Procédé composite à grandes cadences pour l'allégement des pièces mécaniques

Le CETIM développe des procédés pour la mise en oeuvre à grandes cadences et à bas coût de pièces mécaniciennes en matériaux composite thermoplastique. Un triangle de suspension définie par PSA a été développé et testé à titre de démonstration. Les performances et la cadence de production sont satisfaisantes, mais pas le coût de revient. C'est pourquoi le CETIM a développé un nouveau procédé, le QSP®, permettant de fabriquer des pièces composites à coût réduit. Ce développement procédé repose sur la pultrusion thermoplastique pour l'imprégnation des fibres, puis sur le thermoformage de préforme multi-épaisseur et multi-orientation. De nouvelles méthodes de conception sont mise au point pour optimiser les conceptions de pièces QSP

Fast Mapping of Terahertz Bursting Thresholds and Characteristics at Synchrotron Light Sources

Dedicated optics with extremely short electron bunches enable synchrotron light sources to generate intense coherent THz radiation. The high degree of spatial compression in this so-called low-alpha optics entails a complex longitudinal dynamics of the electron bunches, which can be probed studying the fluctuations in the emitted terahertz radiation caused by the micro-bunching instability ("bursting"). This article presents a "quasi-instantaneous" method for measuring the bursting characteristics by simultaneously collecting and evaluating the information from all bunches in a multi-bunch fill, reducing the measurement time from hours to seconds. This speed-up allows systematic studies of the bursting characteristics for various accelerator settings within a single fill of the machine, enabling a comprehensive comparison of the measured bursting thresholds with theoretical predictions by the bunched-beam theory. This paper introduces the method and presents first results obtained at the ANKA synchrotron radiation facility.Comment: 7 pages, 7 figures, to be published in Physical Review Accelerators and Beam

A neural network-based data-driven local modeling of spotwelded plates under impact

Solving large structural problems with multiple complex localized behaviors is extremely challenging. To address this difficulty, both intrusive and non-intrusive Domain Decomposition Methods (DDM) have been developed in the past, where the refined model (local) is solved separately in its own space and time scales. In this work, the Finite Element Method (FEM) at the local scale is replaced with a data-driven Reduced Order Model (ROM) to further decrease computational time. The reduced model aims to create a low-cost, accurate and efficient mapping from interface velocities to interface forces and enable the prediction of their time evolution. The present work proposes a modeling technique based on the Physics-Guided Architecture of Neural Networks (PGANNs), which incorporates physical variables other than input/output variables into the neural network architecture. We develop this approach on a 2D plate with a hole as well as a 3D case with spot-welded plates undergoing fast deformation, representing nonlinear elastoplasticity problems. Neural networks are trained using simulation data generated by explicit dynamic FEM solvers. The PGANN results are in good agreement with the FEM solutions for both test cases, including those in the training dataset as well as the unseen dataset, given the loading type is present in the training set

Fast mapping of terahertz bursting thresholds and characteristics at synchrotron light sources

Dedicated optics with extremely short electron bunches enable synchrotron light sources to generate intense coherent THz radiation. The high degree of spatial compression in this so-called low-α$_{c}$ optics entails a complex longitudinal dynamics of the electron bunches, which can be probed studying the fluctuations in the emitted terahertz radiation caused by the microbunching instability (“bursting”). This article presents a “quasi-instantaneous” method for measuring the bursting characteristics by simultaneously collecting and evaluating the information from all bunches in a multibunch fill, reducing the measurement time from hours to seconds. This speed-up allows systematic studies of the bursting characteristics for various accelerator settings within a single fill of the machine, enabling a comprehensive comparison of the measured bursting thresholds with theoretical predictions by the bunched-beam theory. This paper introduces the method and presents first results obtained at the ANKA synchrotron radiation facility

Systematic Studies of the Micro-Bunching Instability at Very Low Bunch Charges

At KARA, the KArlsruhe Research Accelerator of the KIT synchrotron, the so called short bunch operation mode allows the reduction of the bunch length down to a few picoseconds. The micro- bunching instability resulting from the high degree of longitudinal compression leads to fluctuations in the emitted THz radiation, referred to as bursting. For extremely compressed bunches at KARA, bursting occurs not only in one but in two different bunch-current ranges that are separated by a stable region. This work presents measurements of the bursting behavior in both regimes. Good agreement is found between data and numerical solutions of the Vlasov-Fokker-Planck equation.Comment: 6 pages, 5 figures, to be submitte

Shp-2 is critical for ERK and metabolic engagement downstream of IL-15 receptor in NK cells

The phosphatase Shp-2 was implicated in NK cell development and functions due to its interaction with NK inhibitory receptors, but its exact role in NK cells is still unclear. Here we show, using mice conditionally deficient for Shp-2 in the NK lineage, that NK cell development and responsiveness are largely unaffected. Instead, we find that Shp-2 serves mainly to enforce NK cell responses to activation by IL-15 and IL-2. Shp-2-deficient NK cells have reduced proliferation and survival when treated with high dose IL-15 or IL-2. Mechanistically, Shp-2 deficiency hampers acute IL-15 stimulation-induced raise in glycolytic and respiration rates, and causes a dramatic defect in ERK activation. Moreover, inhibition of the ERK and mTOR cascades largely phenocopies the defect observed in the absence of Shp-2. Together, our data reveal a critical function of Shp-2 as a molecular nexus bridging acute IL-15 signaling with downstream metabolic burst and NK cell expansion

A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

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