665 research outputs found

    Empirische Shortcuts:Studentische Forschungsprojekte in der Methodenlehre

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    Die empirische Bildungsforschung hat in den letzten Jahren einen nachhaltigen quantitativen und qualitativen Aufschwung genommen. Erziehungswissenschaftliche Forschung erschöpft sich jedoch nicht im M&E des schulischen Lernstands im nationalen und internationalen Vergleich und seiner Ursachen sondern umfasst ein weites Feld an Fragestellungen aus unterschiedlichsten Bereichen. Dies muss den Studierenden, neben den methodischen Modellen und Instrumentarien exemplarisch vermittelt werden. Das ideale didaktische Modell hierfĂŒr ist zweifellos ein von den Studierenden selbst konzipiertes und durchgefĂŒhrtes Forschungsprojekt, wie es seit Jahren im Programmbereich „Empirische PĂ€dagogik“ des Instituts fĂŒr Erziehungswissenschaft der WWU MĂŒnster praktiziert. Dadurch werden den Studierenden Dimensionen eröffnet, die im Zeitalter von Modularisierung, OECD-Statistiken und Ressourcenverknappung sich zunehmend verengen. Die damit verbundenen Impulse und Erfahrungsgewinne sind in eine Belebung und Bereicherung des Studiums

    Dark Matter and Baryons in the Most X-ray Luminous and Merging Galaxy Cluster RX J1347.5-1145

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    The galaxy cluster RX J1347-1145 is one of the most X-ray luminous and most massive clusters known. Its extreme mass makes it a prime target for studying issues addressing cluster formation and cosmology. In this paper we present new high-resolution HST/ACS and Chandra X-ray data. The high resolution and sensitivity of ACS enabled us to detect and quantify several new multiply imaged sources, we now use a total of eight for the strong lensing analysis. Combining this information with shape measurements of weak lensing sources in the central regions of the cluster, we derive a high-resolution, absolutely-calibrated mass map. This map provides the best available quantification of the total mass of the central part of the cluster to date. We compare the reconstructed mass with that inferred from the new Chandra X-ray data, and conclude that both mass estimates agree extremely well in the observed region, namely within 400 / h_70 kpc of the cluster center. In addition we study the major baryonic components (gas and stars) and hence derive the dark matter distribution in the center of the cluster. We find that the dark matter and baryons are both centered on the BCG within the uncertainties (alignment is better than <10 kpc). We measure the corresponding 1-D profiles and find that dark matter distribution is consistent with both NFW and cored profiles, indicating that a more extended radial analysis is needed to pinpoint the concentration parameter, and hence the inner slope of the dark matter profile.Comment: 12 pages, Accepted for publication in ApJ, full-res version http://www.physics.ucsb.edu/~marusa/RXJ1347.pd

    VLT observations of the z=6.28 quasar SDSS 1030+0524

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    We present new VLT spectroscopic observations of the most distant quasar known, SDSS J1030+0524 at z=6.28 which was recently discovered by the Sloan Digital Sky Survey. We confirm the presence of a complete Gunn-Peterson trough caused by neutral hydrogen in the intergalactic medium. There is no detectable flux over the wavelength range from 8450 to 8710 A. We set an improved limit on the drop of the flux level blueward of the Ly alpha line: a factor of > 200. Below 8450 A the spectrum shows a rise in flux, with a large fraction (> 60 %) of the total emission produced by few narrow features of transmitted flux. We discuss the obvious proximity effect around this quasar, with the presence of transmitted flux with many absorption features in a region of about 23h^{-1} comoving Mpc. If assuming the surrounding medium were completely neutral, the size of this region would imply a quasar lifetime of \~1.3x10^7 years. We also present near-IR spectroscopy of both SDSS J1030+0524 and of SDSS J1306+05, the second most distant quasar known at redshift 6.0. We combine measurements of the CIV line and limits on the HeII emission with the NV line measurements from the optical spectra to derive line ratios, and by implication the abundances of these early quasar environments. The results are indistinguishable from those of lower redshift quasars and indicate little or no evolution in the abundances from z ~ 6 to z ~ 2. The line ratios suggest supersolar metallicities, implying that the first stars around the quasars must have formed at least a few hundreds of Myrs prior to the observation, i.e. at redshift higher than 8.Comment: Accepted by the Astronomical Journal (scheduled for May 2002). Proximity effect section revise

    Halo shapes constrained from a pure sample of central galaxies in KiDS-1000

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    We present measurements of fh, the ratio of the aligned components of the projected halo and galaxy ellipticities, for a sample of central galaxies using weak gravitational lensing data from the Kilo-Degree Survey (KiDS). Using a lens galaxy shape estimation that is more sensitive to outer galaxy regions, we find fh = 0.50 ± 0.20 for our full sample and fh = 0.55 ± 0.19 for an intrinsically red sub-sample (that therefore has a higher stellar mass), rejecting the hypothesis that round halos and/or galaxies are not aligned with their parent halo at 2.5σ and 2.9σ, respectively. We quantify the 93.4% purity of our central galaxy sample using numerical simulations and overlapping spectroscopy from the Galaxy and Mass Assembly survey. This purity ensures that the interpretation of our measurements is not complicated by the presence of a significant fraction of satellite galaxies. Restricting our central galaxy ellipticity measurement to the inner isophotes, we find fh = 0.34 ± 0.17 for our red sub-sample, suggesting that the outer galaxy regions are more aligned with their dark matter halos than the inner regions. Our results are in agreement with previous studies and suggest that lower mass halos are rounder and/or less aligned with their host galaxy than samples of more massive galaxies, studied in galaxy groups and clusters

