11 research outputs found
Evaluación de los riesgos laborales generados por el formaldehido, a los trabajadores de la dependencia de patología en el Hospital Universitario Santa Gracias E.S.E
- Publication venue
- Publication date
- 01/01/2016
- Field of study
40p
Análisis microbiológico de la etnofarmacología empleada por el pueblo Misak
- Publication venue
- Universidad Nacional de Colombia - Sede Bogotá - Facultad de Medicina - Instituto de Salud Pública
- Publication date
- 01/07/2014
- Field of study
Objetivo Evaluar la presencia, tipo y cantidad de microorganismos en algunos de los principales productos etnofarmacológicos de administración oral, comercializados en el laboratorio Sierra Morena ubicado en el resguardo indígena de Guambia, en el Departamento del Cauca.Materiales y Métodos Se llevó a cabo un estudio observacional, descriptivo, de corte transversal. Se realizó un análisis microbiológico a través de la filtración por membrana de seis muestras escogidas de forma aleatoria que incluyeron el agua y cinco productos etnofarmacológicos listos para la distribución comercial.Resultados Las muestras tomadas fueron no aptas microbiológicamente para el consumo humano debido a la presencia de Escherichia coli y coliformes. El recuento de UFC (Unidades Formadoras de Colonias)/100ml, (parámetro de referencia 0 UFC/100ml) llegó a ser de hasta 63.000 UFC/100ml en el caso del agua y de 110 UFC/100ml para los etnofármacos.Conclusiones Los resultados cuantitativos revelaron la presencia de organismos patógenos, lo que evidencia un fallo en la infraestructura del abastecimiento rural y purificación del agua. Es necesario un monitoreo continuo de la calidad del agua y una intervención urgente de la elaboración de los etnofármacos debido a que también se encuentran contaminados
Long-term safety and efficacy of patisiran for hereditary transthyretin-mediated amyloidosis with polyneuropathy: 12-month results of an open-label extension study
- Author
- Abu-Manneh Rana
- Adams David
- Agathangelou Petros
- Ajroud-Driss Senda Ajroud-Driss
- Al-Salameh Abdallah
- Aldinc Emre
- Algalarrondo Vincent
- Allen Adriane C.
- Altinkurt Emre
- Alves Cristina
- Anan Intissar
- Ando Rina
- Arrouasse Raphaele
- Attarian Shahram
- aus dem Siepen Fabian
- Ayache Samar S.
- Balaya-Gouraya Line
- Barroso Fabio
- Baskin Amber
- Bauer Ralf
- Beaudonnet Guillemette
- Becquemont Laurent
- Berber Erhan
- Berk John L.
- Bernardo Daniela
- Berthelot Emeline
- Bisogni Giulia
- Blasco Pelicano Josep Miquel
- Blume Brianna
- Borrachero Cristina
- Boubrit Yasmine
- Bournane Halima
- Boyer Leslie
- Brannagan III Thomas H.
- Brice Sylvie
- Brueckner Caitlin
- Bulthuis-Kuiper Janita
- Burks Kathleen L.
- Cakar Arman
- Campana-Salort Emmanuelle
- Campistol Josep M.
- Cantú Brito Carlos Gerardo
- Cardoso Berensztejn Amanda
- Cardoso Marcio
- Carrillo Esmeralda
- Casey Patricia
- Castro Isabel
- Castro Jose
- Cauquil-Michon Cécile
- Chacko Liza
- Chahine Ilonah
- Chamova Teodora
- Chan Soo Looi
- Chao Chi-Chao
- Charlin Cyril
- Chaudhry Vinay
- Cherneva Zheyna
- Cherninkova-Gopina Sylvia
- Cho Eun Bin
- Choi Kyomin
- Choumert Ariane
- Chu Hanh
- Cioroiu Comana
- Cisneros Barroso Eugenia
- Coelho Teresa
- Cohen Oliver
- Conceição Isabel M.
- Correia Nuno
- Cortese Andrea
- Coskun Derya J.
- Criollo Mora Elia
- Cárdenas-Soto Karla
- Daccach Marques Vanessa
- Dalia Samir
- Dalton James
- Dang Lien
- de Azevedo Coutinho Conceição
- del Mar Saniger Alba Maria
- Delmont Emilien
- DeLong Douglas
- Deplanque Dominique
- Descals Cristina
- Di Paolantonio Andrea
- Diallo Saran
- Dias da Silva Moises
- Dimberg Elliot
- Dingli David
- Dioso Holly
- Dispenzieri Angela
- Dixon Stacy
- Do Thi Hoa (Therese)
- Durmus Hacer
- Dyck Peter
- Dávila Lucía Galán
- Echaniz-Laguna Andoni
- Ehinger Vincent
- Elabed Mongia
- Eliahou Ludivine
- Elitok Ali
- Elrezzi Elise
- Endo Hironobu
- Ernande Laura
- Falcao de Campos Catarina
- Falk Malin
- Fayerman Raisy
- Ferreira Natalia
- Figuerola Antoni
- Florence Julaine
- Focseneanu Cecile
- Fonder Amie
- Franco Ana
- Freimer Miriam
- Freitas Monica
- Frenzel Lukas F.
- Friebel Frauke
- Fujita Akemi
- Fukase Emi
- Gamez Martinez Jose M
- Gaouar Amina
- García Feijoo Julián
- Gauvain Clement
- Gendre Thierry
- Gentile Luca
- Gerk Olga
- Gertz Morie A.
- Gervais de Santa Rosa Renata
- Giang Lien
- Giardino Elena
- Gillmore Julian D.
- Gilmore Catherine
- Go Ronald
- Goh Khean Jin
- Gonsalves Wilson
- Gonzalez Leidy J.
- González Moreno Juan
- González-Duarte Alejandra
- Gorevic Peter
- Gragera Martínez Álvaro
- Grapperon Aude-Marie
- Green Sinikka
- Guerrero Sola Antonio
- Guglielmino Valeria
- Guimaraes Nadia
- Hachulla Eric
- Hamaguchi Hirotoshi
- Harada Masaya
- Hayman Suzanne R.
- Hein Selina
- Heintzman Sarah
- Hernandez Reyes Jose Pablo
- Hineno Akiyo
- Hipólito Reis Antonio
- Hobbs Miriam
- Hokezu Youichi
- Holtick Udo
- Horga Alejandro
- Hosokawa Yuko
- Hrkman Nicole
- Hsieh Sung-Tsang
- Huesing-Kabar Anna
- Hwa Lisa
- Imai Akira
- Inamo Jocelyn
- Itoya Amenze
- Jack Kristin
- Jarrett Raquel
- Jehan Lacour Nathalie
- Jeon Eun-Seok
- Jiménez López Brenda Poled
- Jose Vega Francisco
- Joslin Benjamin C.
- Jozefowicz Elsa
- Judge Daniel P.
- Kabar Iyad
- Kapoor Prashant
- Karamursel Sacit
- Kasprzyk Emmanuelle
- Katanazaka Kimitaka
- Kato Nagaaki
- Kenepp Amanda
- Khoshnoodi Mohammad
- Kim Arreum
- Kim Byoung-Joon
- Kim Hee Jin
- Kim JuHyeon
- Kishida Dai
- Kleinschmidt Natalia
- Kleyman Inna
- Kodaira Minori
- Koto Shusuke
- Koujin Yoko
- Kraus Deborah
- Kristen Arnt V.
- Kumar Shaji K.
- Kuzume Daisuke
- Kyriakides Theodoros
- Labeyrie Celine
- Lachmann Helen J.
- Lahme Larissa
- Lamas Filipa
- Lambrianides Sakis
- Lautre Andrea
- Law Steven
- Lazzari Victoria
- Le Corvoisier Philippe
- Le An
- Lebellec Loic
- Lecoq Anne-Lise
- Lee Ga Yeon
- Lee Hye Lim
- Lee Kia
- Lee Ming-Jen
- Lee Yi-Chung
- Leonidou Eleni
- Leung Nelson
- Li Steve
- Lim He Eng Li
- Lin Kon-Ping
- Lin Yi
- Lindqvist Per
- Litcanov Debora Cristina
- Liu Qingfeng
- Lopate Glenn
- Lopes Ana
- LoRusso Samantha
- Losada López Inés Asunción
- Low Soon Chai
- Lozza Alessandro
- Luigetti Marco
- Lust John A
- Marques Coutinho Barbara
- Marques Júnior Wilson
- Martin Nathalie
- Martinez-Naharro Ana
- Martins da Silva Ana
- Mason Garnette
- Masuda Teruaki
- Matsumoto Kazuhiko
- Mauricio Elizabeth A.
- May John
- Mazzeo Anna
- Megelin Thomas
- Meguig Sayah
- Mekhael Linda
- Meng Ulrike
- Merlini Giampaolo
- Meyle Eva
- Meyrath David
- Mezei Michelle M.
- Migaud-Chervy Maria-Claire
- Mihailovic Natasa
- Miller Sarah
- Min Ju-Hong
- Misumi Yohei
- Miyahara Teruyoshi
- Miyazawa Chinatsu
- Montala Carles
- Monte Julia R.
- Moreira Carolina Lavigne
- Morino Hiroyuki
- Moritaka Taiga
- Moscardini Mariana
- Munoz Beamud Francisco
- Nagai Masahiro
- Nakahara Keiichi
- Nakano Takahiro
- Neshige Shuichiro
- Neves Carlos
- Nezu Tomohisa
- Nguyen David
- Nguyen Tyler
- Nienhuis Hans
- Noe-Schwenn Simone
- Nordh Erik
- Not Adeline
- O'Riordan William
- Obici Laura
- Oda Junko
- Oda Tetsuya
- Oh Jeeyoung
- Orellana Lucas G.
- Oshita Tomohiko
- Overcash J. Scott
- Owusu-Sekyere Mercy
- Palacios Marta
- Paras Allan
- Park Jae Hong
- Parman Yesim
- Pedrosa Salve
- Pedrosa-Domellöf Fatima
- Pereira Pedro
- Perez de Isla Leopoldo
- Perez Javier M.
- Pessoa Bernardete
- Pester Lars
- Pilebro Bjorn
- Pinto Luiz Felipe
- Pinto Marcus Vinicius
- Planté-Bordeneuve Violaine
- Polydefkis Michael
- Pouget Jean
- Pu Helen
- Pytel Cordoba Vanesa
- Pérez-Castañeda Sandra Lorena
- Quan Dianna
- Rajkumar Vincent S.
- Rakotondratafika Fetra
- Ramalho Joana
- Rezk Tamer
- Rezzan Kus Jülide
- Rigo Oliver Elena
- Rivera de la Parra David
- Rodas Marin Lida Maria
- Rodrigues Leonardo
- Rodríguez Rodríguez Adrián
- Romano Angela
- Rosti Vittorio
- Rougeaux Isabelle
- Rousseau Antoine
- Ruiz Julie
- Russell Stephen J.
- Russo Massimo
- Ryder Julie
- Sabatelli Mario
- Sacko Niamey
- Sahin Erdi
- Sakurada Naonori
- Salhi Hayet
- Sankey Alison
- Santos Miguel Oliveira
- Sanz Monica
- Sarafov Staiko
- Scheid Christof
- Schilling Matthias
- Schmidt Hartmut H.
- Schubert Friederike
- Segawa Akiko
- Sekijima Yoshiki
- Sellers Peter
- Seok Jin Myoung
- Serbest Nail G.
- Shah Syed Mahmood
- Shije Jeffrey
- Shimomura Masahiro
- Shin Hyun Jin
- Signate Aissatou
- Sirin Inan Nermin G.
- Slama Michel S.
- Smith Ashley
- Soderberg Karin
- Sommerville R. Brian
- Stephant Maeva
- Stewart Graeme
- Stone Paula
- Su Jen-Jen
- Suan Daniel
- Suhr Ole
- Sweetser Marianne T.
- Tada Satoshi
- Takahashi Tetsuya
- Taniguchi Ikuko
- Taniwaki Takayuki
- Tard Celine
- Taylor Lenka
- Taylor Mark
- Thai Desmond
- Théaudin-Saliou Marie
- Tournev Ivaylo
- Tran Leyla
- Truong Nghi
- Tsai Li-Kai
- Tsang Steven
- Tsuruhisa Seiko
- Tugal Tutkun Nuriye Ilknur
- Ueda Akihiko
- Ueda Mitsuharu
- Ueno Hiroki
- Ulane Christina
- Ulbricht Hannah
- Uson Mercedes
- Valdrez Katia
- Verschueren Annie
- Vervoitte Laetitia
- Vest John
- Victory Jennifer
- Viera Lima Ana Flavia
- Vinas Maita
- Vista Geno
- Vorona Elena
- Vuong Thao
- Waddington-Cruz Márcia
- Wade N. Kevin
- Wajnsztajn Fernanda
- Walter Doreen
- Wang Jing Jing
- Waters Michael
- Waucquier Nawal
- Weimer Louis
- Wells Karen
- White Matthew T.
- Wiesman Janice
- Witzig Thomas E.
- Wixner Jonas
- Yamanishi Yuki
- Yamashita Taro
- Yang Chih-Chao
- Ye Jing
- Yeh Shin-Joe
- Yorita Akiko
- Yoshinaga Tsuneaki
- Zamba-Papanicolaou Eleni
- Zeldenrust Steven R
- Zepeda Karla A.
- Zhelyazkova-Glaveeva Sashka
- Zibert Andree
- Zueiter Andreas
- Zwijack Brittany
- Özdemir Betül
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2021
- Field of study
© 2020 Elsevier Ltd. All rights reserved.Background: Hereditary transthyretin-mediated amyloidosis is a rare, inherited, progressive disease caused by mutations in the transthyretin (TTR) gene. We assessed the safety and efficacy of long-term treatment with patisiran, an RNA interference therapeutic that inhibits TTR production, in patients with hereditary transthyretin-mediated amyloidosis with polyneuropathy.
Methods: This multicentre, open-label extension (OLE) trial enrolled patients at 43 hospitals or clinical centres in 19 countries as of Sept 24, 2018. Patients were eligible if they had completed the phase 3 APOLLO or phase 2 OLE parent studies and tolerated the study drug. Eligible patients from APOLLO (patisiran and placebo groups) and the phase 2 OLE (patisiran group) studies enrolled in this global OLE trial and received patisiran 0·3 mg/kg by intravenous infusion every 3 weeks with plans to continue to do so for up to 5 years. Efficacy assessments included measures of polyneuropathy (modified Neuropathy Impairment Score +7 [mNIS+7]), quality of life, autonomic symptoms, nutritional status, disability, ambulation status, motor function, and cardiac stress, with analysis by study groups (APOLLO-placebo, APOLLO-patisiran, phase 2 OLE patisiran) based on allocation in the parent trial. The global OLE is ongoing with no new enrolment, and current findings are based on the interim analysis of the patients who had completed 12-month efficacy assessments as of the data cutoff. Safety analyses included all patients who received one or more dose of patisiran up to the data cutoff. This study is registered with ClinicalTrials.gov, NCT02510261.
Findings: Between July 13, 2015, and Aug 21, 2017, of 212 eligible patients, 211 were enrolled: 137 patients from the APOLLO-patisiran group, 49 from the APOLLO-placebo group, and 25 from the phase 2 OLE patisiran group. At the data cutoff on Sept 24, 2018, 126 (92%) of 137 patients from the APOLLO-patisiran group, 38 (78%) of 49 from the APOLLO-placebo group, and 25 (100%) of 25 from the phase 2 OLE patisiran group had completed 12-month assessments. At 12 months, improvements in mNIS+7 with patisiran were sustained from parent study baseline with treatment in the global OLE (APOLLO-patisiran mean change -4·0, 95 % CI -7·7 to -0·3; phase 2 OLE patisiran -4·7, -11·9 to 2·4). Mean mNIS+7 score improved from global OLE enrolment in the APOLLO-placebo group (mean change from global OLE enrolment -1·4, 95% CI -6·2 to 3·5). Overall, 204 (97%) of 211 patients reported adverse events, 82 (39%) reported serious adverse events, and there were 23 (11%) deaths. Serious adverse events were more frequent in the APOLLO-placebo group (28 [57%] of 49) than in the APOLLO-patisiran (48 [35%] of 137) or phase 2 OLE patisiran (six [24%] of 25) groups. The most common treatment-related adverse event was mild or moderate infusion-related reactions. The frequency of deaths in the global OLE was higher in the APOLLO-placebo group (13 [27%] of 49), who had a higher disease burden than the APOLLO-patisiran (ten [7%] of 137) and phase 2 OLE patisiran (0 of 25) groups.
Interpretation: In this interim 12-month analysis of the ongoing global OLE study, patisiran appeared to maintain efficacy with an acceptable safety profile in patients with hereditary transthyretin-mediated amyloidosis with polyneuropathy. Continued long-term follow-up will be important for the overall assessment of safety and efficacy with patisiran.info:eu-repo/semantics/publishedVersio
Global variation in postoperative mortality and complications after cancer surgery: a multicentre, prospective cohort study in 82 countries
- Author
- A Yacoub Mina
- A. Adam Mohammed
- A. Nassar Mahmoud
- A.Nemer Ayoob
- Aahlin Eirik Kjus
- Ab Rahim Mohd Fadliyazid
- Abad Gurumeta Alfredo
- Abad-Motos Ane
- Abang Jamari Dyg Zahratul Hamrak
- Abantanga Francis
- Abarca Sol
- Abazid Eias
- Abbas Abbas
- Abbas Khalid
- Abbas Mohammad Monir
- Abbasy Jibran
- Abbosh Ali
- Abd Karim Muhammad Fairuz Shah
- Abd Wahab Haidar Hadri
- Abd Barook
- Abdalei Abdulwahab
- Abdalla Ahmed Elkamel Ahmed
- Abdallah Aya
- AbdAllah Mostafa Salim Mohamed
- Abdel Malik Abu Baker
- Abdelhady Mousa Heba
- Abdelhady Samar
- Abdelhakim Ahmed
- Abdelkader Muhammad
- Abdelkawy Shaza
- Abdelkhalek Mohamed
- Abdellatif Esraa
- Abdelmaksoud Tawakel Noura
- Abdelmohsen Naglaa
- Abdelmotaleb Ibrahem
- Abdelrazek Aly
- Abdelsalam Israa
- Abdelshakour Mahmoud
- Abdelwahed Ahmed Mohamed
- Abdou Abdulrahman Osama
- Abdou Alrawy
- Abdou Hossam
- Abdul Aziz Mohamed Rezal
- Abdul Aziz Nora
- Abdulgawad Almogy Mariam
- Abdulla Mazin A.
- Abdullah Muhammad Tariq
- Abdullahi Lawal
- Abdullayev Seymur
- Abed Saeed
- Abelló David
- Abiola Olajide
- Abo mahadi Asmaa'
- Abo-khammash Areej
- Abou Chaar Mohamad K.
- Abou El.soud Moustafa Ramadan
- Abouelsoad Nervana
- Abraham Joyner
- Abreu da Silva Alberto
- Abu Ahammala Ayman B.
- Abu Al Amrain Mahmoud
- Abu Al-saleem Hasan
- Abu Alamrain Abdulwhhab
- Abu Alqumboz Amjad
- Abu Ataya Ahmed
- Abu hallalah Muad fathi khalleefah
- Abu Jamie Najlaa
- Abu Jayyab Israa
- Abu shua'ib Rana
- Abu Zainah Baraa
- Abu-Nimeh Samar
- Abu-Rous Mohammed R.
