The Ultraviolet and Infrared Star Formation Rates of Compact Group Galaxies: An Expanded Sample

Compact groups of galaxies provide insight into the role of low-mass, dense environments in galaxy evolution because the low velocity dispersions and close proximity of galaxy members result in frequent interactions that take place over extended timescales. We expand the census of star formation in compact group galaxies by \citet{tzanavaris10} and collaborators with Swift UVOT, Spitzer IRAC and MIPS 24 \micron\ photometry of a sample of 183 galaxies in 46 compact groups. After correcting luminosities for the contribution from old stellar populations, we estimate the dust-unobscured star formation rate (SFR$_{\mathrm{UV}}$) using the UVOT uvw2photometry. Similarly, we use the MIPS 24 \micron\ photometry to estimate the component of the SFR that is obscured by dust (SFR$_{\mathrm{IR}}$). We find that galaxies which are MIR-active (MIR-"red"), also have bluer UV colours, higher specific star formation rates, and tend to lie in H~{\sc i}-rich groups, while galaxies that are MIR-inactive (MIR-"blue") have redder UV colours, lower specific star formation rates, and tend to lie in H~{\sc i}-poor groups. We find the SFRs to be continuously distributed with a peak at about 1 M$_{\odot}$ yr$^{-1}$, indicating this might be the most common value in compact groups. In contrast, the specific star formation rate distribution is bimodal, and there is a clear distinction between star-forming and quiescent galaxies. Overall, our results suggest that the specific star formation rate is the best tracer of gas depletion and galaxy evolution in compact groups.Comment: 19 pages, 17 figure

Global Properties of Neutral Hydrogen in Compact Groups

Compact groups of galaxies provide a unique environment to study the evolution of galaxies amid frequent gravitational encounters. These nearby groups have conditions similar to those in the earlier universe when galaxies were assembled and give us the opportunity to witness hierarchical formation in progress. To understand how the compact group environment affects galaxy evolution, we examine the gas and dust in these groups. We present new single-dish GBT neutral hydrogen (HI) observations of 30 compact groups and define a new way to quantify the group HI content as the HI-to-stellar mass ratio of the group as a whole. We compare the HI content with mid-IR indicators of star formation and optical [g-r] color to search for correlations between group gas content and star formation activity of individual group members. Quiescent galaxies tend to live in HI-poor groups, and galaxies with active star formation are more commonly found in HI-rich groups. Intriguingly, we also find "rogue" galaxies whose star formation does not correlate with group HI content. In particular, we identify three galaxies (NGC 2968 in RSCG 34, KUG 1131+202A in RSCG 42, and NGC 4613 in RSCG 64) whose mid-IR activity is discrepant with the HI. We speculate that this mismatch between mid-IR activity and HI content is a consequence of strong interactions in this environment that can strip HI from galaxies and abruptly affect star-formation. Ultimately, characterizing how and on what timescales the gas is processed in compact groups will help us understand the interstellar medium in complex, dense environments similar to the earlier Universe.Comment: Accepted to A

Some Like It Hot: Linking Diffuse X-ray Luminosity, Baryonic Mass, and Star Formation Rate in Compact Groups of Galaxies

We present an analysis of the diffuse X-ray emission in 19 compact groups of galaxies (CGs) observed with Chandra. The hottest, most X-ray luminous CGs agree well with the galaxy cluster X-ray scaling relations in $L_X-T$ and $L_X-\sigma$, even in CGs where the hot gas is associated with only the brightest galaxy. Using Spitzer photometry, we compute stellar masses and classify HCGs 19, 22, 40, and 42 and RSCGs 32, 44, and 86 as fossil groups using a new definition for fossil systems that includes a broader range of masses. We find that CGs with total stellar and HI masses $\gtrsim10^{11.3}$ M$_\odot$ are often X-ray luminous, while lower-mass CGs only sometimes exhibit faint, localized X-ray emission. Additionally, we compare the diffuse X-ray luminosity against both the total UV and 24 $\mu$m star formation rates of each CG and optical colors of the most massive galaxy in each of the CGs. The most X-ray luminous CGs have the lowest star formation rates, likely because there is no cold gas available for star formation, either because the majority of the baryons in these CGs are in stars or the X-ray halo, or due to gas stripping from the galaxies in CGs with hot halos. Finally, the optical colors that trace recent star formation histories of the most massive group galaxies do not correlate with the X-ray luminosities of the CGs, indicating that perhaps the current state of the X-ray halos is independent of the recent history of stellar mass assembly in the most massive galaxies.Comment: 20 pages, 7 figures, accepted for publication in Ap

