741 research outputs found
Mass loss in red giants and supergiants
The circumstellar envelopes surrounding late-type giants and supergiants were studied using high resolution, photoelectric scans of strong optical resonance lines. A method for extracting the circumstellar from the stellar components of the lines allowed a quantitative determination of the physical conditions in the envelopes and the rates of mass loss at various positions in the red giant region of the HR diagram. The observed strengthening of the circumstellar spectrum with increasing luminosity and later spectral type is probably caused by an increase in the mass of the envelopes. The mass loss rate for individual stars is proportional to the visual luminosity; high rates for the supergiants suggest that mass loss is important in their evolution. The bulk of the mass return to the interstellar medium in the red giant region comes from the normal giants, at a rate comparable to that of planetary nebulae
Psychological Safety and Norm Clarity in Software Engineering Teams
In the software engineering industry today, companies primarily conduct their
work in teams. To increase organizational productivity, it is thus crucial to
know the factors that affect team effectiveness. Two team-related concepts that
have gained prominence lately are psychological safety and team norms. Still,
few studies exist that explore these in a software engineering context.
Therefore, with the aim of extending the knowledge of these concepts, we
examined if psychological safety and team norm clarity associate positively
with software developers' self-assessed team performance and job satisfaction,
two important elements of effectiveness.
We collected industry survey data from practitioners (N = 217) in 38
development teams working for five different organizations. The result of
multiple linear regression analyses indicates that both psychological safety
and team norm clarity predict team members' self-assessed performance and job
satisfaction. The findings also suggest that clarity of norms is a stronger
(30\% and 71\% stronger, respectively) predictor than psychological safety.
This research highlights the need to examine, in more detail, the
relationship between social norms and software development. The findings of
this study could serve as an empirical baseline for such, future work.Comment: Submitted to CHASE'201
Cyclic Peptides as Protein Kinase Inhibitors: StructureâActivity Relationship and Molecular Modeling
Under-expression or overexpression of protein kinases has been shown to be associated with unregulated cell signal transduction in cancer cells. Therefore, there is major interest in designing protein kinase inhibitors as anticancer agents. We have previously reported [WR]5, a peptide containing alternative arginine (R) and tryptophan (W) residues as a non-competitive c-Src tyrosine kinase inhibitor. A number of larger cyclic peptides containing alternative hydrophobic and positively charged residues [WR]x (x = 6â9) and hybrid cyclic-linear peptides, [R6K]W6 and [R5K]W7, containing R and W residues were evaluated for their protein kinase inhibitory potency. Among all the peptides, cyclic peptide [WR]9 was found to be the most potent tyrosine kinase inhibitor. [WR]9 showed higher inhibitory activity (IC50 = 0.21 ÎŒM) than [WR]5, [WR]6, [WR]7, and [WR]8 with IC50 values of 0.81, 0.57, 0.35, and 0.33 ÎŒM, respectively, against c-Src kinase as determined by a radioactive assay using [Îł-33P]ATP. Consistent with the result above, [WR]9 inhibited other protein kinases such as Abl kinase activity with an IC50 value of 0.35 ÎŒM, showing 2.2-fold higher inhibition than [WR]5 (IC50 = 0.79 ÎŒM). [WR]9 also inhibited PKCa kinase activity with an IC50 value of 2.86 ÎŒM, approximately threefold higher inhibition than [WR]5 (IC50 = 8.52 ÎŒM). A similar pattern was observed against Braf, c-Src, Cdk2/cyclin A1, and Lck. [WR]9 exhibited IC50 values of 9 is consistently more potent than other cyclic peptides with a smaller ring size and hybrid cyclic-linear peptides [R6K]W6 and [R5K]W7 against selected protein kinases. Thus, the presence of R and W