Identificación y evaluación de vulnerabilidades de la Red Lan Capa 1 y 2, para el ejército Nacional de Colombia dependencia fortaleza ubicado en la ciudad de Bogotá

En este documento se evalúa y se analiza la topología de una red LAN compuesta por un número de dispositivos finales, switch, router y su cableado estructurado. Se busca verificar las condiciones actuales de esta red respecto a su estado, configuración, diseño y arquitectura. A partir del resultado, se expondrán las posibles transformaciones y mejoras que se pueden implementar en la red seleccionada para la investigación, ubicada en la unidad militar GRUPO FORTALEZA DEL EJERCITO NACIONAL.This document evaluates and analyzes the topology of a LAN network consisting of a number of end devices, switch, router and structured cabling. It seeks to verify the current conditions of this network regarding its status, configuration, design and architecture. From the result, the possible transformations and improvements that can be implemented in the network selected for the investigation, located in the military unit GRUPO FORTALEZA DEL NACIONAL ARMY, will be presented.Glosario. -- Resumen. -- Introducción. -- 1. Esquematización del tema. -- 1.1. Descripción y formulación del problema. -- 1.2. Justificación. -- 1.3. Objetivos. -- 1.3.1. Objetivo General. -- 1.3.2. Objetivos Específicos. -- 1.4. Alcances y limitaciones del proyecto. -- 1.4.1. Alcances. -- 1.4.2. Limitaciones. -- 2. Marco de referencia. -- 2.1. RED. -- 2.1.1. Red LAN. -- 2.1.2. Red WAN. -- 2.2. Switch. -- 2.3. Router. -- 2.4. Port Security. -- 3. Metodología. -- 3.1. Verificar. -- 3.2. Actuar. -- 3.3. Planear. -- 3.4. Hacer. -- 4. Condiciones actuales de la red ejército nacional dependencia fortaleza. -- 4.1. Extracción y obtención de la información de la red actual. -- 4.1.1. Ubicación de Equipos. -- 4.1.2. Condiciones Eléctricas. -- 4.2. Características del Router. -- 4.3. Características de los Switch. -- 4.4. Condiciones del cableado estructurado. -- 5. Análisis e identificación de vulnerabilidades. -- 5.1. Cableado estructurado. -- 5.2. Equipos intermedios. -- Conclusiones. -- Recomendaciones. -- Anexos. -- Webgrafia

Historia familiar y Consumo de Alcohol en Adolescentes

Objetivo: Determinar la relación de la historia familiar del consumo de alcohol y el consumo de alcohol de los adolescentes. Material y Métodos: Se llevó a cabo un estudio descriptivo correlacional en 191 adolescentes de una institución pública de educación básica de Ciudad del Carmen Campeche, se utilizó el Inventario de Historia Familiar de Consumo de Alcohol. Resultados: El 57.6% de los adolescente manifestó que alguna de las personas con las que vive consume bebidas alcohólicas, siendo el padre el principal consumir con un 24.6%, seguido de ambos padres (13.1%); llegando a consumir hasta 12.6 bebidas alcohólicas por ocasión de consumo. Los resultados muestran una relación positiva y significativa entre los antecedentes familiares y el número de bebidas alcohólicas consumidas en un día típico por los adolescentes (rs= .329, p= .001). Conclusiones: La familia juega un papel primordial en la adquisición de conductas de los adolescentes, dado que la adolescencia representa una etapa de vulnerabilidad donde se definen aspectos biopsicosociales de la edad adulta, de ahí la importancia de fomentar estilos de vida saludables dentro del núcleo familiar que repercutirán en la salud integral de los adolescentes

SISTEMA DE RECONOCIMIENTO DE DÍGITOS MANUSCRITOS UTILIZANDO REDES NEURONALES

El reconocimiento de dígitos manuscritos es un entorno en creciente uso y por consiguiente requiere ir abordando alternativas para su implementación, el  uso de redes neuronales ha venido retomando el auge dentro del área de reconocimiento de patrones. Este documento muestra el uso de redes neuronales, a través de un software personalizado, como el motor detrás un sistema de reconocimiento de caracteres ópticos. En este sistema los dígitos numéricos son simplificados a través de filtros de imagen y luego presentados como entrada a la red neuronal para entrenarla (usando el algoritmo de retro-propagación) y ser capaz de clasificar otras muestras en la etapa de pruebas. Los resultados muestran tasas de reconocimiento cercanas al 85%, que se pueden considerar como aceptables para topologías de una sola capa, dejando pendiente para futuros experimentos el trabajo con redes multicapa pre-entrenadas, ya que suelen incrementar fuertemente su eficiencia

