Who's afraid of pedestrianisation? Residents' perceptions and preferences on street transformation

Altres ajuts: acords transformatius de la UABWhile urban pedestrianisation schemes typically attract vociferous opposition, it is often unclear whether these negative views are representative of the general population. For this reason, understanding how residents perceive the impacts of such schemes is critical to their evaluation. To this aim, this article assesses residents' perceptions and preferences regarding the pedestrianisation of multiple streets in the Eixample district of Barcelona in recent years, through a representative survey of the district's residents (n = 1211). Our research examines how residents' views on pedestrianisation vary depending on their mobility habits, sociodemographic background, and the level of traffic calming of the street they live on. Our results show that most respondents (66%) consider that the impacts of existing pedestrianisations have been positive regardless of whether they live on a pedestrianised street or not, even though residents of recently pedestrianised streets are more positive than those living on other streets. At the same time, many residents of pedestrianised streets consider that the benefits of reduced traffic externalities may be partially counterbalanced by new problems caused by an intensive use of public space (e.g. noise from people and cafes, touristification, nightlife). Our results also show that there is a strong relationship between support for pedestrianisation, age and mobility habits: daily car and motorbike users are much less supportive of pedestrianisation than public transport users and cyclists, while support for pedestrianisation decreases markedly with advancing age

A Phd thesis working plan: application of Dinsar technology to prevent natural and induced geological risks in cities and priority infrastructures in Central America

[EN] This communication presents the formulation and first steps of an Industrial PhD project, developed in the frame of the “Kuk ahpán” project (Spanish National R&D Plan, 2019-2022) that aims to understand, monitor and model tectonic processes at the lithospheric scale in Central America. For this purpose, an international team from six countries (Nicaragua, Costa Rica, El Salvador, Guatemala, Norway and Spain) works integrating research in diverse geophysical techniques and engineering, with the aim of updating Seismic Risk Maps for the Region, a critical input for Safety and Construction Codes. The proposed PhD project is framed on the research and development of technologies to prevent natural and induced geological risks that affect cities and infrastructures in highly vulnerable countries, using the DInSAR (Differential Interferometry with Synthetic Aperture Radar) technology optimized by the startup Detektia Earth Surface Monitoring in collaboration with Universidad Politécnica de Madrid. Differential Synthetic Aperture Radar Interferometry is a technique based on the processing and analysis of long series of Synthetic Aperture Radar images. This technology provides records (since 1992) and up-to-date movements on any surface anywhere in the world without the need for ground instrumentation, with accuracies about 1 mm/year (velocity). In this context satellite radar provides valuable information on very large areas that complement the field work and in-situ instrumentation. The methodological approach starts by integrating DInSAR data with geophysical and geodesical data such as bathymetry, geomagnetism, gravimetry, seismic profiles, GNSS series… to fully map the Swan fault over Honduras and Guatemala. We use this technology to address the seismic risk over the fault and nearby areas. Then, on a second step, we will apply this seismic risk assessment (including natural and anthropogenic hazards) in prioritized cities and critical infrastructures in Central America.[ES] Este documento presenta la formulación y primeros pasos de un proyecto de Doctorado Industrial, desarrollado en el marco del proyecto Kuk ahpán que tiene como objetivo comprender, monitorear y modelar procesos tectónicos a escala litosférica en Centroamérica. Para ello, un equipo internacional de seis países (Nicaragua, Costa Rica, El Salvador, Guatemala, Noruega y España) trabaja integrando la investigación en diversas técnicas e ingenierías Geofísicas, con el objetivo de actualizar los Mapas de Riesgo Sísmico de la Región, un insumo crítico. para los códigos de seguridad y construcción. El proyecto de doctorado propuesto se enmarca en la investigación y desarrollo de tecnologías para prevenirlos riesgos geológicos naturales e inducidos que afectan a ciudades e infraestructuras en países altamente vulnerables, utilizando la tecnología DInSAR (Differential Interferometry with Synthetic Aperture Radar) optimizada por la startup Detektia Earth Surface Monitoring en colaboración con la Universidad Politécnica de Madrid. La interferometría diferencial de radar de apertura sintética es una técnica basada en el procesamiento y análisis de series largas de imágenes de radar de apertura sintética. Esta tecnología proporciona registros (desde 1992) y movimientos actualizados en cualquier superficie en cualquier parte del mundo sin necesidad de instrumentación terrestre, con precisiones de alrededor de 1 mm/ año (velocidad). En este contexto, el radar satelital proporciona información valiosa sobre áreas muy grandes que complementan el trabajo de campo y la instrumentación in situ. Primero, comenzamos integrando datos DInSAR con diversos datos geofísicos como batimetría, geomagnetismo, gravimetría, perfiles sísmicos… para mapear completamente la falla Swan sobre Honduras y Guatemala. Usamos esta tecnología para abordar el riesgo sísmico sobre la falla y áreas cercanas. En un segundo paso, aplicaremos esta evaluación de riesgo sísmico (incluyendo amenazas naturales y antropogénicas) en ciudades e infraestructuras críticas en Centroamérica.Esta línea de investigación ha sido desarrollada con el apoyo de los equipos de Detektia Earth Surface Monitoring SL, la E.T.S.I. de Caminos, Canales y Puertos de la Universidad Politécnica de Madrid y el equipo de trabajo de Kuk ahpán.García-Lanchares, C.; Marchamalo, M.; Sancho, C. (2021). Descripción del proyecto de tesis doctoral: aplicación de la tecnología Dinsar a la prevención de los riesgos geológicos naturales e inducidos en ciudades e infraestructuras prioritarias de Centroamérica. En Proceedings 3rd Congress in Geomatics Engineering. Editorial Universitat Politècnica de València. 170-176. https://doi.org/10.4995/CiGeo2021.2021.12749OCS17017

