Efectos del envejecimiento y la restricción calórica en la respuesta a la endotelina-1 y la insulina en el sistema cardiovascular

Tesis doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Medicina, Departamento de Fisiología. Fecha de lectura: 4-07-201

Relationships Among Granulosa Cell Insulin- like Growth Factor Binding Proteins and Pregnancy-Associated Plasma Protein-A mRNA Expression and Follicular Fluid Contents in Dominant and Large Subordinate Follicles of Preovulatory Cattle

Department of Animal Scienc

Impact of Region-of-Interest Delineation Methods, Reconstruction Algorithms, and Intra- and Inter-Operator Variability on Internal Dosimetry Estimates Using PET

Purpose: Human dosimetry studies play a central role in radioligand development for positron emission tomography (PET). Drawing regions of interest (ROIs) on the PET images is used to measure the dose in each organ. In the study aspects related to ROI delineation methods were evaluated for two radioligands of different biodistribution (intestinal vs urinary). Procedures: PET images were simulated from a human voxel-based phantom. Several ROI delineation methods were tested: antero-posterior projections (AP), 3D sub-samples of the organs (S), and a 3D volume covering the whole-organ (W). Inter- and intra-operator variability ROI drawing was evaluated by using human data. Results: The effective dose estimates using S and W methods were comparable to the true values. AP methods overestimated (49 %) the dose for the radioligand with intestinal biodistribution. Moreover, the AP method showed the highest inter-operator variability: 11 ± 1 %. Conclusions: The sub-sampled organ method showed the best balance between quantitative accuracy and inter- and intra-operator variability

An Unsaturated Four-Coordinate Dimethyl Dimolybdenum Complex with a Molybdenum–Molybdenum Quadruple Bond

We describe the synthesis and the molecular and electronic structures of the complex [Mo2Me2{μ‐HC(NDipp)2}2] (2; Dipp=2,6‐iPr2C6H3), which contains a dimetallic core with an Mo–Mo quadruple bond and features uncommon four‐coordinate geometry and has a fourteen‐electron count for each molybdenum atom. The coordination polyhedron approaches a square pyramid, with one of the molybdenum atoms nearly co‐planar with the basal square plane, in which the trans coordination position with respect to the Mo−Me bond is vacant. The other three sites are occupied by two trans nitrogen atoms of different amidinate ligands and the methyl group. The second Mo atom occupies the apex of the pyramid and forms an Mo–Mo bond of length 2.080(1) Å, consistent with a quadruple bond. Compound 2 reacts with tetrahydrofuran (THF) and trimethylphosphine to yield the mono‐adducts [Mo2Me(μ‐Me){μ‐HC(NDipp)2}2(L)] (3⋅THF and 3⋅PMe3, respectively) with one terminal and one bridging methyl group. In contrast, 4‐dimethylaminopyridine (dmap) forms the bis‐adduct [Mo2Me2{μ‐HC(NDipp)2}2(dmap)2] (4), with terminally coordinated methyl groups. Hydrogenolysis of complex 2 leads to the bis(hydride) [Mo2H2{μ‐HC(NDipp)2}2(thf)2] (5⋅THF) with elimination of CH4. Computational, kinetic, and mechanistic studies, which included the use of D2 and of complex 2 labelled with 13C (99 %) at the Mo–CH3 sites, supported the intermediacy of a methyl‐hydride reactive species. A computational DFT analysis of the terminal and bridging coordination of the methyl groups to the Mo≣Mo core is also reported.Ministerio de Ciencia e Innovación CTQ2010-15833, CTQ2013-42501-P, CTQ2014-52769-C3-3-R, CTQ2015-64579-C3-1-P, Consolider-Ingenio 2010 CSD2007-00006Junta de Andalucía FQM-119, P09-FQM-5117Ministerio de Educación AP-4193Ministerio de Ciencia e Innovación BES-2011-04764

An unsaturated four-coordinate dimethyl dimolybdenum complex with a molybdenum-molybdenum quadruple bond

