Det spadserende i 2010ernes Berlin-litteratur

Two contemporary German books – Hanns Zischler‘s Berlin ist zu groß für Berlin (2013) and Tanja Dückers‘ Mein altes West-Berlin (2016) – express the criticism that inhabitants of big cities have stopped walking. The main subject in these texts is the walk in Berlin without having a specific purpose. The big city Berlin is considered a space of formation that should be ‘read’ to disclose history. The article examines if Zischler’s and Dückers’ walk is merely a part of a nostalgic culture of remembrance or still is a current way to move around in contemporary Berlin physically and intellectually

Globaliseringen hos Ernst Jünger: Fra verdenskrig til verdensstat

In The globalization in Ernst Jünger. From World War to World State, Jan Schlosser follows the German writer's understanding of global phenomena and the development of global narratives in his writings. In the early works of Jünger he reflected on the modern technology that was developed in connection with World War I. In this period he had the controversial view that there are people who master these technologies. After Germany's defeat Jünger was a spokesman for a world state and already questioned the national state, which he considered the source of mass extinction. Schlosser shows that Jünger continued to be a supporter of the vision of a world state, but that in his later days he developed a critical narrative of globalization for different reasons. One reason was the ecological imbalance created by human greed for energy. Another reason was globalization's cultural homogenization with the following loss of cultural diversity.&nbsp

Genitiv på tysk: - en undersøgelse af stil og brug

Jan T. Schlosser and Lasse Holmgren Brunø Genitiv på tysk - en undersøgelse af stil og brug. (The German genitive case an examination of its use and style). The article examines how the genitive case is used in different style registers e.g. internet debates, fiction, officialese and legal texts. The examination utilizes a scale created by the Danish Germanist Peter Jørgensen of the stylistic use of the genitive case. This is supplemented by an examination of the specific genitive construction's syntactic function. This method makes it possible for the article to describe the use of the genitive case in modern German

Das deutsche Gespenst verflüchtigt sich allmählich: Die Darstellung Deutschlands in Weekendavisen

Jan T. Schlosser and Sandra Tyra Helms Das deutsche Gespenst verflüchtigt sich allmählich Die Darstellung Deutschlands in Weekendavisen. (The German ghost gradually escapes The depiction of Germany in Weekendavisen). The article is a qualitative and quantitative linguistic discursive analysis of articles in the weekly Danish paper Weekendavisen in a period from the end of 2020 to the beginning of 2011. The article concludes among other things that themes of National Socialism still prevail, but also that the depiction of Germany is no longer one of an enemy. Jan T. Schlosser and Lasse Holmgren Brunø, Genitiv på tysk - en undersøgelse af stil og brug (The German genitive case an examination of its use and style) The article examines how the genitive case is used in different style registers e.g. internet debates, fiction, officialese and legal texts. The examination utilizes a scale created by the Danish Germanist Peter Jørgensen of the stylistic use of the genitive case. This is supplemented by an examination of the specific genitive construction's syntactic function. This method makes it possible for the article to describe the use of the genitive case in modern German

Genitiv på tysk: - en undersøgelse af stil og brug

Jan T. Schlosser and Lasse Holmgren Brunø Genitiv på tysk - en undersøgelse af stil og brug. (The German genitive case an examination of its use and style). The article examines how the genitive case is used in different style registers e.g. internet debates, fiction, officialese and legal texts. The examination utilizes a scale created by the Danish Germanist Peter Jørgensen of the stylistic use of the genitive case. This is supplemented by an examination of the specific genitive construction's syntactic function. This method makes it possible for the article to describe the use of the genitive case in modern German

A comparison of Antarctic ice sheet surface mass balance from atmospheric climate models and in situ observations

In this study, 3265 multiyear averaged in situ observations and 29 observational records at annual time scale are used to examine the performance of recent reanalysis and regional atmospheric climate model products [ERA-Interim, JRA-55, MERRA, the Polar version of MM5 (PMM5), RACMO2.1, and RACMO2.3] for their spatial and interannual variability of Antarctic surface mass balance (SMB), respectively. Simulated precipitation seasonality is also evaluated using three in situ observations and model intercomparison. All products qualitatively capture the macroscale spatial variability of observed SMB, but it is not possible to rank their relative performance because of the sparse observations at coastal regions with an elevation range from 200 to 1000 m. In terms of the absolute amount of observed snow accumulation in interior Antarctica, RACMO2.3 fits best, while the other models either underestimate (JRA-55, MERRA, ERA-Interim, and RACMO2.1) or overestimate (PMM5) the accumulation. Despite underestimated precipitation by the three reanalyses and RACMO2.1, this feature is clearly improved in JRA-55. However, because of changes in the observing system, especially the dramatically increased satellite observations for data assimilation, JRA-55 presents a marked jump in snow accumulation around 1979 and a large increase after the late 1990s. Although precipitation seasonality over the whole ice sheet is common for all products, ERA-Interim provides an unrealistic estimate of precipitation seasonality on the East Antarctic plateau, with high precipitation strongly peaking in summer. ERA-Interim shows a significant correlation with interannual variability of observed snow accumulation measurements at 28 of 29 locations, whereas fewer than 20 site observations significantly correlate with simulations by the other models. This suggests that ERA-Interim exhibits the highest performance of interannual variability in the observed precipitatio

