Reductive Leaching Kinetics of Low Grade Manganese Deposits in H2SO4 Solution Using Malonic Acid as Reducing Agent

A leaching process was developed to extract manganese and metal values from Alloga manganese concentrate. The preferential leaching process was achieved through reductive leaching in dilute sulfuric acid medium with malonic acid as the reducing agent. Leaching parameters were optimized as 1.0 M H2SO4, 10% malonic acid in solid/liquid ratio 1:10 for 90 min at 8

Radiological Hazard Evaluation of Some Egyptian Magmatic Rocks Used as Ornamental Stone: Petrography and Natural Radioactivity

Magmatic rocks represent one of the most significant rocks due to their abundance, durability and appearance; they can be used as ornamental stones in the construction of dwellings. The current study is concerned with the detailed petrography and natural radioactivity of seven magmatic rocks. All are commercial granitic rocks and are identified as black Aswan, Nero Aswan, white Halayeb, Karnak, Verdi, red Hurghada and red Aswan. Their respective mineralogical com-positions are classified as porpheritic granodiorite, granodiorite, tonalite, monzogranite, syenogran-ite, monzogranite and syenogranite. A total of nineteen samples were prepared from these seven rock types in order to assess their suitability as ornamental stones. Concentrations of 226Ra, 232Th and 40K radionuclides were measured using NaI (Tl) scintillation gamma-ray spectrometry. Among the studied magmatic rocks, white Halayeb had the lowest average values of226Ra (15.7 Bq/kg),232Th (4.71 Bq/kg) and40K (~292 Bq/kg), all below the UNSCEAR reported average world values or rec-ommended reference limits. In contrast, the other granitic rocks have higher values than the recom-mended limit. Except for the absorbed dose rate, other radiological hazard parameters including radium equivalent activity, annual effective dose equivalent, external, and internal hazard indices reflect that the White Halyeb rocks are favorable for use as ornamental stone in the construction of luxurious and high-demand residential buildings. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.Funding: We deeply acknowledge Taif University for supporting the researchers through Taif University Researchers Supporting Project number (TURSP-2020/287), Taif University, Taif, Saudi Arabia

Distribution of Radionuclides and Radiological Health Assessment in Seih-Sidri Area, Southwestern Sinai

The current contribution goal is to measure the distribution of the radionuclide within the exposed rock units of southwestern Sinai, Seih-Sidri area, and assess the radiological risk. Gneisses, older granites, younger gabbro, younger granites, and post granitic dikes (pegmatites) are the main rock units copout in the target area. Radioactivity, as well as radiological implications, were investigated for forty-three samples from gneisses (seven hornblende biotite gneiss and seven biotite gneiss), older granites (fourteen samples), and younger granites (fifteen samples of syenogranites) using NaI (Tl) scintillation detector. External and internal hazard index (Hex, Hin), internal and external level indices (Iα, Iγ), absorbed dose rates in the air (D), the annual effective dose equivalent (AED), radium equivalent activity (Raeq), annual gonadal dose (AGDE), excess lifetime cancer risk (ELCR), and the value of Upper Continental Core 232Th/238U mass fractions were determined from the obtained values of 238U, 232Th and 40K for the examined rocks of Seih-Sidri area. The average 238U mg/kg in hornblende biotite gneiss and biotite gneiss, older granites, and syenogranites is 2.3, 2.1, 2.7, and 8.4 mg/kg, respectively, reflecting a relatively higher concentration of uranium content in syenogranites. The results suggest that using these materials may pose risks to one’s radiological health. © 2022 by the authors.PNURSP2022R173; Universitatea 'Dunărea de Jos' Galați, UDJGConceptualization, M.S.K.; data curation, M.S.K., E.S.R.L., A.E., H.A.A. and H.M.H.Z.; formal analysis, M.S.K., E.S.R.L., A.E., H.A.A. and H.M.H.Z.; funding acquisition, A.E., G.A.A. and H.M.H.Z.; investigation, M.S.K., E.S.R.L., A.E., H.A.A. and H.M.H.Z.; methodology, M.S.K., E.S.R.L., A.E., M.A.M.U., H.A.A., S.A.M.I. and H.M.H.Z.; project administration, A.E. and H.M.H.Z.; resources, M.S.K., E.S.R.L. and H.M.H.Z.; software, A.E. and H.M.H.Z.; supervision, A.E. and H.M.H.Z.; validation, G.A.A., M.S.K., E.S.R.L., M.A.M.U., H.A.A., S.A.M.I. and H.M.H.Z.; visualization, H.M.H.Z.; writing—original draft, M.S.K., E.S.R.L., A.E., H.A.A. and H.M.H.Z.; writing—review and editing, G.A.A., M.S.K., E.S.R.L., A.E., M.A.M.U., S.A.M.I., H.A.A. and H.M.H.Z. The researcher H.A.A. is funded by a scholarship under the Joint (Executive Program between Egypt and Russia). All authors have read and agreed to the published version of the manuscript