Examining the Role of Environment in a Comprehensive Sample of Compact Groups

(Abridged) Compact groups, with their high number densities, small velocity dispersions, and an interstellar medium that has not been fully processed, provide a local analog to conditions of galaxy interactions in the earlier universe. The frequent and prolonged gravitational encounters that occur in compact groups affect the evolution of the constituent galaxies in a myriad of ways, for example gas processing and star formation. Recently, a statistically significant "gap" has been discovered mid-infrared IRAC colorspace of compact group galaxies. This gap is not seen in field samples and is a new example of how the compact group environment may affect the evolution of member galaxies. In order to investigate the origin and nature of this gap, we have compiled a sample of 49 compact groups. We find that a statistically significant deficit of galaxies in this gap region of IRAC colorspace is persistant in this sample, lending support to the hypothesis that the compact group environment inhibits moderate SSFRs. We note a curvature in the colorspace distribution, which is fully consistent with increasing dust temperature as the activity in a galaxy increases. This full sample of 49 compact groups allows us to subdivide the data according to physical properties of the groups. An analysis of these subsamples indicates that neither projected physical diameter nor density show a trend in colorspace within the values represented by this sample. We hypothesize that the apparent lack of a trend is due to the relatively small range of properties in this sample. Thus, the relative influence of stochastic effects becomes dominant. We analyze spectral energy distributions of member galaxies as a function of their location in colorspace and find that galaxies in different regions of MIR colorspace contain dust with varying temperatures and/or PAH emission.Comment: 24 pages, 13 figures. Accepted for publication in The Astronomical Journa

Mid-Infrared Evidence for Accelerated Evolution in Compact Group Galaxies

We find evidence for accelerated evolution in compact group galaxies from the distribution in mid-infrared colorspace of 42 galaxies from 12 Hickson Compact Groups (HCGs) compared to the the distributions of several other samples including the LVL+SINGS galaxies, interacting galaxies, and galaxies from the Coma Cluster. We find that the HCG galaxies are not uniformly distributed in colorspace, as well as quantitative evidence for a gap. Galaxies in the infall region of the Coma cluster also exhibit a non-uniform distribution and a less well defined gap, which may reflect a similarity with the compact group environment. Neither the Coma Center or interacting samples show evidence of a gap, leading us to speculate that the gap is unique to the environment of high galaxy density where gas has not been fully processed or stripped.Comment: To appear in the Proceedings of the Galaxy Wars: Stellar Populations and Star Formation in Interacting Galaxies Conferenc

The Optical Green Valley Versus Mid-infrared Canyon in Compact Groups

Compact groups of galaxies provide conditions similar to those experienced by galaxies in the earlier universe. Recent work on compact groups has led to the discovery of a dearth of mid-infrared transition galaxies (MIRTGs) in Infrared Array Camera (3.6-8.0 micrometers) color space as well as at intermediate specific star formation rates. However, we find that in compact groups these MIRTGs have already transitioned to the optical ([gr]) red sequence. We investigate the optical color-magnitude diagram (CMD) of 99 compact groups containing 348 galaxies and compare the optical CMD with mid-infrared (mid-IR) color space for compact group galaxies. Utilizing redshifts available from Sloan Digital Sky Survey, we identified new galaxy members for four groups. By combining optical and mid-IR data, we obtain information on both the dust and the stellar populations in compact group galaxies. We also compare with more isolated galaxies and galaxies in the Coma Cluster, which reveals that, similar to clusters, compact groups are dominated by optically red galaxies. While we find that compact group transition galaxies lie on the optical red sequence, LVL (Local Volume Legacy) + (plus) SINGS (Spitzer Infrared Nearby Galaxies Survey) mid-IR (infrared) transition galaxies span the range of optical colors. The dearth of mid-IR transition galaxies in compact groups may be due to a lack of moderately star-forming low mass galaxies; the relative lack of these galaxies could be due to their relatively small gravitational potential wells. This makes them more susceptible to this dynamic environment, thus causing them to more easily lose gas or be accreted by larger members

Selective Immune Suppression Using Interleukin-6 Receptor Inhibitors for Management of Immune-related Adverse Events

