Impacto de las nuevas tecnologías de la comunicación en la educación a distancia

Tesis ( Maestría en Ciencias de la Comunicación) U.A.N.L.UANLhttp://www.uanl.mx

El Rol del Docente como Influencer Académico

Los Influencer son personas que tienen autoridad sobre un tema determinado y tiene resonancia en las demás personas. De igual manera el ambiente digital de las redes sociales como Instagram, Twitter y Facebook, han favorecido la comunicación social más allá de los espacios territoriales y la intervención de las personas y su interacción con sus distintas comunidades se extienden hoy en día por medio de las tecnologías digitales desarrollándose de manera global. Indiscutiblemente los profesores son agentes educativos que no deben sustraerse de los fenómenos digitales de los medios, pero tampoco pueden ser usados indiscriminadamente y sin un objetivo didáctico o sin un programa pedagógico seleccionado. La educación es y será una praxis de interacción entre seres humanos mediada por valores, sentimientos, emociones y regulada hoy por hoy por la tecnología

Highly sensitive dendrimer-based nanoplasmonic biosensor for drug allergy diagnosis

A label-free biosensing strategy for amoxicillin (AX) allergy diagnosis based on the combination of novel dendrimer-based conjugates and a recently developed nanoplasmonic sensor technology is reported. Gold nanodisks were functionalized with a custom-designed thiol-ending-polyamido-based dendron (d-BAPAD) peripherally decorated with amoxicilloyl (AXO) groups (d-BAPAD-AXO) in order to detect specific IgE generated in patient's serum against this antibiotic during an allergy outbreak. This innovative strategy, which follows a simple one-step immobilization procedure, shows exceptional results in terms of sensitivity and robustness, leading to a highly-reproducible and long-term stable surface which allows achieving extremely low limits of detection. Moreover, the viability of this biosensor approach to analyze human biological samples has been demonstrated by directly analyzing and quantifying specific anti-AX antibodies in patient's serum without any sample pretreatment. An excellent limit of detection (LoD) of 0.6. ng/mL (i.e. 0.25. kU/L) has been achieved in the evaluation of clinical samples evidencing the potential of our nanoplasmonic biosensor as an advanced diagnostic tool to quickly identify allergic patients. The results have been compared and validated with a conventional clinical immunofluorescence assay (ImmunoCAP test), confirming an excellent correlation between both techniques. The combination of a novel compact nanoplasmonic platform and a dendrimer-based strategy provides a highly sensitive label free biosensor approach with over two times better detectability than conventional SPR. Both the biosensor device and the carrier structure hold great potential in clinical diagnosis for biomarker analysis in whole serum samples and other human biological samples

Role of age and comorbidities in mortality of patients with infective endocarditis

[Purpose]: The aim of this study was to analyse the characteristics of patients with IE in three groups of age and to assess the ability of age and the Charlson Comorbidity Index (CCI) to predict mortality. [Methods]: Prospective cohort study of all patients with IE included in the GAMES Spanish database between 2008 and 2015.Patients were stratified into three age groups:<65 years,65 to 80 years,and ≥ 80 years.The area under the receiver-operating characteristic (AUROC) curve was calculated to quantify the diagnostic accuracy of the CCI to predict mortality risk. [Results]: A total of 3120 patients with IE (1327 < 65 years;1291 65-80 years;502 ≥ 80 years) were enrolled.Fever and heart failure were the most common presentations of IE, with no differences among age groups.Patients ≥80 years who underwent surgery were significantly lower compared with other age groups (14.3%,65 years; 20.5%,65-79 years; 31.3%,≥80 years). In-hospital mortality was lower in the <65-year group (20.3%,<65 years;30.1%,65-79 years;34.7%,≥80 years;p < 0.001) as well as 1-year mortality (3.2%, <65 years; 5.5%, 65-80 years;7.6%,≥80 years; p = 0.003).Independent predictors of mortality were age ≥ 80 years (hazard ratio [HR]:2.78;95% confidence interval [CI]:2.32–3.34), CCI ≥ 3 (HR:1.62; 95% CI:1.39–1.88),and non-performed surgery (HR:1.64;95% CI:11.16–1.58).When the three age groups were compared,the AUROC curve for CCI was significantly larger for patients aged <65 years(p < 0.001) for both in-hospital and 1-year mortality. [Conclusion]: There were no differences in the clinical presentation of IE between the groups. Age ≥ 80 years, high comorbidity (measured by CCI),and non-performance of surgery were independent predictors of mortality in patients with IE.CCI could help to identify those patients with IE and surgical indication who present a lower risk of in-hospital and 1-year mortality after surgery, especially in the <65-year group

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio

Who are the visitors of the art museums: Particularities of the publics of the weekends at the Art Museum of Tigre (Argentina)