We describe the synthesis and the molecular and electronic structures of the complex [Mo2Me2{mu-HC(NDipp)(2)}(2)] (2; Dipp=2,6-iPr(2)C(6)H(3)), which contains a dimetallic core with an Mo-Mo quadruple bond and features uncommon four-coordinate geometry and has a fourteen-electron count for each molybdenum atom. The coordination polyhedron approaches a square pyramid, with one of the molybdenum atoms nearly co-planar with the basal square plane, in which the trans coordination position with respect to the Mo-Me bond is vacant. The other three sites are occupied by two trans nitrogen atoms of different amidinate ligands and the methyl group. The second Mo atom occupies the apex of the pyramid and forms an Mo-Mo bond of length 2.080(1) angstrom, consistent with a quadruple bond. Compound 2 reacts with tetrahydrofuran (THF) and trimethylphosphine to yield the mono-adducts [Mo2Me(mu-Me){mu-HC(NDipp)(2)}(2)(L)] (3 center dot THF and 3 center dot PMe3, respectively) with one terminal and one bridging methyl group. In contrast, 4-dimethylaminopyridine (dmap) forms the bis-adduct [Mo2Me2{mu-HC(NDipp)(2)}(2)(dmap)(2)] (4), with terminally coordinated methyl groups. Hydrogenolysis of complex 2 leads to the bis(hydride) [Mo2H2{mu-HC(NDipp)(2)}(2)(thf)(2)] (5 center dot THF) with elimination of CH4. Computational, kinetic, and mechanistic studies, which included the use of D-2 and of complex 2 labelled with C-13 (99%) at the Mo-CH3 sites, supported the intermediacy of a methyl-hydride reactive species. A computational DFT analysis of the terminal and bridging coordination of the methyl groups to the Mo Mo core is also reported

Experimental and computational studies of the molybdenum-flanking arene interaction in quadruply bonded dimolybdenum complexes with terphenyl ligands

To clarify the nature of the MoCarene interaction in terphenyl complexes with quadruple MoMo bonds, ether adducts of composition [Mo2(Ar′)(I)(O2CR)2(OEt2)] have been prepared and characterized (Ar′=ArXyl2, R=Me; Ar′=ArMes2, R=Me; Ar′=ArXyl2, R=CF3) (Mes=mesityl; Xyl=2,6‐Me2C6H3, from now on xylyl) and their reactivity toward different neutral Lewis bases investigated. PMe3, P(OMe)3 and PiPr3 were chosen as P‐donors and the reactivity studies complemented with the use of the C‐donors CNXyl and CN2C2Me4 (1,3,4,5‐tetramethylimidazol‐2‐ylidene). New compounds of general formula [Mo2(Ar′)(I)(O2CR)2(L)] were obtained, except for the imidazol‐2‐ylidene ligand that yielded a salt‐like compound of composition [Mo2(ArXyl2)(O2CMe)2(CN2C2Me4)2]I. The MoCarene interaction in these complexes has been analyzed with the aid of X‐ray data and computational studies. This interaction compensates the coordinative and electronic unsaturation of one of the Mo atoms in the above complexes, but it seems to be weak in terms of sharing of electron density between the Mo and Carene atoms and appears to have no appreciable effect in the length of the MoMo, MoX, and MoL bonds present in these molecules

El cielo, el mar, el pergamino y la virgen: la expresión de lo inagotable en la poesía mariana medieval

Sunt autem et alia multa quae fecit Iesus quae si scribantur per singula nec ipsum arbitror mundum capere eos qui scribendi sunt libros (Jn 21, 25) (Hay también muchas otras cosas que hizo Jesús, las cuales, si se escribieran una a una, pienso que no bastaría todo el mundo para contener aquellos libros que deberían escribirse). Con estas palabras culmina el Evangelio según San Juan, sellando con un concepto conocido de la literatura antigua el texto mismo que se acaba de exponer: sólo se ha dicho de Jesús “algo” de todo aquello que hizo, por la imposibilidad fáctica de decirlo todo. Esta expresión de lo inagotable aplicada a la alabanza o a la glorificación de lo Infinito, por supuesto, es frecuente de las Sagradas Escrituras.Facultad de Humanidades y Ciencias de la Educació

The Effect of Social Media Addiction and Social Anxiety on the Happiness of Tertiary Students Amidst the COVID-19 Pandemic.

