328 research outputs found
ÂżAfecta la calidad del hĂĄbitat alimentario a la capacidad reproductiva de la garceta comĂșn, Egretta garzetta?
In order to understand the role of foraging habitat quality on fecundity parameters we measured habitat use, breeding parameters, and body condition of chicks in six colonies of Little Egrets in southern France. The foraging habitat available differed between colonies; it was mainly natural marshes around the Carrelet colony, agricultural lands (rice fields and dry crops) around the Agon colony, a mix of agricultural and natural lands around the Redon and FiĂ©louse colonies, a mix of natural and urbanised/industrial lands around the Palissade colony, and mainly cultivated and urbanised lands around the Chaumont colony. The habitat attractiveness to adult Little Egret breeding was higher for natural marshes than for other habitat types. Agricultural marshes (rice fields) came next. Other humanâmade habitats came last. Clutch size and body condition index of chicks did not differ between colonies. Brood size was influenced by both the association of the proportion of natural marshes in the foraging area and clutch size, and the association of clutch size and the total number of heron pairs in the colony. The effect of the proportion of natural marshes could not be distinguished from the effects of the colony size. The potential influence of other parameters not taken into account in this study is discussed.Con la finalidad de conocer el papel que ejerce la calidad del hĂĄbitat alimentario sobre los parĂĄmetros de fecundidad, se evaluaron el uso del hĂĄbitat, los parĂĄmetros reproductivos y las condiciones fĂsicas de los polluelos de seis colonias de garceta comĂșn en el sur de Francia. El hĂĄbitat alimentario disponible variaba de unas colonias a otras, siendo principalmente marismas naturales en el entorno de la colonia de Carrelet, terrenos agrĂcolas (campos de arroz y cultivos de secano) alrededor de la colonia de Agon, una combinaciĂłn de terrenos agrĂcolas y naturales alrededor de las colonias de Redon y FiĂ©louse, una combinaciĂłn de terrenos naturales y urbanizados/industriales alrededor de la colonia de Palissade, y principalmente terrenos cultivados y urbanizados alrededor de la colonia de Chaumont. En la Ă©poca de reproducciĂłn, los adultos de garceta comĂșn se sienten atraĂdos principalmente por las marismas naturales, en detrimento de otros tipos de hĂĄbitat. Las tierras agrĂcolas anegadas (campos de arroz) siguen en orden de preferencia, mientras los hĂĄbitats construidos por el hombre ocupan el Ășltimo lugar. El tamaño de la puesta y el Ăndice de estado fĂsico de los polluelos no mostraron diferencias entre las colonias. El tamaño de la nidada estuvo influenciado tanto por la asociaciĂłn de la proporciĂłn de marismas naturales en el hĂĄbitat alimentario y el tamaño de la puesta, como por la asociaciĂłn del tamaño de la puesta y el nĂșmero total de parejas de garzas de la colonia. El efecto de la proporciĂłn de marismas naturales no se puede diferenciar del ejercido por el tamaño de la colonia. Se discute tambiĂ©n la influencia potencial de otros parĂĄmetros que no se han tenido en cuenta en este estudio
From Antenna to Antenna: Lateral Shift of Olfactory Memory Recall by Honeybees
Honeybees, Apis mellifera, readily learn to associate odours with sugar rewards and we show here that recall of the olfactory memory, as demonstrated by the bee extending its proboscis when presented with the trained odour, involves first the right and then the left antenna. At 1â2 hour after training using both antennae, recall is possible mainly when the bee uses its right antenna but by 6 hours after training a lateral shift has occurred and the memory can now be recalled mainly when the left antenna is in use. Long-term memory one day after training is also accessed mainly via the left antenna. This time-dependent shift from right to left antenna is also seen as side biases in responding to odour presented to the bee's left or right side. Hence, not only are the cellular events of memory formation similar in bees and vertebrate species but also the lateralized networks involved may be similar. These findings therefore seem to call for remarkable parallel evolution and suggest that the proper functioning of memory formation in a bilateral animal, either vertebrate or invertebrate, requires lateralization of processing
The practices of apartheid as a war crime: a critical analysis
