Preliminary study on the effect of castration and testosterone replacement on testosterone level in the New Zealand male rabbit

To study the effect of castration and testosterone replacement on the testosterone level of the New Zealand  rabbit, 16 apparently healthy adult male rabbits were used. The animals were divided into four groups with  each group having four rabbits. The first group served as the control group. The rabbits in the second group  were unilaterally castrated, while those in the third group were bilaterally castrated. The rabbits in the fourth group were bilaterally castrated and then had testosterone replacement. The normal value of plasma  testosterone in the male New Zealand rabbit was 7.17 ± 0.72 nmol/L. There was a sharp significant (p<0.05) drop in the level of testosterone one week after unilateral castration and by 2nd week, it returned to the  pre-castration value. The plasma level of testosterone also dropped significantly (p<0.05) after one week of  castration in the bilaterally castrated and bilaterally castrated with testosterone replacement groups, and by 2nd week in the latter group (bilaterally castrated with testosterone replacement), the plasma level had risen to a slightly higher value than pre-castration value. In the bilaterally castrated group, the plasma level of  testosterone also rose but was lower than the pre-castration value. The study shows that the unilateral  castration does not permanently alter the plasma testosterone level as does the bilateral castration.Key words: Castration, New Zealand rabbit, testosterone, testosterone replacement

Blindness Caused by Pterygium – A Case Report

Pterygium leading to bilateral blindness and forcing patient to quit job is uncommon. This is a case report of a 46 year old indigent woman who had blinding pterygia over 10 years. She could not afford pterygium excision offered in a private eye clinic where she initially presented after a period of unsuccessful self medication. She was forced out of sewing job consequent to her inability to thread needle, difficulty reading number on the tape rule and difficulty recognising faces of her clients. Six years later, she presented at eye clinic of the University of Ilorin Teaching Hospital, Nigeria with advanced bilateral pterygia. Having defaulted from clinic over 4 months for lack of fund, the patient, after concession, had successful bilateral pterygia excision using bare sclera technique with Mitomycin C (MMC) dab. There was restoration of the lost vision. Pterygium is a cause of avoidable blindness with consequential impact on quality of life. Eye care providers should identify individual patient challenges to reduce avoidable blindness. Keywords: Avoidable blindness, Patient challenges, Pterygium, Quality of lif

Psychoactive substance intake and gender on crime

This study investigated the influence of psychoactive substance (alcohol, marijuana, and cocaine) intake and gender on crime. Three hundred and eighty participants (380) were randomly selected from inmates as models of prisons in Uyo, Akwa Ibom State. The participants comprised 314males (82.63%) and 66 females (17.37%) with the mean age of 28.3 years. The design of the study was a survey. In this study four hypotheses were predicted. The first hypothesis indicates that there was a statistically significant influence of alcohol intake on crime committed among prisoners, X2 (df=4, N = 380) = 29.51, p<0.01. The result of the second hypothesis indicates that there was also a significant influence of marijuana intake on crimes committed among prisoners, X2 (4, N = 380) = 38.1, p<0.01. Hypothesis three indicates that Cocaine intake does not significantly influence crime committed among prisoners, X2 (4, N = 380) = 12.32, ns. While the result of hypothesis four indicates there was nosignificant difference in crimes committed among male and female prisoners, X2 (2, N = 380) = 0.12, ns. The findings of the present study were discussed in the context of previous studies. The policy implications of the findings in this study were also discussed

Comparative studies of drying methods on the seed quality of interspecific NERICA rice varieties (Oryza glaberrima x Oryza sativa) and their parents