- Abu-srour Abrar
- Abuelhatal Hasan
- Abuelqomboz Ayham
- Abuhilal Baseel
- Abuhlaiga Ma'aly
- Abujamra Saleh
- Abukhalaf Sadi A.
- Abusalem Lana
- AbuSirrees Mahmoud
- Acevedo Veronica
- Acharya Rajgopal
- Achkasov Sergey
- Acosta Eric
- Adamo Karin
- Adamou Harissou
- Adams Jamie
- Adams Lawrence
- Adawi Samer
- Adebanjo Ademola
- Adel Marina
- Adel Sawsan
- Ademuyiwa Adesoji
- Ademuyiwa Adesoji
- Adenuga Adedire
- Aderounmu Adewale
- Adesanya Opeoluwa
- Adesina Alaba
- Adesunkanmi Abdul-Rashid
- Adeyeye Ademola
- Adidharma Peter
- Adisa Adewale O
- Adnan Nour
- Afifi Amr Abdelghani
- Afifi Eman
- Afolayan Michael Olatunji
- Afzal Asma
- Agarwal Arnav
- Agarwal Raksheeth
- Agbakwuru Augustine
- Agbeko Anita Eseenam
- Aguilar Martinez Maria Del Mar
- Aguilera Maria Lorena
- Aguilera-Arevalo Maria-Lorena
- Ahlqvist Sandra
- Ahmad Izzuddin Ahmad Imran
- Ahmad Kasim
- Ahmad Sarwat
- Ahmed Ahmedgaber
- Ahmed Hazem Abdelkarem
- Ahmed Mariam
- Ahmed Nabila
- Ahmed Zahra
- Ainoa Eppu
- Aithie Joanna M S
- Ajani Costanza
- Ajao Akinlabi
- Ajiboye Anthony
- Ajmera Ankit
- Akande Oluwatosin
- Akaydin Elif
- Akbaba Ata Cem
- Akbar Sana Amir
- Akeel Nouf
- Akeem Aderogba Adeleke
- Akin Alp
- Akinkuolie Akinbolaji
- Akisheva Aygulya
- Akitikori Mabel Temisanren
- Akrida Ioanna
- Aktas Melik Kagan
- Al basos Iyad
- Al Farsi Maryam
- Al Nassrallah Majdi
- Al Sagheir Eman
- Al Saqqa Sara
- Al Saqqa Sara
- Al-Allaf Omar
- Al-Busaidi Ibrahim S.
- Al-Dhufri Ali
- Al-Himyari Hamza S.
- Al-Masri Mahmoud
- Al-Najjar Hani
- Al-Sabbagh Yusra
- Al-Shwaikh Samar
- Al-Slaibi Ibrahim
- Al-Taher Raed
- Al-Tammam Hiba
- Alabuzidi Aya
- Alagha Othman
- Alammarin Mohammad
- Alapatt John
- Alasttal Mohammed
- Alatise Olusegun Isaac
- Albaggar Marwa
- Albahnasawi Moath A.
- Albati Naif
- Alberga Anna
- Alberts Justin
- AlBsoul Ahmad
- Albsoul Nader
- Alcorta Rodrigo
- Alejandre Villalobos Cristina
- Alemdag Gökçe nur
- Alexander Philip
- Alfarra Nada
- Alfitory Asma
- Alhabil Belal
- Alhaj Ahmad
- Alherz Mohammad
- Alhimyar Maryam
- Ali Ahmad Syed Mustafa
- Ali SANI Samuel
- Ali Amr
- Ali Asmaa
- Ali Mahmoud
- Ali Shabina
- Alimi Marjan
- Aliosin Oleg
- Aliyu Halima
- Aljaafreh Almoutuz
- Aljaber Dana
- Aljaberi Loay
- Aljanfi Asma
- Aljiffry Murad
- Aljohmani Lylas
- Alkhaledi Ahmad
- Alkhatib Ala'a Aldeen
- Alkhatib Haya
- Alkhatib Mo'min
- Allen Ingabire J.C.
- Almasri Murad
- Almeida Braga Sara
- Almeida Filipe
- Almigheerbi Alabas
- Almoqayyad Abdelrahman
- Almuzghi Fakhruddin
- Alnoury Mostafa
- Alonso Batanero Ester
- Alqadi Mohammad
- Alsaid Bayan
- Alsalameh Barah
- Alsallaq Osama
- Alser Osaid
- Alshaar Muhammad
- Alsharef Tagwa
- Alsharqawi Nourah
- Alswerki Mohammad
- Altaf Amna
- Altaf Rabiya
- AlTaweel Mohammed
- Althini Abdulmunem Ahmed Mustafa
- Altibi Ahmed M.
- Altinel Yuksel
- Altiner Saygin
- Altomare Donato Francesco
- Altumei Zohoor
- Alvarez Rivera Alvaro Eduardo
- Alvarez-Cano Alethia
- Alves do Canto Brum Homero
- Alves Daniela Macedo
- Alves Magda
- Alvi Abdul
- Alwaheidi Malak
- Alwali Abdallah
- Alwerfally AbdulMawlay
- Alwhaidi Noor
- Alyafi Amr
- Alzabti Fatima
- Alzahaf Ahmed
- AlZohour Mohammad
- Amadou Magagi Ibrahim
- Amandito Radhian
- Amarin Justin Z.
- Amaro Margarida
- Ambrazevicius Marijus
- Amendola Alfonso
- Amin Leila
- Amine Souadka
- Amjad Talal
- Amorim Edgar
- Amro Adham
- Anandan Premkumar
- Anas khalifa Rawda
- Anastasio Lorenzo
- Andersson Yvette
- Andreotti Dario
- Andrew David
- André Benoît
- Ang Sue Ean
- Angel Miguel
- Anggita Gultom Phebe
- Annapureddy Naga
- Anokhin Evgeny
- Ansaloni Luca
- Ansarei Dhirar
- Ansari Abdul Basit
- Antaky Marco
- Anthony Natasha
- Anthoulakis Christos
- Antonopoulou Maria Ioanna
- Anwar Mohamed
- Anwer Abdul Wahid
- Anyanwu Chikamuche
- Anyanwu Lofty-John
- Anyanwu Mercy Chinemerem
- Anyomih Theophilus Teddy Kojo
- Appukuttan Akhila
- Aquilino Fabrizio
- Archibald Jess
- Arciénega Yañez María del pilar
- Argentou Maria-Ioanna
- Argudo Nuria
- Argyriou Eleftherios Orestis
- Arias Madrid Natalia
- Aribi Sarra
- Arifin Ghafur Rasyid
- Arizpe Daniel
- Arnaud Alexis P
- Arora Bharti
- Arora Deeksha
- Arowolo Olukayode
- Arrangoiz Rodrigo
- Arslan Ekin
- Artigau Eva
- Ashfaq Ahsan
- Ashour Dina
- Ashour Firas
- Ashoushan Hana
- Ashraf Ahmed
- Ashraf Alaa
- Asif Ashar
- Asnel Dorisme
- Asok Anjitha
- Assa Rawan
- Assalhi Mohamed
- Asta Martina
- Asti Emanuele Luigi Giuseppe
- Atakul Onur
- Atallah Khalid
- Atanasov Boyko
- Atawneh Mohammad
- Athamneh Sarah
- Ather Muaaz
- Athisayaraj Thomas
- Atkociunas Aivaras
- Attia Mohamed
- Au Angela
- Awad Israa
- Awadallah Haneen
- Awaji Kholoud
- Awesat Eman
- Awolowo Ajibola
- Ayandipo Omobolaji
- Ayash Mohammad
- Ayau Fernanda
- Ayesh Kholoud
- Ayman El-sawy Esraa
- Ayoub Rami
- Aytac Erman
- Ayub Bushra
- Ayub Saima
- Ayyad Rawan
- Azevedo José
- Azodo Ijeoma
- Azzubia Joma
- B L Ashika
- Ba Mouhamadou Bachir
- Babaa Basheer
- Babirye Lilian
- Bacic Ivan
- Badr Esraa Tarek
- Badr Helmy
- Badran Abdul
- Badwe Rajendra
- Bafford Andrea Chao M.D.
- Baggaley Caitlin
- Bahroun Sumayyah Ghayth
- Baiao José Miguel
- Baiocchi Daniella
- Bairos Menezes Maria
- Baiu Ioana
- Bajilan Mohammad
- Bajomo Oreoluwa
- Bake Jacques
- Baki Bahadir Emre
- Bakoleas Panagiotis
- Balaawi Reem
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- Dominguez Joaquina
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- Hall Timothy
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- Zahran Diaaaldin
- Zakaria Andee Dzulkarnaen
- Zakaria Mai
- Zakaria Omar
- Zakaria Zaidi
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- Zammit Matthew
- Zanini Nicola
- Zara Vlu Jean
- Zara Vlu Jean
- Zarti Heba
- Zarzycki Piotr
- Zattoni Davide
- Zavala Gabriela
- Zawahrah Hassan
- Zeiton Asaid
- Zeko Amanda
- Zeng Zhi
- Zeromskas Paulius
- Zhang Geoffrey
- Zhivkov Evgeni
- Zid Esraa
- Zidan Ahmed Mohy
- Zielasek Christian
- Zilinskas Justas
- Zimmermann Bernd
- Ziprin Paul
- Zizzo Maurizio
- Zografos George
- Zoikas Athanasios
- Zorrilla Matilla Laura Patricia
- Zoulamoglou Menelaos
- Zreeg Dafer
- Zub-Pokrowiecka Anna
- Zubiaurre Vanessa
- Zuhdy Mohammed
- Zuikyte Diana
- Zuloaga Fernandez del Valle Carlos Jose
- Zulu Stanley
- Ângelo Miguel
- Älgå Andreas
- Çolak Elif
- Ümarik Toomas
- Šatkauskas Mindaugas
- Škimelyte Monika
- Šlenfuktas Vygintas
- Šuman Oliver
- Žatecký Jan
- Žumbakys Žygimantas
- Župan Domagoj
- Publication venue
- 'Elsevier BV'
- Publication date
- 30/01/2021
- Field of study
© 2021 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 licenseBackground: 80% of individuals with cancer will require a surgical procedure, yet little comparative data exist on early outcomes in low-income and middle-income countries (LMICs). We compared postoperative outcomes in breast, colorectal, and gastric cancer surgery in hospitals worldwide, focusing on the effect of disease stage and complications on postoperative mortality. Methods: This was a multicentre, international prospective cohort study of consecutive adult patients undergoing surgery for primary breast, colorectal, or gastric cancer requiring a skin incision done under general or neuraxial anaesthesia. The primary outcome was death or major complication within 30 days of surgery. Multilevel logistic regression determined relationships within three-level nested models of patients within hospitals and countries. Hospital-level infrastructure effects were explored with three-way mediation analyses. This study was registered with ClinicalTrials.gov, NCT03471494. Findings: Between April 1, 2018, and Jan 31, 2019, we enrolled 15 958 patients from 428 hospitals in 82 countries (high income 9106 patients, 31 countries; upper-middle income 2721 patients, 23 countries; or lower-middle income 4131 patients, 28 countries). Patients in LMICs presented with more advanced disease compared with patients in high-income countries. 30-day mortality was higher for gastric cancer in low-income or lower-middle-income countries (adjusted odds ratio 3·72, 95% CI 1·70–8·16) and for colorectal cancer in low-income or lower-middle-income countries (4·59, 2·39–8·80) and upper-middle-income countries (2·06, 1·11–3·83). No difference in 30-day mortality was seen in breast cancer. The proportion of patients who died after a major complication was greatest in low-income or lower-middle-income countries (6·15, 3·26–11·59) and upper-middle-income countries (3·89, 2·08–7·29). Postoperative death after complications was partly explained by patient factors (60%) and partly by hospital or country (40%). The absence of consistently available postoperative care facilities was associated with seven to 10 more deaths per 100 major complications in LMICs. Cancer stage alone explained little of the early variation in mortality or postoperative complications. Interpretation: Higher levels of mortality after cancer surgery in LMICs was not fully explained by later presentation of disease. The capacity to rescue patients from surgical complications is a tangible opportunity for meaningful intervention. Early death after cancer surgery might be reduced by policies focusing on strengthening perioperative care systems to detect and intervene in common complications. Funding: National Institute for Health Research Global Health Research Unit
Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study
- Author
- A Yacoub Mina
- A. Adam Mohammed
- A. Nassar Mahmoud
- A.Nemer Ayoob
- Aahlin Eirik Kjus
- Ab Rahim Mohd Fadliyazid
- Abad Gurumeta Alfredo
- Abad-Motos Ane
- Abang Jamari Dyg Zahratul Hamrak
- Abantanga Francis
- Abarca Sol
- Abazid Eias
- Abbas Abbas
- Abbas Khalid
- Abbas Mohammad Monir
- Abbasy Jibran
- Abbosh Ali
- Abd Karim Muhammad Fairuz Shah
- Abd Wahab Haidar Hadri
- Abd Barook
- Abdalei Abdulwahab
- Abdalla Ahmed Elkamel Ahmed
- Abdallah Aya
- AbdAllah Mostafa Salim Mohamed
- Abdel Malik Abu Baker
- Abdelhady Mousa Heba
- Abdelhady Samar
- Abdelhakim Ahmed
- Abdelkader Muhammad
- Abdelkawy Shaza
- Abdelkhalek Mohamed
- Abdellatif Esraa
- Abdelmaksoud Tawakel Noura
- Abdelmohsen Naglaa
- Abdelmotaleb Ibrahem
- Abdelrazek Aly
- Abdelsalam Israa
- Abdelshakour Mahmoud
- Abdelwahed Ahmed Mohamed
- Abdou Abdulrahman Osama
- Abdou Alrawy
- Abdou Hossam
- Abdul Aziz Mohamed Rezal
- Abdul Aziz Nora
- Abdulgawad Almogy Mariam
- Abdulla Mazin A.
- Abdullah Muhammad Tariq
- Abdullahi Lawal
- Abdullayev Seymur
- Abed Saeed
- Abelló David
- Abiola Olajide
- Abo mahadi Asmaa'
- Abo-khammash Areej
- Abou Chaar Mohamad K.
- Abou El.soud Moustafa Ramadan
- Abouelsoad Nervana
- Abraham Joyner
- Abreu da Silva Alberto
- Abu Ahammala Ayman B.
- Abu Al Amrain Mahmoud
- Abu Al-saleem Hasan
- Abu Alamrain Abdulwhhab
- Abu Alqumboz Amjad
- Abu Ataya Ahmed
- Abu hallalah Muad fathi khalleefah
- Abu Jamie Najlaa
- Abu Jayyab Israa
- Abu shua'ib Rana
- Abu Zainah Baraa
- Abu-Nimeh Samar
- Abu-Rous Mohammed R.
- Abu-srour Abrar
- Abuelhatal Hasan
- Abuelqomboz Ayham
- Abuhilal Baseel
- Abuhlaiga Ma'aly
- Abujamra Saleh
- Abukhalaf Sadi A.
- Abusalem Lana
- AbuSirrees Mahmoud
- Acevedo Veronica
- Acharya Rajgopal
- Achkasov Sergey
- Acosta Eric
- Adamo Karin
- Adamou Harissou
- Adams Jamie
- Adams Lawrence
- Adawi Samer
- Adebanjo Ademola
- Adel Marina
- Adel Sawsan
- Ademuyiwa Adesoji
- Ademuyiwa Adesoji O
- Adenuga Adedire
- Aderounmu Adewale
- Adesanya Opeoluwa
- Adesina Alaba
- Adesunkanmi Abdul-Rashid
- Adeyeye Ademola
- Adidharma Peter
- Adisa Adewale
- Adisa Adewale O
- Adnan Nour
- Afifi Amr Abdelghani
- Afifi Eman
- Afolayan Michael Olatunji
- Afzal Asma
- Agarwal Arnav
- Agarwal Raksheeth
- Agbakwuru Augustine
- Agbeko Anita Eseenam
- Aguilar Martinez Maria Del Mar
- Aguilera Maria Lorena
- Aguilera-Arevalo Maria-Lorena
- Ahlqvist Sandra
- Ahmad Izzuddin Ahmad Imran
- Ahmad Kasim
- Ahmad Sarwat
- Ahmed Ahmedgaber
- Ahmed Hazem Abdelkarem
- Ahmed Mariam
- Ahmed Nabila
- Ahmed Zahra
- Ainoa Eppu
- Aithie Joanna M S
- Ajani Costanza
- Ajao Akinlabi
- Ajiboye Anthony
- Ajmera Ankit
- Akande Oluwatosin
- Akaydin Elif
- Akbaba Ata Cem
- Akbar Sana Amir
- Akeel Nouf
- Akeem Aderogba Adeleke
- Akin Alp
- Akinkuolie Akinbolaji
- Akisheva Aygulya
- Akitikori Mabel Temisanren
- Akrida Ioanna
- Aktas Melik Kagan
- Al basos Iyad
- Al Farsi Maryam
- Al Nassrallah Majdi
- Al Sagheir Eman
- Al Saqqa Sara
- Al Saqqa Sara
- Al-Allaf Omar
- Al-Busaidi Ibrahim S.
- Al-Dhufri Ali
- Al-Himyari Hamza S.
- Al-Masri Mahmoud
- Al-Najjar Hani
- Al-Sabbagh Yusra
- Al-Shwaikh Samar
- Al-Slaibi Ibrahim
- Al-Taher Raed
- Al-Tammam Hiba
- Alabuzidi Aya
- Alagha Othman
- Alammarin Mohammad
- Alapatt John
- Alasttal Mohammed
- Alatise Olusegun Isaac
- Albaggar Marwa
- Albahnasawi Moath A.
- Albati Naif
- Alberga Anna
- Alberts Justin
- AlBsoul Ahmad
- Albsoul Nader
- Alcorta Rodrigo
- Alejandre Villalobos Cristina
- Alemdağ Gökçe nur
- Alexander Philip
- Alfarra Nada
- Alfitory Asma
- Alhabil Belal
- Alhaj Ahmad
- Alherz Mohammad
- Alhimyar Maryam
- Ali Ahmad Syed Mustafa
- Ali SANI Samuel
- Ali Amr
- Ali Asmaa
- Ali Mahmoud
- Ali Shabina
- Alimi Marjan
- Aliosin Oleg
- Aliyu Halima
- Aljaafreh Almoutuz
- Aljaber Dana
- Aljaberi Loay
- Aljanfi Asma
- Aljiffry Murad
- Aljohmani Lylas
- Alkhaledi Ahmad
- Alkhatib Ala'a Aldeen
- Alkhatib Haya
- Alkhatib Mo'min
- Allen Ingabire J.C.
- Almasri Murad
- Almeida Braga Sara
- Almeida Filipe
- Almigheerbi Alabas
- Almoqayyad Abdelrahman
- Almuzghi Fakhruddin
- Alnoury Mostafa
- Alonso Batanero Ester
- Alqadi Mohammad
- Alsaid Bayan
- Alsalameh Barah
- Alsallaq Osama
- Alser Osaid
- Alshaar Muhammad
- Alsharef Tagwa
- Alsharqawi Nourah
- Alswerki Mohammad
- Altaf Amna
- Altaf Rabiya
- AlTaweel Mohammed
- Althini Abdulmunem Ahmed Mustafa
- Altibi Ahmed M.
