Hepatitis C virus infection in blood donors from the state of Puebla, Mexico

<p>Abstract</p> <p>Background</p> <p>Worldwide, 130 million persons are estimated to be infected with HCV. Puebla is the Mexican state with the highest mortality due to hepatic cirrhosis. Therefore, it is imperative to obtain epidemiological data on HCV infection in asymptomatic people of this region. The objective of present study was to analyze the prevalence of antibodies and genotypes of hepatitis C virus (HCV) in blood donors from Puebla, Mexico.</p> <p>Results</p> <p>The overall prevalence was 0.84% (515/61553). Distribution by region was: North, 0.86% (54/6270); Southeast, 1.04% (75/7197); Southwest, 0.93% (36/3852); and Central, 0.79% (350/44234). Ninety-six donors were enrolled for detection and genotyping of virus, from which 37 (38.5%) were HCV-RNA positive. Detected subtypes were: 1a (40.5%), 1b (27.0%), mixed 1a/1b (18.9%), undetermined genotype 1 (5.4%), 2a (2.7%), 2b (2.7%), and mixed 1a/2a (2.7%). All recovered donors with S/CO > 39 were HCV-RNA positive (11/11) and presented elevated ALT; in donors with S/CO < 39 HCV-RNA, positivity was of 30.4%; and 70% had normal values of ALT. The main risk factors associated with HCV infection were blood transfusion and surgery.</p> <p>Conclusions</p> <p>HCV prevalence of donors in Puebla is similar to other Mexican states. The most prevalent genotype is 1, of which subtype 1a is the most frequent.</p

American College of Rheumatology Provisional Criteria for Clinically Relevant Improvement in Children and Adolescents With Childhood-Onset Systemic Lupus Erythematosus

10.1002/acr.23834ARTHRITIS CARE & RESEARCH715579-59

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Anales de Edafología y Fisiología Vegetal Tomo 13