    Inhibitors of Helicobacter pylori Protease HtrA Found by ‘Virtual Ligand’ Screening Combat Bacterial Invasion of Epithelia

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    Background: The human pathogen Helicobacter pylori (H. pylori) is a main cause for gastric inflammation and cancer. Increasing bacterial resistance against antibiotics demands for innovative strategies for therapeutic intervention. Methodology/Principal Findings: We present a method for structure-based virtual screening that is based on the comprehensive prediction of ligand binding sites on a protein model and automated construction of a ligand-receptor interaction map. Pharmacophoric features of the map are clustered and transformed in a correlation vector (‘virtual ligand’) for rapid virtual screening of compound databases. This computer-based technique was validated for 18 different targets of pharmaceutical interest in a retrospective screening experiment. Prospective screening for inhibitory agents was performed for the protease HtrA from the human pathogen H. pylori using a homology model of the target protein. Among 22 tested compounds six block E-cadherin cleavage by HtrA in vitro and result in reduced scattering and wound healing of gastric epithelial cells, thereby preventing bacterial infiltration of the epithelium. Conclusions/Significance: This study demonstrates that receptor-based virtual screening with a permissive (‘fuzzy’) pharmacophore model can help identify small bioactive agents for combating bacterial infection

    Soil fungal community shift evaluation as a potential cadaver decomposition indicator

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    Fungi metabolise organic matter in situ and so alter both the bio-/physico-chemical properties and microbial community structure of the ecosystem. In particular, they are responsible reportedly for specific stages of decomposition. Therefore, this study aimed to extend previous bacteria-based forensic ecogenomics research by investigating soil fungal community and cadaver decomposition interactions in microcosms with garden soil (20 kg, fresh weight) and domestic pig (Sus scrofa domesticus) carcass (5 kg, leg). Soil samples were collected at depths of 0–10 cm, 10–20 cm and 20–30 cm on days 3, 28 and 77 in the absence (control −Pg) and presence (experimental +Pg) of Sus scrofa domesticus and used for total DNA extraction and nested polymerase chain reaction and denaturing gradient gel electrophoresis (PCR–DGGE) profiling of the 18S rRNA gene. The Shannon–Wiener (Hâ€Č) community diversity indices were 1.25 ± 0.21 and 1.49 ± 0.30 for the control and experimental microcosms, respectively, while comparable Simpson species dominance (S) values were 0.65 ± 0.109 and 0.75 ± 0.015. Generally, and in contrast to parallel studies of the bacterial 16S rRNA and 16S rDNA profiles, statistical analysis (t-test) of the 18S dynamics showed no mathematically significant shifts in fungal community diversity (Hâ€Č; p = 0.142) and dominance (S; p = 0.392) during carcass decomposition, necessitating further investigations

    Average Properties of a Large Sample of z_abs ~ z_em associated Mg II Absorption Line Systems

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    We have studied a sample of 415 associated (z_ab z_em; relative velocity with respect to QSO <3000km/s) Mg II absorption systems with 1.0<=z_ab<=1.86, in the spectra of SDSS DR3 QSOs, to determine the dust content and ionization state in the absorbers. We studied the dependence of these properties on the properties of the QSOs and also, compared the properties with those of a similarly selected sample of 809 intervening systems (apparent relative velocity with respect to the QSO of >3000km/s), so as to understand their origin. From the analysis of the composite spectra, as well as from the comparison of measured equivalent widths in individual spectra, we conclude that the associated Mg II absorbers have higher apparent ionization, measured by the strength of the C IV absorption lines compared to the Mg II absorption lines, than the intervening absorbers. The ionization so measured appears to be related to apparent ejection velocity, being lower as the apparent ejection velocity is more and more positive. There is clear evidence, from the composite spectra, for SMC like dust attenuation in these systems; the 2175AA absorption feature is not present. The extinction is almost twice that observed in the similarly selected sample of intervening systems. We reconfirm that QSOs with non-zero FIRST radio flux are intrinsically redder than the QSOs with no detection in the FIRST survey. The incidence of associated Mg II systems in QSOs with non-zero FIRST radio flux is 1.7 times that in the QSOs with no detection in the FIRST survey. The associated absorbers in radio-detected QSOs which comprise about 12% of our sample, cause 3 times more reddening than the associated absorbers in radio-undetected QSOs. This excess reddening possibly suggests an intrinsic nature for the associated absorbers in radio-detected QSOs.Comment: Accepted for publication in Ap
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