Photoinduced HS state in the first spin-crossover chain containing a cyanocarbanion as bridging ligand

A new polymeric approach, based on cyanocarbanion ligands, for the design of spin crossover (SCO) compounds led us to the compound [Fe(abpt)2(tcpd)] (1) (tcpd^2 = (C[C(CN)2|3)^2 , abpt = 4-amino-3,5-bis(pyridin-2-yl)-1,2,4-triazole) which has been characterised as the first SCO molecular chain involving a cyanocarbanion as bridging ligand.Gomez Garcia, Carlos Jose, [email protected]

Tropical limestone forest resilience during MIS-2: implications for Pleistocene foraging & modern conservation

In this paper we present a multi-proxy study of tropical limestone forest and its utilization by human groups during the major climatic and environmental upheavals of MIS-2 (29-11.7 ka BP). Our data are drawn from new field research within the Tràng An World Heritage property, on the edge of the Red River Delta, northern Vietnam. Key findings from this study include 1) that limestone forest formations were resilient to the large-scale landscape transformation and inundation of the Sunda continent at the end of the last glaciation; 2) that prehistoric human groups were probably present in this habitat through-out MIS-2; and 3) that the forested, almost insular, karst of Tràng An provided foragers with a stable resource-base in a wider changing landscape. These results have implications for our understanding of the prehistoric utilization of karst environments and resonance for conservation efforts in the face of climate and environmental change today

Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation

Thyroid dysfunction is an important public health problem, which affects 10% of the general population and increases the risk of cardiovascular morbidity and mortality. Many aspects of thyroid hormone regulation have only partly been elucidated, including its transport, metabolism, and genetic determinants. Here we report a large meta-analysis of genome-wide association studies for thyroid function and dysfunction, testing 8 million genetic variants in up to 72,167 individuals. One-hundred-and-nine independent genetic variants are associated with these traits. A genetic risk score, calculated to assess their combined effects on clinical end points, shows significant associations with increased risk of both overt (Graves' disease) and subclinical thyroid disease, as well as clinical complications. By functional follow-up on selected signals, we identify a novel thyroid hormone transporter (SLC17A4) and a metabolizing enzyme (AADAT). Together, these results provide new knowledge about thyroid hormone physiology and disease, opening new possibilities for therapeutic targets

Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation.

Thyroid dysfunction is an important public health problem, which affects 10% of the general population and increases the risk of cardiovascular morbidity and mortality. Many aspects of thyroid hormone regulation have only partly been elucidated, including its transport, metabolism, and genetic determinants. Here we report a large meta-analysis of genome-wide association studies for thyroid function and dysfunction, testing 8 million genetic variants in up to 72,167 individuals. One-hundred-and-nine independent genetic variants are associated with these traits. A genetic risk score, calculated to assess their combined effects on clinical end points, shows significant associations with increased risk of both overt (Graves' disease) and subclinical thyroid disease, as well as clinical complications. By functional follow-up on selected signals, we identify a novel thyroid hormone transporter (SLC17A4) and a metabolizing enzyme (AADAT). Together, these results provide new knowledge about thyroid hormone physiology and disease, opening new possibilities for therapeutic targets

The management of acute venous thromboembolism in clinical practice. Results from the European PREFER in VTE Registry

Venous thromboembolism (VTE) is a significant cause of morbidity and mortality in Europe. Data from real-world registries are necessary, as clinical trials do not represent the full spectrum of VTE patients seen in clinical practice. We aimed to document the epidemiology, management and outcomes of VTE using data from a large, observational database. PREFER in VTE was an international, non-interventional disease registry conducted between January 2013 and July 2015 in primary and secondary care across seven European countries. Consecutive patients with acute VTE were documented and followed up over 12 months. PREFER in VTE included 3,455 patients with a mean age of 60.8 ± 17.0 years. Overall, 53.0 % were male. The majority of patients were assessed in the hospital setting as inpatients or outpatients (78.5 %). The diagnosis was deep-vein thrombosis (DVT) in 59.5 % and pulmonary embolism (PE) in 40.5 %. The most common comorbidities were the various types of cardiovascular disease (excluding hypertension; 45.5 %), hypertension (42.3 %) and dyslipidaemia (21.1 %). Following the index VTE, a large proportion of patients received initial therapy with heparin (73.2 %), almost half received a vitamin K antagonist (48.7 %) and nearly a quarter received a DOAC (24.5 %). Almost a quarter of all presentations were for recurrent VTE, with >80 % of previous episodes having occurred more than 12 months prior to baseline. In conclusion, PREFER in VTE has provided contemporary insights into VTE patients and their real-world management, including their baseline characteristics, risk factors, disease history, symptoms and signs, initial therapy and outcomes