residues in the ring, ring size, and the number of amino acids in the structure of the cyclic peptide were found to be critical in protein kinase inhibitory potency. We identified three putative binding pockets through automated blind docking of cyclic peptides [WR](5â9). The most populated pocket is located between the SH2, SH3, and N-lobe domains on the opposite side of the ATP binding site. The second putative pocket is formed by the same domains and located on the ATP binding site side of the protein. Finally, a third pocket was identified between the SH2 and SH3 domains. These results are consistent with the non-competitive nature of the inhibition displayed by these molecules. Molecular dynamics simulations of the proteinâpeptide complexes indicate that the presence of either [WR]5 or [WR]9 affects the plasticity of the protein and in particular the volume of the ATP binding site pocket in different ways. These results suggest that the second pocket is most likely the site where these peptides bind and offer a plausible rationale for the increased affinity of [WR]9
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The Observations Of The X-Ray Source Hz Herculis-Hercules X-1
NASAESASRCAstronom
Kinematic parameters and membership probabilities of open clusters in the Bordeaux PM2000 catalogue
We derive lists of proper-motions and kinematic membership probabilities for
49 open clusters and possible open clusters in the zone of the Bordeaux PM2000
proper motion catalogue (). We test
different parametrisations of the proper motion and position distribution
functions and select the most successful one. In the light of those results, we
analyse some objects individually. The segregation between cluster and field
member stars, and the assignment of membership probabilities, is accomplished
by applying a new and fully automated method based on both parametrisations of
the proper motion and position distribution functions, and genetic algorithm
optimization heuristics associated with a derivative-based hill climbing
algorithm for the likelihood optimization. We present a catalogue comprising
kinematic parameters and associated membership probability lists for 49 open
clusters and possible open clusters in the Bordeaux PM2000 catalogue region. We
note that this is the first determination of proper motions for five open
clusters. We confirm the non-existence of two kinematic populations in the
region of 15 previously suspected non-existent objects.Comment: 14 pages, 6 figures, 4 tables. Accepted for publication in Astronomy
& Astrophysic
Velocity Dispersion of Dissolving OB Associations Affected by External Pressure of Formation Environment
This paper presents a possible way to understand dissolution of OB
associations (or groups). Assuming rapid escape of parental cloud gas from
associations, we show that the shadow of the formation environment for
associations can be partially imprinted on the velocity dispersion at their
dissolution. This conclusion is not surprising as long as associations are
formed in a multiphase interstellar medium, because the external pressure
should suppress expansion caused by the internal motion of the parental clouds.
Our model predicts a few km s as the internal velocity dispersion.
Observationally, the internal velocity dispersion is km s which
is smaller than our prediction. This suggests that the dissipation of internal
energy happens before the formation of OB associations.Comment: 6 pages. AJ accepte
Deterministic Preparation of a Tunable Few-Fermion System
Systems consisting of few interacting fermions are the building blocks of
matter with atoms and nuclei being the most prominent examples. We have created
an artificial few-body quantum system with complete control over the system's
quantum state using ultracold fermionic atoms in an optical dipole trap. We
deterministically prepare ground state systems consisting of one to ten
particles with fidelities of ~ 90%. We can tune the inter-particle interactions
to arbitrary values using a Feshbach resonance and have observed the
interaction-induced energy shift for a pair of repulsively interacting atoms.