Influence of subclinical endometritis on the reproductive performance of dairy cows

The aim of this study was to evaluate the influence of subclinical endometritis (SE) on the reproductive performance of dairy cows. Ninety-four dairy cows of parity 1 to 8, distributed in 25 herds, were examined once between 30 and 45 days in milk using transrectal palpation, vaginoscopy and ultrasonography. A cytological sample of the endometrium was taken only from cows with an apparent healthy uterus (n=65). Serum glucose, total cholesterol, triglycerides, non-esterified fatty acids, β-hydroxybutyrate, total proteins, albumin, urea and hepatic enzymes were analyzed. Reproductive indexes were recorded during the next 11 months. Endometrial cytology was considered indicative of SE if percentage of polymorphonuclear neutrophils was superior to 5% of all cells present in the smear, except erythrocytes. Results indicated that 14.9% of the cows sampled for uterine cytology had SE, and that healthy cows become pregnant significantly before than those with SE (hazard ratio=2.35; 95% confidece interval: 1.05-5.3). From all the metabolic and productive variables analyzed, only triglycerides affected negatively to reproduction; serum albumin concentration, body condition score and milk production had positive effects on the reproductive performance. In conclusion, our results indicate that SE has a negative impact on reproductive performance and uterine cytology is necessary to diagnose it since almost 15% of the affected animals were not detected by other diagnosis methodsXunta de Galicia (Programa Sectorial de Medio Rural, Proyecto Ref. PGIDIT07MRU002E) and FEFRIGA, Santiago de Compostela, SpainS

Nutrients and Dietary Approaches in Patients with Type 2 Diabetes Mellitus and Cardiovascular Disease: A Narrative Review

Cardiovascular disease (CVD) is the most common cause of morbidity and mortality in developed countries. The prevalence of CVD is much higher in patients with type 2 diabetes mellitus (T2DM), who may benefit from lifestyle changes, which include adapted diets. In this review, we provide the role of different groups of nutrients in patients with T2DM and CVD, as well as dietary approaches that have been associated with better and worse outcomes in those patients. Many different diets and supplements have proved to be beneficial in T2DM and CVD, but further studies, guidelines, and dietary recommendations are particularly required for patients with both diseases

Biochemical and structural characterization of a novel thermophilic esterase EstD11 provide catalytic insights for the HSL family

[Abstract]: A novel esterase, EstD11, has been discovered in a hot spring metagenomic library. It is a thermophilic and thermostable esterase with an optimum temperature of 60 C. A detailed substrate preference analysis of EstD11 was done using a library of chromogenic ester substrate that revealed the broad substrate specificity of EstD11 with significant measurable activity against 16 substrates with varied chain length, steric hindrance, aromaticity and flexibility of the linker between the carboxyl and the alcohol moiety of the ester. The tridimensional structures of EstD11 and the inactive mutant have been determined at atomic resolutions. Structural and bioinformatic analysis, confirm that EstD11 belongs to the family IV, the hormone-sensitive lipase (HSL) family, from the α/β-hydrolase superfamily. The canonical a/b hydrolase domain is completed by a cap domain, composed by two subdomains that can unmask of the active site to allow the substrate to enter. Eight crystallographic complexes were solved with different substrates and reaction products that allowed identification of the hot-spots in the active site underlying the specificity of the protein. Crystallization and/or incubation of EstD11 at high temperature provided unique information on cap dynamics and a first glimpse of enzymatic activity in vivo. Very interestingly, we have discovered a unique Met zipper lining the active site and the cap domains that could be essential in pivotal aspects as thermo-stability and substrate promiscuity in EstD11Ministerio de Ciencia e Innovación; BFU2017-90030-

Aproximación a la checklist de los gipsófitos ibéricos

Approximation to the Iberian gypsophytes checklist. The close relationship between some kinds of soils and the flora growing on them has been long known. Gypsum soils stand as a prominent example of this relationship, since some plants exclusively grow on gypsum outcrops. Nowadays this close relationship is known as gypsophily and the plant species exhibiting it are called gypsophytes. As Cavanilles already found out in the 18th century, the Iberian flora is rich in gypsophytes. From then on many botanists have considerably enlarged the list of gypsophytes. However we still lack a more or less conclusive catalogue of the Iberian gypsophytes. Only some publications dealing with the gypsum flora or vegetation may serve as references for the drafting of a preliminary catalogue. This idea has recently inspired a preliminary list of gypsophytes which has been later enlarged with the addition of new species recorded now and then in a number of specific Floras and other works of a general scope. On the basis of this list, 12 botanists adept at gypsum flora have been asked to rank the liking of these species for gypsum soils. The gypsophilous character of 140 species have been thus ranked on a scale ranging from 1 to 5 (with 5 representing an absolute liking for gypsum soils). According to the median values, some 50 species can be considered as either absolute or preferent gypsophytes

