Haurren ahozko kontakizunen hizkuntza gaitasuna: D ereduko eta euskarazko familiarik gabeko 5 urteko klasean

[EUS] Gaur egun, eskoletan ikasle etorkinen presentzia gero eta ugariagoa da. Hortaz, eskolek euskara hizkuntza sustatzeaz gain, haur bakoitzaren ama-hizkuntza errespetatu eta landu behar du. Hori horrela, lan honetan murgiltze programan eskolatuta dauden 5 urteko 8 haur etorkin eta 8 haur autoktono aztertu dira, horiek ezaugarri linguistiko batzuetan (izenak, aditzak, adjektiboak, adberbioak, determinatzaileak, konjuntzioak eta deklinabidea) daukaten jabekuntza maila ahoz zein den dokumentatzeko eta hobetzeko jarduerak proposatzeko. Horretarako, haurrei irudi bidezko elkarrizketak egin zaizkie. Geroago, horiek transkribatu dira eta taulak erabiliz, emaitzen azterketa kuantitatiboa eta kualitatiboa egin da.[ES] Hoy día, la presencia de alumnos/as extranjeros/as ha aumentado en las escuelas, por lo que éstas, además de impulsar el euskera, deben respetar y tratar la lengua materna de cada niño/a. Por eso, en este trabajo se ha analizado el uso de la lengua analizando varias características lingüísticas (sustantivos, verbos, adjetivos, adverbios, determinantes, conjunciones y declinación) en 8 niños/as extranjeros/as y 8 niños/as autóctonos/as de 5 años, escolarizados en un programa de inmersión lingüística, con el objetivo de documentar el conocimiento oral de los mismos/as y proponer actividades de mejora. Para ello, los/as niños/as han sido entrevistados utilizando secuencias de imágenes. Estas entrevistas han sido transcritas y mediante tablas se ha hecho un análisis cuantitativo y cualitativo de los resultados obtenidos.[EN] Nowadays, the presence of foreign students in schools has increased which in addition to promoting the Basque language, must respect and treat each child's mother tongue. Therefore, in this task we have examined 8 foreign and 8 autochthonous 5-year-old children enrolled in a language immersion programme, making use of several linguistic features (nouns, verbs, adjectives, adverbs, determinants, conjunctions and declination) with the aim of assesing their the oral knowledge and proposing activites for them to make progresss. For this, the children were interviewed using some pictures. These interviews were transcribed and analised quantitatively and qualitatively using charts

Haurren ahozko kontakizunen hizkuntza gaitasuna: D ereduko eta euskarazko familiarik gabeko 5 urteko klasean

[EUS] Gaur egun, eskoletan ikasle etorkinen presentzia gero eta ugariagoa da. Hortaz, eskolek euskara hizkuntza sustatzeaz gain, haur bakoitzaren ama-hizkuntza errespetatu eta landu behar du. Hori horrela, lan honetan murgiltze programan eskolatuta dauden 5 urteko 8 haur etorkin eta 8 haur autoktono aztertu dira, horiek ezaugarri linguistiko batzuetan (izenak, aditzak, adjektiboak, adberbioak, determinatzaileak, konjuntzioak eta deklinabidea) daukaten jabekuntza maila ahoz zein den dokumentatzeko eta hobetzeko jarduerak proposatzeko. Horretarako, haurrei irudi bidezko elkarrizketak egin zaizkie. Geroago, horiek transkribatu dira eta taulak erabiliz, emaitzen azterketa kuantitatiboa eta kualitatiboa egin da.[ES] Hoy día, la presencia de alumnos/as extranjeros/as ha aumentado en las escuelas, por lo que éstas, además de impulsar el euskera, deben respetar y tratar la lengua materna de cada niño/a. Por eso, en este trabajo se ha analizado el uso de la lengua analizando varias características lingüísticas (sustantivos, verbos, adjetivos, adverbios, determinantes, conjunciones y declinación) en 8 niños/as extranjeros/as y 8 niños/as autóctonos/as de 5 años, escolarizados en un programa de inmersión lingüística, con el objetivo de documentar el conocimiento oral de los mismos/as y proponer actividades de mejora. Para ello, los/as niños/as han sido entrevistados utilizando secuencias de imágenes. Estas entrevistas han sido transcritas y mediante tablas se ha hecho un análisis cuantitativo y cualitativo de los resultados obtenidos.[EN] Nowadays, the presence of foreign students in schools has increased which in addition to promoting the Basque language, must respect and treat each child's mother tongue. Therefore, in this task we have examined 8 foreign and 8 autochthonous 5-year-old children enrolled in a language immersion programme, making use of several linguistic features (nouns, verbs, adjectives, adverbs, determinants, conjunctions and declination) with the aim of assesing their the oral knowledge and proposing activites for them to make progresss. For this, the children were interviewed using some pictures. These interviews were transcribed and analised quantitatively and qualitatively using charts

