Church, state and society; the attitudes of John Keble, Richard Hurrell Froude and John Henry Newman. 1827-1845

Keble, Froude and Newman's understanding of the Church in relationship to State and society is considered against an- eighteenth century background which, thanks partly to the Tractarians, has been painted in colours which portray Godlessness, belief in progress and the perfection of man with a tepid Church and a torpid religion willing onlookers. The Enlightenment was far more complicated than this caricature. Yet it is not always the accuracy of the picture but the supposed image which matters. In that sense, Keble, Froude and Newman shared the reaction of the Romantic Movement to what was seen as the prevailing Rationalist and Utilitarian spirit witnessed inside the Church by her powerful alliance with governments and political economists and outside by the united attacks from Roman Catholics, Radicals, Nonconformists and philosophers. Chapter 1 studies the political and social implications of The Christian Year, Keble's abhorrence of the 1832 Reform Bill and his sermon "National Apostasy". His views about Poor Law reform and the importance of Tradition are also considered. Froude's articles on "State Interference in Matters Spiritual", his influence upon the political and social outlook of Keble and Newman and the political significance of the posthumously published Remains are the themes of Chapter 2. In Chapter 3, Newman's opposition to Peel and Roman Catholic Emancipation in 1829, his attitude to the 1832 Reform Bill, his views on history in The Arians and the relationship of the Church to society are studied. His criticism of Peel in 1841, his views on change, development and progress between 1841 and 1845 and his final view as an Anglican of the Church as an imperial power are also considered. For Keble, Froude and Newman, the Church's mission to society was always spiritual with no thought of accommodation to the needs of the age. Saints are more important than reformers. The three figures studied upheld Tory paternalism in their concepts of the interrelationship between rich and poor and their detestation of democracy. Their understanding of the Church's relationship with the State, however, was different in that Keble was a critical orthodox thinker, Froude a radical catalyst and Newman a theoretician of profound development. They completely rejected the progressive spirit of Peelite Conservatism and brought to Toryism a powerful moral and spiritual temper, seen in Keble's perseverance in adversity, Froude's search for an alternative in Feudal times and Newman's advocacy of a transcendental, eternal and triumphant Orthodoxy and Orthopraxis

The sensory acceptance of fibre-enriched cereal foods:a meta-analysis

Improved understanding of the sensory responses to fibre fortification may assist manufacturers and health promotion efforts. The effects of fibre fortification (or modified ingredients) on sensory acceptability of baked cereal foods (bread, cookies, muffins) were estimated by linear random-effects meta-analysis of twenty eligible studies (869 panellists, 34% male). As little as 2 g per 100 g fortification caused moderate–large reductions in overall acceptability, flavour acceptability, and appearance acceptability in most items, with cookies most negatively affected. Fortification of base nonfortified foods with low initial acceptability improved acceptability; however, at higher basic levels, fortification lowered acceptability. Fortification improved texture acceptability of muffins and bread with low base acceptability, but lowered texture acceptability when base acceptability was high. Flavour improvement of muffins with fortification decreased with increasing base food acceptability. Fibre fortification of baked cereal foods lowers acceptability, but food format and base food acceptability affect the magnitude and direction of responses. Refining fibre fortification approaches could improve consumer uptake

Joint modelling of repeated measurements and event time: Application to performance traits and survival of lambs bred in sub-humid tropics

We considered the analysis of a study for Dorper, Red Maasai and crossbred lambs born over a period of 6 years at the Diani Estate, Kenya. The study was designed to compare survival and performance traits of genotypes with differing susceptibilities to helminthiasis. The available data include information on time to death and repeated measurements of body weight, packed cell volume (PCV) and faecal egg count (FEC) of the animals. In the paper, we consider joint modelling of the survival time and the repeated measurements. Such an approach allows to account for the possible association between the survival and repeated measurement processes. The advantages and limitations of the joint modelling are discussed and illustrated using the Diani Estate study data

17O NMR spectroscopy as a tool to study hydrogen bonding of cholesterol in lipid bilayers

Cholesterol is a crucial component of biological membranes and can interact with other membrane components through hydrogen bonding. NMR spectroscopy has been used previously to investigate this bonding, however this study represents the first 17O NMR spectroscopy study of isotopically enriched cholesterol. We demonstrate the 17O chemical shift is dependent on hydrogen bonding, providing a novel method for the study of cholesterol in bilayers

Wear Compliance and Activity in Children Wearing Wrist and Hip-Mounted Accelerometers.