The human suffering caused by the political ideology of apartheid in South Africa during the Apartheid era (1948-1994) prompted worldwide condemnation and a variety of diplomatic and legal responses. Amongst these responses was the attempt to have apartheid recognised both as a crime against humanity in the 1973 Apartheid Convention as well as a war crime in Article 85(4)(c) of Additional Protocol I. This article examines the origins, nature and current status of the practices of apartheid as a war crime and its possible application to the Israeli-Palestinian conflict
Determinants of the voltage dependence of G protein modulation within calcium channel ÎČ subunits
CaVÎČ subunits of voltage-gated calcium channels contain two conserved domains, a src-homology-3 (SH3) domain and a guanylate kinase-like (GK) domain with an intervening HOOK domain. We have shown in a previous study that, although GÎČÎł-mediated inhibitory modulation of CaV2.2 channels did not require the interaction of a CaVÎČ subunit with the CaVα1 subunit, when such interaction was prevented by a mutation in the α1 subunit, G protein modulation could not be removed by a large depolarization and showed voltage-independent properties (Leroy et al., J Neurosci 25:6984â6996, 2005). In this study, we have investigated the ability of mutant and truncated CaVÎČ subunits to support voltage-dependent G protein modulation in order to determine the minimal domain of the CaVÎČ subunit that is required for this process. We have coexpressed the CaVÎČ subunit constructs with CaV2.2 and α2ÎŽ-2, studied modulation by the activation of the dopamine D2 receptor, and also examined basal tonic modulation. Our main finding is that the CaVÎČ subunit GK domains, from either ÎČ1b or ÎČ2, are sufficient to restore voltage dependence to G protein modulation. We also found that the removal of the variable HOOK region from ÎČ2a promotes tonic voltage-dependent G protein modulation. We propose that the absence of the HOOK region enhances GÎČÎł binding affinity, leading to greater tonic modulation by basal levels of GÎČÎł. This tonic modulation requires the presence of an SH3 domain, as tonic modulation is not supported by any of the CaVÎČ subunit GK domains alone
Live to cheat another day: bacterial dormancy facilitates the social exploitation of beta-lactamases
The breakdown of antibiotics by ÎČ-lactamases may be cooperative, since resistant cells can detoxify their environment and facilitate the growth of susceptible neighbours. However, previous studies of this phenomenon have used artificial bacterial vectors or engineered bacteria to increase the secretion of ÎČ-lactamases from cells. Here, we investigated whether a broad-spectrum ÎČ-lactamase gene carried by a naturally occurring plasmid (pCT) is cooperative under a range of conditions. In ordinary batch culture on solid media, there was little or no evidence that resistant bacteria could protect susceptible cells from ampicillin, although resistant colonies could locally detoxify this growth medium. However, when susceptible cells were inoculated at high densities, late-appearing phenotypically susceptible bacteria grew in the vicinity of resistant colonies. We infer that persisters, cells that have survived antibiotics by undergoing a period of dormancy, founded these satellite colonies. The number of persister colonies was positively correlated with the density of resistant colonies and increased as antibiotic concentrations decreased. We argue that detoxification can be cooperative under a limited range of conditions: if the toxins are bacteriostatic rather than bacteridical; or if susceptible cells invade communities after resistant bacteria; or if dormancy allows susceptible cells to avoid bactericides. Resistance and tolerance were previously thought to be independent solutions for surviving antibiotics. Here, we show that these are interacting strategies: the presence of bacteria adopting one solution can have substantial effects on the fitness of their neighbours
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Single-session visuospatial task procedure to prevent childbirth-related posttraumatic stress disorder: a multicentre double-blind randomised controlled trial