Variaciones de los límites de Atterberg en materiales arcillosos de estructura laminar, en función del catión de saturación, por Angel Hoyos de Castro y Mercedes García Muñoz.--Estudio mineralógico y tecnológico de un grupo de tierras de moldeo, por Antonio García Verduch y Manuel Muñoz Taboadela.--Determinación de los iones oxalato por colorimetría indirecta y su aplicación a la determinación de pequeñas cantidades de calcio, por F. Burriel-Martí, J. Ramirez-Muñoz y E. Femández-Caldas.--Acerca de los suelos tropicales, por Paul Schaufclberger.--El diagnóstico de la situación mineral de los cultivos, por M. l. Candela y W. A. Forster.--Caracterización y propiedades de una vermiculita de Badajoz, por F. González, Fca. Tristán de Chaves y M. Chaves.--Estudio mineralógico de algunas rocas sedimentarias, por José García Vicente y Mª del Carmen Sánchez Calvo.--Contribución al conocimiento de los tardígrados de España. Estudio sistemático-ecológico, por F. Mihelcic.--Los minerales de la arcilla : su identificación y relaciones con la Ciencia del Suelo, por Robert C. Mackenzie.--Estudio mineralógico y técnico de algunas tierras de moldeo españolas. I. Identificación mineralógica de la fracción aglomerante, por Vicente Aleixandre Ferrandis, Jaime Robndo Olave y Julia Mª González Peña.--Geofogía de Valencia. l. El Terciario de La Cañada, por P. J. J. Alonso Pasma! y B. García Rodrigo.--Determinación cuantitativa de los aminoácidos por cromatografía ascendente sobre papel, por R. Díaz Cadavieco.--AIteraciones de la superficie de bentonitas homoiónicas por tratamiento térmico. l. Capacidad de cambio y rehidratación, por Angel Hoyos y Julio RodriguezAlteraciones de la superficie de bentonitas homoiónicas por tratamiento térmico. ll. Imbibición, por Angel Hoyos y Julio Rodríguez.--Sobre el análisis espectrográfico en la determinación simultánea de los cationes de cambio en suelos. l. por F. Burriel Martí, S. Jimenez Gómez y C. Alvarez Herrero.--Análisis foliar. l. Aplicación del análisis químico de la hoja y del método de diagnosis visual a la investigación de deficiencia, minerales en relación con los suelos de cultivo, por R. Dios Vidal y J. Mª Albareda Herrera.--Estudio de las formas de fósforo presentes en una serie de suelos, por V. Hernando y M. Losada.--Determinación de yeso en suelos, por J. M. Albareda, V. Hernando y G. Bilbao.--Estudio mineralógico y técnico de algunas tierras de moldeo españolas. II. Estudio de la resistencia a la compresión en verde; por Vicente Aleixandre y Jaime Robredo.--Los arenales costeros de Galicia. I. La ría de Lage por Isidro Parga-Pondal y Josefina Pérez Mateos.--Sobre el método de la Paleoedafología, por W. L. Kübiena.--Contribución al estudio de las reacciones en estado sólido entre el ortosilicato de circonio y el óxido de calcio, por D. A. Estrada.--Análisis foliar. II. El concepto de diagnosis foliar aplicado al control bioquímico de la nutrición de maíz y patatas en una edad fisiológica determinada, por R. Dios Vidal y J. Mª Albareda Herrara.--Influencia de los azúcares en el cultivo in vitro de raíces aisladas de berenjena, por María Bausá Alcalde.--Identificación en el microscopio electrónico de algunas arcillas y caolines españoles, por Vicente Aleixaudre Ferrandis y Julia Mª González Peña.--La península de Anaga y estudio de algunos arenales del litoral de Tenerife (Islas Canarias), por Josefina Pérez Mateos y Manel Martel Sangil.--Clave para la clasificación de los tipos de suelos tropicales, por P. Schaufelberger.--Paralización de la podredumbre del tubérculo de patata durante su período de germinación, por Román Vicente.-- Nota sobre la aditividad de algunas propiedades en mezclas de caolín y bentonita, por Angel Hoyos de Castro y Julio Rodríguez Martínez.--Estudio del pH en suelos de distintas características, por Valentín Hernando y Pilar Sanchez-Conde.--Sobre la determinación espectrofotométrica de fósforo con amidol, por F. Capitán García y F. Martínez Alvarez.--Propiedades termodinámicas del cambio iónico, por E. Gutiérrez Rios y l. Cano Ruiz.--Influencia de la vegetación en la composición del humus. Suelos bajo Quercus ilex y bajo Pinus pinea. El Pardo (Madrid), por José Mª Albareda, Narcisa Martín Retortillo y Mariano Claver.-- Experiencias con fetilizantes en suelos gallegos. l. Acción combinada de los fertilizantes orgánicos y minerales sobre la producción · y el contenido de "proteína en maíces híbridos, por Ramón Dios, Benito Sánchez yMaría Ameijeiras.--Determinación del B. en el suelo por vía espectroquímica, por A. Rodríguez Pérez.--Electroforesis sobre papel de filtro. por R. Díaz CadaviecoPeer reviewe