PURPOSE: This study aimed to (i) explore children's compliance to wearing wrist and hip-mounted accelerometers, (ii) compare children's physical activity (PA) derived from wrist and hip raw accelerations, and (iii) examine differences in raw and counts PA measured by hip-worn accelerometry. METHODS: One hundred and twenty nine 9-10 y old children wore a wrist-mounted GENEActiv accelerometer (GAwrist) and a hip-mounted ActiGraph GT3X+ accelerometer (AGhip) for 7 d. Both devices measured raw accelerations and the AGhip also provided counts-based data. RESULTS: More children wore the GAwrist than the AGhip regardless of wear time criteria applied (p<.001 - .035). Raw data signal vector magnitude (SVM; r = .68), moderate PA (MPA; r = .81), vigorous PA (VPA; r = .85), and moderate-to-vigorous PA (MVPA; r = .83) were strongly associated between devices (p<.001). GAwrist SVM (p = .001), MPA (p = .037), VPA (p = .002), and MVPA (p = .016) were significantly greater than AGhip. According to GAwrist raw data, 86.9% of children engaged in at least 60 min MVPA[BULLET OPERATOR]d, compared to 19% for AGhip. ActiGraph MPA (raw) was 42.00 ± 1.61 min[BULLET OPERATOR]d compared to 35.05 ± 0.99 min[BULLET OPERATOR]d (counts) (p=.02). Actigraph VPA was 7.59 ± 0.46 min[BULLET OPERATOR]d (raw) and 37.06 ± 1.85 min[BULLET OPERATOR]d (counts; p=.19). CONCLUSION: In children accelerometer wrist placement promotes superior compliance than the hip. Raw accelerations were significantly higher for GAwrist compared to AGhip, possibly due to placement location and technical differences between devices. AGhip PA calculated from raw accelerations and counts differed substantially, demonstrating that PA outcomes derived from cutpoints for raw output and counts cannot be directly compared

Integrating Narcissus-derived galanthamine production into traditional upland farming systems

Alzheimer’s disease (AD) is a disorder associated with progressive degeneration of memory and cognitive function. Galantamine is a licenced treatment for AD but supplies of the plant alkaloid that it is produced from, galanthamine, are limited. This three-year system study tested the potential to combine Narcissus-derived galanthamine production with grassland-based ruminant production. Replicate plots of permanent pasture were prepared with and without bulbs of Narcissus pseudonarcissus sown as lines into the sward. Two different fertiliser regimes were imposed. The above-ground green biomass of N. pseudonarcissus was harvested in early spring and the galanthamine yield determined. In the second harvest year a split-plot design was implemented with lines of N. pseudonarcissus cut annually and biennially. All plots were subsequently grazed by ewes and lambs and animal performance recorded. Incorporation of N. pseudonarcissus into grazed permanent pasture had no detrimental effects on the health or performance of the sheep which subsequently grazed the pasture. There was no consistency to the effects of fertiliser rates on galanthamine yields. There was no difference in overall galanthamine yield if N. pseudonarcissus was cut biennially (1.64 vs. 1.75 kg galanthamine/ha for annual combined vs biennial cuts respectively; s.e.d = 0.117 kg galanthamine/ha; ns). This study verified the feasibility of a dual cropping approach to producing plant-derived galanthamine

Up-beat UK: a programme of research into the relationship between coronary heart disease and depression in primary care patients.

Coronary heart disease and depression are both common health problems and by 2020 will be the two leading causes of disability worldwide. Depression has been found to be more common in patients with coronary heart disease but the nature of this relationship is uncertain. In the United Kingdom general practitioners are now being remunerated for case-finding for depression in patients with coronary heart disease, however it is unclear how general practitioners should manage these patients. We aim to explore the relationship between coronary heart disease and depression in a primary care population and to develop an intervention for patients with coronary heart disease and depression