Exploring Mobile Social Networking Sites Continuance Intention from the Perspective of Network Externalities and Mobile Value

Key shifts in the nature and characteristics of technology have led to evolutions in social media usage. For the first time in history, the internet is being accessed from more mobile devices than desktop computers. This revolution is especially felt among social networking sites, many of whom have presciently developed and released mobile applications of their platforms. Drawing from the Perceived Value Theory, Network Externalities and the Expectation Confirmation Theory of IS Continuance, we tested a model that sought to explain the effect of Network Externalities on Perceived Value and in turn Continuance Intention. Data was collected from 452 students from a university in Ghana and analyzed using the Partial Least Square approach to Structural Equation Modeling. Results from the current study showed that Referent Network Size and Perceived Complementarity had significant effects on both Utilitarian and Hedonic Value as well as Satisfaction. Hedonic Value, Utilitarian Value and Satisfaction in turn were found to be significant predictors of Continuance Intention. In all, the model accounted for 58.0% of the variance in continuance intention. The implications and limitations of the current study are discussed, and directions for future research proposed

Shaping the global communications milieu : the EU's influence on internet and telecommunications governance

This article evaluates the European Union's (EU) influence in shaping the global governance for telecommunications and the Internet. Through analysing EU behaviour within an actorness framework, we demonstrate how the external opportunity structure and the EU's internal environment has impacted on its ability to exert and maximize its presence in order to meet its goals and aims in these two very different sub-sectors of global communications in terms of evolution and development. Such a comparison of EU actorness, we argue, is revealing in terms of uncovering the underlying factors and conditions that allow the EU to influence two important and dynamic communications sub-sectors

The Nature of LINERs

We present $J$-band ($1.15-1.35 \mu$m) spectroscopy of a sample of nine galaxies showing some degree of LINER activity (classical LINERs, weak-[O {\sc i}] LINERs and transition objects), together with $H$-band spectroscopy for some of them. A careful subtraction of the stellar continuum allows us to obtain reliable [Fe {\sc ii}]$1.2567 \mu$m/Pa$\beta$ line ratios. We conclude that different types of LINERs (i.e., photoionized by a stellar continuum or by an AGN) cannot be easily distinguished based solely on the [Fe {\sc ii}]$1.2567 \mu$m/Pa$\beta$ line ratio. The emission line properties of many LINERs can be explained in terms of an aging starburst. The optical line ratios of these LINERs are reproduced by a model with a metal-rich H {\sc ii} region component photoionized with a single stellar temperature $T_* = 38,000$K, plus a supernova remnant (SNR) component. The [Fe {\sc ii}] line is predominantly excited by shocks produced by SNRs in starbursts and starburst-dominated LINERs, while Pa$\beta$ tracks H {\sc ii} regions ionized by massive young stars. The contribution from SNRs to the overall emission line spectrum is constrained by the [Fe {\sc ii}]$1.2567 \mu$m/Pa$\beta$ line ratio. Although our models for aging starbursts are constrained only by these infrared lines, they consistently explain the optical spectra of the galaxies also. The LINER-starburst connection is tested by predicting the time dependence of the ratio of the ionizing luminosity ($L_{\rm ion}$) to the supernova rate (SNr), $L_{\rm ion}$/(SNr). We predict the relative number of starbursts to starburst-dominated LINERs (aging starbursts) and show that it is in approximate agreement with survey findings for nearby galaxies.Comment: Accepted in ApJ (19 pages, 8 figures, uses emulateapj.sty

Self-similarity and Reynolds number invariance in Froude modelling

This review aims to improve the reliability of Froude modelling in fluid flows where both the Froude number and Reynolds number are a priori relevant. Two concepts may help to exclude significant Reynolds number scale effects under these conditions: (i) self-similarity and (ii) Reynolds number invariance. Both concepts relate herein to turbulent flows, thereby excluding self-similarity observed in laminar flows and in non-fluid phenomena. These two concepts are illustrated with a wide range of examples: (i) irrotational vortices, wakes, jets and plumes, shear-driven entrainment, high-velocity open channel flows, sediment transport and homogeneous isotropic turbulence and (ii) tidal energy converters, complete mixing in contact tanks and gravity currents. The limitations of self-similarity and Reynolds number invariance are also highlighted. Many fluid phenomena with the limitations under which self-similarity and Reynolds number invariance are observed are summarised in tables, aimed at excluding significant Reynolds number scale effects in physical Froude-based models