- Altinel Yuksel
- Altiner Saygin
- Altomare Donato Francesco
- Altumei Zohoor
- Alvarez Rivera Alvaro Eduardo
- Alvarez-Cano Alethia
- Alves do Canto Brum Homero
- Alves Daniela Macedo
- Alves Magda
- Alvi Abdul
- Alwaheidi Malak
- Alwali Abdallah
- Alwerfally AbdulMawlay
- Alwhaidi Noor
- Alyafi Amr
- Alzabti Fatima
- Alzahaf Ahmed
- AlZohour Mohammad
- Amadou Magagi Ibrahim
- Amandito Radhian
- Amarin Justin Z.
- Amaro Margarida
- Ambrazevicius Marijus
- Amendola Alfonso
- Amin Leila
- Amine Souadka
- Amjad Talal
- Amorim Edgar
- Amro Adham
- Anandan Premkumar
- Anas khalifa Rawda
- Anastasio Lorenzo
- Andersson Yvette
- Andreotti Dario
- Andrew David
- André Benoît
- Ang Sue Ean
- Angel Miguel
- Anggita Gultom Phebe
- Annapureddy Naga
- Anokhin Evgeny
- Ansaloni Luca
- Ansarei Dhirar
- Ansari Abdul Basit
- Antaky Marco
- Anthony Natasha
- Anthoulakis Christos
- Antonopoulou Maria Ioanna
- Anwar Mohamed
- Anwer Abdul Wahid
- Anyanwu Chikamuche
- Anyanwu Lofty-John
- Anyanwu Mercy Chinemerem
- Anyomih Theophilus Teddy Kojo
- Appukuttan Akhila
- Aquilino Fabrizio
- Archibald Jess
- Arciénega Yañez María del pilar
- Argentou Maria-Ioanna
- Argudo Nuria
- Argyriou Eleftherios Orestis
- Arias Madrid Natalia
- Aribi Sarra
- Arifin Ghafur Rasyid
- Arizpe Daniel
- Arnaud Alexis P
- Arora Bharti
- Arora Deeksha
- Arowolo Olukayode
- Arrangoiz Rodrigo
- Arslan Ekin
- Artigau Eva
- Ashfaq Ahsan
- Ashour Dina
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- Ashoushan Hana
- Ashraf Ahmed
- Ashraf Alaa
- Asif Ashar
- Asnel Dorisme
- Asok Anjitha
- Assa Rawan
- Assalhi Mohamed
- Asta Martina
- Asti Emanuele Luigi Giuseppe
- Atakul Onur
- Atallah Khalid
- Atanasov Boyko
- Atawneh Mohammad
- Athamneh Sarah
- Ather Muaaz
- Athisayaraj Thomas
- Atkociunas Aivaras
- Attia Mohamed
- Au Angela
- Awad Israa
- Awadallah Haneen
- Awaji Kholoud
- Awesat Eman
- Awolowo Ajibola
- Ayandipo Omobolaji
- Ayash Mohammad
- Ayau Fernanda
- Ayesh Kholoud
- Ayman El-sawy Esraa
- Ayoub Rami
- Aytac Erman
- Ayub Bushra
- Ayub Saima
- Ayyad Rawan
- Azevedo José
- Azodo Ijeoma
- Azzubia Joma
- B L Ashika
- Ba Mouhamadou Bachir
- Babaa Basheer
- Babirye Lilian
- Bacic Ivan
- Badr Esraa Tarek
- Badr Helmy
- Badran Abdul
- Badwe Rajendra
- Bafford Andrea Chao M.D.
- Baggaley Caitlin
- Bahroun Sumayyah Ghayth
- Baiao José Miguel
- Baiocchi Daniella
- Bairos Menezes Maria
- Baiu Ioana
- Bajilan Mohammad
- Bajomo Oreoluwa
- Bake Jacques
- Baki Bahadir Emre
- Bakoleas Panagiotis
- Balaawi Reem
- Balalis Dimitrios
- Balata Mohamed
- Balkarov Artem
- Ballouhey Quentin
- Balogun Olanrewaju
- Baloyiannis Ioannis
- Baltaci Ege
- Bamaca Ixcajoc Elvis Benjamin
- Banaz Tuba
- Banda Bitiel
- Banglani Muntaha
- Bani Hani Farah
- Bani hani Mohammad
- Bani hani Zeina
- Baniowda Muath
- Banks Alexander
- Bannister Sharon
- Baranyai Zsolt
- Barati Nastaran
- Barbosa Camacho Francisco José
- Barbosa José
- Bardos David
- Barendegere Venerand
- Barghuthi Lutfi
- Barhoush Ola
- Barnes Nicole
- Baronio Gianluca
- Barreda Zelaya Lilian Elizabeth
- Barrera López Francisco Javier
- Barsic Neven
- Barter Charlotte
- Bartosiak Katarzyna
- Basarab Maksym
- Basso Stefano Maria Massimiliano.
- Bastiaenen Vivian
- Batashki Ilia
- Bath Michael
- Beattie Miriam
- Bedada Alemayehu Ginbo
- Belais Fanny
- Belal qadomi Asef
- Belev Nikolay
- Belli Andrea
- Beltrán de Heredia Juan
- Belvedere Angela
- Ben Dallah Najah
- Ben Saoud Abdulsalam Ali
- Bengur Fuat Baris
- Benkabbou Amine
- Benke Marton
- Benyaiche Chaymae
- Bergeat Damien
- Bernstein Mitchell
- Beshtawi Doha
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- Beuran Mircea
- Bhandare Manish
- Bhangu Aneel
- Bhatti Muhammad Iqbal
- Bianchini Stefania
- Bianco Francesco
- Bibas Fatma
- Biccard Bruce M
- Bielosludtsev Oleksii
- Bienfait Mumbere
- Billy Matthew
- Bin Mohamad Sithik Muhammad Navid
- Binetti Margherita
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- Blunnie Eimear
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- Bogusevicius Algirdas
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- Borghi Felice
- Borham Hala
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- Venskutonis Donatas
- Venturelli Paolina
- Venturini Sara
- Verdaguer Tremolosa Mireia
- Vergara María
- Vergara-Fernandez Omar
- Verjee Azmina
- Vervoort Dominique
- Vescio Giuseppina
- Viacheslav Nezamai
- Vicario Bravo Marina
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- Vieira Barros Aldo
- Vieira Caroço Teresa
- Vieira Ana
- Vieira Bárbara
- Vigorita Vincenzo
- Vijeyan Harinthiran
- Viljoen Francois
- Villalobos Santiago
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- Volovetskyi Anton
- Wafaa Mariam
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- Wakkaf Habib
- Wall Ellen
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- Walędziak Maciej
- Wan Khazim Wan Khamizar
- Wan Muhmad Wan Farahiyah
- Wandschneider Wiebke
- Wanniang Cliff
- Waqar Shahzad Hussain
- Warden Claire
- Warren Craig Russell
- Warren Oliver
- Warwick Andrea
- Warwicker Sean
- Wason Deepender
- Waterman Ade
- Watts Daniel
- Weiser Thomas G
- Welch Matthew
- Wellington Jack
- Wells Anna
- Wells Cameron
- West Malcolm
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- Weyl Ariane
- Whisker Lisa
- Whitaker John
- White Rebecca
- Wiberg Rebecca
- Widmer Lukas Werner
- Wierdak Mateusz
- Wijekoon Arachchilage Nimeshi
- Wilguens Lartigue Jean
- Willemin Melissa
- Williams Christopher Yee Khang
- Wills Vanessa
- Wilson Karim
- Wilson Michael
- Wimmer Kerstin
- Windsor John
- Wineberg Devorah
- Winiarski Marek
- Winoto Hadi
- Winter Beatty Jasmine
- Winter Des
- Wisal Maham
- Wisselink Daan
- Wogensen Fredrik
- Wondoh Paul M.
- Wong Florence
- Wong Hsu Ven
- Wong Jane J
- Wong Jeremy
- Wong Lai Fen
- Wong Michael Pak-Kai
- Wong Sui-Weng
- Wong Tsz Lun Ernest
- Wood Lauren
- Woon-Shoo-Tong Xiao-Ming Sarah
- Wren Sherry
- Wuraola Funmilola
- Xanthopoulou Georgia
- Yabut Kenneth
- Yacoub Aseel
- Yaghi Nadine
- Yaghi Yasmine
- Yahia Mohamed Ali Mohamed
- Yakushkina Al'ona
- Yalçinkaya Ali
- Yang P Zichu
- Yanikoğlu Erkan
- Yanni Fady
- Yates Charlotte
- Ye Geoffrey
- Yeen Chin Leow
- Yemez Kürşat
- Yenidünya Nilüfer
- Yenli Edwin
- Yeo Jeremy
- Yeoh Andrea
- Yepez Raul
- Yeşilsancak Merve
- Yildirim Reyyan
- Yildiz Alp
- Yilmaz Duygu
- Yip Ching Wan
- Ylatoma Díaz Edgar Alcides
- Yong Shun Qi
- Yoong Andrel
- Yorke Joseph
- Yotsov Tsanko
- You Lucia
- Younes Eman
- Younes Maha
- Yousry Basant
- Yozgatli Tahir Koray
- Yu Kristin
- Yue Sum Yu Pansy
- Yunes Asmaa
- Yusuf Baasil
- Yüksel Osman
- Zabiyaka Mikhail
- Zachariah Sanoop Koshy
- Zafar Syed Nabeel
- Zaffaroni Gloria
- Zahra Baryab
- Zahran Diaaaldin
- Zakaria Andee Dzulkarnaen
- Zakaria Mai
- Zakaria Omar
- Zakaria Zaidi
- Zambrana Campos Vanesa
- Zammit Matthew
- Zanini Nicola
- Zara Vlu Jean
- Zarti Heba
- Zarzycki Piotr
- Zattoni Davide
- Zavala Gabriela
- Zawahrah Hassan
- Zeiton Asaid
- Zeko Amanda
- Zeng Zhi
- Zeromskas Paulius
- Zhang Geoffrey
- Zhivkov Evgeni
- Zid Esraa
- Zidan Ahmed Mohy
- Zielasek Christian
- Zilinskas Justas
- Zimmermann Bernd
- Ziprin Paul
- Zizzo Maurizio
- Zografos George
- Zoikas Athanasios
- Zorrilla Matilla Laura Patricia
- Zoulamoglou Menelaos
- Zreeg Dafer
- Zub-Pokrowiecka Anna
- Zubiaurre Vanessa
- Zuhdy Mohammed
- Zuikyte Diana
- Zuloaga Fernandez del Valle Carlos Jose
- Zulu Stanley
- Ângelo Miguel
- Älgå Andreas
- Çolak Elif
- Ümarik Toomas
- Čepuliené Daiva
- Şahin Can
- Šatkauskas Mindaugas
- Škimelytè Monika
- Šlenfuktas Vygintas
- Šuman Oliver
- Žatecký Jan
- Žumbakys Žygimantas
- Župan Domagoj
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/07/2022
- Field of study
© 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 licenseBackground: Early death after cancer surgery is higher in low-income and middle-income countries (LMICs) compared with in high-income countries, yet the impact of facility characteristics on early postoperative outcomes is unknown. The aim of this study was to examine the association between hospital infrastructure, resource availability, and processes on early outcomes after cancer surgery worldwide. Methods: A multimethods analysis was performed as part of the GlobalSurg 3 study—a multicentre, international, prospective cohort study of patients who had surgery for breast, colorectal, or gastric cancer. The primary outcomes were 30-day mortality and 30-day major complication rates. Potentially beneficial hospital facilities were identified by variable selection to select those associated with 30-day mortality. Adjusted outcomes were determined using generalised estimating equations to account for patient characteristics and country-income group, with population stratification by hospital. Findings: Between April 1, 2018, and April 23, 2019, facility-level data were collected for 9685 patients across 238 hospitals in 66 countries (91 hospitals in 20 high-income countries; 57 hospitals in 19 upper-middle-income countries; and 90 hospitals in 27 low-income to lower-middle-income countries). The availability of five hospital facilities was inversely associated with mortality: ultrasound, CT scanner, critical care unit, opioid analgesia, and oncologist. After adjustment for case-mix and country income group, hospitals with three or fewer of these facilities (62 hospitals, 1294 patients) had higher mortality compared with those with four or five (adjusted odds ratio [OR] 3·85 [95% CI 2·58–5·75]; p<0·0001), with excess mortality predominantly explained by a limited capacity to rescue following the development of major complications (63·0% vs 82·7%; OR 0·35 [0·23–0·53]; p<0·0001). Across LMICs, improvements in hospital facilities would prevent one to three deaths for every 100 patients undergoing surgery for cancer. Interpretation: Hospitals with higher levels of infrastructure and resources have better outcomes after cancer surgery, independent of country income. Without urgent strengthening of hospital infrastructure and resources, the reductions in cancer-associated mortality associated with improved access will not be realised. Funding: National Institute for Health and Care Research
Risk of COVID-19 after natural infection or vaccinationResearch in context
- Author
- A. Lina Rosengren
- Abram Burgher
- Adam B. Brosz
- Adam Rosen
- Adam Schwartz
- Adriana Sordo Duran
- Adrienna Marquez
- Adrienne E. Shapiro
- Aeiress Duhart
- Afsoon Roberts
- Albert Liu
- Alejandro Hoberman
- Alejandro Quintín Barrat Hernández
- Alex Greninger
- Alexander Clark
- Alfredo Gilberto Guerreros Benavides
- Alice McGarry
- Alicia Arrazcaeta
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- Alison Pellecchia
- Allie Oplinger
- Allison Green
- Allison O'Brien
- Alpa Patel
- Alyssa-Kay Peay
- Amanda Horn
- Amanda Lilienthal
- Amanda Occhino
- Amanda Philyaw
- Amaran Moodley
- Amber Grant
- Amber Stanford
- Amesika Nyaku
- Amie Shannon
- Amina Z. Haggag
- Amit Paliwal
- Amy Caldwell
- Amy Chamberlain
- Amy Dye
- Amy Falk
- Amy Kelley
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- Trina L. Reynolds
- Troy Holdeman
- Tyler D. Bold
- Uriel R. Felsen
- Valentine M. Ebuh
- Valeria D. Cantos
- Valerie K. Arnold
- Vanessa Abad
- Vanessa Raabe
- Veronica G. Fragoso
- Veronica Garcia-Fragoso
- Veronica Procasky
- Veronica Viar
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- Vickie Leathers
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- Victoria Engler
- Victoria Mosteller
- Victoria R. Anderson
- Vida Veronica Ruiz Herrera
- Vincent Huynh
- Vincent Mirkil
- Vivek Rajasekhar
- Viviana Gonzalez
- Vladimir Berthaud
- Walter Patton
- Wanda Ramon
- Waseem Chughtai
- Wayne L. Harper
- Wayne Woo
- Wendell Lewis
- Wendell Lewis III
- Wendy A. Keitel
- Wesley Campbell
- Wesley Van Ever
- Westly Keating
- Whitney West
- Will Hernandez
- William B. Davis
- William B. Smith
- William H. Jones
- William Jennings
- William Kirby
- William P. Silver
- William R. Hartman
- William S. Davis Jr.
- William Schnitz
- William Seger
- Winniberg Stephany Alvarez León
- Winston Cavert
- Xiaomi Tong
- Yaa D. Oppong
- Yi H. Wu
- Ying Huang
- Yogesh K. Paliwal
- Youyi Fong
- Yunda Huang
- Yunda Huang
- Yvonne Davis
- Zachary Bittner
- Zainab Rizvi
- Zindy Yazmín Zárate Hinojosa
- Zudi-Mwak Takizala
- Publication venue
- Elsevier
- Publication date
- 01/10/2023
- Field of study
Summary: Background: While vaccines have established utility against COVID-19, phase 3 efficacy studies have generally not comprehensively evaluated protection provided by previous infection or hybrid immunity (previous infection plus vaccination). Individual patient data from US government-supported harmonized vaccine trials provide an unprecedented sample population to address this issue. We characterized the protective efficacy of previous SARS-CoV-2 infection and hybrid immunity against COVID-19 early in the pandemic over three-to six-month follow-up and compared with vaccine-associated protection. Methods: In this post-hoc cross-protocol analysis of the Moderna, AstraZeneca, Janssen, and Novavax COVID-19 vaccine clinical trials, we allocated participants into four groups based on previous-infection status at enrolment and treatment: no previous infection/placebo; previous infection/placebo; no previous infection/vaccine; and previous infection/vaccine. The main outcome was RT-PCR-confirmed COVID-19 >7–15 days (per original protocols) after final study injection. We calculated crude and adjusted efficacy measures. Findings: Previous infection/placebo participants had a 92% decreased risk of future COVID-19 compared to no previous infection/placebo participants (overall hazard ratio [HR] ratio: 0.08; 95% CI: 0.05–0.13). Among single-dose Janssen participants, hybrid immunity conferred greater protection than vaccine alone (HR: 0.03; 95% CI: 0.01–0.10). Too few infections were observed to draw statistical inferences comparing hybrid immunity to vaccine alone for other trials. Vaccination, previous infection, and hybrid immunity all provided near-complete protection against severe disease. Interpretation: Previous infection, any hybrid immunity, and two-dose vaccination all provided substantial protection against symptomatic and severe COVID-19 through the early Delta period. Thus, as a surrogate for natural infection, vaccination remains the safest approach to protection. Funding: National Institutes of Health
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Risk of COVID-19 after natural infection or vaccinationResearch in context
- Author
- Abad Vanessa
- Abate Getahun
- Abbas Anum
- Ackerman Jamie
- Ackerman Ronald
- Ackermann Jeremy
- Adams Atoya
- Adams Mark S.
- Adams Michael R.
- Adelglass Jeffrey
- Afework Sarah
- Ahmad Nina
- Akamine Christine
- Ake Julie A.
- Al-Ibrahim Mohamed S.
- Albert Gary
- Alcaide Maria L.
- Alderson Nathan
- Aleman Lily
- Alemán José O.
- Allaw Mohammed
- Alva E. Javier Pretell
- Alvarado Hilario
- Amador Carmen
- Andersen James
- Anderson Corey G.
- Anderson Evan J.
- Anderson Victoria R.
- Andes David R.
- Andrasik Michele P.
- Andree Stephanie
- Andrews Jeb
- Andriesen Jessica G.
- Andriulis Victoria
- Ansel Jessica L.
- Anthony Codi M.
- Antwi Mohammed
- Arduino Roberto C.
- Aristy Florida
- Arnold Valerie K.
- Arrazcaeta Alicia
- Atmar Robert L.
- Avworo Ayoade
- Bacher Christina
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- Baka Michele
- Baker Sherrie
- Balani Bindu
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- Peacock James
- Pearlman Laura
- Peay Alyssa-Kay
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- Pena-Renteria Issac
- Peraita Noris
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- Percy Donna
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- Rodman Shannon
- Rodriguez Carina A.
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- Vega Norma
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- Vertucci Michele
- Viar Veronica
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- Villegas Marysol
- Vingerhoets Johan
- Vogler Mary
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- Wilson Clint
- Wilson Greg
- Wilson Natasha
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- Winkle Peter J.
- Winokur Patricia L.
- Witbeck John
- Wohl David
- Woo Wayne
- Woodside Leana
- Wortman Glenn
- Wu Yi H.
- Wylie Paul E.
- Yang Fan
- Yang Kinara S.
- Yoon Anelgine C.
- York Jill
- Young Cheryl
- Yu Chenchen
- Yusin Joseph
- Zapata Luz
- Zash Rebecca
- Zegarra Eneyda Giuvanela Llerena
- Zemanek Arthur L.
- Zenlea Kate
- Zepeda Karla
- Zervos Marcus J.
- Zhai Nan
- Zhang Kevin
- Zhou James
- Zimmer Andrea
- Zingman Barry S.
- Zorrilla Carmen D.