Learning to adapt to the new set of conditions that confound behavioral standards was made possible by the pandemic-driven change in the school system. Due to these conditions and the COVID-19 pandemic, students may experience behaviors like social media addiction and social anxiety that may affect their well-being or happiness. Thus, this study aims to investigate the effects of social media addiction and social anxiety on the happiness of tertiary students amidst the COVID-19 pandemic. The study was conducted on 316 first-year college students utilizing Google forms to disseminate questionnaires. After utilizing Bergen Social Media Addiction Scale, Social Anxiety Scale, and Oxford Happiness Questionnaire, it was found that social media addiction (β = -0.30, p\u3c.00) and social anxiety (β = -0.003, p\u3c.00) has a significant negative effect on happiness. Therefore, the study recommended and designed a student wellness program that provides a range of recreational, healthimproving, self-esteem-boosting, and relationship-strengthening activities for students in order to mitigate the negative effects of problematic social media usage and social anxiety that negatively effect their happiness

Steppes, savannahs, forests and phytodiversity reservoirs during the Pleistocene in the Iberian Peninsula

A palaeobotanical analysis of the Pleistocene floras and vegetation in the Iberian Peninsula shows the existence of patched landscapes with Pinus woodlands, deciduous and mixed forests, parklands (savannah-like), shrublands, steppes and grasslands. Extinctions of Arctotertiary woody taxa are recorded during the Early and Middle Pleistocene, but glacial refugia facilitated the survival of a number of temperate, Mediterranean and Ibero-North African woody angiosperms. The responses of Iberian vegetation to climatic changes during the Pleistocene have been spatially and temporarily complex, including rapid changes of vegetation in parallel to orbital and suborbital variability, and situations of multi-centennial resilience or accommodation to climatic changes. Regional characteristics emerged as soon as for the Middle Pleistocene, if not earlier: Ericaceae in the Atlantic coast indicating wetter climate, thermo-mediterranean elements in the south as currently, and broad-leaf trees in the northeastern. Overall, steppe landscapes and open Pinus woodlands prevailed over many continental regions during the cold spells of the Late Pleistocene. The maintenance of a high phytodiversity during the glacials was linked to several refuge zones in the coastal shelves of the Mediterranean and intramountainous valleys. Northern Iberia, especially on coastal areas, was also patched with populations of tree species, and this is not only documented by palaeobotanical data (pollen, charcoal) but also postulated by phylogeographical models

Desarrollo del derecho de sociedades en la UE

Este es el blog del Proyecto de Investigación «"Desarrollo del Derecho de Sociedades en la Unión Europea: libertad de establecimiento, fiscalidad e interacción con los ordenamientos nacionales". El proyecto es continuación de dos anteriores en los que se habían desarrollado otro temas relativos a Derecho de sociedades y demás personas jurídica y específicamente las conexiones entre el Derecho material de sociedades y el DIPr de sociedades. El primero de estos proyectos se desarrolló entre los años 2005 y 2008 y tuvo como objeto el estudio del impacto de la globalización de la economía en el DIPr de sociedades. El segundo se desarrolló entre los años 2010 y 2013 y estuvo dedicado a analizar la relación entre la autonomía de la voluntad y las exigencias imperativas en el Derecho de sociedades y otras personas jurídicas. Como resultado de ambos proyectos se concluyeron varias publicaciones que aparecen detalladas en el apartado de publicaciones de esta página web. Partimos en este proyecto de los anteriores, aunque aquí abordamos un problema más concreto que los que le precedieron. En los dos primeros proyectos estudiamos los presupuestos generales del Derecho de sociedades en una sociedad globalizada y en el que el papel de los Derechos estatales se ve condicionado por la movilidad societaria facilitada dentro de Europa por la proyección de la libertad de establecimiento sobre el Derecho de sociedades. Esta situación es causa de algunos problemas que ya habían sido apuntados en proyectos anteriores y que la UE debe abordar. Los próximos años serán cruciales para ello y nuestro objetivo es realizar un seguimiento crítico de las novedades que nos depare la UE en lo que se refiere a la evolución del Derecho de sociedades