Expression of sterol regulatory element-binding proteins in epicardial adipose tissue in patients with coronary artery disease and diabetes mellitus: preliminary study

[Abstract] Objectives: Sterol regulatory element-binding proteins (SREBP) genes are crucial in lipid biosynthesis and cardiovascular homeostasis. Their expression in epicardial adipose tissue (EAT) and their influence in the development of coronary artery disease (CAD) and type-2 diabetes mellitus remain to be determined. The aim of our study was to evaluate the expression of SREBP genes in EAT in patients with CAD according to diabetes status and its association with clinical and biochemical data. Methods: SREBP-1 and SREBP-2 mRNA expression levels were measured in EAT from 49 patients with CAD (26 with diabetes) and 23 controls without CAD or diabetes. Results: Both SREBPs mRNA expression were significantly higher in patients with CAD and diabetes (p<0.001) and were identified as independent cardiovascular risk factor for coronary artery disease in patients with type-2 diabetes (SREBP-1: OR 1.7, 95%CI 1.1-2.5, p=0.02; SREBP-2: OR 1.6, 95%CI 1.2-3, p=0.02) and were independently associated with the presence of multivessel CAD, left main and anterior descending artery stenosis, and higher total and LDL cholesterol levels, and lower HDL cholesterol levels, in patients with CAD and diabetes. Conclusions: SREBP genes are expressed in EAT and were higher in CAD patients with diabetes than those patients without CAD or diabetes. SREBP expression was associated as cardiovascular risk factor for the severity of CAD and the poor lipid control. In this preliminary study we suggest the importance of EAT in the lipid metabolism and cardiovascular homeostasis for coronary atherosclerosis of patients with diabetes and highlight a future novel therapeutic target.Instituto de Salud Carlos III; PI13/02542Instituto de Salud Carlos III; PI11/01661Red de Investigación Cardiovascular; RD12/0042/003

Adaptación al bilingüismo del material docente de prácticas de Zoología

El objetivo principal de este proyecto de innovación docente es la adaptación al bilingüismo, concretamente al inglés, del material de prácticas (presenciales y virtuales) de la asignatura de Zoología del grado de Biología. Este objetivo se enmarca dentro del actual proceso de internacionalización de la UGR, que en el caso concreto del grado de Biología se ha iniciado el curso académico 2021/2022 con algunas asignaturas impartidas en inglés. Aunque el bilingüismo en la asignatura de Zoología se ha retrasado hasta el curso 2022/2023.Universidad de Granad

Pancreatic metastases from renal cell carcinoma. Postoperative outcome after surgical treatment in a Spanish multicenter study (PANMEKID)

Background: Renal Cell Carcinoma (RCC) occasionally spreads to the pancreas. The purpose of our study is to evaluate the short and long-term results of a multicenter series in order to determine the effect of surgical treatment on the prognosis of these patients. Methods: Multicenter retrospective study of patients undergoing surgery for RCC pancreatic metastases, from January 2010 to May 2020. Variables related to the primary tumor, demographics, clinical characteristics of metastasis, location in the pancreas, type of pancreatic resection performed and data on short and long-term evolution after pancreatic resection were collected. Results: The study included 116 patients. The mean time between nephrectomy and pancreatic metastases' resection was 87.35 months (ICR: 1.51-332.55). Distal pancreatectomy was the most performed technique employed (50 %). Postoperative morbidity was observed in 60.9 % of cases (Clavien-Dindo greater than IIIa in 14 %). The median follow-up time was 43 months (13-78). Overall survival (OS) rates at 1, 3, and 5 years were 96 %, 88 %, and 83 %, respectively. The disease-free survival (DFS) rate at 1, 3, and 5 years was 73 %, 49 %, and 35 %, respectively. Significant prognostic factors of relapse were a disease free interval of less than 10 years (2.05 [1.13-3.72], p 0.02) and a history of previous extrapancreatic metastasis (2.44 [1.22-4.86], p 0.01). Conclusions: Pancreatic resection if metastatic RCC is found in the pancreas is warranted to achieve higher overall survival and disease-free survival, even if extrapancreatic metastases were previously removed. The existence of intrapancreatic multifocal compromise does not always warrant the performance of a total pancreatectomy in order to improve survival. (C) 2021 The Authors. Published by Elsevier Ltd