- Áñez Germán
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/10/2023
- Field of study
Background: While vaccines have established utility against COVID-19, phase 3 efficacy studies have generally not comprehensively evaluated protection provided by previous infection or hybrid immunity (previous infection plus vaccination). Individual patient data from US government-supported harmonized vaccine trials provide an unprecedented sample population to address this issue. We characterized the protective efficacy of previous SARS-CoV-2 infection and hybrid immunity against COVID-19 early in the pandemic over three-to six-month follow-up and compared with vaccine-associated protection. Methods: In this post-hoc cross-protocol analysis of the Moderna, AstraZeneca, Janssen, and Novavax COVID-19 vaccine clinical trials, we allocated participants into four groups based on previous-infection status at enrolment and treatment: no previous infection/placebo; previous infection/placebo; no previous infection/vaccine; and previous infection/vaccine. The main outcome was RT-PCR-confirmed COVID-19 >7–15 days (per original protocols) after final study injection. We calculated crude and adjusted efficacy measures. Findings: Previous infection/placebo participants had a 92% decreased risk of future COVID-19 compared to no previous infection/placebo participants (overall hazard ratio [HR] ratio: 0.08; 95% CI: 0.05–0.13). Among single-dose Janssen participants, hybrid immunity conferred greater protection than vaccine alone (HR: 0.03; 95% CI: 0.01–0.10). Too few infections were observed to draw statistical inferences comparing hybrid immunity to vaccine alone for other trials. Vaccination, previous infection, and hybrid immunity all provided near-complete protection against severe disease. Interpretation: Previous infection, any hybrid immunity, and two-dose vaccination all provided substantial protection against symptomatic and severe COVID-19 through the early Delta period. Thus, as a surrogate for natural infection, vaccination remains the safest approach to protection. Funding: National Institutes of Health
Incidence of severe critical events in paediatric anaesthesia (APRICOT): a prospective multicentre observational study in 261 hospitals in Europe
- Author
- Aantaa Riku
- Abdel-Hafiz Mostafa
- Abdelaal Amr
- Abou-Samra Mark
- Absalom Anthony
- Acevedo Bambaren Ismael
- Adam Christian
- Adriaens Veronique
- Afshari Arash
- Ahmed Samira
- Alanoglu Zekeriyya
- Albarello Raffaella
- Albokrinov Andrew
- Alders David
- Alderson Peter
- Alexandri Bogdan
- Ali Eissa Eid Mohamed
- Alkis Neslihan
- Allen Claire
- Allison Celia
- Almenrader Nicole
- Amaral Rosa
- Amory Catherine
- Ancupans Agris
- Anders Kroken Bjørn
- Anders Nicola
- Angadi Pradeep
- Angeles Sanz M.
- Anselmi Irene
- Anselmi Luciano
- Antonio Idone Francesco
- Anuncia Escontrela Rodríguez Blanca
- Armoniene Inesa
- Artes David
- Aslami Hamid
- Astuto Marinella
- Audren Noémie
- Aurilio Caterina
- Ayyash Reema
- Babici Remus
- Badarau Victoria
- Badeti Rodica
- Baethge Sabine
- Bakken Boerke Wenche
- Balamat Stefania
- Bandrabur Daniela
- Banerjee Indrani
- Banus Ester
- Bapat Smita
- Baraggia Paolo
- Barak Yuri
- Baranowski Artur
- Barber Nicola
- Barbera Cinzia
- Barbunc Danut
- Bari Francoise
- Baris Sibel
- Barlow Victoria
- Barr Katharine
- Bartholomew Karen
- Bartkowska-Sniatkowska Alicja
- Barzdina Arta
- Basiewicz Ewa
- Basov Mikhail
- Bassett Mike
- Batoz Hélène
- Bauer Annette
- Bauer Martin
- Bauer Michael
- Baujard Catherine
- Bauwman Arthur
- Beate Solas Anne
- Becke Karin
- Becke Karin
- Begec Zekine
- Bekavac Ivan
- Bell Graham
- Bell Sarah J
- Benito Pilar
- Berger Jelena
- Berghmans Johan
- Bergland Unni
- Bergsma Margot
- Bermede Onat
- Bernhard Eich Christoph
- Bernotiene Aurelija
- Berton Jerome
- Bevilacqua Michela
- Bew Stephanie
- Bird Victoria
- Birliba Mihaela-Petronela
- Biskupova Vera
- Bloomfield Tom
- Blythe Elizabeth
- Boda Krisztina
- Boda Krisztina B
- Boegli Yann
- Bollinger Matthias
- Book Malte
- Bordes Maryline
- Bortone Luciano
- Boryshkevych Ivanna
- Bourdaud Nathalie
- Boyd Matthew
- Boyle David
- Bracci Paolo
- Brackhahn Michael
- Bradbury Carol L.
- Breschan Christian
- Brezac Gilles
- Briggs Sandra
- Brotatsch Philipp
- Browning Mike
- Budic Ivana
- Buhre Wolfgang
- Busche René
- Busi Ilaria
- Bussolin Leonardo
- Butkovic Diana
- Butler Patrick
- Byers Gordon
- Börjesson Glenda
- Bøttger Morten
- Cabanova Barbora
- Cagney Brid
- Cakar Turhan K. Sanem
- Calderini Edoardo
- Calvao Santos Carolina
- Camporesi Anna
- Camus Blandine
- Capusan Alin
- Carachi Peter
- Carre Anne-Charlotte
- Cartal Marielle
- Casaer Sari
- Castellheim Albert
- Casutt Mattias
- Catalina Ionescu Gabriela
- Cavalier Alison
- Cecini Mariateresa
- Cento Valeria
- Cerati Giorgia
- Cerne Uros
- Cerutti Elisabetta
- Cettler Maciej
- Ceuca Daniela
- Ceyda Meco Basak
- Chapotte Catherine
- Chazelet Chantal
- Checinska Magdalena
- Checuti Sarah
- Chee Lew-Chin
- Childs Sophie
- Chirichiello Luca
- Chizhov Dmitri
- Chlopin Mikhail
- Chloropoulou Pelagia
- Christian Nilsson Jens
- Chrysi Mpratzou
- Cigdem Tütüncü Ayse
- Cillis Annagrazia
- Cimpeanu Luminita
- Cindea Iulia
- Ciobanu Tudor
- Clausen Nicola G.
- Cloherty Marianne
- Cnudde Steven
- Cohen Marc
- Colbus Laurent
- Coppens Marc
- Corouge Julien
- Cortegiani Andrea
- Coucke Patricia
- Crawford Michael
- Cristina Mondardini Maria
- Cuciuc Veaceslav
- Cucui-Cozma Cosmina
- Cullen Julia
- Cullen Pauline
- Cumming Craig
- D'Alessandro Sandra
- Dadure Christophe
- Dahmani Souhayl
- Dalton Andrew
- Dalton Mark
- Damps Maria
- Darwin Leanne
- Daugelavicius Vidunas
- Davidescu Irina
- Davidson Sarah
- Davies Jack
- Davies Kay
- Davin Isabelle
- Davison Rachel
- Day Alexandra
- De Abreu Leidy
- de Graaff Jurgen C.
- De Groote Françoise
- De Hert Stefan
- De Josemaria Belen
- de la Brière Francois
- De La Cruz Benito Fausto
- De Lorenzo Brita
- De Melo Eric
- De Pooter Françoise
- De Smet Karen
- De Villé Andrée
- Debrabant Lise
- Dei Giudici Luigi
- Dekens Jacky
- Dekker Elsa
- del Río Cristina
- Delcuze Axelle
- Desjeux Luc
- Diacono Jacques
- Dickinson Matthew
- Didier Anne
- Diers Anja
- Dirckx Maaike
- Disma Nicola
- Disma Nicola
- Divák Jan
- Diwan Rishi
- Dix Philippa
- Djapic Dajana
- Dockiene Ilona
- Dogger Jaap
- Dolci Mirko
- Dolinaj Vladimir
- Domingas Patuleia M.
- Domínguez Fernando
- Dons-Sinke Ilse
- Dorman Teresa
- Draskovic Biljana
- Druot Emilie
- Duflo Frédéric
- Dumitru Rusu Florin
- Dupont Hervé
- Eberl Susanne
- Ecoffey Claude
- Ehm Birgit
- Eisner Christoph
- Eissa Ayman
- Elena Malos Anca
- Elizabeth Biercamp Claire
- Ellekvist Marguerite B.
- Ellerkmann Richard
- Ellwood James
- Engel Nicole
- Engelhardt Thomas
- Eniko Kovacs
- Ephraim Erik
- Erb Christian
- Erb Thomas
- Errass Loreen
- Fairgrieve Ross
- Faliszewski Isabella
- Farinelli Ivano
- Farquharson Pamela
- Feliu Montserrat
- Fiedler Fritz
- Fischer Thomas
- Fisher Haran
- Flewin Lisa
- Foster Brian
- Franco Teresa
- Fredrik Lund Ole
- Frelich Michal
- Frey Denise
- Fritzsche Katrin
- Funk Wolfgang
- Gabilondo Garcia Gustavo
- Gabriella Elena Clement Maria
- Gaebler Ralf
- Gagey Anne-Charlotte
- Gaidelyte Lina
- Galinescu Irena
- Galvin Deborah
- Gande Richard
- Gandhi Monica
- Garces Antonio
- García Irene
- Garrigue Delphine
- Garrioch Sweyn
- Gatt David
- Gaynor James
- Geary Tim
- Geil Dfominik
- Genco Daniele
- Gerin Marc
- Gerling Volker
- Germann Reinhard
- Gernoth Christian
- Gestautaite Dalia
- Ghent Robert
- Gillberg Lars
- Gillet Patricia
- Giuseppe Picardo Sergio
- Glasgow Russell
- Glazunov Anton
- Godsiff Leisha
- Goebel Ulrich
- Gomes Cristina
- Goncharenko Galyna
- Gonçalves Marta
- Gooch Ingrid
- Gordeeva Elena
- Grau Catharina
- Grazzini Maurizia
- Grein Elodie
- Grindheim Guro
- Grundmann Ulrich
- Grynyuk Andry
- Guarracino Fabio
- Guddo Annamaria
- Guedes Isabel
- Guericke Holger
- Guerin Christilynn
- Guido Locatelli Bruno
- Guillier Marion
- Gurita Adriana
- Gurita Adriana
- Guskov Igor
- Gutierrez Valcarcel Andrea
- Gutierrez Ignacio
- Gutmann Anton
- Guzman Ines
- Gymoese Berthelsen Kasper
- Habre Walid
- Habre Walid
- Hammerschlag Jacinda
- Hamonic Yann
- Hannie J.
- Hansen Tom G
- Hansen Tom G.
- Hanula Miloslav
- Happo Johanna
- Harden Alison
- Hare Alison
- Harlet Pierre
- Harmen Herrema Idse
- Harris Sarah
- Harrison Richard
- Hasani Antigona
- Hashimi Medita
- Hatipoglu Zehra
- Hawksworth Chris
- Hayem Catherine
- Hearn Robert
- Hedlund Lars
- Hein Maximilian
- Helena Gaitan M.
- Heli Litvic Dubravka
- Helm Emma
- Heyse Björn
- Himpe Dirk
- Hinz José
- Hivey Sarah
- Hizal Ayse
- Hobbs Amy
- Hochhold Christoph
- Hodgetts Vanessa
- Hoeft Andreas
- Hoehne Claudia
- Hofmann Ulrich
- Hogea Cristiana
- Holy Rolf
- Homer Rachel
- Hopman Geranne A. J.
- Horhota Lucian
- Huber Matthias
- Hullatt Laurence
- Hunter Catherine
- Hurni Thomas
- Hussain Nageena
- Hussey Joseph
- Hutchinson Adel
- Huygens Christel
- Hölzle Martin
- Ilie Luminita
- Ilksen Toprak Huseyin
- Ilmoja Mari-Liis
- Ingeborg Madsen Birgitte
- Ioannou Ioannis
- Iordanidou Despoina
- Ireland Nicholas
- Irwin Janice
- Isohanni Mika
- Isselhorst Carsten
- Ivani Giorgio
- Ivanov Alexander
- Ivascu Constantin
- Izzo Francesca
- Jack Ewan
- Jacomet Alfred
- Jacqmarcq Olivier
- Jamil Yosry
- jan Scheffer Gert
- Janjevic Dusanka
- Jeng Min Law Savio
- Jerome Kevin
- Jetzek-Zader Martin
- Jiménez Anabel
- Joao Susano Maria
- Johanne Lynch
- Johansen Mathias
- John Robert
- Johnston Graham
- Jokinen Johanna
- Jones Gareth
- Joukes Ellen
- Julien-Marsollier Florence
- Jureckova Lucie
- Juzwa Magdalena
- Jöhr Martin
- Jöhr Martin
- Kachko Ludmyla
- Kahn David
- Kalagac Fabris Lada
- Kalliardou Evagelia
- Kappen Teus H.
- Karadeniz Meltem Savran
- Karjagin Juri
- Katz Jacob
- Kaufmann Nils
- Kazak Bengisun Zuleyha
- Keilhauer Julia
- Kelgeri Nivedita
- Kemal Arslantas Mustafa
- Kendigelen Pinar
- Kerovec Soric Ivana
- Kesic-Valpotic Gordana
- Khaffaf Ranj
- Khotcholava Magda
- Khrapak Maksym
- Kienbaum Peter
- Kikas Reet
- Kindermann Petra
- King Stephanie
- Kirilov Dmitry
- Kirton Christine
- Kiviluoma Kai
- Klimscha Walter
- Kloessing Jan
- Klymenko Tetyana
- Knauss Kristina
- Knezevic Mirjana
- Kochkin Vladimir
- Koessler Herbert
- Konecny Regina
- Kopycinska Renata
- Kortgen Andreas
- Kotecha Ami
- Kotzeva Svetlana
- Kranke Peter
- Krikstaponiene Jolita
- Kroess Ruth
- Kuehhirt Thomas
- Kuppers Beate
- Kusnirikova Zuzana
- Kyselova Iryna
- Ladak Nadia
- Laffargue Anne
- Lagarde Sylvaine
- Lako Sandra
- Lalot Michaël
- Lambelin Veronique
- Lambotte Patricia
- Lang Colin
- Lapi Maria
- Larcher Claire
- Laschat Michael
- Lauweryns Julie
- Lazarev Vladimir
- Lazaro Juan J
- Le Freche Hélène
- Leal Teresa
- Lechat Jean-Paul
- Leclercq Mickeal
- Lee Clover-Ann
- Lee Corina
- Lee Juliette
- Legrand Aurélien
- Lehousse Thierry
- Lejus Corinne
- Lesmes Carlos
- Leva Brigitte
- Leva Brigitte
- Levinzon Michael
- Levitchi Roxana
- Levy David
- León Carsi Irene
- Lhubat Elizabeth
- Lindenskov Pal H H
- Lipczynski Dariusz
- Liyanage Ganga
- Locke Christie
- Lofino Giuseppe
- Lomas Bernadette
- Longobardo Annalisa
- Lonsdale Hannah
- Love David
- Loveniers Birgit
- Lucia Pinciroli Rosa
- Ludot Hugues
- Lugovoy Alexander
- Lukosiene Laura
- Luntzer Robert
- Lyly Anniina
- López Galera Sílvia
- Machado Elvira
- Machotta Andreas
- Mackiewicz Tomasz
- Mackova Iveta
- Maddalena Schellino Maria
- Mader Thomas
- Magasich Natalia
- Magner Claire
- Mahadewsing Ravin
- Majid Saleem Mohammed
- Makin Andrew
- Malarkkan Nalini
- Malisiova Anna
- Mameli Leila
- Mandras Ana
- Manen Berga Ferran
- Manevich Yair
- Maniora Maud
- Manner Tuula
- Marchesini Laura
- Marchetti Giuliano
- Marco Valls Joan
- Marcucci Carine
- Marcus Ritchie
- Maretic Hrvoje
- Maria Gago Martinez Andrea
- Maria Nistor Alina
- Marie Drage Inger
- Marie Anais
- Marjanovic Vesna
- Marthe Ballovarre Kari
- Martikainen Kati
- Martinez Maldonado Ever
- Martínez Ruiz Alberto
- Mascarenhas Catia
- Masip Nuria
- Mauch Jacqueline
- Maupain Olivier
- Maurizio Raineri Santi
- Mausser Gerlinde
- Mawer Rebecca
- Mayell Antonia
- McClintock Joanna
- McKee Lesley
- Megens A. M.
- Meijer Patrick
- Melero Alicia
- Meneghini Luisa
- Merella Federica
- Mesbah Ahmed
- Messerer Brigitte
- Metrangolo Salvatore
- Meybohm Patrick
- Meyer-Treschan Tanja
- Michelon Stefania
- Micici Slobodan
- Mielke Golo
- Mierzewska-Schmidt Magdalena
- Mifsud Mark
- Mifsud Stephanie
- Migeon Anne
- Mihaela Gheorghe Ligia
- Mihaela Dubau
- Milde Alexander
- Milojevic Irina
- Minardi Carmelo
- Mircetic Maja
- Mitchell John
- Miulescu Magdalena
- Mixa Vladimir
- Mocioiu Gabriel
- Molies Dolors
- Monclus Enric
- Moncreiff Michael
- Moniz Antonio
- Monrigal Jean
- Montague James
- Montferrer Núria
- Montobbio Giovanni
- Moors Xavier
- Moraru-Draghici Lucia
- Morawk-Wintersperger Ulrike
- Morgan Judith
- Morton Neil
- Morton Neil S
- Moscaliuc Melania
- Moscatello Djurdjica
- Mossetti Valeria
- Muir Vimty
- Munar Francisca
- Munteanu Valentin
- Muro Cristina
- Najafi Nadia
- Nakhjavani Solmaz
- Nasser Leila
- Nastran Andraz
- Navaro Montserrat
- Nechaev Vladislav
- Neckebroek Martine
- Neiger Franz
- Nekrasov Konstantin
- Neri Simona
- Neumann Claudia
- Nicoleta Daraban
- Nolte Claire
- Noriega Bryant
- Nouette-Gaulain Karine
- Ntavlis Merkourios
- Numan Sandra C.