Clinical management of homocystinuria; case report and review of the literature

La homocistinuria es un error congénito del metabolismo de la metionina que conduce al acúmulo de metionina y de su principal metabolito, homocisteína, en plasma, orina y tejidos. El acúmulo de homocisteína posee toxicidad sobre los sistemas óseo (osteoporosis), ocular (luxación del cristalino), nervioso (convulsiones, alteraciones psiquiátricas) y vascular (accidentes cerebrovasculares, enfermedad cardiovascular). Presentamos 2 casos de homocistinuria en 2 pacientes hermanos y, a continuación, revisamos las estrategias terapéuticas disponiblesHomocystinuria is a congenital disorder of methyonine metabolism that leads to increased plasmatic, urinary and tissue deposits of methyonine and its main metabolite: homocysteine. Homocysteine deposits are toxic for the skeletal system (osteoporosis), the eyes (lens dislocation), central nervous system (seizures, psychiatric disorders) and also induce vascular damage (stroke and other cardiovascular events). This article reports two patients with homocystinuria in two siblings, followed by a concise review on the therapeutic strategies available for this disorde

Declaración de Chinchón: decálogo sobre eldulcorantes sin y bajos en calorías (ESBC)

Multidisciplinary experts in the areas of nutrition and health met in Chinchón, Madrid, on November 25-26, 2013 under the auspices of the Fundación para la Investigación Nutricional (Nutrition Research Foundation) and with the collaboration of the Madrid Regional Government’s Health Ministry, the International Sweeteners Association and the Carlos III Health Institute CIBER of Physiopathology of Obesity and Nutrition. They analyzed the current status of scientific knowledge on low- and no-calorie sweeteners (LNCS) and developed a consensus Decalogue on their use; this constitutes the Chinchón Declaration. Sweeteners, including sugar, represent a subject of undeniable interest and are currently a popular topic, although areas relating to their safety and benefits remain unknown to segments of academia and the general public. The nature of LNCS makes them vulnerable to biased and even contradictory information. They are food additives that are broadly used as sugar substitutes to sweeten foods, medicines and food supplements when non-nutritional or non-caloric alternatives are needed. The Chinchón Decalogue is the outcome of a meeting for reflection and consensus by a group of experts with backgrounds in different scientific disciplines (toxicology, clinical nutrition, community nutrition, physiology, food science, public health, pediatrics, endocrinology and nutrition, nursing, pharmaceutical care and food legislation). The Decalogue includes different aspects of LNCS related to regulation, use, benefits and safety. In general, benefits of LNCS have been traditionally neglected in comparison with the tendency for emphasising unexisting or unproven possible risks. The need to strengthen research on LNCS in Spain was emphasized, as well as the need to educate both professionals and the publicExpertos de carácter multidisciplinar de las áreas de conocimiento de la nutrición y la salud reunidos en Chinchón, Madrid, los días 25 y 26 de noviembre de 2013 , bajo los auspicios de la Fundación para la Investigación Nutricional y con la colaboración de la Consejería de Sanidad del Gobierno de la Comunidad de Madrid, la International Sweeteners Association y el CIBER de Fisiopatología de la Obesidad y la Nutrición del Instituto de Salud Carlos III, analizaron el estado actual del conocimiento científico en torno a los Edulcorantes sin y bajos en calorías (ESBC) y desarrollaron un Decálogo sobre su uso que constituye la Declaración de Chinchón. Los edulcorantes, incluido el azúcar, constituyen un elemento de indudable interés y actualidad, aunque no exento de desconocimiento por algunos sectores tanto académicos como de la población en general. La propia naturaleza de los ESBC los hace susceptibles de informaciones tergiversadas e incluso contradictorias. Son aditivos alimentarios ampliamente utilizados como sustitutivos del azúcar para endulzar alimentos, medicamentos y complementos alimenticios cuando se persiguen fines no nutritivos. El Decálogo de Chinchón es fruto de una reunión de reflexión y consenso por parte de un grupo de expertos procedentes de distintas disciplinas científicas (toxicología, nutrición clínica, nutrición comunitaria, fisiología, bromatología, salud pública, atención primaria, pediatría, endocrinología y nutrición, enfermería, atención farmacéutica y legislación alimentaria). El decálogo incluye diferentes aspectos de los EBSC relacionados con la legislación, uso, beneficios y seguridad. En general, los beneficios de los EBSC han sido tradicionalmente desatendidos en comparación con la tendencia de destacar posibles riesgos inexistentes o que no han sido probados. Hace especial hincapié en la necesidad de fortalecer la investigación de los EBSC en España, así como la necesidad de formar en este ámbito a los profesionales y a los consumidores en genera

