Intra-metropolitan migration: six Boston area municipalities

Thesis (M.C.P.)--Massachusetts Institute of Technology, Dept. of City and Regional Planning, 1963.Includes bibliographical references (leaves 69-70).by Edgar C. Rust, 3rd.M.C.P

Análise projetual da habitação de interesse social no município de Erechim/RS

A pesquisa busca avaliar o ciclo, os conceitos, princípios e estratégias dos projetos para Habitações de Interesse Social (HIS) construídas na cidade de Erechim/RS, durante as últimas décadas. Realizaram-se estudos teóricos e análises de projetos de habitações já executados no Brasil, buscando avaliar o estado da arte e a aquisição de repertório para analisar os projetos de HIS executados na cidade. Posteriormente obteve-se acesso aos projetos, sendo estes disponibilizados pela Secretaria de Habitação do município, e iniciou-se o processo de análise e discussão com aporte de uma planilha elaborada a partir dos modelos estudados, esta organiza os dados relevantes para avaliação, apontando as características gerais e a qualidade projetual. Cada projeto é avaliado identificando-se características físicas e espaciais da edificação, de composição arquitetônica, possibilidade de ampliação pelo usuário e de inserção do mobiliário básico de cada ambiente. Foram analisados 11 projetos arquitetônicos, para os quais as análises realizadas apresentam como resultado a não contemplação de aspectos fundamentais em uma moradia, como a falta de espaço físico para instalação de mobiliário básico, à exemplo, a falta de espaço para a mesa de refeições. A funcionalidade também é prejudicada ao situar-se o tanque do lado de fora da edificação, em mais da metade dos projetos analisados. Há dificuldades de ampliação da edificação sem gerar alterações que comprometam a subtração de janelas, por exemplo. Também há comprometimento da salubridade dos ambientes devido ao descumprimento do código de obras, em relação aos índices adequados de ventilação e iluminação. Os projetos não preveem acessibilidade para portadores de necessidades especiais ou mesmo para pessoas com mobilidade reduzida. Em suma, as análises projetuais, retratam muitas inadequações em relação às necessidades dos usuários. Ainda que contribua na diminuição do déficit habitacional, a qualidade vista nos projetos analisados não proporciona uma moradia adequada

An eScience-Bayes strategy for analyzing omics data

<p>Abstract</p> <p>Background</p> <p>The omics fields promise to revolutionize our understanding of biology and biomedicine. However, their potential is compromised by the challenge to analyze the huge datasets produced. Analysis of omics data is plagued by the curse of dimensionality, resulting in imprecise estimates of model parameters and performance. Moreover, the integration of omics data with other data sources is difficult to shoehorn into classical statistical models. This has resulted in <it>ad hoc </it>approaches to address specific problems.</p> <p>Results</p> <p>We present a general approach to omics data analysis that alleviates these problems. By combining eScience and Bayesian methods, we retrieve scientific information and data from multiple sources and coherently incorporate them into large models. These models improve the accuracy of predictions and offer new insights into the underlying mechanisms. This "eScience-Bayes" approach is demonstrated in two proof-of-principle applications, one for breast cancer prognosis prediction from transcriptomic data and one for protein-protein interaction studies based on proteomic data.</p> <p>Conclusions</p> <p>Bayesian statistics provide the flexibility to tailor statistical models to the complex data structures in omics biology as well as permitting coherent integration of multiple data sources. However, Bayesian methods are in general computationally demanding and require specification of possibly thousands of prior distributions. eScience can help us overcome these difficulties. The eScience-Bayes thus approach permits us to fully leverage on the advantages of Bayesian methods, resulting in models with improved predictive performance that gives more information about the underlying biological system.</p

All-sky search for gravitational-wave bursts in the second joint LIGO-Virgo run

We present results from a search for gravitational-wave bursts in the data collected by the LIGO and Virgo detectors between July 7, 2009 and October 20, 2010: data are analyzed when at least two of the three LIGO-Virgo detectors are in coincident operation, with a total observation time of 207 days. The analysis searches for transients of duration < 1 s over the frequency band 64-5000 Hz, without other assumptions on the signal waveform, polarization, direction or occurrence time. All identified events are consistent with the expected accidental background. We set frequentist upper limits on the rate of gravitational-wave bursts by combining this search with the previous LIGO-Virgo search on the data collected between November 2005 and October 2007. The upper limit on the rate of strong gravitational-wave bursts at the Earth is 1.3 events per year at 90% confidence. We also present upper limits on source rate density per year and Mpc^3 for sample populations of standard-candle sources. As in the previous joint run, typical sensitivities of the search in terms of the root-sum-squared strain amplitude for these waveforms lie in the range 5 10^-22 Hz^-1/2 to 1 10^-20 Hz^-1/2. The combination of the two joint runs entails the most sensitive all-sky search for generic gravitational-wave bursts and synthesizes the results achieved by the initial generation of interferometric detectors.Comment: 15 pages, 7 figures: data for plots and archived public version at https://dcc.ligo.org/cgi-bin/DocDB/ShowDocument?docid=70814&version=19, see also the public announcement at http://www.ligo.org/science/Publication-S6BurstAllSky

Global Biodiversity and Phylogenetic Evaluation of Remipedia (Crustacea)

Remipedia is one of the most recently discovered classes of crustaceans, first described in 1981 from anchialine caves in the Bahamas Archipelago. The class is divided into the order Enantiopoda, represented by two fossil species, and Nectiopoda, which contains all known extant remipedes. Since their discovery, the number of nectiopodan species has increased to 24, half of which were described during the last decade. Nectiopoda exhibit a disjunct global distribution pattern, with the highest abundance and diversity in the Caribbean region, and isolated species in the Canary Islands and in Western Australia. Our review of Remipedia provides an overview of their ecological characteristics, including a detailed list of all anchialine marine caves, from which species have been recorded. We discuss alternative hypotheses of the phylogenetic position of Remipedia within Arthropoda, and present first results of an ongoing molecular-phylogenetic analysis that do not support the monophyly of several nectiopodan taxa. We believe that a taxonomic revision of Remipedia is absolutely essential, and that a comprehensive revision should include a reappraisal of the fossil record

Circadian oscillator proteins across the kingdoms of life : Structural aspects 06 Biological Sciences 0601 Biochemistry and Cell Biology

Circadian oscillators are networks of biochemical feedback loops that generate 24-hour rhythms and control numerous biological processes in a range of organisms. These periodic rhythms are the result of a complex interplay of interactions among clock components. These components are specific to the organism but share molecular mechanisms that are similar across kingdoms. The elucidation of clock mechanisms in different kingdoms has recently started to attain the level of structural interpretation. A full understanding of these molecular processes requires detailed knowledge, not only of the biochemical and biophysical properties of clock proteins and their interactions, but also the three-dimensional structure of clockwork components. Posttranslational modifications (such as phosphorylation) and protein-protein interactions, have become a central focus of recent research, in particular the complex interactions mediated by the phosphorylation of clock proteins and the formation of multimeric protein complexes that regulate clock genes at transcriptional and translational levels. The three-dimensional structures for the cyanobacterial clock components are well understood, and progress is underway to comprehend the mechanistic details. However, structural recognition of the eukaryotic clock has just begun. This review serves as a primer as the clock communities move towards the exciting realm of structural biology