot be explained by any classical physical concept), when combined with full quantum reasoning (probability, superposition and interference), influences students’ readiness to use quantum elements for interpretation

Zukunftstechnologien fuer Schleswig-Holstein: Bericht ueber die Vorphase ; Studie im Auftrag der Staatskanzlei Schleswig-Holstein

Available from Bibliothek des Instituts fuer Weltwirtschaft, ZBW, Duesternbrook Weg 120, D-24105 Kiel C 179482 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman

Genome-wide association study identifies 25 known breast cancer susceptibility loci as risk factors for triple-negative breast cancer.

Triple-negative (TN) breast cancer is an aggressive subtype of breast cancer associated with a unique set of epidemiologic and genetic risk factors. We conducted a two-stage genome-wide association study of TN breast cancer (stage 1: 1529 TN cases, 3399 controls; stage 2: 2148 cases, 1309 controls) to identify loci that influence TN breast cancer risk. Variants in the 19p13.1 and PTHLH loci showed genome-wide significant associations (P < 5 × 10(-) (8)) in stage 1 and 2 combined. Results also suggested a substantial enrichment of significantly associated variants among the single nucleotide polymorphisms (SNPs) analyzed in stage 2. Variants from 25 of 74 known breast cancer susceptibility loci were also associated with risk of TN breast cancer (P < 0.05). Associations with TN breast cancer were confirmed for 10 loci (LGR6, MDM4, CASP8, 2q35, 2p24.1, TERT-rs10069690, ESR1, TOX3, 19p13.1, RALY), and we identified associations with TN breast cancer for 15 additional breast cancer loci (P < 0.05: PEX14, 2q24.1, 2q31.1, ADAM29, EBF1, TCF7L2, 11q13.1, 11q24.3, 12p13.1, PTHLH, NTN4, 12q24, BRCA2, RAD51L1-rs2588809, MKL1). Further, two SNPs independent of previously reported signals in ESR1 [rs12525163 odds ratio (OR) = 1.15, P = 4.9 × 10(-) (4)] and 19p13.1 (rs1864112 OR = 0.84, P = 1.8 × 10(-) (9)) were associated with TN breast cancer. A polygenic risk score (PRS) for TN breast cancer based on known breast cancer risk variants showed a 4-fold difference in risk between the highest and lowest PRS quintiles (OR = 4.03, 95% confidence interval 3.46-4.70, P = 4.8 × 10(-) (69)). This translates to an absolute risk for TN breast cancer ranging from 0.8% to 3.4%, suggesting that genetic variation may be used for TN breast cancer risk prediction