2013. Documento Sevilla de Consenso sobre Alternativas a la Transfusión de Sangre Alogénica. Actualización del Documento Sevilla

La transfusión de sangre alogénica (TSA) no es inocua, y como consecuencia han surgido múltiples alternativas a la misma (ATSA). Existe variabilidad respecto a las indicaciones y buen uso de las ATSA. Dependiendo de la especialidad de los médicos que tratan a los pacientes, el grado de anemia, la política transfusional, la disponibilidad de las ATSA y el criterio personal, estas se usan de forma variable. Puesto que las ATSA tampoco son inocuas y pueden no cumplir criterios de coste-efectividad, la variabilidad en su uso es inaceptable. Las sociedades españolas de Anestesiología y Reanimación (SEDAR), Hematología y Hemoterapia (SEHH), Farmacia Hospitalaria (SEFH), Medicina Intensiva y Unidades Coronarias (SEMICYUC), Trombosis y Hemostasia (SETH) y Transfusiones Sanguíneas (SETS) han elaborado un documento de consenso para el buen uso de la ATSA. Un panel de expertos de las 6 sociedades ha llevado a cabo una revisión sistemática de la literatura médica y elaborado el 2013. Documento Sevilla de Consenso sobre Alternativas a la Transfusión de Sangre Alogénica. Solo se contempla las ATSA dirigidas a disminuir la transfusión de concentrado de hematíes. Se definen las ATSA como toda medida farmacológica y no farmacológica encaminada a disminuir la transfusión de concentrado de hematíes, preservando siempre la seguridad del paciente. La cuestión principal que se plantea en cada ítem se formula, en forma positiva o negativa, como: «La ATSA en cuestión reduce/no reduce la tasa transfusional». Para formular el grado de recomendación se ha usado la metodología Grades of Recommendation Assessment, Development and Evaluation (GRADE)

Mutations, Genes, and Phenotypes Related to Movement Disorders and Ataxias

26 páginas, 4 figuras, 3 tablasOur clinical series comprises 124 patients with movement disorders (MDs) and/or ataxia with cerebellar atrophy (CA), many of them showing signs of neurodegeneration with brain iron accumulation (NBIA). Ten NBIA genes are accepted, although isolated cases compatible with abnormal brain iron deposits are known. The patients were evaluated using standardised clinical assessments of ataxia and MDs. First, NBIA genes were analysed by Sanger sequencing and 59 patients achieved a diagnosis, including the detection of the founder mutation PANK2 p.T528M in Romani people. Then, we used a custom panel MovDisord and/or exome sequencing; 29 cases were solved with a great genetic heterogeneity (34 different mutations in 23 genes). Three patients presented brain iron deposits with Fe-sensitive MRI sequences and mutations in FBXO7, GLB1, and KIF1A, suggesting an NBIA-like phenotype. Eleven patients showed very early-onset ataxia and CA with cortical hyperintensities caused by mutations in ITPR1, KIF1A, SPTBN2, PLA2G6, PMPCA, and PRDX3. The novel variants were investigated by structural modelling, luciferase analysis, transcript/minigenes studies, or immunofluorescence assays. Our findings expand the phenotypes and the genetics of MDs and ataxias with early-onset CA and cortical hyperintensities and highlight that the abnormal brain iron accumulation or early cerebellar gliosis may resembling an NBIA phenotype.This work was supported by the Instituto de Salud Carlos III (ISCIII)—Subdirección General de Evaluación y Fomento de la Investigación within the framework of the National R + D+I Plan co-funded with European Regional Development Funds (ERDF) [Grants PI18/00147 and PI21/00103 to CE]; the Fundació La Marató TV3 [Grants 20143130 and 20143131 to BPD and CE]; and by the Generalitat Valenciana [Grant PROMETEO/2018/135 to CE]. Part of the equipment employed in this work was funded by Generalitat Valenciana and co-financed with ERDF (OP ERDF of Comunitat Valenciana 2014–2020). PS had an FPU-PhD fellowship funded by the Spanish Ministry of Education, Culture and Sport [FPU15/00964]. IH has a PFIS-PhD fellowship [FI19/00072]. ASM has a contract funded by the Spanish Foundation Per Amor a l’Art (FPAA)Peer reviewe