The formation, properties and impact of secondary organic aerosol: current and emerging issues

Secondary organic aerosol (SOA) accounts for a significant fraction of ambient tropospheric aerosol and a detailed knowledge of the formation, properties and transformation of SOA is therefore required to evaluate its impact on atmospheric processes, climate and human health. The chemical and physical processes associated with SOA formation are complex and varied, and, despite considerable progress in recent years, a quantitative and predictive understanding of SOA formation does not exist and therefore represents a major research challenge in atmospheric science. This review begins with an update on the current state of knowledge on the global SOA budget and is followed by an overview of the atmospheric degradation mechanisms for SOA precursors, gas-particle partitioning theory and the analytical techniques used to determine the chemical composition of SOA. A survey of recent laboratory, field and modeling studies is also presented. The following topical and emerging issues are highlighted and discussed in detail: molecular characterization of biogenic SOA constituents, condensed phase reactions and oligomerization, the interaction of atmospheric organic components with sulfuric acid, the chemical and photochemical processing of organics in the atmospheric aqueous phase, aerosol formation from real plant emissions, interaction of atmospheric organic components with water, thermodynamics and mixtures in atmospheric models. Finally, the major challenges ahead in laboratory, field and modeling studies of SOA are discussed and recommendations for future research directions are proposed

A functional siRNA screen identifies genes modulating angiotensin II-mediated EGFR transactivation

The angiotensin type 1 receptor (AT1R) transactivates the epidermal growth factor receptor (EGFR) to mediate cellular growth, however, the molecular mechanisms involved have not yet been resolved. To address this, we performed a functional siRNA screen of the human kinome in human mammary epithelial cells that demonstrate a robust AT1R-EGFR transactivation. We identified a suite of genes encoding proteins that both positively and negatively regulate AT1R-EGFR transactivation. Many candidates are components of EGFR signalling networks, whereas others, including TRIO, BMX and CHKA, have not been previously linked to EGFR transactivation. Individual knockdown of TRIO, BMX or CHKA attenuated tyrosine phosphorylation of the EGFR by angiotensin II stimulation, but this did not occur following direct stimulation of the EGFR with EGF, indicating that these proteins function between the activated AT1R and the EGFR. Further investigation of TRIO and CHKA revealed that their activity is likely to be required for AT1R-EGFR transactivation. CHKA also mediated EGFR transactivation in response to another G protein-coupled receptor (GPCR) ligand, thrombin, indicating a pervasive role for CHKA in GPCR-EGFR crosstalk. Our study reveals the power of unbiased, functional genomic screens to identify new signalling mediators important for tissue remodelling in cardiovascular disease and cancer.This work was supported by the Australian National Health and Medical Research Council project grants [grant numbers 472640, 1024726 to W.G.T. and R.D.H]; and a project grant awarded to R.D.H, funded in Australia by the Captain Courageous Foundation (http://www.captaincourageousfoundation.com). R.D.H also holds an NHMRC senior research fellowship [grant number 1022402]

Evolving collective structures in the transitional nuclei W-162 and W-164

Excited states in the neutron-deficient nuclides W8874162 and W9074164 were investigated by using the γ-ray spectrometer Jurogam. A change in structure is apparent from the first rotational alignments in W162 and W164, whose rotationally aligned bands are interpreted as ν(h9/2)2 and ν(i13/2)2 configurations, respectively. The level schemes have been extended using recoil (-decay) correlations with the observation of excited collective structures. Configuration assignments have been made on the basis of comparisons of the deduced aligned angular momentum, as a function of rotational frequency, with the predictions of the cranked shell model