Saber quiénes son sus visitantes es una de las principales tareas de los museos en la actualidad, en la medida en que fluctúan entre ajustarse a las imposiciones del sistema capitalista y convertirse en instituciones democráticas y participativas. No obstante, este aspecto resulta aun más dificultoso en los museos de arte, en virtud de los atributos particulares de su estructura y actores. El presente trabajo tiene como objetivo aproximar algunos criterios que permitan conocer quiénes son los visitantes de los museos de arte creados en Argentina desde el inicio del nuevo milenio. Dada la magnitud del desafío, se procura, con el foco puesto en un caso particular, trazar algunos lineamientos sostenidos en los enfoques teórico-críticos aplicados a la museología y en los estudios de públicos. En cuanto a lo metodológico, se recurrió a un estudio de visitantes que apeló a orientaciones cuantitativas y cualitativas, realizado en el Museo de Arte de Tigre durante 2017, centrado en los públicos del fin de semana. Se considera que, al indagar los rasgos singulares de esta entidad patrimonial, pueden identificarse algunos indicios que permitan comenzar a trazar un perfil, tanto general como específico, de los visitantes de los museos de arte.Knowing who its visitors are is one of the main tasks of museums today, as they fluctuate between conforming to the impositions of the capitalist system and becoming democratic and participatory institutions. However, this aspect is even more difficult in the arts museums because of the particular attributes of their structure and its diverse actors. The present work has as main object to bring near some criteria that may allow to know who are the visitors of the art museums in Argentina since the beginning of the new millennium. Given the extent of the challenge, we’ll try, focusing in a particular case, draw some guidelines sustained in the theorical-critical approaches applied to museology and studies of the publics. In terms of methodology, a visitor study was carried out at the Tigre Art Museum in 2017, using both quantitative and qualitative guidelines, focusing on weekend audiences. It is considered that, when we question the singularities of this entity, there are some indications that a general and specific profile of visitors to art museums can begin to be identified.Saber quem são seus visitantes é uma das principais tarefas dos museus na atualidade, na medida em que flutuam entre amoldar-se às imposições do sistema capitalista e converter-se em instituições democráticas e participativas. Não obstante, este aspecto resulta ainda mais dificultoso nos museus de arte, devido aos atributos particulares de sua estrutura e atores. O presente trabalho tem por objetivo aproximar alguns critérios que permitam conhecer quem são os visitantes dos museus de arte criados na Argentina desde o início do novo milênio. Dada a magnitude do desafio, e com o foco posto em um caso particular, buscou-se traçar alguns lineamentos sustentados nos enfoques teórico-críticos aplicados à museologia e nos estudos de públicos. Quanto à metodologia, a pesquisa teve como base um estudo de visitantes que apelou a orientações quantitativas e qualitativas, realizado no Museu de Arte de Tigre durante o ano de 2017, focado nos públicos de fim de semana. Considera-se que, ao indagarmos os traços singulares desta entidade, podem ser identificados alguns indícios que permitam começar a esboçar um perfil, tanto geral quanto específico, dos visitantes dos museus de arte.Fil: Panozzo Zenere, Alejandra Gabriela. Universidad Nacional de Rosario. Facultad de Ciencias Políticas y Relaciones Internacionales. Instituto de Investigaciones. Centro de Investigaciones en Mediatizaciones; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentin

Highly sensitive dendrimer-based nanoplasmonic biosensor for drug allergy diagnosis

A label-free biosensing strategy for amoxicillin (AX) allergy diagnosis based on the combination of novel dendrimer-based conjugates and a recently developed nanoplasmonic sensor technology is reported. Gold nanodisks were functionalized with a custom-designed thiol-ending-polyamido-based dendron (d-BAPAD) peripherally decorated with amoxicilloyl (AXO) groups (d-BAPAD-AXO) in order to detect specific IgE generated in patient's serum against this antibiotic during an allergy outbreak. This innovative strategy, which follows a simple one-step immobilization procedure, shows exceptional results in terms of sensitivity and robustness, leading to a highly-reproducible and long-term stable surface which allows achieving extremely low limits of detection. Moreover, the viability of this biosensor approach to analyze human biological samples has been demonstrated by directly analyzing and quantifying specific anti-AX antibodies in patient's serum without any sample pretreatment. An excellent limit of detection (LoD) of 0.6. ng/mL (i.e. 0.25. kU/L) has been achieved in the evaluation of clinical samples evidencing the potential of our nanoplasmonic biosensor as an advanced diagnostic tool to quickly identify allergic patients. The results have been compared and validated with a conventional clinical immunofluorescence assay (ImmunoCAP test), confirming an excellent correlation between both techniques. The combination of a novel compact nanoplasmonic platform and a dendrimer-based strategy provides a highly sensitive label free biosensor approach with over two times better detectability than conventional SPR. Both the biosensor device and the carrier structure hold great potential in clinical diagnosis for biomarker analysis in whole serum samples and other human biological samples