BACKGROUND: Management of immune-related adverse events (irAEs) is important as they cause treatment interruption or discontinuation, more often seen with combination immune checkpoint inhibitor (ICI) therapy. Here, we retrospectively evaluated the safety and effectiveness of anti-interleukin-6 receptor (anti-IL-6R) as therapy for irAEs. METHODS: We performed a retrospective multicenter study evaluating patients diagnosed with de novo irAEs or flare of pre-existing autoimmune disease following ICI and were treated with anti-IL-6R. Our objectives were to assess the improvement of irAEs as well as the overall tumor response rate (ORR) before and after anti-IL-6R treatment. RESULTS: We identified a total of 92 patients who received therapeutic anti-IL-6R antibodies (tocilizumab or sarilumab). Median age was 61 years, 63% were men, 69% received anti-programmed cell death protein-1 (PD-1) antibodies alone, and 26% patients were treated with the combination of anti-cytotoxic T lymphocyte antigen-4 and anti-PD-1 antibodies. Cancer types were primarily melanoma (46%), genitourinary cancer (35%), and lung cancer (8%). Indications for using anti-IL-6R antibodies included inflammatory arthritis (73%), hepatitis/cholangitis (7%), myositis/myocarditis/myasthenia gravis (5%), polymyalgia rheumatica (4%), and one patient each with autoimmune scleroderma, nephritis, colitis, pneumonitis and central nervous system vasculitis. Notably, 88% of patients had received corticosteroids, and 36% received other disease-modifying antirheumatic drugs (DMARDs) as first-line therapies, but without adequate improvement. After initiation of anti-IL-6R (as first-line or post-corticosteroids and DMARDs), 73% of patients showed resolution or change to ≤grade 1 of irAEs after a median of 2.0 months from initiation of anti-IL-6R therapy. Six patients (7%) stopped anti-IL-6R due to adverse events. Of 70 evaluable patients by RECIST (Response Evaluation Criteria in Solid Tumors) V.1.1 criteria; the ORR was 66% prior versus 66% after anti-IL-6R (95% CI, 54% to 77%), with 8% higher complete response rate. Of 34 evaluable patients with melanoma, the ORR was 56% prior and increased to 68% after anti-IL-6R (p=0.04). CONCLUSION: Targeting IL-6R could be an effective approach to treat several irAE types without hindering antitumor immunity. This study supports ongoing clinical trials evaluating the safety and efficacy of tocilizumab (anti-IL-6R antibody) in combination with ICIs (NCT04940299, NCT03999749)

Selective Immune Suppression Using Interleukin-6 Receptor Inhibitors for Management of Immune-Related Adverse Events

BACKGROUND: Management of immune-related adverse events (irAEs) is important as they cause treatment interruption or discontinuation, more often seen with combination immune checkpoint inhibitor (ICI) therapy. Here, we retrospectively evaluated the safety and effectiveness of anti-interleukin-6 receptor (anti-IL-6R) as therapy for irAEs. METHODS: We performed a retrospective multicenter study evaluating patients diagnosed with de novo irAEs or flare of pre-existing autoimmune disease following ICI and were treated with anti-IL-6R. Our objectives were to assess the improvement of irAEs as well as the overall tumor response rate (ORR) before and after anti-IL-6R treatment. RESULTS: We identified a total of 92 patients who received therapeutic anti-IL-6R antibodies (tocilizumab or sarilumab). Median age was 61 years, 63% were men, 69% received anti-programmed cell death protein-1 (PD-1) antibodies alone, and 26% patients were treated with the combination of anti-cytotoxic T lymphocyte antigen-4 and anti-PD-1 antibodies. Cancer types were primarily melanoma (46%), genitourinary cancer (35%), and lung cancer (8%). Indications for using anti-IL-6R antibodies included inflammatory arthritis (73%), hepatitis/cholangitis (7%), myositis/myocarditis/myasthenia gravis (5%), polymyalgia rheumatica (4%), and one patient each with autoimmune scleroderma, nephritis, colitis, pneumonitis and central nervous system vasculitis. Notably, 88% of patients had received corticosteroids, and 36% received other disease-modifying antirheumatic drugs (DMARDs) as first-line therapies, but without adequate improvement. After initiation of anti-IL-6R (as first-line or post-corticosteroids and DMARDs), 73% of patients showed resolution or change to ≤grade 1 of irAEs after a median of 2.0 months from initiation of anti-IL-6R therapy. Six patients (7%) stopped anti-IL-6R due to adverse events. Of 70 evaluable patients by RECIST (Response Evaluation Criteria in Solid Tumors) V.1.1 criteria; the ORR was 66% prior versus 66% after anti-IL-6R (95% CI, 54% to 77%), with 8% higher complete response rate. Of 34 evaluable patients with melanoma, the ORR was 56% prior and increased to 68% after anti-IL-6R (p=0.04). CONCLUSION: Targeting IL-6R could be an effective approach to treat several irAE types without hindering antitumor immunity. This study supports ongoing clinical trials evaluating the safety and efficacy of tocilizumab (anti-IL-6R antibody) in combination with ICIs (NCT04940299, NCT03999749)

The state of the Martian climate

60°N was +2.0°C, relative to the 1981–2010 average value (Fig. 5.1). This marks a new high for the record. The average annual surface air temperature (SAT) anomaly for 2016 for land stations north of starting in 1900, and is a significant increase over the previous highest value of +1.2°C, which was observed in 2007, 2011, and 2015. Average global annual temperatures also showed record values in 2015 and 2016. Currently, the Arctic is warming at more than twice the rate of lower latitudes