Preventive evidence-based interventions for childbirth-related posttraumatic stress disorder (CB-PTSD) are lacking. Yet, 18.5% of women develop CB-PTSD symptoms following an unplanned caesarean section (UCS). This two-arm, multicentre, double-blind superiority trial tested the efficacy of an early single-session intervention including a visuospatial task on the prevention of maternal CB-PTSD symptoms. The intervention was delivered by trained maternity clinicians. Shortly after UCS, women were included if they gave birth to a live baby, provided consent, and perceived their childbirth as traumatic. Participants were randomly assigned to the intervention or attention-placebo group (allocation ratio 1:1). Assessments were done at birth, six weeks, and six months postpartum. Group differences in maternal CB-PTSD symptoms at six weeks (primary outcomes) and six months postpartum (secondary outcomes) were assessed with the self-report PTSD Checklist for DSM-5 (PCL-5) and by blinded research assessors with the Clinician-administered PTSD scale for DSM-5 (CAPS-5). Analysis was by intention-to-treat. The trial was prospectively registered (ClinicalTrials.gov, NCT03576586). Of the 2068 women assessed for eligibility, 166 were eligible and 146 were randomly assigned to the intervention (nâ=â74) or attention-placebo control group (nâ=â72). For the PCL-5, at six weeks, a marginally significant intervention effect was found on the total PCL-5 PTSD symptom count (ÎČâ=â-0.43, S.E.â=â0.23, zâ=â-1.88, pâ<â0.06), and on the intrusions (ÎČâ=â-0.73, S.E.â=â0.38, zâ=â-1.94, pâ<â0.0525) and arousal (ÎČâ=â-0.55, S.E.â=â0.29, zâ=â-1.92, pâ<â0.0552) clusters. At six months, a significant intervention effect on the total PCL-5 PTSD symptom count (ÎČâ=â-0.65, S.E.â=â0.32, zâ=â-2.04, pâ=â0.041, 95%CI[-1.27, -0.03]), on alterations in cognition and mood (ÎČâ=â-0.85, S.E.â=â0.27, zâ=â-3.15, pâ=â0.0016) and arousal (ÎČâ=â-0.56, S.E.â=â0.26, zâ=â-2.19, pâ<â0.0289, 95%CI[-1.07, -0.06]) clusters appeared. No group differences on the CAPS-5 emerged. Results provide evidence that this brief, single-session intervention carried out by trained clinicians can prevent the development of CB-PTSD symptoms up to six months postpartum
Spadin, a Sortilin-Derived Peptide, Targeting Rodent TREK-1 Channels: A New Concept in the Antidepressant Drug Design
We found that spadin, a natural peptide derived from sortilin, blocks the mouse TREK-1 channel and might be an efficient and fast-acting antidepressant
Report of the ACBS Task Force on the Strategies and Tactics of Contextual Behavioral Science Research
Throughout its history the strategy and tactics of contextual behavioral science (CBS) research have had distinctive features as compared to traditional behavioral science approaches. Continued progress in CBS research can be facilitated by greater clarity about how its strategy and tactics can be brought to bear on current challenges. The present white paper is the result of a 2 1/2-year long process designed to foster consensus among representative producers and consumers of CBS research about the best strategic pathway forward. The Task Force agreed that CBS research should be multilevel, process-based, multidimensional, prosocial, and pragmatic, and provided 33 recommendations to the CBS community arranged across these characteristics. In effect, this report provides a detailed research agenda designed to maximize the impact of CBS as a field. Scientists and practitioners are encouraged to mount this ambitious agenda
Actin and microtubules drive differential aspects of planar cell polarity in multiciliated cells
Actin dynamics are required for proper cilia spacing, global coordination of cilia polarity, and coordination of metachronic cilia beating, whereas cytoplasmic microtubule dynamics are required for local coordination of polarity between neighboring cilia
Co-Swarming and Local Collapse: Quorum Sensing Conveys Resilience to Bacterial Communities by Localizing Cheater Mutants in Pseudomonas aeruginosa
Background: Members of swarming bacterial consortia compete for nutrients but also use a co-operation mechanism called quorum sensing (QS) that relies on chemical signals as well as other secreted products (ââpublic goodsââ) necessary for swarming. Deleting various genes of this machinery leads to cheater mutants impaired in various aspects of swarming cooperation. Methodology/Principal Findings: Pairwise consortia made of Pseudomonas aeruginosa, its QS mutants as well as B. cepacia cells show that a interspecies consortium can ââcombine the skillsâ â of its participants so that the strains can cross together barriers that they could not cross alone. In contrast, deleterious mutants are excluded from consortia either by competition or by local population collapse. According to modeling, both scenarios are the consequence of the QS signalling mechanism itself. Conclusion/Significance: The results indirectly explain why it is an advantage for bacteria to maintain QS systems that can cross-talk among different species, and conversely, why certain QS mutants which can be abundant in isolated niches
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