Biosensors for cardiac biomarkers detection: a review

The cardiovascular disease (CVD) is considered as a major threat to global health. Therefore, there is a growing demand for a range of portable, rapid and low cost biosensing devices for the detection of CVD. Biosensors can play an important role in the early diagnosis of CVD without having to rely on hospital visits where expensive and time-consuming laboratory tests are recommended. Over the last decade, many biosensors have been developed to detect a wide range of cardiac marker to reduce the costs for healthcare. One of the major challenges is to find a way of predicting the risk that an individual can suffer from CVD. There has been considerable interest in finding diagnostic and prognostic biomarkers that can be detected in blood and predict CVD risk. Of these, C-reactive protein (CRP) is the best known biomarker followed by cardiac troponin I or T (cTnI/T), myoglobin, lipoprotein-associated phospholipase A(2), interlukin-6 (IL-6), interlukin-1 (IL-1), low-density lipoprotein (LDL), myeloperoxidase (MPO) and tumor necrosis factor alpha (TNF-α) has been used to predict cardiovascular events. This review provides an overview of the available biosensor platforms for the detection of various CVD markers and considerations of future prospects for the technology are addressed

B(s)-B(s)bar Mixing in Supersymmetric Grand Unified Models

We study B_s-\bar{B}_s mixing in grand unified SO(10), SU(5) models where the mixings among the second and third generation squarks arise due to the existence of flavor violating sources in the Dirac and Majorana couplings which are responsible for neutrino mixings. We find that when the branching ratio of tau->mu gamma decay is enhanced to be around the current experimental bound, B_s-\bar{B}_s mixing may also contain large contribution from supersymmetry in the SO(10) boundary condition. Consequently, the phase of B_s-\bar{B}_s mixing is large (especially for small tan beta and large scalar mass m_0) and can be tested by measuring CP asymmetries of B_s decay modes.Comment: 5 pages, 3 figures. Modifications in the text and the title, references added, results unchanged, to appear in PR

New Physics in b --> s bar(s) s Decay

We perform a model-independent analysis of the data on branching ratios and CP asymmetries of $B\to\phi K$ and $B\to\eta^{(')} K^{(*)}$ modes. The present data is encouraging to look for indirect evidences of physics beyond the Standard Model. We investigate the parameter spaces for different possible Lorentz structures of the new physics four-Fermi interaction. It is shown that if one takes the data at $1\sigma$ confidence level, only one particular Lorentz structure is allowed. Possible consequences for the $B_s$ system are also discussed.Comment: 9 pages, 3 encapsulated figures, minor changes in the text, conclusions unchanged, a few references added, version to appear in PL

Exact αs\alpha _s Calculation of b→s+γb\rightarrow s + \gamma , \ b→s+gb\rightarrow s + g

We present an exact $\alpha_s$ calculation of the Wilson coefficients associated with the dipole moment operators. We also give an estimate of the branching ratio for $b\rightarrow s \gamma$. We find that higher dimensional effects are under control within $9\%$ for $BR(b\rightarrow s \gamma)=(4.3\pm 0.37 )\times 10^{-4}$.Comment: 12 pages (plain TeX), 2 postscript figures available upon request. UM-TH-93-20 , IP-ASTP-29-9

Measurements of the branching fractions of the decays B°s → D∓s K± and B°s → D¯sπ+

The decay mode B°s → D∓s K± allows for one of the theoretically cleanest measurements of the CKM angle γ through the study of time-dependent CP violation. This paper reports a measurement of its branching fraction relative to the Cabibbo-favoured mode B°s → D¯sπ+ based on a data sample corresponding to 0.37 fb¯¹ of proton-proton collisions at √s = 7TeV collected in 2011 with the LHCb detector. In addition, the ratio of B meson production fractions fs/fd, determined from semileptonic decays, together with the known branching fraction of the control channel B°s → D¯sπ+ is used to perform an absolute measurement of the branching fractions: B(B°s → D¯sπ+) = (2.95 ± 0.05 ± 0.17 -0.22 +0.18) × 10¯³ ; B(B°s → D∓s K±) = (1.90 ± 0.12 ± 0.13 -0.14 +0.12) × 10¯4 ; where the first uncertainty is statistical, the second the experimental systematic uncertainty, and the third the uncertainty due to f s/f

Complete next-to-leading order gluino contributions to b--> s gamma and b--> s g

We present the first complete order alpha_s corrections to the Wilson coefficients (at the high scale) of the various versions of magnetic and chromomagnetic operators which are induced by a squark-gluino exchange. For this matching calculation, we work out the on-shell amplitudes b--> s gamma and b --> s g, both in the full and in the effective theory up to order alpha_s^2. The most difficult part of the calculation is the evaluation of the two-loop diagrams in the full theory; these can be split into two classes: a) diagrams with one gluino and a virtual gluon; b) diagrams with two gluinos or with one gluino and a four-squark vertex. Accordingly, the Wilson coefficients can be split into a part a) and a part b). While part b) of the Wilson coefficients is presented in this paper for the first time, part a) was given in (Bobeth et al.). We checked their results for the coefficients of the magnetic operators and found perfect agreement. Moreover, we work out the renormalization procedure in great detail. Our results for the complete next-to-leading order Wilson coefficients are fully analytic, but far too long to be printed. We therefore publish them in the form of a C++ program. They constitute a crucial building block for the phenomenological next-to-leading logarithmic analysis of the branching ratio Bbar --> X_s gamma in a supersymmetric model beyond minimal flavor violation.Comment: 38 pages, including c++ cod