Anales de Edafología y Agrobiología Tomo 26 Número 1-4

Semblanza, por el Excmo. Sr. Prof. Dr. M. Lora Tamayo.-- José María Albareda Herrera, por el Prof. Dr. A. Hoyos.-- Biografía y Bibliografía del Profesor Albareda.-- Ueber die Carotinkristalle in der Nebenkrone der Narzissenbluete, por A. Frey-Wyssling.-- Beiträge zur Kenntnis der Bodenentwicklung in NW-Spanien auf grund fossiler Biiden, por H. Franz.—La chenaie acidophile ibéro-atlantique (quercion occidentale) en Sologne, por J. Braun-Blanquet .-- Carbon and nitrogen transformations in world soils, por N. R. Dhar.-- Compounds isolated from woody cuttings of Platanus orientalis and their growth promoting activity, por E. Vieitez, E. Seoane, M. D. V. Gesto, A. Vázquez, M. C. Mato, J. Méndez and A. Carnicer.-- Der Boden als Wohnraum fiir Tardigraden, por F. Mihelcic.-- Physiographic systems in soil surveys, por A. P. A. Vink.-- The bulk volume of compacted soil as affected by water content and particle size, por Geoffrey B. Bodman über die Verwitterung der Sedimentgesteine por Carl W. Correns.-- Effects of heating on vermiculite saturated with different cations, por O. T. Rotini, G. Lotti and R. Riffaldi.-- La distribución de los vertebrados en el Alto Aragón, por E. Balcells R. y col.-- Nuevos sustratos con poder de orientación cristalina, por M. Morante, F. Arrende y J. Rodríguez.-- L'application de la méthode des variantes systématiques en recherche agronomique, por Marcel V. Homes et Germaine H. van Schoor .-- La podzolisation en climat atlantique, por Ph. Duchaufour .-- Ferredoxin and photosynthetic phosphorylation, por Daniel l. Arnon, Harry Y. Tsujimoto and Berah D. McSwain.-- Modificaciones de la lignina y formación de material húmico en el tracto digestivo de los rumiantes, por E. Zorita, A. Suárez y Mª L. Calvo.-- Las aguas subterráneas de Tenerife, por E. Fernández Caldas y V. Pérez García.-- Variedades anisoploides de remolacha azucarera (B. vulgaris L.) en España y sus problemas biológicos, por Antonio Silván y Mechtild Rommel.-- Conducción eléctrica de suelo y arcilla a bajas humedades, por R. Santamaría y M. Tschapek.-- Reducción de nitrato y nitrito por cloroplastos, por M. Losada. y A. Paneque.-- Ein Beitrag zur Kenntnis der MIikrostruktur von solifluidal bewegtem Bodenmaterial in der Sierra Nevada (Andalusien), por Walter Beckmann.-- El problema de los suelos in ter grados en España, por A. Guerra Delgado.-- Adsorption of calcium, magnesium, potassium and sodium as influenced by liming, por L. Wiklander and A. Lax.-- Tonverlagerung in Lössböden unter: Laubmischwald und Acker. por Heinz W. Zottl.-- Fertilidad de los suelos de cultivo de Pontevedra.: Estudio inicial, por B. Sánchez, A. García Sánchez y G. Dios.-- Pastúre science and the Spanish scene, por William Davies.-- Relaciones nutritivas y «grados» en los abonos compuestos, por . C. Tamés.-- The classification of soils under rice cultivation (Paddy soils), por Kazutake Kyuma and Keizaburo Kawaguchi.-- Milk production on a protein-free feed, using urea and ammonium salts as the sole source of nitrogen, por Artturi l. Virtanen.-- Evoluciones foliares de pares nutritivos en el género Citrus, por Octavio Carpena Artés.-- Estudio •del enzima ascórbico oxidasa aislado de diferentes materiales vegetales, por A. Carlos Blesa y Antonio Pretel.-- On the hypsometric change of morphology and micromorphology of terrestric soils, por W. L. Kubiena.-- The intensity and quantity aspects of soil phosphate status and laboratory exctraction values por E. G. Williams.-- Entstehung, Ursache und Wirkuhg von Schlieren in keramischen Giesschlickern, por Adolf Dietzel und Rolf Bruckner.-- Mountain rendzina soils in Israel, por S. Ravikovitch and F. Pines.-- Primeros estudios nematológicos en cultivos de la zona costera granadino-malagueña por Antonio Gómez Barcina y Fernando Jiménez-Millán.-- Influencia de diversos mineralizadores y .del óxido magnésico sobre la formación de forsterita a partir de serpentinas españolas, por V. Aleixandre Ferrandis y Julia Mª. González Peña.-- Nota preliminar sobRe la sedimentación en paleocanales terciarios de la zona de Caspe-Chiprana (provincia de Zaragoza), por Oriol Riba, Joaquín Villena y Jose Quirantes.-- The mineral nutrient relations of conifer seedlings with special reference to the phosphate relations of Pinus radiata, D. Don. por L. Leyton.-- Über die tirse Marokkos-schwarzerdeartige Böden unter subtropischem Klima, por F. Scheffer, U. Schoen und C. Hess.-- Geology, physiography relief and drainage of the Cauca Valley, Colombia, por Doeko Goosen.-- Die Bedeutung der Beschattung fuer unzureichend ernaehrte Nadelbaeume, por W. Laatsch.-- Die. Feinsuhstanz vulkanogener Edaphoide, por E. Mückenhausen.-- El espectro de las emulsioness foliares como índice de la nutrición del trigo, por L. Sánchez de la Puente y F. Lucena Conde.-- Estado de nutrición, equilibrio nutritivo y rendimiento en el olivar de la provincia de Sevilla, por F. González García, A. M•. García Gómez, M. Chaves Sánchez y C. Mazuelos Vela.-- Clasificación y distribución de Algunos virus de leguminosas en España, por M. Rubio-Huertos, M. Santaolalla y R. Moreno.-- Oligoelementos en árboles de bosques (Pinus), por M. Dean Guelbenzu y A. Santos Ruiz.-- Organische Verbindungen als Stickstoffquelle fur die Erniihrung der Ptlanzen, por W. Flaig und H. Söchtig.-- Centro de origen de las plantas cultivadas, por A. Cámara.-- Cassification pedologique, cartographie des sois et mise en valeur des terres, por G. Aubert.-- Interpretation de l'analyse granulometrique. Le concept de texture, por S. Hennin.-- Soil genesis in Southern Portugal, por J. Carvalho Cardoso .-- Soil resources appraisal for development, por Luis Bramao and J. Riquier.-- Almería en el Itinerarium Hispanicum de Jerónimo Münzer, por Manuel Mendizábal.-- Neueste Entwicklungen im Weltkampf gegen den Hunger, por Frita Baade.—On the importance of ion activity method for the theory of soil formation and soil fertility, por V. A. Kovda and D. S. Orlov.—Nuevo método para la determinación de la capacidad de cambio radicular de los vegetales, por J. Cardús y A . Pons.-- Ofrenda, por Gonzalo Bilbao.-- El suelo y la ganadería, por Gaspar González GonzálezPeer reviewe

