Search for the B 0s → η′ϕ decay

A search for the charmless $B^{0}_{s} \to \eta^{\prime}\phi$ decay is performed using $pp$ collision data collected by the LHCb experiment at centre-of-mass energies of $7$ and $8$ TeV, corresponding to an integrated luminosity of 3 fb$^{-1}$. No signal is observed and upper limits on the $B^{0}_{s} \to \eta^{\prime}\phi$ branching fraction are set to $0.82\times 10^{-6}$ at $90\%$ and $1.01\times 10^{-6}$ at $95\%$ confidence level.Comment: All figures and tables, along with any supplementary material and additional information, are available at https://lhcbproject.web.cern.ch/lhcbproject/Publications/LHCbProjectPublic/LHCb-PAPER-2016-060.htm

Measurement of CPCP observables in B±→DK∗±B^{\pm} \rightarrow D K^{*\pm} decays using two- and four-body DD final states

Measurements of CP observables in B$^{±}$ → DK$^{*±}$ decays are presented, where D denotes a superposition of D$^{0}$ and ${\overline{D}}^0$ meson states. Decays of the D meson to K$^{−}$ π$^{+}$, K$^{−}$ K$^{+}$, π$^{−}$ π$^{+}$, K$^{−}$ π$^{+}$ π$^{−}$ π$^{+}$ and π$^{−}$ π$^{+}$ π$^{−}$ π$^{+}$ are used and the K$^{*±}$ meson is reconstructed in the K$_{S}^{0}$ π$^{±}$ final state. This analysis uses a data sample of pp collisions collected with the LHCb experiment, corresponding to integrated luminosities of 1 fb$^{−1}$, 2 fb$^{−1}$ and 1.8 fb$^{−1}$ at centre-of-mass energies $\sqrt{s}=7$ TeV, 8 TeV and 13 TeV, respectively. The sensitivity of the results to the CKM angle γ is discussed.Measurements of $CP$ observables in $B^{\pm} \rightarrow D K^{*\pm}$ decays are presented, where $D$ denotes a superposition of $D^0$ and $\overline{D^0}$ meson states. Decays of the $D$ meson to $K^{-}\pi^{+}$, $K^{-}K^{+}$, $\pi^{-}\pi^{+}$, $K^{-}\pi^{+}\pi^{-}\pi^{+}$ and $\pi^{-}\pi^{+}\pi^{-}\pi^{+}$ are used and the $K^{*\pm}$ meson is reconstructed in the $K^{0}_{\mathrm{S}}\pi^{\pm}$ final state. This analysis uses a data sample of $pp$ collisions collected with the LHCb experiment, corresponding to integrated luminosities of 1 $\mathrm{fb}^{-1}$, 2 $\mathrm{fb}^{-1}$ and 1.8 $\mathrm{fb}^{-1}$ at centre-of-mass energies $\sqrt{s} =$ 7 TeV, 8 TeV and 13 TeV, respectively. The sensitivity of the results to the CKM angle $\gamma$ is discussed

Synthesis of benzylidenemalononitrile by Knoevenagel condensation through monodisperse carbon nanotube-based NiCu nanohybrids

Monodisperse nickel/copper nanohybrids (NiCu@MWCNT) based on multi-walled carbon nanotubes (MWCNT) were prepared for the Knoevenagel condensation of aryl and aliphatic aldehydes. The synthesis of these nanohybrids was carried out by the ultrasonic hydroxide assisted reduction method. NiCu@MWCNT nanohybrids were characterized by analytical techniques such as X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), transmission electron microscopy (TEM), high-resolution transmission electron microscopy (HR-TEM), and Raman spectroscopy. According to characterization results, NiCu@MWCNT showed that these nanohybrids form highly uniform, crystalline, monodisperse, colloidally stable NiCu@MWCNT nanohybrids were successfully synthesized. Thereafter, a model reaction was carried out to obtain benzylidenemalononitrile derivatives using NiCu@MWCNT as a catalyst, and showed high catalytic performance under mild conditions over 10-180 min.Dumlupinar UniversityDumlupinar University [2014-05, 2015-35, 2015-50]; Duzce UniversityDuzce University [2015.26.04.371]The authors would like to thank Dumlupinar University (2014-05, 2015-35, and 2015-50) and Duzce University (grant no. 2015.26.04.371) for funding.WOS:0005563883000122-s2.0-85088705103PubMed: 3272817

Late sodium current associated cardiac electrophysiological and mechanical dysfunction

Late sodium current (INaL) is a small sustained inward current observed during the cardiac action potential plateau phase following decay of the early peak INa. The endogenous INaL is relatively small in normal hearts but exerts functionally significant effects on cardiomyocyte repolarization with potentially pro-arrhythmic effects in hearts with reduced repolarization reserve. Enhanced INa,L occurs in long QT syndrome 3 (LQTS 3) patients, and under a number of pathological and pharmacological cardiovascular conditions, including bradycardia, myocardial ischemia, reperfusion injury, and heart failure. It may there play important roles in arrhythmogenesis and mechanical dysfunction. Experimental and clinical research suggests that INaL inhibition may prevent and treat cardiac arrhythmias and improve ventricular pump function. Selective INa,L inhibitors, exemplified by ranolazine, GS-967 and GS-458967 have little or no effect on peak sodium current and/or IKr, and carry no or minimal pro-arrhythmic risk compared to those associated with administration of classical class I or III antiarrhythmic drugs, particularly in patients with ischemic heart disease. This increased understanding of INaL may be encouraging to clinicians in use of INaL inhibitors to treat cardiac arrhythmias and mechanical dysfunction directly associated with enhanced INaL such as LQTS type 3, and myocardial ischemia. This review discusses the roles of endogenous and enhanced INaL in arrhythmogenesis and mechanical dysfunction, and the basic and clinical research of INaL inhibitors