Polynitriles as ligands: New coordination polymers with the 1,1,3,3-tetracyano-2-ethoxypropenide (tcnp-) bridging ligand

cited By 23International audienceNew polymeric materials of formula [M(tcnp)2(H2O)2] (M = MnII, 1; FeII, 2; CoII, 3 and CuII, 4; tcnp- = [(NC)2CC(OEt)C(CN)2]- = 1,1,3,3-tetracyano-2-ethoxypropenide anion) have been synthesized and characterized by infrared spectroscopy and X-ray crystallography. Crystal structures were determined for 1, 3 and 4. In these compounds, the organic ligand acts in a bridging mode with two of its four nitrogen atoms arising from the two different C(CN)2 units; each metal ion has a centrosymmetric pseudo-octahedral trans-MN4O2 environment with four nitrogen atoms from four organic ligands and two oxygen atoms from water molecules. The octahedron, almost regular in 1 and 3, is distorted in 4, with a strong elongation along the pseudo fourfold axis. In all compounds (1-4), the molecular arrangement, which involves 16-membered M(NCCCCCN)2M dimetallacycles arising from the bridging mode of the organic ligand, can be described as chains of such dimetallacycles running along the [1-10] direction. Intra-chain M⋯M distances (9.017 Å in 1, 8.887 Å in 3 and 9.133 Å in 4) are significantly longer than those observed in the corresponding μ2-bridging dicyanamide derivatives (≈7.4 Å); these large differences can be explained from the coordination mode of the μ2-bridging tcnp ligand. Consequently, the shortest M⋯M distances are of the inter-chain type (8.282 Å in 1, 8.245 Å in 3 and 8.120 Å in 4); they occur along the [100] direction between metal ions of eclipsed chains and correspond to the a parameter. In the ab plane, the adjacent chains are connected by hydrogen bonds between the coordinated water molecules and one of the uncoordinated nitrogen atoms of the organic ligand, giving rise to 2D structures. For each compound, magnetic susceptibility measurements show a Curie law in the whole temperature range in agreement with the large separation between the paramagnetic ions. © 2003 Elsevier Science Ltd. All rights reserved

([CuII(tn)]2[FeII(CN)6])· KCl·5H2O (tn=1,3-diaminopropane): A two-dimensional bimetallic layered material with "Cu4Fe3" defective cubane units

International audienceThe new two-dimensional coordination compound ([CuII(tn)]2[-FeII(CN)6]) ·KCl·5H2O (1) (tn=1,3-diaminopropane), generated by six -Fe-CN-Cu- bridges, shows weak ferromagnetic interactions between the nearest Cu(II) ions through the diamagnetic [Fe(CN)6]4- anion

The cyanocarbanion (C[C(CN)2]3)2- as monodentate ligand: Synthesis, structure and magnetic properties of [Mn 2(bpym)3(tcpd)2(H2O)2] (tcpd2- = (C[C(CN)2]3)2- and bpym = 2,2′-bipyrimidine)

cited By 27International audienceOne-pot reaction between MnCl2•4H2O, K 2tcpd (tcpd2- = [C10N6]2- = (C[C(CN)2]3)2- = 2-dicyanomethylene-1,1,3,3- tetracyanopropanediide anion) and 2,2′-bipyrimidine (bpym = C 8H6N4) in aqueous solution yields the new compound [Mn2(bpym)3(tcpd)2(H 2O)2] (1). The molecular structure of 1 consists of a centrosymmetrical binuclear complex which includes unprecedented unidentate tcpd ligands with two bidentate and a bis-chelate bpym units. Examination of the intermolecular distances reveals that the dinuclear units are held together by hydrogen bonds involving coordinated water molecules and two nitrile groups of the tcpd ligand, giving rise to a 2D structure overall. Variable-temperature magnetic susceptibility data show the occurrence of slight antiferromagnetic coupling (J = -0.58 cm-1) between the Mn(II) ions through bridging bpym (the exchange Hamiltonian being defined as Ĥ=- 2JŜA·ŜB). © 2005 Elsevier B.V. All rights reserved