- Nuño Rosario
- O'Donahue Lizanne
- O'Hare Brendan
- Oberhauser Markus
- Ochsenreiter Miriam
- Oeding Joachim
- Olaru Valentin
- Oller Duque Lara
- Olmos Mendez Alberto
- Olteanu Dana
- Oppenrieder Karin
- Orliaguet Gilles
- Oshan Vimmi
- Ostreikov Ivan
- Ottolina Davide
- Ovezov Alexey
- Ozcengiz Dilek
- Ozer Yetkin
- Paal Peter
- Paiu Corneliu
- Paliokaite Evelina
- Pamies Carmen
- Pandurov Marina
- Parashchanka Aliaksandra
- Parasuraman Tamaraichelvi
- Pasini Lorena
- Passariello Leandro
- Patel Pradip
- Patel Shivali
- Pattar Alexander
- Paul Mission Jean
- Pauling Mark
- Pavlenko Vitaliy
- Pavlickova Jana
- Pearson Karen
- Pedro Pina António
- Pedrotti Dino
- Pegg Rachel
- Peiris Kawshala
- Peled Elia
- Pellegrini Michel
- Pereira Ricardo
- Perelló Marina
- Perera Remel
- Peresbota Daliana
- Perez Garcia Anibal
- Perez- Ferrer Antonio
- Perova-Sharonova Valentina
- Perry Nicole
- Peter Laura
- Petrescu Luxita
- Petrovic Sladjana
- Phaff Steen Nick
- Phillips Trudie
- Pick Darina
- Picker Olaf
- Pilla Clotaire
- Pino Gema
- Pirat Philippe
- Pirc Dejan
- Pirotte Thierry
- Pistidda Laura
- Pitino Sofia
- Plant Nina
- Platzer Manuela
- Plichon Benoit
- Plumb James
- Poduskov Evgeny
- Podvin Alexandre
- Poelaert Jan
- Popescu Barbura
- Popic Rok
- Popov Alexander
- Popovic Ljiljana
- Powell Alex
- Prat Mar
- Pratt Thomas
- Pregardien Caroline
- Preussler Niels-Peter
- Pribul Vicky
- Prysiazhniuk Dmytro
- Pryzmont Miroslaw
- Punt Kees
- Punzo Cinzia
- Puric Selena
- Pé d'Arca Sandra
- Quintel Michael
- Qureshi Arif
- Raber Manfred
- Rad Mandana
- Raffoflandreur Celine
- Raistrick Christopher
- Rajamani Balaji
- Ramminger Axel
- Ravi Radha
- Rawlinson Ellen
- Razlevice Ilona
- Reali Simone
- Rebac Vlatka
- Reikvam Tore
- Reindl Doris
- Reinert Jennifer
- Reinoso Barbero Francisco
- Retka Wlodzimierz
- Ribo Laura
- Richart Pierre
- Riche Jean-Claude
- Ricol Lainez Laura
- Riggenbach Christine
- Rizzo Giuliana
- Robert Philippe
- Roberts Steve
- Rodrigues Sara
- Rogerson David
- Roofthooft Eva
- Roos Torbjörn
- Rosada-Kurasinska Jowita
- Ross Mark
- Rossetti Francesca
- Rosu Lilica
- Roth Benjamin
- Roth Jens
- Roth Winfried
- Roulleau Philippe
- Roxo Helena
- Rubio Paloma
- Rudewicz Iwona
- Rudio Olga
- Rushman Sarah
- Russell Susan
- Russell William
- Russo Sebastian G.
- Rustemeyer Lydia
- Rutherford John
- Rutherford William
- Rémond Charlotte
- Sa Angela
- Sabau Lucie
- Sabourdin Nada
- Sage Frederic
- Saha Rita
- Salgado Helena
- Salici Fabiana
- Salota Vishal
- Salvo Ida
- Samani Amee
- Sammartino Maria
- Sanchez Torres Cristel
- Sandström Kerstin
- Sanko Elena
- Sanna Andrea
- Sansone Pasquale
- Santos Maria
- Saour Anne-Charlotte
- Saviciene Nijole
- Savu Anca
- Sawicki Piotr
- Sbaraglia Fabio
- Scalisi Rita
- Schaefer Maximilian S.
- Schierlinger Bettina
- Schindler Ehrenfried
- Schink Cornel
- Schmain Dmitri
- Schmucker Erika
- Schoeler Michael
- Scholten Harm
- Schorer Clemens
- Schousboe Birgitte MB
- Schouten Anton N. J.
- Schramm Michael
- Schwarzkopf Konrad
- Sciascia Angela
- Scordo Lucia
- Scott-Warren Victoria
- Seabra Manuel
- Seidel-Ahyai Natascha
- Semjen François
- Serrano Silvia
- Seyhan Ozkan Tulay
- Sharman Sarah-Jane
- Shaw Neil
- Sheinkin Olga
- Shepherd Elizabeth
- Short Judith
- Sidlovskaite-Baltake Dominika
- Sieben Anne
- Siemek-Mitela Jadzia
- Sileo Rosanna
- Simhi Eliahu
- Simic Dusica
- Simic Irena
- Simin Jovana
- Simitzes Helena
- Simon Dominique
- Simpson Joanna
- Simurina Tatjana
- Sinclair John
- Singh Piyush
- Sinner Barbara
- Sirghie Rodica
- Sivrikoz Nuket
- Skaaden Lene
- Skacel Monika
- Sketcher Jonathan
- Sklyar Vitaliy
- Skordou Natalia
- Slater Patricia
- Slavkovic Bojana
- Smith Carolyn
- Smith Fiona
- Smith Natalie
- Smitz Carine
- Snoek Aarjan
- Sobczyk Jaek
- Sodhi Puja
- Sola Ruiz Eva
- Sola Chrystelle
- Sonzogni Valter
- Soskova Tereza
- Spahr-Schopfer Isabelle
- Spanjer Vera
- Spanjersberg Rob
- Sponheim Sjur
- Staals Lonneke
- Stack Charles
- Staiti Giuseppe
- Standl Thomas
- Starita Giusi
- Stasevski Vladyslav
- Steel Simon
- Stefan Violeta
- Steiner Maria
- Steinmann Johannes
- Stevanovic Vesna
- Stevens France
- Stevens Markus F
- Stevic Marija
- Steward Heather
- Stoegermüller Birgit
- Stoia Paolo
- Strachan Dominic
- Stranjanac Vladimir
- Straume Zane
- Stuck Tus Ivana
- Stupnik Spela
- Sulen Nina
- Supthut Hauke
- Surkov Denis
- Sutherland Paul
- Suvejan Mirela
- Svircevic Vesna
- Sweeney Lorraine
- Tabacaru Radu
- Takala Annika
- Takil Arzu
- Talalaj Mariola
- Talbot Laura
- Tarabikin Alex
- Taright Hanna
- Taylor Christopher
- Taylor Matthew
- Taylor Matthew
- Teodora Nastase Alina
- Teresa Rocha Maria
- Tesoro Simonetta
- Thadsad Muthu
- Thil Elke
- Thomas Alun
- Thomas Deborah
- Thomson Wendy
- Tielens Luc
- Tognon Costanza
- Tolasov Konstantin
- Toller Wolfgang
- Tomlinson William
- Tonise Virge
- Tore Altun Gülbin
- Trabkin Evelina
- Trante Irinel
- Trieschmann Uwe
- Trifan Oana
- Trikash Nikolay
- Tsiotou Adelais
- Turner Nigel M.
- Uhrig Lynn
- Ullensvang Kyrre
- Ulrici Johanna
- Umuroglu Tumay
- Underhill Helen
- Urbanec René
- Vaidyanath Chandra
- Vail Hannah
- Vaitoskaite Agne
- Vallejo Tarrat Andrea
- Valzan Silvia
- van de Riet Yvette
- Van de Velde Anne
- Van Deenen Denise
- Van Den Eynde Nancy
- van der Knijff - van Dortmont Anouk
- van der Marel Caroline
- van der Schatte Olivier Roelof
- Van Der Werff Désirée B. M.
- van der Zwan Tim
- van Doorn Thea
- Van Hecke Rachel
- Van Limmen Jurgen
- Van Mossevelde Veerle
- van Osch Rob
- Van Reeth Veronique
- van Stijn Mireille F M
- Vanpeteghem Caroline
- Varyvoda Mykhailo
- Vason Milo
- Velcev Ana
- Veldhuizen Marianne
- Verchere-Montmayeur Juliette
- Vermeulen Petronella M
- Vermeulen Petronella M
- Veyckemans Francis
- Veyckemans Francis
- Viacava Rosanna
- Viken Oddbjorn
- Vilo Sanna
- Virag Katalin
- Vittinghoff Maria
- Vittori Alessandro
- Vodianytskyi Sergii
- Voet Marieke
- Volger Hauke
- Volkers Martin
- Volpe Claudia
- Vons Mark Hendriks Kristy
- Vossen Carine
- Wai Carolynn
- Wappler Frank
- Wasiluk Malgorzata
- Watson Karen
- Weber Stefan
- Weinlichova Stanislava
- Weiss Katja
- Wellesley Hugo
- Wensing Renee T. M.
- Weyland Andreas
- Whiteside Jeanette
- Whiteside Jonathan
- Whyte Emma
- Wieczorek Pawel
- Wiefelspütz Christina
- Wilkins Andrew
- Wilson Catharine
- Wilson Graham
- Wilson-Smith Elaine
- Wodey Eric
- Wojciechowski Dariusz
- Wolfe Barry Juliet
- Wolfler Andrea
- Woodward Tom
- Wossner Stephanie
- Wright Dave
- Wyffels Piet
- Yagudaev Irena
- Yamamoto Tomohiro
- Yildirim Guclu Cigdem
- Zadra Nicola
- Zaghet Brigitte
- Zalewska Dorota
- Zammit Simone
- Zanaboni Clelia
- Zang Aurélien
- Zangl Gregor
- Zani Gianluca
- Zederer Nicole
- Zeitlin Deborah
- Zeitlin Yelena
- Zettl Angelika
- Ziegler Bernhard
- Zielinska Marzena
- Zielinska Marzena
- Zoppellari Roberto
- Zundane Anda
- Zunser Igor
- Zurawska Magdalena
- Žurek Jirí
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2017
- Field of study
Background Little is known about the incidence of severe critical events in children undergoing general anaesthesia in Europe. We aimed to identify the incidence, nature, and outcome of severe critical events in children undergoing anaesthesia, and the associated potential risk factors. Methods The APRICOT study was a prospective observational multicentre cohort study of children from birth to 15 years of age undergoing elective or urgent anaesthesia for diagnostic or surgical procedures. Children were eligible for inclusion during a 2-week period determined prospectively by each centre. There were 261 participating centres across 33 European countries. The primary endpoint was the occurence of perioperative severe critical events requiring immediate intervention. A severe critical event was defined as the occurrence of respiratory, cardiac, allergic, or neurological complications requiring immediate intervention and that led (or could have led) to major disability or death. This study is registered with ClinicalTrials.gov, number NCT01878760. Findings Between April 1, 2014, and Jan 31, 2015, 31â127 anaesthetic procedures in 30â874 children with a mean age of 6·35 years (SD 4·50) were included. The incidence of perioperative severe critical events was 5·2% (95% CI 5·0â5·5) with an incidence of respiratory critical events of 3·1% (2·9â3·3). Cardiovascular instability occurred in 1·9% (1·7â2·1), with an immediate poor outcome in 5·4% (3·7â7·5) of these cases. The all-cause 30-day in-hospital mortality rate was 10 in 10â000. This was independent of type of anaesthesia. Age (relative risk 0·88, 95% CI 0·86â0·90; p<0·0001), medical history, and physical condition (1·60, 1·40â1·82; p<0·0001) were the major risk factors for a serious critical event. Multivariate analysis revealed evidence for the beneficial effect of years of experience of the most senior anaesthesia team member (0·99, 0·981â0·997; p<0·0048 for respiratory critical events, and 0·98, 0·97â0·99; p=0·0039 for cardiovascular critical events), rather than the type of health institution or providers. Interpretation This study highlights a relatively high rate of severe critical events during the anaesthesia management of children for surgical or diagnostic procedures in Europe, and a large variability in the practice of paediatric anaesthesia. These findings are substantial enough to warrant attention from national, regional, and specialist societies to target education of anaesthesiologists and their teams and implement strategies for quality improvement in paediatric anaesthesia. Funding European Society of Anaesthesiology
Incidence of severe critical events in paediatric anaesthesia (APRICOT): a prospective multicentre observational study in 261 hospitals in Europe
- Author
- Aantaa Riku
- Abdel-Hafiz Mostafa
- Abdelaal Amr
- Abou-Samra Mark
- Absalom Anthony
- Acevedo Bambaren Ismael
- Adam Christian
- Adriaens Veronique
- Afshari Arash
- Ahmed Samira
- Alanoglu Zekeriyya
- Albarello Raffaella
- Albokrinov Andrew
- Alders David
- Alderson Peter
- Alexandri Bogdan
- Ali Eissa Eid Mohamed
- Alkis Neslihan
- Allen Claire
- Allison Celia
- Almenrader Nicole
- Amaral Rosa
- Amory Catherine
- Ancupans Agris
- Anders Kroken Bjørn
- Anders Nicola
- Angadi Pradeep
- Angeles Sanz M.
- Anselmi Irene
- Anselmi Luciano
- Antonio Idone Francesco
- Anuncia Escontrela Rodríguez Blanca
- Armoniene Inesa
- Artes David
- Aslami Hamid
- Astuto Marinella
- Audren Noémie
- Aurilio Caterina
- Ayyash Reema
- Babici Remus
- Badarau Victoria
- Badeti Rodica
- Baethge Sabine
- Bakken Boerke Wenche
- Balamat Stefania
- Bandrabur Daniela
- Banerjee Indrani
- Banus Ester
- Bapat Smita
- Baraggia Paolo
- Barak Yuri
- Baranowski Artur
- Barber Nicola
- Barbera Cinzia
- Barbunc Danut
- Bari Francoise
- Baris Sibel
- Barlow Victoria
- Barr Katharine
- Bartholomew Karen
- Bartkowska-Sniatkowska Alicja
- Barzdina Arta
- Basiewicz Ewa
- Basov Mikhail
- Bassett Mike
- Batoz Hélène
- Bauer Annette
- Bauer Martin
- Bauer Michael
- Baujard Catherine
- Bauwman Arthur
- Beate Solas Anne
- Becke Karin
- Becke Karin
- Begec Zekine
- Bekavac Ivan
- Bell Graham
- Bell Sarah J.
- Benito Pilar
- Berger Jelena
- Berghmans Johan
- Bergland Unni
- Bergsma Margot
- Bermede Onat
- Bernotiene Aurelija
- Berton Jerome
- Bevilacqua Michela
- Bew Stephanie
- Bird Victoria
- Birliba Mihaela-Petronela
- Biskupova Vera
- Bloomfield Tom
- Blythe Elizabeth
- Boda Krisztina
- Boda Krisztina B.
- Boegli Yann
- Bollinger Matthias
- Book Malte
- Bordes Maryline
- Bortone Luciano
- Boryshkevych Ivanna
- Bourdaud Nathalie
- Boyd Matthew
- Boyle David
- Bracci Paolo
- Brackhahn Michael
- Bradbury Carol L.
- Breschan Christian
- Brezac Gilles
- Briggs Sandra
- Brotatsch Philipp
- Browning Mike
- Budic Ivana
- Buhre Wolfgang
- Busche René
- Busi Ilaria
- Bussolin Leonardo
- Butkovic Diana
- Butler Patrick
- Byers Gordon
- Börjesson Glenda
- Bøttger Morten
- Cabanova Barbora
- Cagney Brid
- Cakar Turhan K. Sanem
- Calderini Edoardo
- Calvao Santos Carolina
- Camporesi Anna
- Camus Blandine
- Capusan Alin
- Carachi Peter
- Carre Anne-Charlotte
- Cartal Marielle
- Casaer Sari
- Castellheim Albert
- Casutt Mattias
- Catalina Ionescu Gabriela
- Cavalier Alison
- Cecini Mariateresa
- Cento Valeria
- Cerati Giorgia
- Cerne Uros
- Cerutti Elisabetta
- Cettler Maciej
- Ceuca Daniela
- Ceyda Meco Basak
- Chapotte Catherine
- Chazelet Chantal
- Checinska Magdalena
- Checuti Sarah
- Chee Lew-Chin
- Childs Sophie
- Chirichiello Luca
- Chizhov Dmitri
- Chlopin Mikhail
- Chloropoulou Pelagia
- Christian Nilsson Jens
- Chrysi Mpratzou
- Cigdem Tütüncü Ayse
- Cillis Annagrazia
- Cimpeanu Luminita
- Cindea Iulia
- Ciobanu Tudor
- Clausen Nicola G.
- Clement Maria Gabriella Elena
- Cloherty Marianne
- Cnudde Steven
- Cohen Marc
- Colbus Laurent
- Coppens Marc
- Corouge Julien
- Cortegiani Andrea
- Coucke Patricia
- Crawford Michael
- Cristina Mondardini Maria
- Cuciuc Veaceslav
- Cucui-Cozma Cosmina
- Cullen Julia
- Cullen Pauline
- Cumming Craig
- D'Alessandro Sandra
- Dadure Christophe
- Dahmani Souhayl
- Dalton Andrew
- Dalton Mark
- Damps Maria
- Darwin Leanne
- Daugelavicius Vidunas
- Davidescu Irina
- Davidson Sarah
- Davies Jack
- Davies Kay
- Davin Isabelle
- Davison Rachel
- Day Alexandra
- De Abreu Leidy
- de Graaff Jurgen C.
- De Groote Françoise
- De Hert Stefan
- De Josemaria Belen
- de la Brière Francois
- De La Cruz Benito Fausto
- De Lorenzo Brita
- De Melo Eric
- De Pooter Françoise
- De Smet Karen
- De Villé Andrée
- Debrabant Lise
- Dei Giudici Luigi
- Dekens Jacky
- Dekker Elsa
- del Río Cristina
- Delcuze Axelle
- Desjeux Luc
- Diacono Jacques
- Dickinson Matthew
- Didier Anne
- Diers Anja
- Dirckx Maaike
- Disma Nicola
- Disma Nicola
- Divák Jan
- Diwan Rishi
- Dix Philippa
- Djapic Dajana
- Dockiene Ilona
- Dogger Jaap
- Dolci Mirko
- Dolinaj Vladimir
- Domingas Patuleia M.
- Domínguez Fernando
- Dons-Sinke Ilse
- Dorman Teresa
- Draskovic Biljana
- Druot Emilie
- Duflo Frédéric
- Dumitru Rusu Florin
- Dupont Hervé
- Eberl Susanne
- Ecoffey Claude
- Ehm Birgit
- Eich Christoph Bernhard
- Eisner Christoph
- Eissa Ayman
- Elena Malos Anca
- Elizabeth Biercamp Claire
- Ellekvist Marguerite B.
- Ellerkmann Richard
- Ellwood James
- Engel Nicole
- Engelhardt Thomas
- Eniko Kovacs
- Ephraim Erik
- Erb Christian
- Erb Thomas
- Errass Loreen
- Fairgrieve Ross
- Faliszewski Isabella
- Farinelli Ivano
- Farquharson Pamela
- Feliu Montserrat
- Fiedler Fritz
- Fischer Thomas
- Fisher Haran
- Flewin Lisa
- Foster Brian
- Franco Teresa
- Fredrik Lund Ole
- Frelich Michal
- Frey Denise
- Fritzsche Katrin
- Funk Wolfgang
- Gabilondo Garcia Gustavo
- Gaebler Ralf
- Gagey Anne-Charlotte
- Gaidelyte Lina
- Galinescu Irena
- Galvin Deborah
- Gande Richard
- Gandhi Monica
- Garces Antonio
- García Irene
- Garrigue Delphine
- Garrioch Sweyn
- Gatt David
- Gaynor James
- Geary Tim
- Geil Dominik
- Genco Daniele
- Gerin Marc
- Gerling Volker
- Germann Reinhard
- Gernoth Christian
- Gestautaite Dalia
- Ghent Robert
- Gillberg Lars
- Gillet Patricia
- Giuseppe Picardo Sergio
- Glasgow Russell
- Glazunov Anton
- Godsiff Leisha
- Goebel Ulrich
- Gomes Cristina
- Goncharenko Galyna
- Gonçalves Marta
- Gooch Ingrid
- Gordeeva Elena
- Grau Catharina
- Grazzini Maurizia
- Grein Elodie
- Grindheim Guro
- Grundmann Ulrich
- Grynyuk Andry
- Guarracino Fabio
- Guddo Annamaria
- Guedes Isabel
- Guericke Holger
- Guerin Christilynn
- Guido Locatelli Bruno
- Guillier Marion
- Gurita Adriana
- Gurita Adriana
- Guskov Igor
- Gutierrez Valcarcel Andrea
- Gutierrez Ignacio
- Gutmann Anton
- Guzman Ines
- Gymoese Berthelsen Kasper
- Habre Walid
- Habre Walid
- Hammerschlag Jacinda
- Hamonic Yann
- Hannie J.