Evaluation of appendicitis risk prediction models in adults with suspected appendicitis

Background Appendicitis is the most common general surgical emergency worldwide, but its diagnosis remains challenging. The aim of this study was to determine whether existing risk prediction models can reliably identify patients presenting to hospital in the UK with acute right iliac fossa (RIF) pain who are at low risk of appendicitis. Methods A systematic search was completed to identify all existing appendicitis risk prediction models. Models were validated using UK data from an international prospective cohort study that captured consecutive patients aged 16–45 years presenting to hospital with acute RIF in March to June 2017. The main outcome was best achievable model specificity (proportion of patients who did not have appendicitis correctly classified as low risk) whilst maintaining a failure rate below 5 per cent (proportion of patients identified as low risk who actually had appendicitis). Results Some 5345 patients across 154 UK hospitals were identified, of which two‐thirds (3613 of 5345, 67·6 per cent) were women. Women were more than twice as likely to undergo surgery with removal of a histologically normal appendix (272 of 964, 28·2 per cent) than men (120 of 993, 12·1 per cent) (relative risk 2·33, 95 per cent c.i. 1·92 to 2·84; P < 0·001). Of 15 validated risk prediction models, the Adult Appendicitis Score performed best (cut‐off score 8 or less, specificity 63·1 per cent, failure rate 3·7 per cent). The Appendicitis Inflammatory Response Score performed best for men (cut‐off score 2 or less, specificity 24·7 per cent, failure rate 2·4 per cent). Conclusion Women in the UK had a disproportionate risk of admission without surgical intervention and had high rates of normal appendicectomy. Risk prediction models to support shared decision‐making by identifying adults in the UK at low risk of appendicitis were identified

Mitochondrial Dysfunction, Oxidative Stress and Neuroinflammation in Neurodegeneration with Brain Iron Accumulation (NBIA)

The syndromes of neurodegeneration with brain iron accumulation (NBIA) encompass a group of invalidating and progressive rare diseases that share the abnormal accumulation of iron in the basal ganglia. The onset of NBIA disorders ranges from infancy to adulthood. Main clinical signs are related to extrapyramidal features (dystonia, parkinsonism and choreoathetosis), and neuropsychiatric abnormalities. Ten NBIA forms are widely accepted to be caused by mutations in the genes PANK2, PLA2G6, WDR45, C19ORF12, FA2H, ATP13A2, COASY, FTL1, CP, and DCAF17. Nonetheless, many patients remain without a conclusive genetic diagnosis, which shows that there must be additional as yet undiscovered NBIA genes. In line with this, isolated cases of known monogenic disorders, and also, new genetic diseases, which present with abnormal brain iron phenotypes compatible with NBIA, have been described. Several pathways are involved in NBIA syndromes: iron and lipid metabolism, mitochondrial dynamics, and autophagy. However, many neurodegenerative conditions share features such as mitochondrial dysfunction and oxidative stress, given the bioenergetics requirements of neurons. This review aims to describe the existing link between the classical ten NBIA forms by examining their connection with mitochondrial impairment as well as oxidative stress and neuroinflammation

TRANSEQUI : Pacificació del trànsit i equitat intraveïnal. Evidències de les intervencions recents a l'Eixample de Barcelona. Resum executiu

El projecte TRANSEQUI s'ha realitzat amb el suport de l'Ajuntament de Barcelona, a través de la convocatòria de Recerca Jove i Emergent 2022

JOLO (Filipinas) (Mar). Cartas náuticas (1897). 1:340000

Escala hallada a partir de un grado de latitud [= 32,7 cm]. Coordenadas referidas a los meridianos de Manila (O 3°10'-O 1°26'/N 8°50'-N 6°00') y San Fernando (E 124°00'-E 125°45'). Red geográfica de 30' en 30'. Señala gráficos de declinación magnéticaRelieve representado por normales y por puntos acotadosIndica sondas batimétricas, veriles, fondeaderos y calidad del fondoSello en seco de la Dirección de Hidrografí