Autoestima y dependencia emocional en mujeres en la adultez temprana víctimas de violencia de Lima Norte 2022

Este trabajo de investigación tuvo como objetivo general determinar la relación entre la autoestima y la dependencia emocional en mujeres en la adultez temprana víctimas de violencia de Lima Norte,2022 y su tipo de investigación es correlacional con diseño no experimental de corte transversal. Asimismo, se obtuvo una población de 272 participantes voluntarias para este estudio con un muestreo no probabilístico. Además, se usaron las siguientes pruebas la escala de Autoestima de Rosenberg y el Cuestionario de Dependencia emocional mostrando como confiabilidad 0.970 y 0.985 respectivamente. Por otro lado, se obtuvieron los siguientes resultados: Se encontró que las variables con Rho de Spearman -0.343 con un p=0.01. Además, se evidencia un nivel bajo de autoestima 85,3% y un nivel alto de dependencia emocional 86.0%. También se encontró que la dimensión de dependencia emocional búsqueda de atención es la más alta y expresión de afecto de pareja es la más baja. Concluyendo que tienen una correlación negativa inversa con un valor significativo entre ambas variables

Beyond Accessibility: The Belonging and Participation of Deaf Subjects in the Art Museum of Rio (MAR)

Based on a Gramscian perspective on accessibility and inclusion, this article aims to analyze the actions carried out by the Art Museum of Rio (Museu de Arte do Rio, MAR, in Portuguese) that provide for the participation and belonging of deaf subjects who use the Brazilian Sign Language (Libras) in their institutional space. MAR, one of the newest museums in Rio de Janeiro, planned and implemented in the context of the revitalization process of the city’s Port Zone, stands out in the Brazilian museum scene with a management that consolidates actions aimed at guaranteeing deaf people’s linguistic rights through Libras

Biomimetic platelet membrane-coated nanoparticles for targeted therapy

The development of cell membrane-modified biomimetic nanoparticles has extensively increased during the past years due to their exceptional biocompatibility, evasion from the immune system, and targeting ability. Known as a cutting-edge area of research in nanomedicine, such novel nanoplatforms can mimic different functions of the primary cells, while successfully delivering their cargos to the defect site with the aim of enhancing the therapeutic responses and reducing the side effects. Platelet is a key factor for haemostasis and a major player in wound healing, inflammation, and many other biological functions and pathological conditions. As a highly responsive cell, platelets can adapt to environment modifications and release several soluble biomolecules, such as growth factors, coagulant factors, and extracellular vesicles. Additionally, platelets are capable of immune system evasion, sub-endothelial adhesion, and pathogen interaction. These characteristics have inspired the design of several platelet membrane-coated nanoparticles as drug delivery systems. This review describes the current developments in platelet membrane-coated nanoparticles for targeted therapy, specifically, their advantages compared to other biomimetic cell-derived nanoparticles and their applicability in the medical field are elucidated. Finally, the challenges and future perspectives associated with this nanoplatform are summarised.Peer reviewe

Inflationary models inducing non-Gaussian metric fluctuations

We construct explicit models of multi-field inflation in which the primordial metric fluctuations do not necessarily obey Gaussian statistics. These models are realizations of mechanisms in which non-Gaussianity is first generated by a light scalar field and then transferred into curvature fluctuations. The probability distribution functions of the metric perturbation at the end of inflation are computed. This provides a guideline for designing strategies to search for non-Gaussian signals in future CMB and large scale structure surveys.Comment: 4 pages, 7 figure

The integrated bispectrum as a test of CMB non-Gaussianity: detection power and limits on f_NL with WMAP data