American college of rheumatology provisional criteria for clinically relevant improvement in children and adolescents with childhood-onset systemic Lupus erythematosus

To develop a Childhood Lupus Improvement Index (CHILI) as a tool to measure response to therapy in childhood-onset systemic lupus erythematosus (cSLE), with a focus on clinically relevant improvement (CRIcSLE). Methods Pediatric nephrology and rheumatology subspecialists (n = 213) experienced in cSLE management were invited to define CRIcSLE and rate a total of 433 unique patient profiles for the presence/absence of CRIcSLE. Patient profiles included the following cSLE core response variables (CRVs): global assessment of patient well-being (patient-global), physician assessment of cSLE activity (MD-global), disease activity index score (here, we used the Systemic Lupus Erythematosus Disease Activity Index), urine protein-to-creatinine ratio, and Child Health Questionnaire physical summary score. Percentage and absolute changes in these cSLE-CRVs (baseline versus follow-up) were considered in order to develop candidate algorithms and validate their performance (sensitivity, specificity, area under the receiver operating characteristic curve [AUC]; range 0-1). Results During an international consensus conference, unanimous agreement on a definition of CRIcSLE was achieved; cSLE experts (n = 13) concurred (100%) that the preferred CHILI algorithm considers absolute changes in the cSLE-CRVs. After transformation to a range of 0-100, a CHILI score of >= 54 had outstanding accuracy for identifying CRIcSLE (AUC 0.93, sensitivity 81.1%, and specificity 84.2%). CHILI scores also reflect minor, moderate, and major improvement for values exceeding 15, 68, and 92, respectively (all AUC >= 0.92, sensitivity >= 93.1%, and specificity >= 73.4%). Conclusion The CHILI is a new, seemingly highly accurate index for measuring CRI in cSLE over time. This index is useful to categorize the degree of response to therapy in children and adolescents with cSLE.715579590CNPQ - Conselho Nacional de Desenvolvimento Científico e TecnológicoFAPESP – Fundação de Amparo à Pesquisa Do Estado De São Paulo303422/2015-7; 7/2016-9; 304255/2015-7215/03756-