The positive transcriptional elongation factor (P-TEFb) is required for neural crest specification

Regulation of gene expression at the level of transcriptional elongation has been shown to be important in stem cells and tumour cells, but its role in the whole animal is only now being fully explored. Neural crest cells (NCCs) are a multipotent population of cells that migrate during early development from the dorsal neural tube throughout the embryo where they differentiate into a variety of cell types including pigment cells, cranio-facial skeleton and sensory neurons. Specification of NCCs is both spatially and temporally regulated during embryonic development. Here we show that components of the transcriptional elongation regulatory machinery, CDK9 and CYCLINT1 of the P-TEFb complex, are required to regulate neural crest specification. In particular, we show that expression of the proto-oncogene c-Myc and c-Myc responsive genes are affected. Our data suggest that P-TEFb is crucial to drive expression of c-Myc, which acts as a ‘gate-keeper’ for the correct temporal and spatial development of the neural crest

The freshwater system west of the Antarctic Peninsula : spatial and temporal changes

Author Posting. © American Meteorological Society, 2013. This article is posted here by permission of American Meteorological Society for personal use, not for redistribution. The definitive version was published in Journal of Climate 26 (2013): 1669–1684, doi:10.1175/JCLI-D-12-00246.1.Climate change west of the Antarctic Peninsula is the most rapid of anywhere in the Southern Hemisphere, with associated changes in the rates and distributions of freshwater inputs to the ocean. Here, results from the first comprehensive survey of oxygen isotopes in seawater in this region are used to quantify spatial patterns of meteoric water (glacial discharge and precipitation) separately from sea ice melt. High levels of meteoric water are found close to the coast, due to orographic effects on precipitation and strong glacial discharge. Concentrations decrease offshore, driving significant southward geostrophic flows (up to ~30 cm s−1). These produce high meteoric water concentrations at the southern end of the sampling grid, where collapse of the Wilkins Ice Shelf may also have contributed. Sea ice melt concentrations are lower than meteoric water and patchier because of the mobile nature of the sea ice itself. Nonetheless, net sea ice production in the northern part of the sampling grid is inferred; combined with net sea ice melt in the south, this indicates an overall southward ice motion. The survey is contextualized temporally using a decade-long series of isotope data from a coastal Antarctic Peninsula site. This shows a temporal decline in meteoric water in the upper ocean, contrary to expectations based on increasing precipitation and accelerating deglaciation. This is driven by the increasing occurrence of deeper winter mixed layers and has potential implications for concentrations of trace metals supplied to the euphotic zone by glacial discharge. As the regional freshwater system evolves, the continuing isotope monitoring described here will elucidate the ongoing impacts on climate and the ecosystem.The Palmer LTER participants acknowledge Award 0823101 from the Organisms and Ecosystems program in NSF OPP2013-09-0

Valvular heart disease: what does cardiovascular MRI add?

Although ischemic heart disease remains the leading cause of cardiac-related morbidity and mortality in the industrialized countries, a growing number of mainly elderly patients will experience a problem of valvular heart disease (VHD), often requiring surgical intervention at some stage. Doppler-echocardiography is the most popular imaging modality used in the evaluation of this disease entity. It encompasses, however, some non-negligible constraints which may hamper the quality and thus the interpretation of the exam. Cardiac catheterization has been considered for a long time the reference technique in this field, however, this technique is invasive and considered far from optimal. Cardiovascular magnetic resonance imaging (MRI) is already considered an established diagnostic method for studying ventricular dimensions, function and mass. With improvement of MRI soft- and hardware, the assessment of cardiac valve function has also turned out to be fast, accurate and reproducible. This review focuses on the usefulness of MRI in the diagnosis and management of VHD, pointing out its added value in comparison with more conventional diagnostic means

Epigenome-wide association study of serum urate reveals insights into urate co-regulation and the SLC2A9 locus

Elevated serum urate levels, a complex trait and major risk factor for incident gout, are correlated with cardiometabolic traits via incompletely understood mechanisms. DNA methylation in whole blood captures genetic and environmental influences and is assessed in transethnic meta-analysis of epigenome-wide association studies (EWAS) of serum urate (discovery, n = 12,474, replication, n = 5522). The 100 replicated, epigenome-wide significant (p < 1.1E–7) CpGs explain 11.6% of the serum urate variance. At SLC2A9, the serum urate locus with the largest effect in genome-wide association studies (GWAS), five CpGs are associated with SLC2A9 gene expression. Four CpGs at SLC2A9 have significant causal effects on serum urate levels and/or gout, and two of these partly mediate the effects of urate-associated GWAS variants. In other genes, including SLC7A11 and PHGDH, 17 urate-associated CpGs are associated with conditions defining metabolic syndrome, suggesting that these CpGs may represent a blood DNA methylation signature of cardiometabolic risk factors. This study demonstrates that EWAS can provide new insights into GWAS loci and the correlation of serum urate with other complex traits