Molecular Hydrogen and [FeII] in Active Galactic Nuclei

(Abridge) Near-infrared spectroscopy is used to study the kinematics and excitation mechanisms of the H2 and [FeII] gas in a sample of AGN. The H2 lines are unresolved in all objects in which they were detected while the [FeII] lines have widths implying gas velocities of up to 650 km/s. This suggests that, very likely, the H2 and [FeII] emission does not originate from the same parcel of gas. Molecular H2 were detected in 90% of the sample, including PG objects, indicating detectavel amounts of molecular material even in objects with low levels of circumnuclear starburst activity. The data favors thermal excitation for the H2 lines. Indeed, in NGC3227, Mrk766, NGC4051 and NGC4151, the molecular emission is found to be purely thermal. This result is also confirmed by the rather similar vibrational and rotational temperatures in the objects for which they were derived. [FeII] lines are detected in all of the AGN. The [FeII] 1.254mu/Pa-beta ratio is compatible with excitation of the [FeII] by the active nucleus, but in Mrk 766 it implies a stellar origin. A correlation between H2/Br-gamma and [FeII]/Pa-beta is found. We confirm that it is a useful diagnostic tool in the NIR to separate emitting line objects by their level of nuclear activity. X-ray excitation models are able to explain the observed H2 and part of the [FeII] emission. Most likely, a combination of X-ray heating, shocks driven by the radio jet, and circumnuclear star formation contributes, in different proportions, to the H2 and [FeII] emission. In most of our spectra, the [FeII] 1.257mu/1.644mu ratio is found to be 30% lower than the intrinsic value based on current atomic data. This implies either than the extinction towards the [FeII] emitting clouds is very similar in most objects or there are possible inaccuracies in the A-values in the [FeII] transitions.Comment: 18 pages, 6 figures, Accepted for publication in Astronomy & Astrophysic

Mycolactone-dependent depletion of endothelial cell thrombomodulin is strongly associated with fibrin deposition in Buruli ulcer lesions

A well-known histopathological feature of diseased skin in Buruli ulcer (BU) is coagulative necrosis caused by the Mycobacterium ulcerans macrolide exotoxin mycolactone. Since the underlying mechanism is not known, we have investigated the effect of mycolactone on endothelial cells, focussing on the expression of surface anticoagulant molecules involved in the protein C anticoagulant pathway. Congenital deficiencies in this natural anticoagulant pathway are known to induce thrombotic complications such as purpura fulimans and spontaneous necrosis. Mycolactone profoundly decreased thrombomodulin (TM) expression on the surface of human dermal microvascular endothelial cells (HDMVEC) at doses as low as 2ng/ml and as early as 8hrs after exposure. TM activates protein C by altering thrombin's substrate specificity, and exposure of HDMVEC to mycolactone for 24 hours resulted in an almost complete loss of the cells' ability to produce activated protein C. Loss of TM was shown to be due to a previously described mechanism involving mycolactone-dependent blockade of Sec61 translocation that results in proteasome-dependent degradation of newly synthesised ER-transiting proteins. Indeed, depletion from cells determined by live-cell imaging of cells stably expressing a recombinant TM-GFP fusion protein occurred at the known turnover rate. In order to determine the relevance of these findings to BU disease, immunohistochemistry of punch biopsies from 40 BU lesions (31 ulcers, nine plaques) was performed. TM abundance was profoundly reduced in the subcutis of 78% of biopsies. Furthermore, it was confirmed that fibrin deposition is a common feature of BU lesions, particularly in the necrotic areas. These findings indicate that there is decreased ability to control thrombin generation in BU skin. Mycolactone's effects on normal endothelial cell function, including its ability to activate the protein C anticoagulant pathway are strongly associated with this. Fibrin-driven tisischemia could contribute to the development of the tissue necrosis seen in BU lesions

Connecting the cosmic infrared background to the X-ray background

We estimate the contribution of AGNs and of their host galaxies to the infrared background. We use the luminosity function and evolution of AGNs recently determined by the hard X-ray surveys, and new Spectral Energy Distributions connecting the X-ray and the infrared emission, divided in intervals of absorption. These two ingredients allow us to determine the contribution of AGNs to the infrared background by using mostly observed quantities, with only minor assumptions. We obtain that AGN emission contributes little to the infrared background ($<$5% over most of the infrared bands), implying that the latter is dominated by star formation. However, AGN host galaxies may contribute significantly to the infrared background, and more specifically 10--20% in the 1--20$\mu$m range and $\sim$5% at $\lambda<60\mu m$. We also give the contribution of AGNs and of their host galaxies to the source number counts in various infrared bands, focusing on those which will be observed with Spitzer. We also report a significant discrepancy between the expected contribution of AGN hosts to the submm background and bright submm number counts with the observational constraints. We discuss the causes and implications of this discrepancy and the possible effects on the Spitzer far-IR bands.Comment: to appear in MNRAS, replaced with accepted version, paper shortened, results unchange