Building the impedance model of a real machine

A reliable impedance model of a particle accelerator can be built by combining the beam coupling impedances of all the components. This is a necessary step to be able to evaluate the machine performance limitations, identify the main contributors in case an impedance reduction is required, and study the interaction with other mechanisms such as optics nonlinearities, transverse damper, noise, space charge, electron cloud, beam-beam (in a collider). The main phases to create a realistic impedance model, and verify it experimentally, will be reviewed, highlighting the main challenges. Some examples will be presented revealing the levels of precision of machine impedance models that have been achieved

Comparative Assessment of Copper, Iron, and Zinc Contents in Selected Indian (Assam) and South African (Thohoyandou) Tea (Camellia sinensis L.) Samples and Their Infusion: A Quest for Health Risks to Consumer

The current study aims to assess the infusion pattern of three important micronutrients namely copper (Cu), iron (Fe), and zinc (Zn) contents from black tea samples produced in Assam (India) and Thohoyandou (South Africa). Average daily intakes and hazardous quotient were reported for these micronutrients. Total content for Cu, Fe, and Zn varied from 2.25 to 48.82 mg kg−1, 14.75 to 148.18 mg kg−1, and 28.48 to 106.68 mg kg−1, respectively. The average contents of each of the three micronutrients were higher in tea leaves samples collected from South Africa than those from India while the contents in tea infusions in Indian samples were higher than in South African tea samples. Results of this study revealed that the consumption of 600 mL tea infusion produced from 24 g of made tea per day may be beneficial to human in terms of these micronutrients content. Application of nonparametric tests revealed that most of the data sets do not satisfy the normality assumptions. Hence, the use of both parametric and nonparametric statistical analysis that subsequently revealed significant differences in elemental contents among Indian and South African tea

Emerging pharmacotherapy for cancer patients with cognitive dysfunction

Advances in the diagnosis and multi-modality treatment of cancer have increased survival rates for many cancer types leading to an increasing load of long-term sequelae of therapy, including that of cognitive dysfunction. The cytotoxic nature of chemotherapeutic agents may also reduce neurogenesis, a key component of the physiology of memory and cognition, with ramifications for the patient's mood and other cognition disorders. Similarly radiotherapy employed as a therapeutic or prophylactic tool in the treatment of primary or metastatic disease may significantly affect cognition. A number of emerging pharmacotherapies are under investigation for the treatment of cognitive dysfunction experienced by cancer patients. Recent data from clinical trials is reviewed involving the stimulants modafinil and methylphenidate, mood stabiliser lithium, anti-Alzheimer's drugs memantine and donepezil, as well as other agents which are currently being explored within dementia, animal, and cell culture models to evaluate their use in treating cognitive dysfunction

Laparoscopy in management of appendicitis in high-, middle-, and low-income countries: a multicenter, prospective, cohort study.