We propose a fast and efficient bispectrum statistic for Cosmic Microwave Background (CMB) temperature anisotropies to constrain the amplitude of the primordial non-Gaussian signal measured in terms of the non-linear coupling parameter f_NL. We show how the method can achieve a remarkable computational advantage by focussing on subsets of the multipole configurations, where the non-Gaussian signal is more concentrated. The detection power of the test, increases roughly linearly with the maximum multipole, as shown in the ideal case of an experiment without noise and gaps. The CPU-time scales as l_{max}^3 instead of l_{max}^5 for the full bispectrum which for Planck resolution l_{max} \sim 3000 means an improvement in speed of a factor 10^7 compared to the full bispectrum analysis with minor loss in precision. We find that the introduction of a galactic cut partially destroys the optimality of the configuration, which will then need to be dealt with in the future. We find for an ideal experiment with l_{max}=2000 that upper limits of f_{NL}<8 can be obtained at 1 sigma. For the case of the WMAP experiment, we would be able to put limits of |f_{NL}|<40 if no galactic cut were present. Using the real data with galactic cut, we obtain an estimate of -80<f_{NL}<80 and -160<f_{NL}<160 at 1 and 2 sigma respectively.Comment: submitted to MNRA

MSCs Conditioned Media and Umbilical Cord Blood Plasma Metabolomics and Composition.

Human mesenchymal stem cells (hMSCs) from umbilical cord (UC) blood (UCB) and matrix are tested clinically for a variety of pathologies but in vitro expansion using culture media containing fetal bovine serum (FBS) is essential to achieve appropriate cell numbers for clinical use. Human UCB plasma (hUCBP) can be used as a supplement for hMSCs culture, since UCB is rich in soluble growth factors and due to worldwide increased number of cryopreserved UCB units in public and private banks, without the disadvantages listed for FBS. On the other hand, the culture media enriched in growth factors produced by these hMSCs in expansion (Conditioned medium--CM) can be an alternative to hMSCs application. The CM of the hMSCs from the UC might be a better therapeutic option compared to cell transplantation, as it can benefit from the local tissue response to the secreted molecules without the difficulties and complications associated to the engraftment of the allo- or xeno-transplanted cells. These facts drove us to know the detailed composition of the hUCBP and CM, by 1H-NMR and Multiplexing LASER Bead Technology. hUCBP is an adequate alternative for the FBS and the CM and hUCBP are important sources of growth factors, which can be used in MSCs-based therapies. Some of the major proliferative, chemotactic and immunomodulatory soluble factors (TGF-β, G-CSF, GM-CSF, MCP-1, IL-6, IL-8) were detected in high concentrations in CM and even higher in hUCBP. The results from 1H-NMR spectroscopic analysis of CM endorsed a better understanding of hMSCs metabolism during in vitro culture, and the relative composition of several metabolites present in CM and hUCBP was obtained. The data reinforces the potential use of hUCBP and CM in tissue regeneration and focus the possible use of hUCBP as a substitute for the FBS used in hMSCs in vitro culture

Primordial non-Gaussianity: local curvature method and statistical significance of constraints on f_NL from WMAP data

We test the consistency of estimates of the non-linear coupling constant f_{NL} using non-Gaussian CMB maps generated by the method described in (Liguori, Matarrese and Moscardini 2003). This procedure to obtain non-Gaussian maps differs significantly from the method used in previous works on estimation of f_{NL}. Nevertheless, using spherical wavelets, we find results in very good agreement with (Mukherjee and Wang 2004), showing that the two ways of generating primordial non-Gaussian maps give equivalent results. Moreover, we introduce a new method for estimating the non-linear coupling constant from CMB observations by using the local curvature of the temperature fluctuation field. We present both Bayesian credible regions (assuming a flat prior) and proper (frequentist) confidence intervals on f_{NL}, and discuss the relation between the two approaches. The Bayesian approach tends to yield lower error bars than the frequentist approach, suggesting that a careful analysis of the different interpretations is needed. Using this method, we estimate f_{NL}=-10^{+270}_{-260} at the 2\sigma level (Bayesian) and f_{NL}=-10^{+310}_{-270} (frequentist). Moreover, we find that the wavelet and the local curvature approaches, which provide similar error bars, yield approximately uncorrelated estimates of f_{NL} and therefore, as advocated in (Cabella et al. 2004), the estimates may be combined to reduce the error bars. In this way, we obtain f_{NL}=-5\pm 85 and f_{NL}=-5\pm 175 at the 1\sigma and 2\sigma level respectively using the frequentist approach.Comment: Accepted for publication in MNRAS. Improved limits on f_{NL} and covariance matrix derivatio

