CO72 357. Reconstrucción del cuerpo fibroso mitroaórtico: Resultados perioperatorios y supervivencia a largo plazo

ObjetivosDescribir las características clínicas, resultados perioperatorios y supervivencia a largo plazo de pacientes sometidos a sustitución valvular mitral y aórtica con reconstrucción de la fbrosa mitroaórtica según técnica de David.MétodosRevisión retrospectiva de pacientes sometidos a sustitución valvular y reconstrucción de la fibrosa mitroaórtica intervenidos en los últimos 14 años. Se incluyen 27 pacientes, 63% varones, edad 55,3±16,1 años, EuroSCORE 34,4±25,9. El 70,4% de los pacientes presentaban al menos una cirugía previa. La indicación para el procedimiento fue endocarditis infecciosa complicada con absceso de la unión mitroaórtica en el 74,1%; en el restante 25,9% la principal indicación fue la necesidad de ampliación del anillo aórtico en el seno de una valvulopatía mitroaórtica.ResultadosLa supervivencia perioperatoria (30 días) fue del 85,2%. No se observó mortalidad entre los pacientes sin endocarditis. Estancia media: 42,8±42,8 días. Complicaciones perioperatorias: accidente cerebrovascular agudo (ACVA) 3,1% (1), balón de contrapulsación intraaórtica (BCIA) 11,1% (3), insuficiencia renal aguda (IRA) 7,4% (2), infarto agudo de miocardio (IAM) 3,7% (1), reintervención por sangrado 14,8% (4), ventilación mecánica prolongada 11,1% (3), necesidad de marcapasos (MP) definitivo 22,2%. La supervivencia acumulada para los supervivientes a 1, 3 y 5 años fue de 85,9±7,6%, 75,8 ± 9,5% y 45,5 ± 11,1%, respectivamente. No se observó diferencia significativa al comparar la super-vivencia a 1, 3 y 5 años entre los grupos intervenidos por endocarditis y los no endocarditis (log rank 0,146).ConclusionesLa reconstrucción de la fibrosa mitroaórtica mediante técnica de David representa una alternativa terapéutica para el manejo de patología compleja que involucra esta estructura. Hemos observado buenos resultados perioperatorios y a largo plazo teniendo en cuenta el perfil de alto riesgo de los pacientes que requieren este tipo de intervención

Multiwavelength observations of V407 Lupi (ASASSN-16kt) --- a very fast nova erupting in an intermediate polar

We present a detailed study of the 2016 eruption of nova V407 Lupi (ASASSN-16kt), including optical, near-infrared, X-ray, and ultraviolet data from SALT, SMARTS, SOAR, Chandra, Swift, and XMM-Newton. Timing analysis of the multiwavelength light-curves shows that, from 168 days post-eruption and for the duration of the X-ray supersoft source phase, two periods at 565 s and 3.57 h are detected. We suggest that these are the rotational period of the white dwarf and the orbital period of the binary, respectively, and that the system is likely to be an intermediate polar. The optical light-curve decline was very fast ($t_2 \leq$ 2.9 d), suggesting that the white dwarf is likely massive ($\gtrsim 1.25$ M$_{\odot}$). The optical spectra obtained during the X-ray supersoft source phase exhibit narrow, complex, and moving emission lines of He II, also characteristics of magnetic cataclysmic variables. The optical and X-ray data show evidence for accretion resumption while the X-ray supersoft source is still on, possibly extending its duration

Determinación del cumplimiento de la normativa de trabajo en alturas (resolución 1409 del 2012 y sus modificaciones) en dos (2) empresas de prestación de servicios generales en la ciudad de santiago de cali (valle del cauca) en el año 2015