BACKGROUND: Appendicitis is the most common abdominal surgical emergency worldwide. Differences between high- and low-income settings in the availability of laparoscopic appendectomy, alternative management choices, and outcomes are poorly described. The aim was to identify variation in surgical management and outcomes of appendicitis within low-, middle-, and high-Human Development Index (HDI) countries worldwide. METHODS: This is a multicenter, international prospective cohort study. Consecutive sampling of patients undergoing emergency appendectomy over 6 months was conducted. Follow-up lasted 30 days. RESULTS: 4546 patients from 52 countries underwent appendectomy (2499 high-, 1540 middle-, and 507 low-HDI groups). Surgical site infection (SSI) rates were higher in low-HDI (OR 2.57, 95% CI 1.33-4.99, p = 0.005) but not middle-HDI countries (OR 1.38, 95% CI 0.76-2.52, p = 0.291), compared with high-HDI countries after adjustment. A laparoscopic approach was common in high-HDI countries (1693/2499, 67.7%), but infrequent in low-HDI (41/507, 8.1%) and middle-HDI (132/1540, 8.6%) groups. After accounting for case-mix, laparoscopy was still associated with fewer overall complications (OR 0.55, 95% CI 0.42-0.71, p < 0.001) and SSIs (OR 0.22, 95% CI 0.14-0.33, p < 0.001). In propensity-score matched groups within low-/middle-HDI countries, laparoscopy was still associated with fewer overall complications (OR 0.23 95% CI 0.11-0.44) and SSI (OR 0.21 95% CI 0.09-0.45). CONCLUSION: A laparoscopic approach is associated with better outcomes and availability appears to differ by country HDI. Despite the profound clinical, operational, and financial barriers to its widespread introduction, laparoscopy could significantly improve outcomes for patients in low-resource environments. TRIAL REGISTRATION: NCT02179112

Global economic burden of unmet surgical need for appendicitis

Background: There is a substantial gap in provision of adequate surgical care in many low-and middle-income countries. This study aimed to identify the economic burden of unmet surgical need for the common condition of appendicitis. Methods: Data on the incidence of appendicitis from 170 countries and two different approaches were used to estimate numbers of patients who do not receive surgery: as a fixed proportion of the total unmet surgical need per country (approach 1); and based on country income status (approach 2). Indirect costs with current levels of access and local quality, and those if quality were at the standards of high-income countries, were estimated. A human capital approach was applied, focusing on the economic burden resulting from premature death and absenteeism. Results: Excess mortality was 4185 per 100 000 cases of appendicitis using approach 1 and 3448 per 100 000 using approach 2. The economic burden of continuing current levels of access and local quality was US $92 492 million using approach 1 and$73 141 million using approach 2. The economic burden of not providing surgical care to the standards of high-income countries was $95 004 million using approach 1 and$75 666 million using approach 2. The largest share of these costs resulted from premature death (97.7 per cent) and lack of access (97.0 per cent) in contrast to lack of quality. Conclusion: For a comparatively non-complex emergency condition such as appendicitis, increasing access to care should be prioritized. Although improving quality of care should not be neglected, increasing provision of care at current standards could reduce societal costs substantially

Pooled analysis of WHO Surgical Safety Checklist use and mortality after emergency laparotomy

Background The World Health Organization (WHO) Surgical Safety Checklist has fostered safe practice for 10 years, yet its place in emergency surgery has not been assessed on a global scale. The aim of this study was to evaluate reported checklist use in emergency settings and examine the relationship with perioperative mortality in patients who had emergency laparotomy. Methods In two multinational cohort studies, adults undergoing emergency laparotomy were compared with those having elective gastrointestinal surgery. Relationships between reported checklist use and mortality were determined using multivariable logistic regression and bootstrapped simulation. Results Of 12 296 patients included from 76 countries, 4843 underwent emergency laparotomy. After adjusting for patient and disease factors, checklist use before emergency laparotomy was more common in countries with a high Human Development Index (HDI) (2455 of 2741, 89.6 per cent) compared with that in countries with a middle (753 of 1242, 60.6 per cent; odds ratio (OR) 0.17, 95 per cent c.i. 0.14 to 0.21, P <0001) or low (363 of 860, 422 per cent; OR 008, 007 to 010, P <0.001) HDI. Checklist use was less common in elective surgery than for emergency laparotomy in high-HDI countries (risk difference -94 (95 per cent c.i. -11.9 to -6.9) per cent; P <0001), but the relationship was reversed in low-HDI countries (+121 (+7.0 to +173) per cent; P <0001). In multivariable models, checklist use was associated with a lower 30-day perioperative mortality (OR 0.60, 0.50 to 073; P <0.001). The greatest absolute benefit was seen for emergency surgery in low- and middle-HDI countries. Conclusion Checklist use in emergency laparotomy was associated with a significantly lower perioperative mortality rate. Checklist use in low-HDI countries was half that in high-HDI countries.Peer reviewe