Inflammatory Markers Associated With Subclinical Coronary Artery Disease: The Multicenter AIDS Cohort Study.

BackgroundDespite evidence for higher risk of coronary artery disease among HIV+ individuals, the underlying mechanisms are not well understood. We investigated associations of inflammatory markers with subclinical coronary artery disease in 923 participants of the Multicenter AIDS Cohort Study (575 HIV+ and 348 HIV- men) who underwent noncontrast computed tomography scans for coronary artery calcification, the majority (n=692) also undergoing coronary computed tomography angiography.Methods and resultsOutcomes included presence and extent of coronary artery calcification, plus computed tomography angiography analysis of presence, composition, and extent of coronary plaques and severity of coronary stenosis. HIV+ men had significantly higher levels of interleukin-6 (IL-6), intercellular adhesion molecule-1, C-reactive protein, and soluble-tumor necrosis factor-α receptor (sTNFαR) I and II (all P<0.01) and a higher prevalence of noncalcified plaque (63% versus 54%, P=0.02) on computed tomography angiography. Among HIV+ men, for every SD increase in log-interleukin-6 and log intercellular adhesion molecule-1, there was a 30% and 60% increase, respectively, in the prevalence of coronary stenosis ≥50% (all P<0.05). Similarly, sTNFαR I and II in HIV+ participants were associated with an increase in prevalence of coronary stenosis ≥70% (P<0.05). Higher levels of interleukin-6, sTNFαR I, and sTNFαR II were also associated with greater coronary artery calcification score in HIV+ men (P<0.01).ConclusionsHigher inflammatory marker levels are associated with greater prevalence of coronary stenosis in HIV+ men. Our findings underscore the need for further study to elucidate the relationships of inflammatory pathways with coronary artery disease in HIV+ individuals

Pion radiative weak decays in nonlocal chiral quark models

We analyze the radiative pion decay pi+ -> e+ nu_e gamma within nonlocal chiral quark models that include wave function renormalization. In this framework we calculate the vector and axial-vector form factors FV and FA at q^2=0 --where q^2 is the (e+ \nu_e) squared invariant mass-- and the slope a of FV(q^2) at q^2 -> 0. The calculations are carried out considering different nonlocal form factors, in particular those taken from lattice QCD evaluations, showing a reasonable agreement with the corresponding experimental data. The comparison of our results with those obtained in the (local) NJL model and the relation of FV and a with the form factor in pi^0 -> gamma* gamma decays are discussed.Comment: 14 pages, 1 figure, minor changes in text introduce

A light-front coupled cluster method

A new method for the nonperturbative solution of quantum field theories is described. The method adapts the exponential-operator technique of the standard many-body coupled-cluster method to the Fock-space eigenvalue problem for light-front Hamiltonians. This leads to an effective eigenvalue problem in the valence Fock sector and a set of nonlinear integral equations for the functions that define the exponential operator. The approach avoids at least some of the difficulties associated with the Fock-space truncation usually used.Comment: 8 pages, 1 figure; to appear in the proceedings of LIGHTCONE 2011, 23-27 May 2011, Dalla

Pressure dependency of retinal arterial pulse wave velocity in the rat

© 2020 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V. This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/). Purpose: The retinal vasculature provides unique in vivo access to the microcirculation and presents the possibility of measuring small artery (retinal) stiffness using pulse wave velocity (PWV). This study investigates whether retinal artery PWV (rPWV) has a blood pressure (BP) dependency. Methods: Fundus videos from eight Sprague-Dawley rats aged 12 weeks were captured (Zeiss fundus microscope with high-speed camera, 125 fps, Optronis, Germany) simultaneously with aortic BP. Retinal artery diameter waveforms at proximal and distal sites were extracted and transit time calculated from the phase delay between frequency components (4–6 Hz, typical heart rate of rats) of the waveforms. rPWV was measured across a physiological range of mean arterial pressure (MAP): baseline (90–110 mmHg); 130 mmHg to baseline following systemic phenylephrine (PE) infusion (30 mg/kg/min); 130 mmHg to baseline during PE infusion with simultaneous inferior vena cava occlusion (VO); 70 mmHg to baseline following systemic sodium nitroprusside infusion; and 70 mmHg to baseline following VO. The correlation between retinal artery rPWV and BP was quantified. Results: There was a significant positive correlation between retinal artery rPWV and MAP as expected (0.19 mm/s/mmHg, R2 = 0.59, p < 0.001). There was a positive correlation between retinal and aortic PWV (R2 = 0.09, p = 0.03). Conclusion: The pressure dependency of the measured rPWV indicates the measure has utility in in vivo quantification of the impact on microvessels of cardiovascular diseases. To elucidate the predictive value of screening rPWV in systemic cardiovascular abnormalities, the relation needs to be investigated in humans