Geometric documentation of the archaeological excavations at Santa Maria Cathedral (Vitoria-Gasteiz, Álava, Spain). May 2000 / June 2003

[ES] Información sobre este proyecto ha servido de base a los siguientes artículos:● LDGP_art_007: "Elementos auxiliares en fotogrametría de objeto cercano", http://hdl.handle.net/10810/9463● LDGP_car_002: "Documentación geométrica de excavaciones arqueológicas", http://hdl.handle.net/10810/6281[ES] Information from this project was included in the following papers:● LDGP_art_007: "Elementos auxiliares en fotogrametría de objeto cercano", http://hdl.handle.net/10810/9463● LDGP_car_002: "Documentación geométrica de excavaciones arqueológicas", http://hdl.handle.net/10810/6281[ES]Excavación arqueológica en parte del interior del templo (gran parte de la nave, capillas y cripta) y la plaza exterior.Toma de pares fotogramétricos con cámara semimétrica en película fotográfica (principalmente diapositiva de 6x6 cm), la mayoría de ellos –correspondientes a la superficie excavada- se han tomado utilizando una estructura portátil para la elevación de la cámara unos 4 metros sobre el terreno. La colección consta de 1.560 pares, todos ellos, clasificados, con su correspondiente apoyo (en el sistema local de coordenadas del proyecto). En campo las fotografías se toman por duplicado, razón por la que existen dos copias de la colección de negativos (diapositivas): la que se encuentra en el Fundación Catedral de Santa María y la copia almacenada en el Laboratorio de Documentación Geométrica del Patrimonio (UPV/EHU).[EN] Archaeological excavation of the most part of the nave (including chapels and crypt) and the square outside.Photogrammetric pairs (stereoscopic) taken with a semi-metric camera (6x6 cm film). Most of the photographs are had been taken by means of a portable structure to held the camera 4 meters above the ground. The collection is composed by 1560 stereoscopic pairs with control points (the project uses a local system for the coordinates). Due to the fact that, during the fieldwork, the photographs are taken twice, there are two copies of the collection: the one at the Fundación Catedral de Santa María de Vitoria and a copy kept at the Laboratorio de Documentación Geométrica del Patrimonio (UPV/EHU).Fundación Catedral de Santa María de Vitoria[ES] 1 documento PDF con la memoria (192 pp)+ 4 documentos con las 1560 fichas correspondientes a los pares fotogramétricos (también en PDF).[EN] General report (192 pp. in PDF) + 4 PDF documents containing 1560 sketches of stereoscopic pairs

Healthcare workers hospitalized due to COVID-19 have no higher risk of death than general population. Data from the Spanish SEMI-COVID-19 Registry

Aim To determine whether healthcare workers (HCW) hospitalized in Spain due to COVID-19 have a worse prognosis than non-healthcare workers (NHCW). Methods Observational cohort study based on the SEMI-COVID-19 Registry, a nationwide registry that collects sociodemographic, clinical, laboratory, and treatment data on patients hospitalised with COVID-19 in Spain. Patients aged 20-65 years were selected. A multivariate logistic regression model was performed to identify factors associated with mortality. Results As of 22 May 2020, 4393 patients were included, of whom 419 (9.5%) were HCW. Median (interquartile range) age of HCW was 52 (15) years and 62.4% were women. Prevalence of comorbidities and severe radiological findings upon admission were less frequent in HCW. There were no difference in need of respiratory support and admission to intensive care unit, but occurrence of sepsis and in-hospital mortality was lower in HCW (1.7% vs. 3.9%; p = 0.024 and 0.7% vs. 4.8%; p<0.001 respectively). Age, male sex and comorbidity, were independently associated with higher in-hospital mortality and healthcare working with lower mortality (OR 0.211, 95%CI 0.067-0.667, p = 0.008). 30-days survival was higher in HCW (0.968 vs. 0.851 p<0.001). Conclusions Hospitalized COVID-19 HCW had fewer comorbidities and a better prognosis than NHCW. Our results suggest that professional exposure to COVID-19 in HCW does not carry more clinical severity nor mortality

