20 research outputs found

    A Tale of Two Markets: How Lower-end Borrowers Are Punished for Bank Regulatory Failures in Nigeria

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    In 2009, the Nigerian banking system witnessed a financial crisis caused by elite borrowers in the financial market. Regulatory response to the Nigerian crisis closely mirrored the international response with increased capital and liquidity thresholds for commercial banks. While the rise of consumer protection on the agenda of prudential supervisors internationally was logical in that consumer debt was the main cause of the global recession, the Nigerian banking reforms of 2009 disproportionately affected access by poorer consumers, who ironically had little to do with the underlying causes of the crisis. As lending criteria become more stringent, poorer consumers of credit products are pushed into informal markets because of liquidity-induced credit rationing. Overall, consumer protection is compromised because stronger consumer protection rules for the formal sector benefits borrowers from formal institutions who constitute the minority of borrowers in all markets. While the passage of regulation establishing credit bureaux and the National Collateral Registry will, in theory, ease access to credit especially by lower-end borrowers, the vast size of the informal market continues to compound the information asymmetry problem, fiscal policies to tackle structural economic issues such as unemployment and illiteracy remain to be initiated, and bank regulators continue to pander to elite customers with policy responses that endorse too big to fail but deems lower-end consumers too irrelevant to save. The essay concluded that addressing the wide disparity in access to credit between the rich and poor through property rights reforms to capture the capital of the informal class, promoting regulation to check loan concentration, and stimulating competition by allowing Telecommunication Companies (TELCOs) and fintech companies to carry on lending activities because of their superior knowledge of lower-end markets will facilitate greater access. The risk of systemic failure deriving from consumer credit in Nigeria is insignificant compared to the consumer vulnerabilities resulting from the exposure of consumers to unregulated products in the informal market

    Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials.

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    BACKGROUND: The ChAdOx1 nCoV-19 (AZD1222) vaccine has been approved for emergency use by the UK regulatory authority, Medicines and Healthcare products Regulatory Agency, with a regimen of two standard doses given with an interval of 4-12 weeks. The planned roll-out in the UK will involve vaccinating people in high-risk categories with their first dose immediately, and delivering the second dose 12 weeks later. Here, we provide both a further prespecified pooled analysis of trials of ChAdOx1 nCoV-19 and exploratory analyses of the impact on immunogenicity and efficacy of extending the interval between priming and booster doses. In addition, we show the immunogenicity and protection afforded by the first dose, before a booster dose has been offered. METHODS: We present data from three single-blind randomised controlled trials-one phase 1/2 study in the UK (COV001), one phase 2/3 study in the UK (COV002), and a phase 3 study in Brazil (COV003)-and one double-blind phase 1/2 study in South Africa (COV005). As previously described, individuals 18 years and older were randomly assigned 1:1 to receive two standard doses of ChAdOx1 nCoV-19 (5 × 1010 viral particles) or a control vaccine or saline placebo. In the UK trial, a subset of participants received a lower dose (2·2 × 1010 viral particles) of the ChAdOx1 nCoV-19 for the first dose. The primary outcome was virologically confirmed symptomatic COVID-19 disease, defined as a nucleic acid amplification test (NAAT)-positive swab combined with at least one qualifying symptom (fever ≥37·8°C, cough, shortness of breath, or anosmia or ageusia) more than 14 days after the second dose. Secondary efficacy analyses included cases occuring at least 22 days after the first dose. Antibody responses measured by immunoassay and by pseudovirus neutralisation were exploratory outcomes. All cases of COVID-19 with a NAAT-positive swab were adjudicated for inclusion in the analysis by a masked independent endpoint review committee. The primary analysis included all participants who were SARS-CoV-2 N protein seronegative at baseline, had had at least 14 days of follow-up after the second dose, and had no evidence of previous SARS-CoV-2 infection from NAAT swabs. Safety was assessed in all participants who received at least one dose. The four trials are registered at ISRCTN89951424 (COV003) and ClinicalTrials.gov, NCT04324606 (COV001), NCT04400838 (COV002), and NCT04444674 (COV005). FINDINGS: Between April 23 and Dec 6, 2020, 24 422 participants were recruited and vaccinated across the four studies, of whom 17 178 were included in the primary analysis (8597 receiving ChAdOx1 nCoV-19 and 8581 receiving control vaccine). The data cutoff for these analyses was Dec 7, 2020. 332 NAAT-positive infections met the primary endpoint of symptomatic infection more than 14 days after the second dose. Overall vaccine efficacy more than 14 days after the second dose was 66·7% (95% CI 57·4-74·0), with 84 (1·0%) cases in the 8597 participants in the ChAdOx1 nCoV-19 group and 248 (2·9%) in the 8581 participants in the control group. There were no hospital admissions for COVID-19 in the ChAdOx1 nCoV-19 group after the initial 21-day exclusion period, and 15 in the control group. 108 (0·9%) of 12 282 participants in the ChAdOx1 nCoV-19 group and 127 (1·1%) of 11 962 participants in the control group had serious adverse events. There were seven deaths considered unrelated to vaccination (two in the ChAdOx1 nCov-19 group and five in the control group), including one COVID-19-related death in one participant in the control group. Exploratory analyses showed that vaccine efficacy after a single standard dose of vaccine from day 22 to day 90 after vaccination was 76·0% (59·3-85·9). Our modelling analysis indicated that protection did not wane during this initial 3-month period. Similarly, antibody levels were maintained during this period with minimal waning by day 90 (geometric mean ratio [GMR] 0·66 [95% CI 0·59-0·74]). In the participants who received two standard doses, after the second dose, efficacy was higher in those with a longer prime-boost interval (vaccine efficacy 81·3% [95% CI 60·3-91·2] at ≥12 weeks) than in those with a short interval (vaccine efficacy 55·1% [33·0-69·9] at <6 weeks). These observations are supported by immunogenicity data that showed binding antibody responses more than two-fold higher after an interval of 12 or more weeks compared with an interval of less than 6 weeks in those who were aged 18-55 years (GMR 2·32 [2·01-2·68]). INTERPRETATION: The results of this primary analysis of two doses of ChAdOx1 nCoV-19 were consistent with those seen in the interim analysis of the trials and confirm that the vaccine is efficacious, with results varying by dose interval in exploratory analyses. A 3-month dose interval might have advantages over a programme with a short dose interval for roll-out of a pandemic vaccine to protect the largest number of individuals in the population as early as possible when supplies are scarce, while also improving protection after receiving a second dose. FUNDING: UK Research and Innovation, National Institutes of Health Research (NIHR), The Coalition for Epidemic Preparedness Innovations, the Bill & Melinda Gates Foundation, the Lemann Foundation, Rede D'Or, the Brava and Telles Foundation, NIHR Oxford Biomedical Research Centre, Thames Valley and South Midland's NIHR Clinical Research Network, and AstraZeneca