Seed moisture content (MC) is a key component that determines storability of germplasm conserved in seed genebanks. The purpose of this research was to compare the efficiency of sun-, shade-, silica geland conventional room drying in terms of rice seed MC and viability using seeds of two interspecific progenies (NERICA 1 and NERICA 3) and their parents Oryza glaberrima and O. sativa varietiesharvested 15 days before, at and 15 days after mass maturity. Sun drying most significantly reduced MC (4-5%) and was comparable with silica gel drying regardless of the variety tested and the maturity stageat harvest. Likewise, sun drying gave the best germination percentages followed by silica gel. Shade and room drying did not significantly lower MC and led to poor germination, especially when rice washarvested prematurely. Except for the sativa variety, harvesting prematurely resulted in no germination. In contrast, the initial germination percentages in all tested varieties improved as rice was harvested at or after mass maturity rather than 15 days earlier. Though comparable to sun drying, silica gel may not be readily available and affordable for resource-limited seed storage facilities. In this case sun drying was found an effective and affordable method for short-term storage, especially farm-saved seeds

Pooled analysis of WHO Surgical Safety Checklist use and mortality after emergency laparotomy

Background The World Health Organization (WHO) Surgical Safety Checklist has fostered safe practice for 10 years, yet its place in emergency surgery has not been assessed on a global scale. The aim of this study was to evaluate reported checklist use in emergency settings and examine the relationship with perioperative mortality in patients who had emergency laparotomy. Methods In two multinational cohort studies, adults undergoing emergency laparotomy were compared with those having elective gastrointestinal surgery. Relationships between reported checklist use and mortality were determined using multivariable logistic regression and bootstrapped simulation. Results Of 12 296 patients included from 76 countries, 4843 underwent emergency laparotomy. After adjusting for patient and disease factors, checklist use before emergency laparotomy was more common in countries with a high Human Development Index (HDI) (2455 of 2741, 89.6 per cent) compared with that in countries with a middle (753 of 1242, 60.6 per cent; odds ratio (OR) 0.17, 95 per cent c.i. 0.14 to 0.21, P <0001) or low (363 of 860, 422 per cent; OR 008, 007 to 010, P <0.001) HDI. Checklist use was less common in elective surgery than for emergency laparotomy in high-HDI countries (risk difference -94 (95 per cent c.i. -11.9 to -6.9) per cent; P <0001), but the relationship was reversed in low-HDI countries (+121 (+7.0 to +173) per cent; P <0001). In multivariable models, checklist use was associated with a lower 30-day perioperative mortality (OR 0.60, 0.50 to 073; P <0.001). The greatest absolute benefit was seen for emergency surgery in low- and middle-HDI countries. Conclusion Checklist use in emergency laparotomy was associated with a significantly lower perioperative mortality rate. Checklist use in low-HDI countries was half that in high-HDI countries.Peer reviewe

Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study

Background: Surgical site infection (SSI) is one of the most common infections associated with health care, but its importance as a global health priority is not fully understood. We quantified the burden of SSI after gastrointestinal surgery in countries in all parts of the world. Methods: This international, prospective, multicentre cohort study included consecutive patients undergoing elective or emergency gastrointestinal resection within 2-week time periods at any health-care facility in any country. Countries with participating centres were stratified into high-income, middle-income, and low-income groups according to the UN's Human Development Index (HDI). Data variables from the GlobalSurg 1 study and other studies that have been found to affect the likelihood of SSI were entered into risk adjustment models. The primary outcome measure was the 30-day SSI incidence (defined by US Centers for Disease Control and Prevention criteria for superficial and deep incisional SSI). Relationships with explanatory variables were examined using Bayesian multilevel logistic regression models. This trial is registered with ClinicalTrials.gov, number NCT02662231. Findings: Between Jan 4, 2016, and July 31, 2016, 13 265 records were submitted for analysis. 12 539 patients from 343 hospitals in 66 countries were included. 7339 (58·5%) patient were from high-HDI countries (193 hospitals in 30 countries), 3918 (31·2%) patients were from middle-HDI countries (82 hospitals in 18 countries), and 1282 (10·2%) patients were from low-HDI countries (68 hospitals in 18 countries). In total, 1538 (12·3%) patients had SSI within 30 days of surgery. The incidence of SSI varied between countries with high (691 [9·4%] of 7339 patients), middle (549 [14·0%] of 3918 patients), and low (298 [23·2%] of 1282) HDI (p < 0·001). The highest SSI incidence in each HDI group was after dirty surgery (102 [17·8%] of 574 patients in high-HDI countries; 74 [31·4%] of 236 patients in middle-HDI countries; 72 [39·8%] of 181 patients in low-HDI countries). Following risk factor adjustment, patients in low-HDI countries were at greatest risk of SSI (adjusted odds ratio 1·60, 95% credible interval 1·05–2·37; p=0·030). 132 (21·6%) of 610 patients with an SSI and a microbiology culture result had an infection that was resistant to the prophylactic antibiotic used. Resistant infections were detected in 49 (16·6%) of 295 patients in high-HDI countries, in 37 (19·8%) of 187 patients in middle-HDI countries, and in 46 (35·9%) of 128 patients in low-HDI countries (p < 0·001). Interpretation: Countries with a low HDI carry a disproportionately greater burden of SSI than countries with a middle or high HDI and might have higher rates of antibiotic resistance. In view of WHO recommendations on SSI prevention that highlight the absence of high-quality interventional research, urgent, pragmatic, randomised trials based in LMICs are needed to assess measures aiming to reduce this preventable complication