- Hansen Tom G.
- Hansen Tom G.
- Hanula Miloslav
- Happo Johanna
- Harden Alison
- Hare Alison
- Harlet Pierre
- Harmen Herrema Idse
- Harris Sarah
- Harrison Richard
- Hasani Antigona
- Hashimi Medita
- Hatipoglu Zehra
- Hawksworth Chris
- Hayem Catherine
- Hearn Robert
- Hedlund Lars
- Hein Maximilian
- Helena Gaitan M.
- Heli Litvic Dubravka
- Helm Emma
- Heyse Björn
- Himpe Dirk
- Hinz José
- Hivey Sarah
- Hizal Ayse
- Hobbs Amy
- Hochhold Christoph
- Hodgetts Vanessa
- Hoeft Andreas
- Hoehne Claudia
- Hofmann Ulrich
- Hogea Cristiana
- Holy Rolf
- Homer Rachel
- Hopman Geranne A. J.
- Horhota Lucian
- Huber Matthias
- Hullatt Laurence
- Hunter Catherine
- Hurni Thomas
- Hussain Nageena
- Hussey Joseph
- Hutchinson Adel
- Huygens Christel
- Hölzle Martin
- Ilie Luminita
- Ilksen Toprak Huseyin
- Ilmoja Mari-Liis
- Ingeborg Madsen Birgitte
- Ioannou Ioannis
- Iordanidou Despoina
- Ireland Nicholas
- Irwin Janice
- Isohanni Mika
- Isselhorst Carsten
- Ivani Giorgio
- Ivanov Alexander
- Ivascu Constantin
- Izzo Francesca
- Jack Ewan
- Jacomet Alfred
- Jacqmarcq Olivier
- Jamil Yosry
- jan Scheffer Gert
- Janjevic Dusanka
- Jeng Min Law Savio
- Jerome Kevin
- Jetzek-Zader Martin
- Jiménez Anabel
- Joao Susano Maria
- Johansen Mathias
- John Robert
- Johnston Graham
- Jokinen Johanna
- Jones Gareth
- Joukes Ellen
- Julien-Marsollier Florence
- Jureckova Lucie
- Juzwa Magdalena
- Jöhr Martin
- Jöhr Martin
- Kachko Ludmyla
- Kahn David
- Kalagac Fabris Lada
- Kalliardou Evagelia
- Kappen Teus H.
- Karadeniz Meltem Savran
- Karjagin Juri
- Katz Jacob
- Kaufmann Nils
- Kazak Bengisun Zuleyha
- Keilhauer Julia
- Kelgeri Nivedita
- Kemal Arslantas Mustafa
- Kendigelen Pinar
- Kerovec Soric Ivana
- Kesic-Valpotic Gordana
- Khaffaf Ranj
- Khotcholava Magda
- Khrapak Maksym
- Kienbaum Peter
- Kikas Reet
- Kindermann Petra
- King Stephanie
- Kirilov Dmitry
- Kirton Christine
- Kiviluoma Kai
- Klimscha Walter
- Kloessing Jan
- Klymenko Tetyana
- Knauss Kristina
- Knezevic Mirjana
- Kochkin Vladimir
- Koessler Herbert
- Konecny Regina
- Kopycinska Renata
- Kortgen Andreas
- Kotecha Ami
- Kotzeva Svetlana
- Kranke Peter
- Krikstaponiene Jolita
- Kroess Ruth
- Kuehhirt Thomas
- Kuppers Beate
- Kusnirikova Zuzana
- Kyselova Iryna
- Ladak Nadia
- Laffargue Anne
- Lagarde Sylvaine
- Lako Sandra
- Lalot Michaël
- Lambelin Veronique
- Lambotte Patricia
- Lang Colin
- Lapi Maria
- Larcher Claire
- Laschat Michael
- Lauweryns Julie
- Lazarev Vladimir
- Lazaro Juan J.
- Le Freche Hélène
- Leal Teresa
- Lechat Jean-Paul
- Leclercq Mickeal
- Lee Clover-Ann
- Lee Corina
- Lee Juliette
- Legrand Aurélien
- Lehousse Thierry
- Lejus Corinne
- Lesmes Carlos
- Leva Brigitte
- Leva Brigitte
- Levinzon Michael
- Levitchi Roxana
- Levy David
- León Carsi Irene
- Lhubat Elizabeth
- Lindenskov Pal H. H.
- Lipczynski Dariusz
- Liyanage Ganga
- Locke Christie
- Lofino Giuseppe
- Lomas Bernadette
- Longobardo Annalisa
- Lonsdale Hannah
- Love David
- Loveniers Birgit
- Lucia Pinciroli Rosa
- Ludot Hugues
- Lugovoy Alexander
- Lukosiene Laura
- Luntzer Robert
- Lyly Anniina
- Lynch Johanne
- López Galera Sílvia
- Machado Elvira
- Machotta Andreas
- Mackiewicz Tomasz
- Mackova Iveta
- Mader Thomas
- Magasich Natalia
- Magner Claire
- Mahadewsing Ravin
- Majid Saleem Mohammed
- Makin Andrew
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- Mandras Ana
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- Maria Nistor Alina
- Marie Drage Inger
- Marie Anais
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- Marthe Ballovarre Kari
- Martikainen Kati
- Martinez Maldonado Ever
- Martínez Ruiz Alberto
- Mascarenhas Catia
- Masip Nuria
- Mauch Jacqueline
- Maupain Olivier
- Maurizio Raineri Santi
- Mausser Gerlinde
- Mawer Rebecca
- Mayell Antonia
- McClintock Joanna
- McKee Lesley
- Megens A. M.
- Meijer Patrick
- Melero Alicia
- Meneghini Luisa
- Merella Federica
- Mesbah Ahmed
- Messerer Brigitte
- Metrangolo Salvatore
- Meybohm Patrick
- Meyer-Treschan Tanja
- Michelon Stefania
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- Mielke Golo
- Mierzewska-Schmidt Magdalena
- Mifsud Mark
- Mifsud Stephanie
- Migeon Anne
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- Mihaela Dubau
- Milde Alexander
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- Mitchell John
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- Mixa Vladimir
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- Moncreiff Michael
- Moniz Antonio
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- Montague James
- Montferrer Núria
- Montobbio Giovanni
- Moors Xavier
- Moraru-Draghici Lucia
- Morawk-Wintersperger Ulrike
- Morgan Judith
- Morton Neil
- Morton Neil S.
- Moscaliuc Melania
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- Muro Cristina
- Najafi Nadia
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- Nasser Leila
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- Nechaev Vladislav
- Neckebroek Martine
- Neiger Franz
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- Neri Simona
- Neumann Claudia
- Nicoleta Daraban
- Nolte Claire
- Noriega Bryant
- Nouette-Gaulain Karine
- Ntavlis Merkourios
- Numan Sandra C.
- Nuño Rosario
- O'Donahue Lizanne
- O'Hare Brendan
- Oberhauser Markus
- Ochsenreiter Miriam
- Oeding Joachim
- Olaru Valentin
- Oller Duque Lara
- Olmos Mendez Alberto
- Olteanu Dana
- Oppenrieder Karin
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- Oshan Vimmi
- Ostreikov Ivan
- Ottolina Davide
- Ovezov Alexey
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- Perez- Ferrer Antonio
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- Pribul Vicky
- Prysiazhniuk Dmytro
- Pryzmont Miroslaw
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- Rad Mandana
- Raffoflandreur Celine
- Raistrick Christopher
- Rajamani Balaji
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- Ravi Radha
- Rawlinson Ellen
- Razlevice Ilona
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- Reikvam Tore
- Reindl Doris
- Reinert Jennifer
- Reinoso Barbero Francisco
- Retka Wlodzimierz
- Ribo Laura
- Richart Pierre
- Riche Jean-Claude
- Ricol Lainez Laura
- Riggenbach Christine
- Rizzo Giuliana
- Robert Philippe
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- Rodrigues Sara
- Rogerson David
- Roofthooft Eva
- Roos Torbjörn
- Rosada-Kurasinska Jowita
- Ross Mark
- Rossetti Francesca
- Rosu Lilica
- Roth Benjamin
- Roth Jens
- Roth Winfried
- Roulleau Philippe
- Roxo Helena
- Rubio Paloma
- Rudewicz Iwona
- Rudio Olga
- Rushman Sarah
- Russell Susan
- Russell William
- Russo Sebastian G.
- Rustemeyer Lydia
- Rutherford John
- Rutherford William
- Rémond Charlotte
- Sa Angela
- Sabau Lucie
- Sabourdin Nada
- Sage Frederic
- Saha Rita
- Salgado Helena
- Salici Fabiana
- Salota Vishal
- Salvo Ida
- Samani Amee
- Sammartino Maria
- Sanchez Torres Cristel
- Sandström Kerstin
- Sanko Elena
- Sanna Andrea
- Sansone Pasquale
- Santos Maria
- Saour Anne-Charlotte
- Saviciene Nijole
- Savu Anca
- Sawicki Piotr
- Sbaraglia Fabio
- Scalisi Rita
- Schaefer Maximilian S.
- Schellino Maria Maddalena
- Schierlinger Bettina
- Schindler Ehrenfried
- Schink Cornel
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- Schmucker Erika
- Schoeler Michael
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- Schwarzkopf Konrad
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- Semjen François
- Serrano Silvia
- Seyhan Ozkan Tulay
- Sharman Sarah-Jane
- Shaw Neil
- Sheinkin Olga
- Shepherd Elizabeth
- Short Judith
- Sidlovskaite-Baltake Dominika
- Sieben Anne
- Siemek-Mitela Jadzia
- Sileo Rosanna
- Simhi Eliahu
- Simic Dusica
- Simic Irena
- Simin Jovana
- Simitzes Helena
- Simon Dominique
- Simpson Joanna
- Simurina Tatjana
- Sinclair John
- Singh Piyush
- Sinner Barbara
- Sirghie Rodica
- Sivrikoz Nuket
- Skaaden Lene
- Skacel Monika
- Sketcher Jonathan
- Sklyar Vitaliy
- Skordou Natalia
- Slater Patricia
- Slavkovic Bojana
- Smith Carolyn
- Smith Fiona
- Smith Natalie
- Smitz Carine
- Snoek Aarjan
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- Sodhi Puja
- Sola Ruiz Eva
- Sola Chrystelle
- Sonzogni Valter
- Soskova Tereza
- Spahr-Schopfer Isabelle
- Spanjer Vera
- Spanjersberg Rob
- Sponheim Sjur
- Staals Lonneke
- Stack Charles
- Staiti Giuseppe
- Standl Thomas
- Starita Giusi
- Stasevski Vladyslav
- Steel Simon
- Stefan Violeta
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- Steinmann Johannes
- Stevanovic Vesna
- Stevens France
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- Stoegermüller Birgit
- Stoia Paolo
- Strachan Dominic
- Stranjanac Vladimir
- Straume Zane
- Stuck Tus Ivana
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- Sulen Nina
- Supthut Hauke
- Surkov Denis
- Sutherland Paul
- Suvejan Mirela
- Svircevic Vesna
- Sweeney Lorraine
- Tabacaru Radu
- Takala Annika
- Takil Arzu
- Talalaj Mariola
- Talbot Laura
- Tarabikin Alex
- Taright Hanna
- Taylor Christopher
- Taylor Matthew
- Taylor Matthew
- Teodora Nastase Alina
- Teresa Rocha Maria
- Tesoro Simonetta
- Thadsad Muthu
- Thil Elke
- Thomas Alun
- Thomas Deborah
- Thomson Wendy
- Tielens Luc
- Tognon Costanza
- Tolasov Konstantin
- Toller Wolfgang
- Tomlinson William
- Tonise Virge
- Tore Altun Gülbin
- Trabkin Evelina
- Trante Irinel
- Trieschmann Uwe
- Trifan Oana
- Trikash Nikolay
- Tsiotou Adelais
- Turner Nigel M.
- Uhrig Lynn
- Ullensvang Kyrre
- Ulrici Johanna
- Umuroglu Tumay
- Underhill Helen
- Urbanec René
- Vaidyanath Chandra
- Vail Hannah
- Vaitoskaite Agne
- Vallejo Tarrat Andrea
- Valzan Silvia
- van de Riet Yvette
- Van de Velde Anne
- Van Deenen Denise
- Van Den Eynde Nancy
- van der Knijff - van Dortmont Anouk
- van der Marel Caroline
- van der Schatte Olivier Roelof
- Van Der Werff Désirée B. M.
- van der Zwan Tim
- van Doorn Thea
- Van Hecke Rachel
- Van Limmen Jurgen
- Van Mossevelde Veerle
- van Osch Rob
- Van Reeth Veronique
- van Stijn Mireille F. M.
- Vanpeteghem Caroline
- Varyvoda Mykhailo
- Vason Milo
- Velcev Ana
- Veldhuizen Marianne
- Verchere-Montmayeur Juliette
- Vermeulen Petronella M.
- Vermeulen Petronella M.
- Veyckemans Francis
- Veyckemans Francis
- Viacava Rosanna
- Viken Oddbjorn
- Vilo Sanna
- Virag Katalin
- Vittinghoff Maria
- Vittori Alessandro
- Vodianytskyi Sergii
- Voet Marieke
- Volger Hauke
- Volkers Martin
- Volpe Claudia
- Vons Mark Hendriks Kristy
- Vossen Carine
- Wai Carolynn
- Wappler Frank
- Wasiluk Malgorzata
- Watson Karen
- Weber Stefan
- Weinlichova Stanislava
- Weiss Katja
- Wellesley Hugo
- Wensing Renee T. M.
- Weyland Andreas
- Whiteside Jeanette
- Whiteside Jonathan
- Whyte Emma
- Wieczorek Pawel
- Wiefelspütz Christina
- Wilkins Andrew
- Wilson Catharine
- Wilson Graham
- Wilson-Smith Elaine
- Wodey Eric
- Wojciechowski Dariusz
- Wolfe Barry Juliet
- Wolfler Andrea
- Woodward Tom
- Wossner Stephanie
- Wright Dave
- Wyffels Piet
- Yagudaev Irena
- Yamamoto Tomohiro
- Yildirim Guclu Cigdem
- Zadra Nicola
- Zaghet Brigitte
- Zalewska Dorota
- Zammit Simone
- Zanaboni Clelia
- Zang Aurélien
- Zangl Gregor
- Zani Gianluca
- Zederer Nicole
- Zeitlin Deborah
- Zeitlin Yelena
- Zettl Angelika
- Ziegler Bernhard
- Zielinska Marzena
- Zielinska Marzena
- Zoppellari Roberto
- Zundane Anda
- Zunser Igor
- Zurawska Magdalena
- Žurek Jirí
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2017
- Field of study
Background Little is known about the incidence of severe critical events in children undergoing general anaesthesia in Europe. We aimed to identify the incidence, nature, and outcome of severe critical events in children undergoing anaesthesia, and the associated potential risk factors. Methods The APRICOT study was a prospective observational multicentre cohort study of children from birth to 15 years of age undergoing elective or urgent anaesthesia for diagnostic or surgical procedures. Children were eligible for inclusion during a 2-week period determined prospectively by each centre. There were 261 participating centres across 33 European countries. The primary endpoint was the occurence of perioperative severe critical events requiring immediate intervention. A severe critical event was defined as the occurrence of respiratory, cardiac, allergic, or neurological complications requiring immediate intervention and that led (or could have led) to major disability or death. This study is registered with ClinicalTrials.gov, number NCT01878760. Findings Between April 1, 2014, and Jan 31, 2015, 31 127 anaesthetic procedures in 30 874 children with a mean age of 6.35 years (SD 4.50) were included. The incidence of perioperative severe critical events was 5.2% (95% CI 5.0-5.5) with an incidence of respiratory critical events of 3.1% (2.9-3.3). Cardiovascular instability occurred in 1.9% (1.7-2.1), with an immediate poor outcome in 5.4% (3.7-7.5) of these cases. The all-cause 30-day in-hospital mortality rate was 10 in 10 000. This was independent of type of anaesthesia. Age (relative risk 0.88, 95% CI 0.86-0.90; p<0.0001), medical history, and physical condition (1.60, 1.40-1.82; p<0.0001) were the major risk factors for a serious critical event. Multivariate analysis revealed evidence for the beneficial effect of years of experience of the most senior anaesthesia team member (0.99, 0.981-0.997; p<0.0048 for respiratory critical events, and 0.98, 0.97-0.99; p=0.0039 for cardiovascular critical events), rather than the type of health institution or providers. Interpretation This study highlights a relatively high rate of severe critical events during the anaesthesia management of children for surgical or diagnostic procedures in Europe, and a large variability in the practice of paediatric anaesthesia. These findings are substantial enough to warrant attention from national, regional, and specialist societies to target education of anaesthesiologists and their teams and implement strategies for quality improvement in paediatric anaesthesia
Diminishing benefits of urban living for children and adolescents’ growth and development
- Author
- Abarca-Gómez Leandra
- Abdeen Ziad A.
- Abdrakhmanova Shynar
- Abdul Rahim Hanan F.
- Abdurrahmonova Zulfiya
- Abril Guadalupe Longo
- Abu-Rmeileh Niveen M.
- Acosta-Cazares Benjamin
- Adam Ishag
- Adamczyk Marzena
- Adams Robert J.
- Adu-Afarwuah Seth
- Aekplakorn Wichai
- Afsana Kaosar
- Afzal Shoaib
- Agbor Valirie N.
- Agdeppa Imelda A.
- Aghazadeh-Attari Javad
- Aguenaou Hassan
- Aguilar-Salinas Carlos A.
- Agyemang Charles
- Ahmad Mohamad Hasnan
- Ahmad Noor Ani
- Ahmadi Ali
- Ahmadi Naser
- Ahmadi Nastaran
- Ahmed Imran
- Ahmed Soheir H.
- Ahrens Wolfgang
- Aitmurzaeva Gulmira
- Ajlouni Kamel
- Al Hourani Huda M.
- Al Qaoud Nawal M.
- Al-Hazzaa Hazzaa M.
- Al-Lahou Badreya
- Al-Raddadi Rajaa
- Alarouj Monira
- AlBuhairan Fadia
- AlDhukair Shahla
- Aldwairji Maryam A.
- Alexius Sylvia
- Ali Mohamed M.
- Alkandari Abdullah
- Alkerwi Ala’a
- Alkhatib Buthaina M.
- Allin Kristine
- Alvarez-Pedrerol Mar
- Aly Eman
- Amarapurkar Deepak N.
- Amoah John
- Amougou Norbert
- Amouyel Philippe
- Andersen Lars Bo
- Anderssen Sigmund A.
- Androutsos Odysseas
- Anjana Ranjit Mohan
- Ansari-Moghaddam Alireza
- Anufrieva Elena
- Aounallah-Skhiri Hajer
- Araújo Joana
- Ariansen Inger
- Aris Tahir
- Arku Raphael E.
- Arlappa Nimmathota
- Aryal Krishna K.
- Aseffa Nega
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- Assah Felix K.
- Assembekov Batyrbek
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- Azizi Fereidoun
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- Barkat Amina
- Barnoya Joaquin
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- Burazeri Genc
- Burns Con
- Cacciottolo Joseph
- Cadena Leticia Hernandez
- Cai Hui
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- Cama Tilema
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- Chan Queenie
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- Chaturvedi Nish
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- Chen Fangfang
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- Chiou Shu-Ti
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- Cho Belong
- Christensen Kaare
- Christofaro Diego G.
