SUSTENTABILIDADE AMBIENTAL E DESIGN DE MODA NA PÓS-MODERNIDADE

Este artigo analisa o contexto histórico social em que surge o conceito de sustentabilidade ambiental, a sua relação com a cultura da pós-modernidade e a adequação do produto de moda ao desenvolvimento sustentável

Fashion Design: fast fashion x slow fashion

The article, based on research for Doctoral thesis in Design, discusses the complex relationship between the fashion system and sustainability issues. The environmental impact of the ephemeral life cycle of fashion products, called fast fashion, and consumerism has been questioned, as a counter point came the slow fashion. A movement in the fashion that aims to reduce consumption, concerns about ethical practices, appreciation of handcrafted work that is durable and versatile. With the slow fashion the logic of the fashion system begins to change

A moda no contexto da sustentabilidade

Este artigo tem como objetivo levantar o estado da arte da moda no contexto da sustentabilidade. A Moda está relacionada com o novo, com o efêmero, com mudanças cada vez mais rápidas, enquanto expressa em produtos, tem uma importância cultural e econômica significativa para a sociedade, por esta razão deve-se questionar e desafiar as suas convenções e os modelos de negócios. Pois, o sistema de moda tem gerado, em especial, grandes impactos ambientais poucos conhecidos pela sociedade. Logo, para que ocorra efetivamente uma mudança significativa no sistema de moda é fundamental uma mudança cultural na produção e no consumo, reduzindo ou eliminando os impactos socioambientais. Conclui-se que há oportunidades do sistema de moda, principalmente, a indústria de transformação, gerar produtos mais sustentáveis com equilíbrio nas relações socioambientai

Methyl-CpG-binding domain sequencing reveals a prognostic methylation signature in neuroblastoma

Accurate assessment of neuroblastoma outcome prediction remains challenging. Therefore, this study aims at establishing novel prognostic tumor DNA methylation biomarkers. In total, 396 low- and high-risk primary tumors were analyzed, of which 87 were profiled using methyl-CpG-binding domain (MBD) sequencing for differential methylation analysis between prognostic patient groups. Subsequently, methylation-specific PCR (MSP) assays were developed for 78 top-ranking differentially methylated regions and tested on two independent cohorts of 132 and 177 samples, respectively. Further, a new statistical framework was used to identify a robust set of MSP assays of which the methylation score (i.e. the percentage of methylated assays) allows accurate outcome prediction. Survival analyses were performed on the individual target level, as well as on the combined multimarker signature. As a result of the differential DNA methylation assessment by MBD sequencing, 58 of the 78 MSP assays were designed in regions previously unexplored in neuroblastoma, and 36 are located in non-promoter or non-coding regions. In total, 5 individual MSP assays (located in CCDC177, NXPH1, lnc-MRPL3-2, lnc-TREX1-1 and one on a region from chromosome 8 with no further annotation) predict event-free survival and 4 additional assays (located in SPRED3, TNFAIP2, NPM2 and CYYR1) also predict overall survival. Furthermore, a robust 58-marker methylation signature predicting overall and event-free survival was established. In conclusion, this study encompasses the largest DNA methylation biomarker study in neuroblastoma so far. We identified and independently validated several novel prognostic biomarkers, as well as a prognostic 58-marker methylation signature

The Zero Waste Tool for Apparel Design

O presente artigo apresenta um recorte de uma pesquisa stricto sensu acerca da abordagem zero waste (resíduo zero) ao Design de Vestuário e possui como objetivo relatar os resultados obtidos com a aplicação da ferramenta projetual Zero Waste Tool for Apparel Design (ZWTAD) no contexto de duas empresas brasileiras. Metodologicamente, o artigo enquadra-se como pesquisa aplicada, qualitativa, descritiva e de campo, com a utilização de parte do design science research por meio das heurísticas de construção de artefatos. Os resultados obtidos na pesquisa de campo permitiram identificar, visualmente, as situações desejável, transitória e indesejável em que se encontram as empresas avaliadas com base em 15 requisitos de projeto voltados à abordagem zero waste. Acredita se que, diante dessas informações, as empresas possam tomar decisões pró-sustentabilidade embasadas na mitigação de resíduos sólidos têxteis no percurso do desenvolvimento de suas peças de vestuário.This article presents an excerpt from a stricto sensu research about the zero waste approach to Apparel Design and its main objective is to report the results obtained with the application of the Zero Waste Tool for Apparel Design (ZWTAD) in the context of two Brazilian companies. Methodologically, the article fits as applied, qualitative and descriptive research with inclinations to design science research through heuristics of artifact construction. The results obtained in the field research carried out allow to visually identify the desirable, transitory and undesirable situations in which the evaluated companies based on 15 design requirements aimed at the zero waste approach. It is believed that, faced with this information, companies can make pro sustainability decisions based on the mitigation of solid textile waste in the development of their clothes