Global variation in anastomosis and end colostomy formation following left-sided colorectal resection

Background End colostomy rates following colorectal resection vary across institutions in high-income settings, being influenced by patient, disease, surgeon and system factors. This study aimed to assess global variation in end colostomy rates after left-sided colorectal resection. Methods This study comprised an analysis of GlobalSurg-1 and -2 international, prospective, observational cohort studies (2014, 2016), including consecutive adult patients undergoing elective or emergency left-sided colorectal resection within discrete 2-week windows. Countries were grouped into high-, middle- and low-income tertiles according to the United Nations Human Development Index (HDI). Factors associated with colostomy formation versus primary anastomosis were explored using a multilevel, multivariable logistic regression model. Results In total, 1635 patients from 242 hospitals in 57 countries undergoing left-sided colorectal resection were included: 113 (6·9 per cent) from low-HDI, 254 (15·5 per cent) from middle-HDI and 1268 (77·6 per cent) from high-HDI countries. There was a higher proportion of patients with perforated disease (57·5, 40·9 and 35·4 per cent; P < 0·001) and subsequent use of end colostomy (52·2, 24·8 and 18·9 per cent; P < 0·001) in low- compared with middle- and high-HDI settings. The association with colostomy use in low-HDI settings persisted (odds ratio (OR) 3·20, 95 per cent c.i. 1·35 to 7·57; P = 0·008) after risk adjustment for malignant disease (OR 2·34, 1·65 to 3·32; P < 0·001), emergency surgery (OR 4·08, 2·73 to 6·10; P < 0·001), time to operation at least 48 h (OR 1·99, 1·28 to 3·09; P = 0·002) and disease perforation (OR 4·00, 2·81 to 5·69; P < 0·001). Conclusion Global differences existed in the proportion of patients receiving end stomas after left-sided colorectal resection based on income, which went beyond case mix alone

Hypoglycaemic activities of the stem bark of Cola Acuminata VAHL and leaf of Ficus Exasperata (P.Beauv) SCHOTT and ENDL

No abstract Nigerian Quarterly Journal of Hospital Medicine Vol. 13(1-2): 58-6

Chemical, Functional and Sensory Properties of Instant Yam - Breadfruit Flour

Yam (Dioscorea rotundata) tubers and breadfruits (Artocarpus communis) were processed separately into instant flour and mixed at different proportions (100% yam flour; 100% breadfruit flour; 80 : 20%, 70 : 30%, 60 : 40%, 50 : 50% yam - breadfruit flour). The chemical, functionaland pasting properties of the composite flours were determined while the instant yam - breadfruit flours were then reconstituted, made into paste and subjected to sensory evaluation. The study showed that there were significant differences (