Are hospitalized or ambulatory patients with heart failure treated in accordance with European Society of Cardiology guidelines? Evidence from 12 440 patients of the ESC Heart Failure Long-Term Registry.

AIMS: To evaluate how recommendations of European guidelines regarding pharmacological and non-pharmacological treatments for heart failure (HF) are adopted in clinical practice. METHODS AND RESULTS: The ESC-HF Long-Term Registry is a prospective, observational study conducted in 211 Cardiology Centres of 21 European and Mediterranean countries, members of the European Society of Cardiology (ESC). From May 2011 to April 2013, a total of 12 440 patients were enrolled, 40.5% with acute HF and 59.5% with chronic HF. Intravenous treatments for acute HF were heterogeneously administered, irrespective of guideline recommendations. In chronic HF, with reduced EF, renin-angiotensin system (RAS) blockers, beta-blockers, and mineralocorticoid antagonists (MRAs) were used in 92.2, 92.7, and 67.0% of patients, respectively. When reasons for non-adherence were considered, the real rate of undertreatment accounted for 3.2, 2.3, and 5.4% of the cases, respectively. About 30% of patients received the target dosage of these drugs, but a documented reason for not achieving the target dosage was reported in almost two-thirds of them. The more relevant reasons for non-implantation of a device, when clinically indicated, were related to doctor uncertainties on the indication, patient refusal, or logistical/cost issues. CONCLUSION: This pan-European registry shows that, while in patients with acute HF, a large heterogeneity of treatments exists, drug treatment of chronic HF can be considered largely adherent to recommendations of current guidelines, when the reasons for non-adherence are taken into account. Observations regarding the real possibility to adhere fully to current guidelines in daily clinical practice should be seriously considered when clinical practice guidelines have to be written

Relationship between method of anastomosis and anastomotic failure after right hemicolectomy and ileo-caecal resection: an international snapshot audit

Aim The anastomosis technique used following right-sided colonic resection is widely variable and may affect patient outcome. This study aimed to assess the association between leak and anastomosis technique (stapled vs handsewn). Method This was a prospective, multicentre, international audit including patients undergoing elective or emergency right hemicolectomy or ileo-caecal resection operations over a 2-month period in early 2015. The primary outcome measure was the presence of anastomotic leak within 30 days of surgery, determined using a prespecified definition. Mixed effects logistic regression models were used to assess the association between leak and anastomosis method, adjusting for patient, disease and operative cofactors, with centre included as a random-effect variable. Results This study included 3208 patients, of whom 78.4\% (n = 2515) underwent surgery for malignancy and 11.7\% (n = 375) underwent surgery for Crohn's disease. An anastomosis was performed in 94.8\% (n = 3041) of patients, which was handsewn in 38.9\% (n = 1183) and stapled in 61.1\% (n = 1858). Patients undergoing hand-sewn anastomosis were more likely to be emergency admissions (20.5\% handsewn vs 12.9\% stapled) and to undergo open surgery (54.7\% handsewn vs 36.6\% stapled). The overall anastomotic leak rate was 8.1\% (245/3041), which was similar following handsewn (7.4\%) and stapled (8.5\%) techniques (P = 0.3). After adjustment for cofactors, the odds of a leak were higher for stapled anastomosis (adjusted OR = 1.43; 95\% CI: 1.04-1.95; P = 0.03). Conclusion Despite being used in lower-risk patients, stapled anastomosis was associated with an increased anastomotic leak rate in this observational study. Further research is needed to define patient groups in whom a stapled anastomosis is safe