Identification of genetic variants associated with Huntington's disease progression: a genome-wide association study

Background Huntington's disease is caused by a CAG repeat expansion in the huntingtin gene, HTT. Age at onset has been used as a quantitative phenotype in genetic analysis looking for Huntington's disease modifiers, but is hard to define and not always available. Therefore, we aimed to generate a novel measure of disease progression and to identify genetic markers associated with this progression measure. Methods We generated a progression score on the basis of principal component analysis of prospectively acquired longitudinal changes in motor, cognitive, and imaging measures in the 218 indivduals in the TRACK-HD cohort of Huntington's disease gene mutation carriers (data collected 2008–11). We generated a parallel progression score using data from 1773 previously genotyped participants from the European Huntington's Disease Network REGISTRY study of Huntington's disease mutation carriers (data collected 2003–13). We did a genome-wide association analyses in terms of progression for 216 TRACK-HD participants and 1773 REGISTRY participants, then a meta-analysis of these results was undertaken. Findings Longitudinal motor, cognitive, and imaging scores were correlated with each other in TRACK-HD participants, justifying use of a single, cross-domain measure of disease progression in both studies. The TRACK-HD and REGISTRY progression measures were correlated with each other (r=0·674), and with age at onset (TRACK-HD, r=0·315; REGISTRY, r=0·234). The meta-analysis of progression in TRACK-HD and REGISTRY gave a genome-wide significant signal (p=1·12 × 10−10) on chromosome 5 spanning three genes: MSH3, DHFR, and MTRNR2L2. The genes in this locus were associated with progression in TRACK-HD (MSH3 p=2·94 × 10−8 DHFR p=8·37 × 10−7 MTRNR2L2 p=2·15 × 10−9) and to a lesser extent in REGISTRY (MSH3 p=9·36 × 10−4 DHFR p=8·45 × 10−4 MTRNR2L2 p=1·20 × 10−3). The lead single nucleotide polymorphism (SNP) in TRACK-HD (rs557874766) was genome-wide significant in the meta-analysis (p=1·58 × 10−8), and encodes an aminoacid change (Pro67Ala) in MSH3. In TRACK-HD, each copy of the minor allele at this SNP was associated with a 0·4 units per year (95% CI 0·16–0·66) reduction in the rate of change of the Unified Huntington's Disease Rating Scale (UHDRS) Total Motor Score, and a reduction of 0·12 units per year (95% CI 0·06–0·18) in the rate of change of UHDRS Total Functional Capacity score. These associations remained significant after adjusting for age of onset. Interpretation The multidomain progression measure in TRACK-HD was associated with a functional variant that was genome-wide significant in our meta-analysis. The association in only 216 participants implies that the progression measure is a sensitive reflection of disease burden, that the effect size at this locus is large, or both. Knockout of Msh3 reduces somatic expansion in Huntington's disease mouse models, suggesting this mechanism as an area for future therapeutic investigation

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

The original version of this article unfortunately contained a mistake

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Contemporary use of cefazolin for MSSA infective endocarditis: analysis of a national prospective cohort

Objectives: This study aimed to assess the real use of cefazolin for methicillin-susceptible Staphylococcus aureus (MSSA) infective endocarditis (IE) in the Spanish National Endocarditis Database (GAMES) and to compare it with antistaphylococcal penicillin (ASP). Methods: Prospective cohort study with retrospective analysis of a cohort of MSSA IE treated with cloxacillin and/or cefazolin. Outcomes assessed were relapse; intra-hospital, overall, and endocarditis-related mortality; and adverse events. Risk of renal toxicity with each treatment was evaluated separately. Results: We included 631 IE episodes caused by MSSA treated with cloxacillin and/or cefazolin. Antibiotic treatment was cloxacillin, cefazolin, or both in 537 (85%), 57 (9%), and 37 (6%) episodes, respectively. Patients treated with cefazolin had significantly higher rates of comorbidities (median Charlson Index 7, P <0.01) and previous renal failure (57.9%, P <0.01). Patients treated with cloxacillin presented higher rates of septic shock (25%, P = 0.033) and new-onset or worsening renal failure (47.3%, P = 0.024) with significantly higher rates of in-hospital mortality (38.5%, P = 0.017). One-year IE-related mortality and rate of relapses were similar between treatment groups. None of the treatments were identified as risk or protective factors. Conclusion: Our results suggest that cefazolin is a valuable option for the treatment of MSSA IE, without differences in 1-year mortality or relapses compared with cloxacillin, and might be considered equally effective