- Chudek Jerzy
- Cifkova Renata
- Cilia Michelle
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- Cirillo Massimo
- Cisneros Julio Zuñiga
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- Clarke Janine
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- Concin Hans
- Confortin Susana C.
- Cooper Cyrus
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- Czenczek-Lewandowska Ewelina
- Cândido Ana Paula C.
- da Silva Bruna Gonçalves Cordeiro
- Dacica Liliana
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- Damasceno Albertino
- Damsgaard Camilla T.
- Danaei Goodarz
- Dankner Rachel
- Dantoft Thomas M.
- Dasgupta Parasmani
- Dastgiri Saeed
- Dauchet Luc
- Davletov Kairat
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- De Backer Gui
- De Bacquer Dirk
- De Curtis Amalia
- de Fragas Hinnig Patrícia
- de Gaetano Giovanni
- De Henauw Stefaan
- de León Antonio Cabrera
- De Miguel-Etayo Pilar
- de Moura Silva Caroline Ramos
- de Oliveira Paula Duarte
- de Paiva Karina Mary
- De Ridder David
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- de Rooij Susanne R.
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- Deepa Mohan
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- Delisle Hélène
- Delpeuch Francis
- Demarest Stefaan
- Dennison Elaine
- Dereń Katarzyna
- Deschamps Valérie
- Dhimal Meghnath
- Di Castelnuovo Augusto
- Di Cesare Mariachiara
- Dias-da-Costa Juvenal Soares
- Diaz Alejandro
- Dika Zivka
- Djalalinia Shirin
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- Dominguez Liria
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- Dong Guanghui
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- Doua Kouamelan
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- D’Arrigo Graziella
- d’Orsi Eleonora
- Echeverría Guadalupe
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- Eftekhar Ebrahim
- Egbagbe Eruke E.
- Eggertsen Robert
- Eghtesad Sareh
- Eiben Gabriele
- Ekelund Ulf
- El Ammari Laila
- El Ati Jalila
- El-Khateeb Mohammad
- Eldemire-Shearer Denise
- Eliasen Marie
- Elliott Paul
- Endevelt Ronit
- Engle-Stone Reina
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- Erbel Raimund
- Erem Cihangir
- Ergor Gul
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- Escobedo-de la Peña Jorge
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- Esmaeili Ali
- Etxezarreta Pilar Amiano
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- Fernandes Romulo A.
- Fernández Pedro Díaz
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- Ferrante Daniel
- Ferrao Thomas
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- Ferreira Haroldo S.
- Ferrer Eldridge
- Ferrieres Jean
- Figueiró Thamara Hubler
- Fijalkowska Anna
- Filho Valter Barbosa
- Fink Günther
- Fisberg Mauro
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- Francis Damian K.
- Fras Zlatko
- Frontera Guillermo
- Fuchs Flavio D.
- Fuchs Sandra C.
- Fujiati Isti I.
- Fujita Yuki
- Fumihiko Matsuda
- Furdela Viktoriya
- Furusawa Takuro
- Gaciong Zbigniew
- Gafencu Mihai
- Galbarczyk Andrzej
- Galenkamp Henrike
- Galeone Daniela
- Galfo Myriam
- Galvano Fabio
- Gao Jingli
- Gao Pei
- Garba Jamila Abubakar
- Garcia-de-la-Hera Manoli
- García Martha Yépez
- Gareta Dickman
- Garnett Sarah P.
- Gaspoz Jean-Michel
- Gasull Magda
- Gaya Adroaldo Cesar Araujo
- Gaya Anelise Reis
- Gazzinelli Andrea
- Gehring Ulrike
- Geiger Harald
- Geleijnse Johanna M.
- George Ronnie
- Ghaderi Ebrahim
- Ghaffar Suhaila Abdul
- Ghanbari Ali
- Ghasemi Erfan
- Gheorghe-Fronea Oana-Florentina
- Gialluisi Alessandro
- Giampaoli Simona
- Gianfagna Francesco
- Gieger Christian
- Gill Tiffany K.
- Giovannelli Jonathan
- Gironella Glen
- Giwercman Aleksander
- Gkiouras Konstantinos
- Glushkova Natalya
- Gluškova Natalja
- Godara Ramesh
- Godos Justyna
- Gogen Sibel
- Goldberg Marcel
- Goltzman David
- Gomez Luis F.
- Gomula Aleksandra
- Gonzalez Angel R.
- Gonzalez-Chica David A.
- Gonzalez-Gross Marcela
- González Enrique Gutiérrez
- González-Alvarez Ana D.
- González-Gil Esther M.
- González-Leon Margot
- González-Rivas Juan P.
- González-Villalpando Clicerio
- González-Villalpando María-Elena
- Gonçalves Helen
- Gonçalves Mauer
- Gottrand Frederic
- Graff-Iversen Sidsel
- Grafnetter Dušan
- Grajda Aneta
- Grammatikopoulou Maria G.
- Graça Antonio Pedro
- Gregg Edward W.
- Gregor Ronald D.
- Gregório Maria João
- Grosso Giuseppe
- Gruden Gabriella
- Grøholt Else Karin
- Grøntved Anders
- Gu Dongfeng
- Guajardo Viviana
- Gualdi-Russo Emanuela
- Guallar-Castillón Pilar
- Gualtieri Andrea
- Gudmundsson Elias F.
- Gudnason Vilmundur
- Guerrero Ramiro
- Guessous Idris
- Guimaraes Andre L.
- Gulliford Martin C.
- Gunnlaugsdottir Johanna
- Gunter Marc J.
- Guo Xiu-Hua
- Guo Yin
- Gupta Prakash C.
- Gupta Rajeev
- Gureje Oye
- Gutierrez Laura
- Gutzwiller Felix
- Gwee Xinyi
- Gómez Georgina
- Gómez Jesús Humberto Gómez
- Gómez Santiago F.
- Ha Seongjun
- Hadaegh Farzad
- Hadjigeorgiou Charalambos A.
- Haghshenas Rosa
- Hakimi Hamid
- Halkjær Jytte
- Hambleton Ian R.
- Hamzeh Behrooz
- Hanekom Willem A.
- Hange Dominique
- Hanif Abu A. M.
- Hantunen Sari
- Hao Jie
- Hardman Carla Menêses
- Harooni Javad
- Hashemi-Shahri Seyed Mohammad
- Hassapidou Maria
- Hata Jun
- Haugsgjerd Teresa
- Hayes Alison J.
- He Jiang
- He Yuan
- He Yuna
- Heidinger-Felső Regina
- Heier Margit
- Heinen Mirjam
- Hejgaard Tatjana
- Hendriks Marleen Elisabeth
- Henriques Ana
- Herrala Sauli
- Herrera Victor M.
- Herrera-Cuenca Marianella
- Herter-Aeberli Isabelle
- Herzig Karl-Heinz
- Heshmat Ramin
- Hill Allan G.
- Ho Sai Yin
- Ho Suzanne C.
- Hobbs Michael
- Holdsworth Michelle
- Homayounfar Reza
- Homs Clara
- Hopman Wilma M.
- Horimoto Andrea R. V. R.
- Hormiga Claudia M.
- Horta Bernardo L.
- Houti Leila
- Howitt Christina
- Htay Thein Thein
- Htet Aung Soe
- Htike Maung Maung Than
- Hu Yonghua
- Huerta José María
- Huhtaniemi Ilpo Tapani
- Huiart Laetitia
- Huisman Martijn
- Husseini Abdullatif
- Huu Chinh Nguyen
- Huybrechts Inge
- Hwalla Nahla
- Hyska Jolanda
- Höfelmann Doroteia A.
- Iacoviello Licia
- Iakupova Ellina M.
- Ibarluzea Jesús M.
- Ibrahim Mohsen M.
- Ikeda Nayu
- Ikram M. Arfan
- Ioannidou Eliza Markidou
- Iotova Violeta
- Irazola Vilma E.
- Ishida Takafumi
- Isiguzo Godsent C.
- Islam Muhammad
- Islam Sheikh Mohammed Shariful
- Islek Duygu
- Iurilli Maria L. C.
- Ivanova-Pandourska Ivaila Y.
- Iwasaki Masanori
- Iñiguez Carmen
- Jackson Rod T.
- Jacobs Jeremy M.
- Jadoul Michel
- Jafar Tazeen
- Jallow Bakary
- James Kenneth
- Jamil Kazi M.
- Jamrozik Konrad
- Jansson Anna
- Janszky Imre
- Janus Edward
- Jarani Juel
- Jarvelin Marjo-Riitta
- Jasienska Grazyna
- Jelaković Ana
- Jelaković Bojan
- Jennings Garry
- Jiang Chao Qiang
- Jimenez Maritza Landaeta
- Jimenez Ramon O.
- Joffres Michel
- Jokelainen Jari J.
- Jonas Jost B.
- Jonnagaddala Jitendra
- Jonsson Kenisha Russell
- Joshi Pradeep
- Josipović Josipa
- Joukar Farahnaz
- Judge Debra S.
- Juolevi Anne
- Jurak Gregor
- Juresa Vesna
- Jääskeläinen Tuija
- Jérome Charles Sossa
- Jóźwiak Jacek J.
- Jöckel Karl-Heinz
- Jørgensen Maja Bæksgaard
- Jørgensen Torben
- Kaaks Rudolf
- Kaducu Felix O.
- Kafatos Anthony
- Kaj Mónika
- Kajantie Eero O.
- Kakutia Natia
- Kalmatayeva Zhanna
- Kalter-Leibovici Ofra
- Kameli Yves
- Kampmann Freja B.
- Kanala Kodanda R.
- Kannan Srinivasan
- Kapantais Efthymios
- Karaglani Eva
- Karakosta Argyro
- Karki Khem B.
- Katchunga Philippe B.
- Katibeh Marzieh
- Katz Joanne
- Katzmarzyk Peter T.
- Kauhanen Jussi
- Kaur Prabhdeep
- Kavousi Maryam
- Kazakbaeva Gyulli M.
- Kaze François F.
- Ke Calvin
- Keil Ulrich
- Keinänen-Kiukaanniemi Sirkka
- Kelishadi Roya
- Kelleher Cecily
- Kemper Han C. G.
- Kengne Andre P.
- Keramati Maryam
- Kerimkulova Alina
- Kersting Mathilde
- Key Timothy
- Khader Yousef Saleh
- Khaledifar Arsalan
- Khalili Davood
- Khang Young-Ho
- Khaw Kay-Tee
- Kheiri Bahareh
- Kheradmand Motahareh
- Khosravi Alireza
- Khouw Ilse M. S. L.
- Kiechl Sophia J.
- Kiechl Stefan
- Kiechl-Kohlendorfer Ursula
- Killewo Japhet
- Kim Hyeon Chang
- Kim Jeongseon
- Kindblom Jenny M.
- Kingston Andrew
- Klakk Heidi
- Klimek Magdalena
- Klimont Jeannette
- Klumbiene Jurate
- Knoflach Michael
- Koirala Bhawesh
- Kolle Elin
- Kolsteren Patrick
- Korpelainen Raija
- Korrovits Paul
- Korzycka Magdalena
- Kos Jelena
- Koskinen Seppo
- Kouda Katsuyasu
- Kovacs Viktoria Anna
- Kovalskys Irina
- Kovtun Olga Petrovna
- Kovács Éva
- Kowlessur Sudhir
- Koziel Slawomir
- Kratenova Jana
- Kratzer Wolfgang
- Kriaucioniene Vilma
- Kriemler Susi
- Kristensen Peter Lund
- Krizan Helena
- Kroker-Lobos Maria F.
- Krokstad Steinar
- Kromhout Daan
- Kruger Herculina S.
- Kruger Ruan
- Kryst Łukasz
- Kubinova Ruzena
- Kuciene Renata
- Kujala Urho M.
- Kujundzic Enisa
- Kulaga Zbigniew
- Kulimbet Mukhtar
- Kumar R. Krishna
- Kumar Rachakulla Hari
- Kunešová Marie
- Kurjata Pawel
- Kusuma Yadlapalli S.
- Kutsenko Vladimir
- Kuulasmaa Kari
- Kyobutungi Catherine
- Kállayová Daniela
- Kårhus Line L.
- König Jürgen
- La Quang Ngoc
- Laamiri Fatima Zahra
- Laatikainen Tiina
- Lachat Carl
- Lackner Karl J.
- Laid Youcef
- Lall Lachmie
- Lam Tai Hing
- Landais Edwige
- Lanska Vera
- Lappas Georg
- Larijani Bagher
- Larissa Simo Pone
- Lassen Tina Harmer
- Latt Tint Swe
- Laurenzi Martino
- Lauria Laura
- Laxmaiah Avula
- Lazo-Porras Maria
- Le Coroller Gwenaëlle
- Le Nguyen Bao Khanh
- Le Port Agnès
- Le Tuyen D.
- Lee Jeannette
- Lee Jeonghee
- Lee Paul H.
- Lehmann Nils
- Lehtimäki Terho
- Lele Elysée Claude Bika
- Lemogoum Daniel
- Leskošek Branimir
- Leszczak Justyna
- Leth-Møller Katja B.
- Leung Gabriel M.
- Levitt Naomi S.
- Lhoste Victor
- Li Yanping
- Liivak Merike
- Lilly Christa L.
- Lim Charlie
- Lim Wei-Yen
- Lima-Costa M. Fernanda
- Lin Hsien-Ho
- Lin Xu
- Lin Yi-Ting
- Lind Lars
- Lingam Vijaya
- Linkohr Birgit
- Linneberg Allan
- Lissner Lauren
- Litwin Mieczyslaw
- Liu Jing
- Liu Lijuan
- Lo Wei-Cheng
- Loit Helle-Mai
- Long Khuong Quynh
- Lopes Luis
- Lopes Marcus V. V.
- Lopes Oscar
- Lopez Tania
- Lopez-Garcia Esther
- Lotufo Paulo A.
- Lozano José Eugenio
- Lukrafka Janice L.
- Luksiene Dalia
- Lundqvist Annamari
- Lunet Nuno
- Lunogelo Charles
- Lustigová Michala
- Ma Guansheng
- Ma Jun
- Ma Xu
- Machado-Coelho George L. L.
- Machado-Rodrigues Aristides M.
- Macia Enguerran
- Macieira Luisa M.
- Madar Ahmed A.
- Madsen Anja L.
- Maestre Gladys E.
- Maggi Stefania
- Magliano Dianna J.
- Magnacca Sara
- Magnazu Moran Blychfeld
- Magriplis Emmanuella
- Mahasampath Gowri
- Maire Bernard
- Majer Marjeta
- Makdisse Marcia
- Malekzadeh Fatemeh
- Malekzadeh Reza
- Malhotra Rahul
- Malyutina Sofia K.
- Maniego Lynell V.
- Manios Yannis
- Manix Masimango Imani
- Mann Jim I.
- Mansour-Ghanaei Fariborz
- Manyanga Taru
- Manzato Enzo
- Marcil Anie
- Margozzini Paula
- Marina Loreto Santa
- Mariño Joany
- Markaki Anastasia
- Markey Oonagh
- Marques Larissa Pruner
- Marques-Vidal Pedro
- Marrugat Jaume
- Martin Rosemarie
- Martin-Prevel Yves
- Martinez Eduardo Salazar
- Martorell Reynaldo
- Martos Eva
- Maruszczak Katharina
- Marventano Stefano
- Masala Giovanna
- Mascarenhas Luis P.
- Masoodi Shariq R.
- Mathiesen Ellisiv B.
- Mathur Prashant
- Matijasevich Alicia
- Matsha Tandi E.
- Matsudo Victor
- Matłosz Piotr
- Mavrogianni Christina
- Mazur Artur
- Mbanya Jean Claude N.
- McFarlane Shelly R.
- McGarvey Stephen T.
- McKee Martin
- McLachlan Stela
- McLean Rachael M.
- McLean Scott B.
- McNairy Margaret L.
- McNulty Breige A.
- Medzioniene Jurate
- Mehdipour Parinaz
- Mehlig Kirsten
- Mehrparvar Amir Houshang
- Meirhaeghe Aline
- Meisfjord Jørgen
- Meisinger Christa
- Melgarejo Jesus D.
- Melkumova Marina
- Mello João
- Mendivil Carlos O.
- Menezes Ana Maria B.
- Menon Geetha R.
- Mensink Gert B. M.
- Menzano Maria Teresa
- Meshram Indrapal I.
- Meto Diane T.
- Mi Jie
- Michaelsen Kim F.
- Michels Nathalie
- Mikkel Kairit
- Milanović Sanja Musić
- Miller Jody C.
- Milushkina Olga
- Minderico Cláudia S.
- Mini G. K.
- Miquel Juan Francisco
- Miranda J. Jaime
- Mirjalili Mohammad Reza
- Mirkopoulou Daphne
- Mirrakhimov Erkin
- Mishra Anu
- Mistretta Antonio
- Miłkowska Karolina
- Mišigoj-Duraković Marjeta
- Mocanu Veronica
- Modesti Pietro A.
- Moghaddam Sahar Saeedi
- Mohajer Bahram
- Mohamed Mostafa K.
- Mohamed Shukri F.
- Mohammad Kazem
- Mohammadi Mohammad Reza
- Mohammadi Zahra
- Mohammadifard Noushin
- Mohammadpourhodki Reza
- Mohamud Wan Nazaimoon Wan
- Mohan Viswanathan
- Mohanna Salim
- Mohebbi Iraj
- Mohebi Farnam
- Moitry Marie
- Molnár Dénes
- Momenan Amirabbas
- Mondo Charles K.
- Monroy-Valle Michele
- Montenegro Mendoza Roger A.
- Monterrubio-Flores Eric
- Monyeki Kotsedi Daniel K.
- Moon Jin Soo
- Moosazadeh Mahmood
- Mopa Hermine T.
- Moradpour Farhad
- Moreira Leila B.
- Morejon Alain
- Moreno Emma Ruiz
- Moreno Luis A.
- Morey Francis
- Morgan Karen
- Morin Suzanne N.
- Mortensen Erik Lykke
- Moschonis George
- Moslem Alireza
- Mossakowska Malgorzata
- Mostafa Aya
- Mostafavi Seyed-Ali
- Mota Jorge
- Mota-Pinto Anabela
- Motlagh Mohammad Esmaeel
- Motta Jorge
- Moura-dos-Santos Marcos André
- Movsesyan Yeva
- Mridha Malay K.
- Msyamboza Kelias P.
- Mu Thet Thet
- Muc Magdalena
- Muca Florian
- Mugoša Boban
- Muiesan Maria L.
- Mursu Jaakko
- Murtagh Elaine M.
- Musa Kamarul Imran
- Musil Vera
- Musinguzi Geofrey
- Muyer Muel Telo M. C.
- Mäki Päivi
- Méndez Fabián
- Mérida María José García
- Møllehave Line T.
- Møller Niels C.
- Müller-Nurasyid Martina
- Münzel Thomas
- M’Buyamba-Kabangu Jean-René
- Nabipour Iraj
- Naderimagham Shohreh
- Nagel Gabriele
- Najafi Farid
- Nakamura Harunobu
- Nalecz Hanna
- Nang Ei Ei K.
- Nangia Vinay B.
- Nankap Martin
- Narake Sameer
- Nardone Paola
- Naseri Take
- Nauck Matthias
- NCD Risk Factor Collaboration (NCD-RisC) [missing]
- Neal William A.