Non-Gaussian Signatures in the Temperature Fluctuation Observed by the Wilkinson Microwave Anisotropy Probe

We present results from a test for the Gaussianity of the whole sky sub-degree scale CMB temperature anisotropy measured by the Wilkinson Microwave Anisotropy Probe (WMAP). We calculate the genus from the foreground-subtracted and Kp0-masked WMAP maps and measure the genus shift parameters defined at negative and positive threshold levels and the asymmetry parameter to quantify the deviation from the Gaussian relation. At WMAP Q, V, and W bands, the genus and genus-related statistics imply that the observed CMB sky is consistent with Gaussian random phase field. However, from the genus measurement on the Galactic northern and southern hemispheres, we have found two non-Gaussian signatures at the W band resolution (0.35 degree scale), i.e., the large difference of genus amplitudes between the north and the south and the positive genus asymmetry in the south, which are statistically significant at 2.6 sigma and 2.4 sigma levels, respectively. The large genus amplitude difference also appears in the WMAP Q and V band maps, deviating the Gaussian prediction with a significance level of about 2 sigma. The probability that the genus curves show such a large genus amplitude difference exceeding the observed values at all Q, V, and W bands in a Gaussian sky is only 1.4%. Such non-Gaussian features are reduced as the higher Galactic cut is applied, but their dependence on the Galactic cut is weak. We discuss possible sources that can induce such non-Gaussian features, and conclude that the CMB data with higher signal-to-noise ratio and the accurate foreground model are needed to understand the non-Gaussian signatures.Comment: 9 pages, 5 figures, MNRAS in press (citation error corrected

A New Approach to Probing Primordial Non-Gaussianity

We address the dual challenge of estimating deviations from Gaussianity arising in models of the Early Universe, whilst retaining information necessary to assess whether a detection of non-Gaussianity is primordial. We do this by constructing a new statistic, the bispectrum-related power spectrum, which is constructed from a map of the Cosmic Microwave Background. The estimator is optimised for primordial non-Gaussianity detection, but can also be useful in distinguishing primordial non-Gaussianity from secondary non-Gaussianity, such as may arise from unsubtracted point sources, or residuals from component separation. Extending earlier studies we present unbiased non-Gaussianity estimators optimised for partial sky coverage and inhomogeneous noise associated with realistic scan strategies, but which retain the ability to assess foreground contamination.Comment: 13 pages, 1 figur

Primordial Non-Gaussianity from a Joint Analysis of Cosmic Microwave Background Temperature and Polarization

We explore a systematic approach to the analysis of primordial non-Gaussianity using fluctuations in temperature and polarization of the Cosmic Microwave Background (CMB). Following Munshi & Heavens (2009), we define a set of power-spectra as compressed forms of the bispectrum and trispectrum derived from CMB temperature and polarization maps; these spectra compress the information content of the corresponding full multispectra and can be useful in constraining early Universe theories. We generalize the standard pseudo-C_l estimators in such a way that they apply to these spectra involving both spin-0 and spin-2 fields, developing explicit expressions which can be used in the practical implementation of these estimators. While these estimators are suboptimal, they are nevertheless unbiased and robust hence can provide useful diagnostic tests at a relatively small computational cost. We next consider approximate inverse-covariance weighting of the data and construct a set of near-optimal estimators based on that approach. Instead of combining all available information from the entire set of mixed bi- or trispectra, i.e multispectra describing both temperature and polarization information, we provide analytical constructions for individual estimators, associated with particular multispectra. The bias and scatter of these estimators can be computed using Monte-Carlo techniques. Finally, we provide estimators which are completely optimal for arbitrary scan strategies and involve inverse covariance weighting; we present the results of an error analysis performed using a Fisher-matrix formalism at both the one-point and two-point level.Comment: 25 Pages, 4 Figure