Trabajo en alturas se considera a la actividad que se realiza a una altura superior de 1.50 metros sobre un nivel inferior, dentro de las actividades que se realizan en trabajo en alturas encontramos trabajos en andamios, andamios elevados, escaleras, plataformas, tejados o cubiertas, plataformas elevadas, trabajos verticales entre otros, el trabajo en alturas en un trabajo de alto riesgo catalogado así dentro de muchas empresas, es una labor que genera altos niveles de accidentabilidad en Colombia, para la vigilancia en relación al trabajo en alturas encontramos la resolución 1409 del 2012 en la cual encontramos la responsabilidad tanto del empleador, los trabajadores y la ARL, las medidas de prevención, protección, medidas colectivas, elementos de protección personal, plan de emergencia.1.Planteamiento del problema2.Justificación3.Objetivos4.Marco de referencia5. Metodologia6.Análisis y resultados7.ConclusionesPregradoProfesional en Seguridad y Salud en el Trabaj

Production of Symbolic Goods in the Museal Field in Colombia: Reconfiguration of the State Narrative with the Peace Agreement

In 2016 with the Peace Agreement between Colombian government and ex guerrilla FARC-EP, there was a reconfiguration of the narratives about the conflict and the armed actors. The proposal to reinsert ex-combatants into the logic of civil society implied a process of humanization and, therefore, the transformation of the figure of the state enemy. In this article, we seek to know this process through museums, understanding them as the spaces in which the official discourse of the state is appropriated and reproduced. To achieve the above, based on the notions of Field, Capital and Symbolic Goods by Pierre Bourdieu, we will go through the historicization and characterization of the Museal Field in Colombia, then the transit that occurred in the perception of the armed actors from the state and, finally, we will observe the production of symbolic goods in museums as of the signing of the Final Agreement

Article ID 259845

Invasiveness of trophoblast and choriocarcinoma cells is in part mediated via leukemia inhibitory factor-(LIF-) induced activation of signal transducer and activator of transcription 3 (STAT3). The regulation of STAT3 phosphorylation at its ser727 binding site, possible crosstalk with intracellular MAPK signaling, and their functional implications are the object of the present investigation. JEG-3 choriocarcinoma cells were cultured in presence/absence of LIF and the specific ERK1/2 inhibitor (U0126). Phosphorylation of signaling molecules (p-STAT3 (ser727 and tyr705) and p-ERK1/2 (thr 202/tyr 204)) was assessed per Western blot. Immunocytochemistry confirmed results, but also pinpointed the location of phosphorylated signaling molecules. STAT3 DNA-binding capacity was studied with a colorimetric ELISA-based assay. Cell viability and invasion capability were assessed by MTS and Matrigel assays. Our results demonstrate that LIF-induced phosphorylation of STAT3 (tyr705 and ser727) is significantly increased after blocking ERK1/2. STAT3 DNA-binding capacity and cell invasiveness are enhanced after LIF stimulation and ERK1/2 blockage. In contrast, proliferation is enhanced by LIF but reduced after ERK1/2 inhibition. The findings herein show that blocking ERK1/2 increases LIF-induced STAT3 phosphorylation and STAT3 DNA-binding capacity by an intranuclear crosstalk, which leads to enhanced invasiveness and reduced proliferation

Genomic epidemiology of severe acute respiratory syndrome Coronavirus 2, Colombia

Coronavirus disease (COVID-19) in Colombia was first diagnosed in a traveler arriving from Italy on February 26, 2020. However, limited data are available on the origins and number of introductions of COVID-19 into the country. We sequenced the causative agent of COVID-19, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), from 43 clinical samples we collected, along with another 79 genome sequences available from Colombia. We investigated the emergence and importation routes for SARS-CoV-2 into Colombia by using epidemiologic, historical air travel, and phylogenetic observations. Our study provides evidence of multiple introductions, mostly from Europe, and documents >12 lineages. Phylogenetic findings validate the lineage diversity, support multiple importation events, and demonstrate the evolutionary relationship of epidemiologically linked transmission chains. Our results reconstruct the early evolutionary history of SARS-CoV-2 in Colombia and highlight the advantages of genome sequencing to complement COVID-19 outbreak investigations