Focal DNA copy number changes in neuroblastoma target MYCN regulated genes

Neuroblastoma is an embryonic tumor arising from immature sympathetic nervous system cells. Recurrent genomic alterations include MYCN and ALK amplification as well as recurrent patterns of gains and losses of whole or large partial chromosome segments. A recent whole genome sequencing effort yielded no frequently recurring mutations in genes other than those affecting ALK. However, the study further stresses the importance of DNA copy number alterations in this disease, in particular for genes implicated in neuritogenesis. Here we provide additional evidence for the importance of focal DNA copy number gains and losses, which are predominantly observed in MYCN amplified tumors. A focal 5 kb gain encompassing the MYCN regulated miR-17,92 cluster as sole gene was detected in a neuroblastoma cell line and further analyses of the array CGH data set demonstrated enrichment for other MYCN target genes in focal gains and amplifications. Next we applied an integrated genomics analysis to prioritize MYCN down regulated genes mediated by MYCN driven miRNAs within regions of focal heterozygous or homozygous deletion. We identified RGS5, a negative regulator of G-protein signaling implicated in vascular normalization, invasion and metastasis, targeted by a focal homozygous deletion, as a new MYCN target gene, down regulated through MYCN activated miRNAs. In addition, we expand the miR-17,92 regulatory network controlling TGFß signaling in neuroblastoma with the ring finger protein 11 encoding gene RNF11, which was previously shown to be targeted by the miR-17,92 member miR-19b. Taken together, our data indicate that focal DNA copy number imbalances in neuroblastoma (1) target genes that are implicated in MYCN signaling, possibly selected to reinforce MYCN oncogene addiction and (2) serve as a resource for identifying new molecular targets for treatment

Mutations in the LRRK2 Roc-COR tandem domain link Parkinson's disease to Wnt signalling pathways

Mutations in PARK8, encoding LRRK2, are the most common known cause of Parkinson's disease. The LRRK2 Roc-COR tandem domain exhibits GTPase activity controlling LRRK2 kinase activity via an intramolecular process. We report the interaction of LRRK2 with the dishevelled family of phosphoproteins (DVL1-3), key regulators of Wnt (Wingless/Int) signalling pathways important for axon guidance, synapse formation and neuronal maintenance. Interestingly, DVLs can interact with and mediate the activation of small GTPases with structural similarity to the LRRK2 Roc domain. The LRRK2 Roc-COR domain and the DVL1 DEP domain were necessary and sufficient for LRRK2–DVL1 interaction. Co-expression of DVL1 increased LRRK2 steady-state protein levels, an effect that was dependent on the DEP domain. Strikingly, LRRK2–DVL1-3 interactions were disrupted by the familial PARK8 mutation Y1699C, whereas pathogenic mutations at residues R1441 and R1728 strengthened LRRK2–DVL1 interactions. Co-expression of DVL1 with LRRK2 in mammalian cells resulted in the redistribution of LRRK2 to typical cytoplasmic DVL1 aggregates in HEK293 and SH-SY5Y cells and co-localization in neurites and growth cones of differentiated dopaminergic SH-SY5Y cells. This is the first report of the modulation of a key LRRK2-accessory protein interaction by PARK8 Roc-COR domain mutations segregating with Parkinson's disease. Since the DVL1 DEP domain is known to be involved in the regulation of small GTPases, we propose that: (i) DVLs may influence LRRK2 GTPase activity, and (ii) Roc-COR domain mutations modulating LRRK2–DVL interactions indirectly influence kinase activity. Our findings also link LRRK2 to Wnt signalling pathways, suggesting novel pathogenic mechanisms and new targets for genetic analysis in Parkinson's disease

Blockchains for Business Process Management - Challenges and Opportunities

Blockchain technology promises a sizable potential for executing inter-organizational business processes without requiring a central party serving as a single point of trust (and failure). This paper analyzes its impact on business process management (BPM). We structure the discussion using two BPM frameworks, namely the six BPM core capabilities and the BPM lifecycle. This paper provides research directions for investigating the application of blockchain technology to BPM.Comment: Preprint for ACM TMI

Update on the correlation of the highest energy cosmic rays with nearby extragalactic matter

Data collected by the Pierre Auger Observatory through 31 August 2007 showed evidence for anisotropy in the arrival directions of cosmic rays above the Greisen-Zatsepin-Kuz'min energy threshold, \nobreak{$6\times 10^{19}$eV}. The anisotropy was measured by the fraction of arrival directions that are less than $3.1^\circ$ from the position of an active galactic nucleus within 75 Mpc (using the V\'eron-Cetty and V\'eron $12^{\rm th}$ catalog). An updated measurement of this fraction is reported here using the arrival directions of cosmic rays recorded above the same energy threshold through 31 December 2009. The number of arrival directions has increased from 27 to 69, allowing a more precise measurement. The correlating fraction is $(38^{+7}_{-6})$, compared with $21$ expected for isotropic cosmic rays. This is down from the early estimate of $(69^{+11}_{-13})$. The enlarged set of arrival directions is examined also in relation to other populations of nearby extragalactic objects: galaxies in the 2 Microns All Sky Survey and active galactic nuclei detected in hard X-rays by the Swift Burst Alert Telescope. A celestial region around the position of the radiogalaxy Cen A has the largest excess of arrival directions relative to isotropic expectations. The 2-point autocorrelation function is shown for the enlarged set of arrival directions and compared to the isotropic expectation.Comment: Accepted for publication in Astroparticle Physics on 31 August 201