- Nejatizadeh Azim
- Nekkantti Chandini
- Nelis Keiu
- Nenko Ilona
- Neovius Martin
- Nervi Flavio
- Ng Tze Pin
- Nguyen Chung T.
- Nguyen Nguyen D.
- Nguyen Quang Ngoc
- Ni Michael Y.
- Nicolescu Rodica
- Nie Peng
- Nieto-Martínez Ramfis E.
- Nikitin Yury P.
- Ning Guang
- Ninomiya Toshiharu
- Nishi Nobuo
- Nishtar Sania
- Noale Marianna
- Noboa Oscar A.
- Nogueira Helena
- Nordendahl Maria
- Nordestgaard Børge G.
- Noto Davide
- Nowak-Szczepanska Natalia
- Nsour Mohannad Al
- Nuhoğlu Irfan
- Nunes Baltazar
- Nurk Eha
- Nuwaha Fred
- Nyirenda Moffat
- Námešná Jana
- Obreja Galina
- Ochimana Caleb
- Ochoa-Avilés Angélica M.
- Oda Eiji
- Odili Augustine N.
- Oh Kyungwon
- Ohara Kumiko
- Ohlsson Claes
- Ohtsuka Ryutaro
- Olafsson Örn
- Olinto Maria Teresa A.
- Oliveira Isabel O.
- Omar Mohd Azahadi
- Omar Saeed M.
- Onat Altan
- Ong Sok King
- Onland-Moret N. Charlotte
- Ono Lariane M.
- Ordunez Pedro
- Ornelas Rui
- Ortiz Ana P.
- Ortiz Pedro J.
- Osler Merete
- Osmond Clive
- Ostojic Sergej M.
- Ostovar Afshin
- Otero Johanna A.
- Overvad Kim
- Owusu-Dabo Ellis
- O’Neill Terence W.
- O’Reilly Dermot
- Paccaud Fred Michel
- Paciorek Christopher J.
- Padez Cristina P.
- Pagkalos Ioannis
- Pahomova Elena
- Pająk Andrzej
- Palloni Alberto
- Palmieri Luigi
- Pan Wen-Harn
- Panda-Jonas Songhomitra
- Pandey Arvind
- Panza Francesco
- Paoli Mariela
- Papadopoulou Sousana K.
- Papandreou Dimitrios
- Pareja Rossina G.
- Park Soon-Woo
- Park Suyeon
- Parnell Winsome R.
- Parsaeian Mahboubeh
- Pascanu Ionela M.
- Pasquet Patrick
- Patel Nikhil D.
- Pattussi Marcos
- Pavlyshyn Halyna
- Pechlaner Raimund
- Pednekar Mangesh S.
- Pedro João M.
- Peer Nasheeta
- Peixoto Sergio Viana
- Peltonen Markku
- Pereira Alexandre C.
- Peres Marco A.
- Peterkova Valentina
- Peters Annette
- Petersmann Astrid
- Petkeviciene Janina
- Petrauskiene Ausra
- Petrescu Constanta Huidumac
- Pettenuzzo Emanuela
- Peykari Niloofar
- Pećin Ivan
- Pfeiffer Norbert
- Phall Modou Cheyassin
- Pham Son Thai
- Phelps Nowell H.
- Pichardo Rafael N.
- Pierannunzio Daniela
- Pigeot Iris
- Pikhart Hynek
- Pilav Aida
- Pilotto Lorenza
- Pistelli Francesco
- Pitakaka Freda
- Piwonska Aleksandra
- Pizarro Andreia N.
- Plans-Rubió Pedro
- Platonova Alina G.
- Poh Bee Koon
- Pohlabeln Hermann
- Polka Nadija S.
- Pop Raluca M.
- Popovic Stevo R.
- Porta Miquel
- Posch Georg
- Poudyal Anil
- Poulimeneas Dimitrios
- Pouraram Hamed
- Pourfarzi Farhad
- Pourshams Akram
- Poustchi Hossein
- Pradeepa Rajendra
- Price Alison J.
- Price Jacqueline F.
- Prista Antonio
- Providencia Rui
- Puder Jardena J.
- Pudule Iveta
- Puiu Maria
- Punab Margus
- Pérez Cynthia M.
- Qadir Muhammed S.
- Qasrawi Radwan F.
- Qorbani Mostafa
- Quintana Hedley K.
- Quiroga-Padilla Pedro J.
- Rach Stefan
- Radic Ivana
- Radisauskas Ricardas
- Rahim Norsyamlina Che Abdul
- Rahimikazerooni Salar
- Rahman Mahfuzar
- Rahman Mahmudur
- Raitakari Olli
- Raj Manu
- Rajabov Tamerlan
- Rakhmatulloev Sherali
- Rakovac Ivo
- Ramachandran Ambady
- Ramadan Otim P. C.
- Ramires Virgílio V.
- Ramke Jacqueline
- Ramos Elisabete
- Ramos Rafel
- Rampal Lekhraj
- Rampal Sanjay
- Rangelova Lalka S.
- Rao Kodavanti Mallikharjuna
- Rao Sudha Ramachandra
- Rarra Vayia
- Rascon-Pacheco Ramon A.
- Rech Cassiano Ricardo
- Redon Josep
- Reganit Paul Ferdinand M.
- Regecová Valéria
- Renner Jane D. P.
- Repasy Judit A.
- Reuter Cézane P.
- Revilla Luis
- Reynolds Andrew
- Rezaianzadeh Abbas
- Rho Yeunsook
- Ribas-Barba Lourdes
- Ribeiro Robespierre
- Riboli Elio
- Richter Adrian
- Rigo Fernando
- Rigotti Attilio
- Riley Leanne M.
- Rinaldo Natascia
- Rinke de Wit Tobias F.
- Ripollés María Pilar Díez
- Rito Ana I.
- Ritti-Dias Raphael M.
- Rivera Juan A.
- Roa Reina G.
- Robinson Louise
- Robitaille Cynthia
- Roccaldo Romana
- Rodrigues Daniela
- Rodriguez-Martinez Andrea
- Rodríguez Andrea Y.
- Rodríguez Inés Sánchez
- Rodríguez-Artalejo Fernando
- Rodríguez-Villamizar Laura A.
- Roggenbuck Ulla
- Rohloff Peter
- Rohner Fabian
- Rojas-Martinez Rosalba
- Rojroongwasinkul Nipa
- Rolandi Gilda Estela Benitez
- Romaguera Dora
- Romeo Elisabetta L.
- Rosario Angelika Schaffrath
- Rosario Rafaela V.
- Rosengren Annika
- Rouse Ian
- Rouzier Vanessa
- Roy Joel G. R.
- Ruano Maira H.
- Rubinstein Adolfo
- Ruidavets Jean-Bernard
- Ruiz-Betancourt Blanca Sandra
- Ruiz-Castell Maria
- Rusakova Iuliia A.
- Russo Paola
- Rust Petra
- Rutkowski Marcin
- Rühli Frank J.
- Saamel Marge
- Sabanayagam Charumathi
- Sabbaghi Hamideh
- Sacchini Elena
- Sachdev Harshpal S.
- Sadjadi Alireza
- Safarpour Ali Reza
- Safi Sare
- Safiri Saeid
- Saghi Mohammad Hossien
- Saidi Olfa
- Saki Nader
- Salanave Benoit
- Saleva Calogero
- Salmerón Diego
- Salomaa Veikko
- Salonen Jukka T.
- Salvetti Massimo
- Samoutian Margarita
- Sandjaja [missing]
- Sans Susana
- Santacruz Ethel
- Santos Diana A.
- Santos Ina S.
- Santos Lèlita C.
- Santos Maria Paula
- Santos Osvaldo
- Santos Rute
- Santos Tamara R.
- Sant’Angelo Victoria Farrugia
- Saramies Jouko L.
- Sardinha Luis B.
- Sarrafzadegan Nizal
- Sathish Thirunavukkarasu
- Saum Kai-Uwe
- Savin Stefan
- Savva Savvas
- Savy Mathilde
- Sawada Norie
- Sbaraini Mariana
- Scazufca Marcia
- Schaan Beatriz D.
- Schargrodsky Herman
- Schienkiewitz Anja
- Schindler Karin
- Schipf Sabine
- Schmidt Carsten O.
- Schmidt Ida Maria
- Schneider Andrea
- Schnohr Peter
- Schramm Sara
- Schramm Stine
- Schröder Helmut
- Schultsz Constance
- Schulze Matthias B.
- Schutte Aletta E.
- Schöttker Ben
- Sebert Sylvain
- Sedaghattalab Moslem
- Selamat Rusidah
- Sember Vedrana
- Sen Abhijit
- Senbanjo Idowu O.
- Sepanlou Sadaf G.
- Sequera Guillermo
- Serra-Majem Luis
- Servais Jennifer
- Shalnova Svetlana
- Shamah-Levy Teresa
- Shamshirgaran Seyed Morteza
- Shanthirani Coimbatore Subramaniam
- Sharafkhah Maryam
- Sharma Sanjib K.
- Shaw Jonathan E.
- Shayanrad Amaneh
- Shayesteh Ali Akbar
- Sheffer Kate E.
- Shengelia Lela
- Shi Zumin
- Shibuya Kenji
- Shimizu-Furusawa Hana
- Shimony Tal
- Shiri Rahman
- Shrestha Namuna
- Si-Ramlee Khairil
- Siani Alfonso
- Siantar Rosalynn
- Sibai Abla M.
- Sidossis Labros S.
- Silitrari Natalia
- Silva Antonio M.
- Silva Diego Augusto Santos
- Silva Kelly S.
- Sim Xueling
- Simina Iulia Jurca
- Simon Mary
- Simons Judith
- Simons Leon A.
- Singleton Rosie K.
- Sjöberg Agneta
- Sjöström Michael
- Skoblina Natalia A.
- Skodje Gry
- Slazhnyova Tatyana
- Slowikowska-Hilczer Jolanta
- Slusarczyk Przemysław
- Smeeth Liam
- So Hung-Kwan
- Soares Fernanda Cunha
- Sobek Grzegorz
- Sobngwi Eugène
- Sodemann Morten
- Soekatri Moesijanti Y. E.
- Soemantri Agustinus
- Sofat Reecha
- Solano Marta García
- Solfrizzi Vincenzo
- Somi Mohammad Hossein
- Sonestedt Emily
- Song Yi
- Soofi Sajid
- Sophiea Marisa K.
- Sorić Maroje
- Soto-Rojas Victoria E.
- Soumaré Aïcha
- Sousa-Poza Alfonso
- Sovic Slavica
- Sparboe-Nilsen Bente
- Sparrenberger Karen
- Spencer Phoebe R.
- Spinelli Angela
- Spiroski Igor
- Staessen Jan A.
- Stamm Hanspeter
- Starc Gregor
- Staub Kaspar
- Stavreski Bill
- Steene-Johannessen Jostein
- Stehle Peter
- Stein Aryeh D.
- Stergiou George S.
- Stessman Jochanan
- Stevanović Ranko
- Stevens Gretchen A.
- Stieber Jutta
- Stokwiszewski Jakub
- Stoyanova Ekaterina
- Stratton Gareth
- Stronks Karien
- Strufaldi Maria Wany
- Sturua Lela
- Stöckl Doris
- Suka Machi
- Sun Chien-An
- Sun Liang
- Sundström Johan
- Sung Yn-Tz
- Sunyer Jordi
- Suriyawongpaisal Paibul
- Suárez-Medina Ramón
- Sweis Nabil William G.
- Swinburn Boyd A.
- Sy Rody G.
- Sylva René Charles
- Szklo Moyses
- Szponar Lucjan
- Sánchez-Abanto Jose
- Söderberg Stefan
- Sørensen Thorkild I. A.
- Sørgjerd Elin P.
- Tabone Lorraine
- Tai E. Shyong
- Tambalis Konstantinos D.
- Tammesoo Mari-Liis
- Tamosiunas Abdonas
- Tan Eng Joo
- Tang Xun
- Tanrygulyyeva Maya
- Tanser Frank
- Tao Yong
- Tarawneh Mohammed Rasoul
- Tarp Jakob
- Tarqui-Mamani Carolina B.
- Taylor Anne
- Taylor Julie
- Tchibindat Félicité
- Te Velde Saskia
- Tebar William R.
- Tell Grethe S.
- Tello Tania
- Tham Yih Chung
- Thankappan K. R.
- Theobald Holger
- Theodoridis Xenophon
- Thomas Nihal
- Thorand Barbara
- Thuesen Betina H.
- Tichá Ľubica
- Timmermans Erik J.
- Tjandrarini Dwi H.
- Tjonneland Anne
- Tolonen Hanna K.
- Tolstrup Janne S.
- Topbas Murat
- Topór-Mądry Roman
- Torheim Liv Elin
- Tormo María José
- Tornaritis Michael J.
- Torrent Maties
- Torres-Collado Laura
- Toselli Stefania
- Touloumi Giota
- Traissac Pierre
- Tran Thi Tuyet-Hanh
- Tremblay Mark S.
- Triantafyllou Areti
- Trichopoulos Dimitrios
- Trichopoulou Antonia
- Trinh Oanh T. H.
- Trivedi Atul
- Tsao Yu-Hsiang
- Tshepo Lechaba
- Tsigga Maria
- Tsintavis Panagiotis
- Tsugane Shoichiro
- Tuitele John
- Tuliakova Azaliia M.
- Tulloch-Reid Marshall K.
- Tullu Fikru
- Tuomainen Tomi-Pekka
- Tuomilehto Jaakko
- Turley Maria L.
- Twig Gilad
- Tynelius Per
- Tzala Evangelia
- Tzotzas Themistoklis
- Tzourio Christophe
- Ueda Peter
- Ugel Eunice
- Ukoli Flora A. M.
- Ulmer Hanno
- Unal Belgin
- Usupova Zhamyila
- Uusitalo Hannu M. T.
- Uysal Nalan
- Vaitkeviciute Justina
- Valdivia Gonzalo
- Vale Susana
- Valvi Damaskini
- van Dam Rob M.
- van den Born Bert-Jan
- Van der Heyden Johan
- van der Schouw Yvonne T.
- Van Herck Koen
- Van Lippevelde Wendy
- Van Minh Hoang
- Van Schoor Natasja M.
- van Valkengoed Irene G. M.
- Vanderschueren Dirk
- Vanuzzo Diego
- Varbo Anette
- Varela-Moreiras Gregorio
- Vargas Luz Nayibe
- Varona-Pérez Patricia
- Vasan Senthil K.
- Vasques Daniel G.
- Vega Tomas
- Veidebaum Toomas
- Velasquez-Melendez Gustavo
- Velika Biruta
- Verloigne Maïté
- Veronesi Giovanni
- Verschuren W. M. Monique
- Victora Cesar G.
- Viegi Giovanni
- Viet Lucie
- Vik Frøydis N.
- Vilar Monica
- Villalpando Salvador
- Vioque Jesus
- Virtanen Jyrki K.
- Visvikis-Siest Sophie
- Viswanathan Bharathi
- Vladulescu Mihaela
- Vlasoff Tiina
- Vocanec Dorja
- Vollenweider Peter
- Voutilainen Ari
- Vrijheid Martine
- Vrijkotte Tanja G. M.
- Vrkic Tajana Zeljkovic
- Völzke Henry
- Wade Alisha N.
- Waldhör Thomas
- Walton Janette
- Wambiya Elvis O. A.
- Wang Ming-Dong
- Wang Ningli
- Wang Qian
- Wang Xiangjun
- Wang Ya Xing
- Wang Ying-Wei
- Wannamethee S. Goya
- Wareham Nicholas
- Weber Adelheid
- Webster-Kerr Karen
- Wedderkopp Niels
- Weghuber Daniel
- Wei Wenbin
- Weres Aneta
- Werner Bo
- Westbury Leo D.
- Whincup Peter H.
- Wickramasinghe Kremlin
- Widhalm Kurt
- Widyahening Indah S.
- Wild Philipp S.
- Wilks Rainford J.
- Willeit Johann
- Willeit Peter
- Williams Julianne
- Wilsgaard Tom
- Wirth James P.
- Więcek Andrzej
- Wojciech Rusek
- Wojtyniak Bogdan
- Wolf Kathrin
- Wong Andrew
- Wong Emily B.
- Wong Jyh Eiin
- Wong Norazizah Ibrahim
- Wong Tien Yin
- Wong-McClure Roy A.
- Woo Jean
- Woodward Mark
- Wu Frederick C.
- Wu Hon-Yen
- Wu Jianfeng
- Wu Li Juan
- Wu Shouling
- Wyszyńska Justyna
- Xu Haiquan
- Xu Liang
- Yaacob Nor Azwany
- Yamborisut Uruwan
- Yan Weili
- Yang Ling
- Yang Xiaoguang
- Yang Yang
- Yardim Nazan
- Yasuharu Tabara
- Yiallouros Panayiotis K.
- Yngve Agneta
- Yoosefi Moein
- Yoshihara Akihiro
- You Qi Sheng
- You San-Lin
- Younger-Coleman Novie O.
- Yu Yu-Ling
- Yu Yunjiang
- Yusof Safiah Md
- Yusoff Ahmad Faudzi
- Yusoff Muhammad Fadhli Mohd
- Zaccagni Luciana
- Zafiropulos Vassilis
- Zainuddin Ahmad A.
- Zakavi Seyed Rasoul
- Zamani Farhad
- Zambon Sabina
- Zampelas Antonis
- Zamrazilová Hana
- Zapata Maria Elisa
- Zargar Abdul Hamid
- Zaw Ko Ko
- Zayed Ayman A.
- Zdrojewski Tomasz
- Zejglicova Kristyna
- Zeng Yi
- Zhang Luxia
- Zhang Zhen-Yu
- Zhao Dong
- Zhao Ming-Hui
- Zhao Wenhua
- Zhecheva Yanitsa V.
- Zhen Shiqi
- Zheng Wei
- Zheng Yingfeng
- Zholdin Bekbolat
- Zhou Bin
- Zhou Maigeng
- Zhu Dan
- Zins Marie
- Zitt Emanuel
- Zocalo Yanina
- Zoghlami Nada
- Zuziak Monika
- Ängquist Lars
- Čapková Naděžda
- Łuszczki Edyta
- Šalaj Sanja
- Ševčíková Ľudmila
- Żegleń Magdalena
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2023
- Field of study
Optimal growth and development in childhood and adolescence is crucial for lifelong health and well-being1–6. Here we used data from 2,325 population-based studies, with measurements of height and weight from 71 million participants, to report the height and body-mass index (BMI) of children and adolescents aged 5–19 years on the basis of rural and urban place of residence in 200 countries and territories from 1990 to 2020. In 1990, children and adolescents residing in cities were taller than their rural counterparts in all but a few high-income countries. By 2020, the urban height advantage became smaller in most countries, and in many high-income western countries it reversed into a small urban-based disadvantage. The exception was for boys in most countries in sub-Saharan Africa and in some countries in Oceania, south Asia and the region of central Asia, Middle East and north Africa. In these countries, successive cohorts of boys from rural places either did not gain height or possibly became shorter, and hence fell further behind their urban peers. The difference between the age-standardized mean BMI of children in urban and rural areas was <1.1 kg m–2 in the vast majority of countries. Within this small range, BMI increased slightly more in cities than in rural areas, except in south Asia, sub-Saharan Africa and some countries in central and eastern Europe. Our results show that in much of the world, the growth and developmental advantages of living in cities have diminished in the twenty-first century, whereas in much of sub-Saharan Africa they have amplified