With this work, quantum simulation of strongly correlated fewbody systems has
become possible. In addition, these microscopic quantum systems can be used as
building blocks for scalable quantum information processing.Comment: 8 pages, 6 figure
Identification of red high proper-motion objects in Tycho-2 and 2MASS catalogues using Virtual Observatory tools
Aims: With available Virtual Observatory tools, we looked for new M dwarfs in
the solar neighbourhood and M giants with high tangential velocities. Methods:
From an all-sky cross-match between the optical Tycho-2 and the near-infrared
2MASS catalogues, we selected objects with proper motions >50mas/yr and very
red V-Ks colours. For the most interesting targets, we collected
multi-wavelength photometry, constructed spectral energy distributions,
estimated effective temperatures and surface gravities from fits to atmospheric
models, performed time-series analysis of ASAS V-band light curves, and
assigned spectral types from low-resolution spectroscopy obtained with CAFOS at
the 2.2m Calar Alto telescope. Results: We got a sample of 59 bright red high
proper-motion objects, including fifty red giants, four red dwarfs, and five
objects reported in this work for the first time. The five new stars have
magnitudes V~10.8-11.3mag, reduced proper motions midway between known dwarfs
and giants, near-infrared colours typical of giants, and effective temperatures
Teff~2900-3400K. From our time-series analysis, we discovered a long secondary
period in Ruber 4 and an extremely long primary period in Ruber 6. With the
CAFOS spectra, we confirmed the red giant nature of Ruber 7 and 8, the last of
which seems to be one of the brightest metal-poor M giants ever identified.Comment: Accepted in Astronomy & Astrophysic
Fifty Years of IMF Variation: The Intermediate-Mass Stars
I track the history of star count estimates of the Milky Way field star and
open cluster IMFs, concentrating on the neglected mass range from 1 to 15
M. The prevalent belief in a universal IMF appears to be without
basis for this mass range. Two recent estimates of the field star IMF using
different methods and samples give values of the average logarithmic slope
between -1.7 and -2.1 in the mass range 1.1 to 4 M. Two
older estimates between 2 and 15 M disagree severely; the field IMF
in this range is essentially unknown from star counts. Variations in
among open cluster IMFs in this mass range have not decreased despite numerous
detailed studies, even for studies using homogeneous data and reduction
procedures and including only clusters with a significant mass range. These
cluster variations \textit{might} be due to the combined effects of sampling,
systematic errors, stellar evolution uncertainties, dynamical evolution, and
unresolved binaries. If so, then the cluster data are consistent with a
universal IMF, but are also consistent with sizeable variations. The cluster
data do not allow an estimate of an average IMF or because the average
depends on the choice of weighting procedure and other effects. If the spread
in cluster IMFs is in excess of the effects listed above, real IMF variations
must occur that do not depend much on physical conditions explored so far. The
complexity of the star formation process seen in observations and simulations
suggests that large realization-to-realization differences might be expected,
in which case an individual cluster IMF would be in part the product of
evolutionary contingency in star formation, and the function of interest is the
probability distribution of IMF parameters.Comment: 18 pages, including 4 figures: invited talk presented at the
conference on "IMF@50: The Stellar Initial Mass Function Fifty Years Later"
held at Abbazia di Spineto, Siena, Italy, May 2004; to be published by Kluwer
Academic Publishers, edited by E. Corbelli, F. Palla, and H. Zinnecke
MEME Suite: tools for motif discovery and searching
The MEME Suite web server provides a unified portal for online discovery and analysis of sequence motifs representing features such as DNA binding sites and protein interaction domains. The popular MEME motif discovery algorithm is now complemented by the GLAM2 algorithm which allows discovery of motifs containing gaps. Three sequence scanning algorithmsâMAST, FIMO and GLAM2SCANâallow scanning numerous DNA and protein sequence databases for motifs discovered by MEME and GLAM2. Transcription factor motifs (including those discovered using MEME) can be compared with motifs in many popular motif databases using the motif database scanning algorithm Tomtom. Transcription factor motifs can be further analyzed for putative function by association with Gene Ontology (GO) terms using the motif-GO term association tool GOMO. MEME output now contains sequence LOGOS for each discovered motif, as well as buttons to allow motifs to be conveniently submitted to the sequence and motif database scanning algorithms (MAST, FIMO and Tomtom), or to GOMO, for further analysis. GLAM2 output similarly contains buttons for further analysis using GLAM2SCAN and for rerunning GLAM2 with different parameters. All of the motif-based tools are now implemented as web services via Opal. Source code, binaries and a web server are freely available for noncommercial use at http://meme.nbcr.net
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