Whightman function and scalar Casimir densities for a wedge with a cylindrical boundary

Whightman function, vacuum expectation values of the field square, and the energy-momentum tensor are investigated for a scalar field inside a wedge with and without a coaxial cylindrical boundary. Dirichlet boundary conditions are assumed on the bounding surfaces. The vacuum energy-momentum tensor is evaluated in the general case of the curvature coupling parameter. Making use of a variant of the generalized Abel-Plana formula, expectation values are presented as the sum of two terms. The first one corresponds to the geometry without a cylindrical boundary and the second one is induced by the presence of this boundary. The asymptotic behaviour of the field square, vacuum energy density and stresses near the boundaries are investigated. The additional vacuum forces acting on the wedge sides due the presence of the cylindrical boundary are evaluated and it is shown that these forces are attractive. As a limiting case, the geometry of two parallel plates perpendicularly intersected by a third one is analyzed.Comment: 19 pages, 6 figures, new section is added on the VEVs for the region outside the cylidrical shell, discussion and references added, accepted for publication in J. Phys.

Vacuum energy in conical space with additional boundary conditions

Total vacuum energy of some quantized fields in conical space with additional boundary conditions is calculated. These conditions are imposed on a cylindrical surface which is coaxial with the symmetry axis of conical space. The explicit form of the matching conditions depends on the field under consideration. In the case of electromagnetic field, the perfectly conducting boundary conditions or isorefractive matching conditions are imposed on the cylindrical surface. For a massless scalar field, the semi-transparent conditions ($\delta$-potential) on the cylindrical shell are investigated. As a result, the total Casimir energy of electromagnetic field and scalar field, per a unit length along the symmetry axis, proves to be finite unlike the case of an infinitely thin cosmic string. In these studies the spectral zeta functions are widely used. It is shown briefly how to apply this technique for obtaining the asymptotics of the relevant thermodynamical functions in the high temperature limit.Comment: 29 pages, 2 figures, the title was changed for a more adequate one, the abstract was rewritten, a few typos and minor grammar mistakes were correcte

Trace anomaly and Casimir effect

The Casimir energy for scalar field of two parallel conductor in two dimensional domain wall background, with Dirichlet boundary conditions, is calculated by making use of general properties of renormalized stress tensor.We show that vacuum expectation values of stress tensor contain two terms which come from the boundary conditions and the gravitational background. In two dimensions the minimal coupling reduces to the conformal coupling and stress tensor can be obtained by the local and non-local contribution of the anomalous trace. This work shows that there exists a subtle relation between Casimir effect and trace anomaly in curved space time.Comment: 6pages, Latex. Journal-ref adde

Scalar Casimir densities for cylindrically symmetric Robin boundaries

Wightman function, the vacuum expectation values of the field square and the energy-momentum tensor are investigated for a massive scalar field with general curvature coupling parameter in the region between two coaxial cylindrical boundaries. It is assumed that the field obeys general Robin boundary conditions on bounding surfaces. The application of a variant of the generalized Abel-Plana formula allows to extract from the expectation values the contribution from single shells and to present the interference part in terms of exponentially convergent integrals. The vacuum forces acting on the boundaries are presented as the sum of self-action and interaction terms. The first one contains well-known surface divergences and needs a further renormalization. The interaction forces between the cylindrical boundaries are finite and are attractive for special cases of Dirichlet and Neumann scalars. For the general Robin case the interaction forces can be both attractive or repulsive depending on the coefficients in the boundary conditions. The total Casimir energy is evaluated by using the zeta function regularization technique. It is shown that it contains a part which is located on bounding surfaces. The formula for the interference part of the surface energy is derived and the energy balance is discussed.Comment: 22 pages, 5 figure

Thermal Dileptons at LHC

We predict dilepton invariant-mass spectra for central 5.5 ATeV Pb-Pb collisions at LHC. Hadronic emission in the low-mass region is calculated using in-medium spectral functions of light vector mesons within hadronic many-body theory. In the intermediate-mass region thermal radiation from the Quark-Gluon Plasma, evaluated perturbatively with hard-thermal loop corrections, takes over. An important source over the entire mass range are decays of correlated open-charm hadrons, rendering the nuclear modification of charm and bottom spectra a critical ingredient.Comment: 2 pages, 2 figures, contributed to Workshop on Heavy Ion Collisions at the LHC: Last Call for Predictions, Geneva, Switzerland, 14 May - 8 Jun 2007 v2: acknowledgment include