    Enfermagem na saúde da criança: estudo bibliográfico acerca da avaliação nutricional La enfermería en la salud del niño: estudio bibliográfico sobre la evaluación nutricional Nursing in child's health: bibliography study on assessment nutritional

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    O objetivo deste estudo foi analisar a produção científica acerca da atuação do enfermeiro na saúde nutricional da criança. Estudo bibliográfico realizado entre abril e maio de 2008, nas bases de dados online, com descritores: avaliação nutricional, antropometria, crescimento, criança. Critérios de inclusão: saúde infantil na avaliação nutricional, enfermeiro/autor e artigos publicados entre 2000 e 2007. Encontraram-se 15 artigos nos seguintes anos: 2000 (1), 2001 (1), 2002 (2), 2003 (4), 2005 (1), 2006 (3) e 2007 (3). Periódicos inscritos nas áreas: enfermagem (1), nutrição (1), saúde pública (3) e médica (1). Tipo de estudo: epidemiológicos (1), descritivos (5), transversais (7), longitudinal (1), estudo de caso (1), revisão de literatura (1) e relato de experiência (1). Unidades temáticas: avaliação nutricional mediante acompanhamento do crescimento e desenvolvimento infantil; fatores determinantes da nutrição infantil e avaliação nutricional como cuidado de enfermagem. Ressalta-se que o enfermeiro tem buscado fundamentação teórica e prática para cuidar da criança com déficit nutricional.<br>Analizar la producción científica que existe sobre el papel que desempeña el enfermero en la salud nutricional del niño. Estudio bibliográfico desarrollado entre abril y mayo/2008 usando bases de datos en línea, a través de los siguientes descriptores: evaluación nutricional, antropometría, crecimiento, niño. Se aplicaron los siguientes criterios de inclusión: salud infantil en la evaluación nutricional, enfermero/autor y artículos publicados entre 2000 y 2007. Se encontraron 15 artículos en los años: 2000 (1), 2001 (1), 2002 (2), 2003 (4), 2005 (1), 2006 (3) e 2007 (3). Periódicos inscriptos en las áreas: enfermería (1), nutrición (1), salud pública (3) y médica (1). Tipo de estudio: epidemiológicos (1), descriptivos (5), transversales (7), longitudinales (1), estudio de caso (1), revisión de literatura (1) y relato de experiencia (1). Unidades temáticas: evaluación nutricional mediante acompañamiento del crecimiento y desarrollo infantil; factores determinantes de la nutrición infantil y evaluación nutricional como cuidado de la enfermería. Descata el hecho que el enfermero ha buscado desarrollar una fundamentación teórico/práctica para cuidar del niño con déficit nutricional.<br>To examine the scientific production about the role of nurses in the nutritional health of child. Bibliographic study, held between April and May 2008 in on line databases, with descriptors: nutritional assessment, anthropometry, growth, child. Criteria for inclusion: child health in nutrition assessment, nurse / author and articles published between 2000 and 2007. Meeting 15 articles in the years: 2000 (1), 2001 (1), 2002 (2), 2003 (4), 2005 (1), 2006 (3) e 2007 (3). Regular subscribers in the areas: nursing (1), nutrition (1), health (3) and medical (1). Type of study: epidemiological (1), descriptive (5), Cross (7), longitudinal (1), the case study (1), review of literature (1) and report of experience (1). Thematic units: nutritional assessment by the monitoring of growth and child development by nurses; determinants of children's nutrition and nutritional assessment and nursing care. It is emphasized that the nurse has sought theoretical and practical reasons to take care of children with nutritional deficiency

    Comparative study of representations of professional autonomy produced by first and last-period undergraduate nursing students

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    ABSTRACT Objective: to compare the social representations of professional nurse autonomy produced by first and last-period undergraduate nursing students. Method: qualitative, descriptive and exploratory study, based on the structural approach of social representations, the Central Core Theory, carried out with 171 students from three federal public universities, using the free association technique on the object “professional nurse autonomy”. The data were submitted to EVOC 2005 software and to similarity analysis. Results: care was the central core of the representational structure identified among the students of the first period. Among last-period students, knowledge stood out as a core element. The term responsibility was identified as common to both central cores. Conclusion: regarding professional autonomy, the results point to an overlapping process of the reified and consensual universes during the undergraduate course. However, responsibility, inherent in the profession, remains cross-sectional. For the first period students, autonomy is resignified in a practical and attitudinal way, whereas for the last period students, the knowledge acquired stimulates them to assign meaning to professional autonomy with a cognitive and attitudinal representation. The data can support the use of innovative teaching practices in nursing undergraduate courses
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