Notas sobre la brioflora balear, 5

Se citan algunos briófitos que son novedad para el catálogo floristico balear: Marchantia paleacea Bertol., Sphaerocarpos texanus Aust., Bryu^ pseudotriquetrum (Hedw.) Gaertn et al., Orthotrichum affine Brid., Pseudoleskeella catenulata (Schrad.) Kindb. y Sematophyllum substrumulosum (Hampe) Britt. Se mencionan especies que no habían sido indicadas en la flora de Ibiza (9), Formentera (1) y Mallorca (1).The following bryophytes are quoted for the first time in the flora of the Balearic Islands: Marchantia paleacea Bertol., Sphaerocarpos texanus Aust., Bryu^ pseudotriquetrum (Hedw.) Gaertn., et al., Orthotrichum affine Brid., Pseudoleskeella catenulata (Schrad.) Kindb. and Sematophyllum substrumulosum (Hampe) Britt. Some species are new for the flora of Ibiza (9), Formentera (1) and Mallorca (1)

Asplenium Balearicum Shivas en la Isla de Menorca

Se estudia la variabilidad morfológica de Asplenium balearicum Shivas en la isla de Menorca, comparándose con los datos conocidos de las poblaciones italianas. Se esboza la ecología de la especie, con especial atención a sus preferencias edafológicasThe morfological variation of Asplenium balearicum Shivas from Menorca is studied and some observations about its ecology are given

Risk of neonatal care unit admission in small for gestational age fetuses at term: a prediction model and internal validation.

OBJECTIVE: Small for gestational age (SGA) fetuses are at increased risk of admission to the neonatal unit, even at term. We aimed to develop and validate a predictive model for the risk of prolonged neonatal unit admission in suspected SGA fetuses at term. METHODS: A single-center cohort study of singleton pregnancies with SGA fetus, defined as estimated fetal weight (EFW) less than the 10th centile, at term. The variables included known risk factors for neonatal unit admissions: maternal characteristics, EFW, abdominal circumference (AC), fetal Dopplers, gestational age (GA) at delivery, and intrapartum risk factors (meconium, pyrexia). Logistic regression analysis was used for model building and the prediction models were validated internally using bootstrapping. RESULTS: 701 SGA pregnancies at term were included; 5.9% had prolonged neonatal unit admission (> 48 hours). The multivariable model (AUC 0.71; 95% CI: 0.63-0.79) included GA at delivery < 39 weeks (OR 2.76; 95% CI 1.23-6.04, p = 0.011), cerebroplacental ratio (CPR) multiples of median (MoM) (OR 0.21; 95% CI 0.05-0.79, p = 0.023), and EFW below the third centile (OR 2.43; 95% CI 1.26-4.68, p < 0.007). The combined model showed a sensitivity 30.9% (95% CI: 16.6-45.2%) for a fixed 10% false positive rate. CONCLUSION: The prediction model shows good accuracy and good calibration for assessing the risk of neonatal unit admission in suspected SGA fetuses. It has the potential to be used for patient counseling, determining the timing of delivery and the individual risk

The response of the hepatocyte to ischemia

BACKGROUND: Ischemia-reperfusion (I/R) injury associated with hepatic resections and liver transplantation remains a serious complication in clinical practice, in spite of several attempts to solve the problem. AIMS: To evaluate the response of the hepatocyte to ischemia METHODS: Published data are thus revised. RESULTS: The response of the hepatocyte to ischemia is based on the sensitivity of hepatocytes to different types of ischemia, the kind of cell death of the hepatocyte when it is subjected to ischemia, and on the response of the hepatocyte to the different times and extents of ischemia. Clinical factors including starvation, graft, age, and hepatic steatosis, all of which contribute to enhancing liver susceptibility to ischemia/reperfusion injury. CONCLUSION: Ischemic preconditioning, based on the induction of a brief ischemia to the liver prior to a prolonged ischemia, has been applied in tumor hepatic resections for reducing hepatic I/R injury and recent clinical studies suggest that this surgical strategy could be appropriate for liver transplantation

Atlantic Shortfin Mako: Chronicle of a Death Foretold?

This article outlines recent events concerning the conservation and management trajectory of a highly migratory shark species, the shortfin mako (Isurus oxyrinchus), in the North Atlantic, where it has been routinely captured recreationally and as part of commercial fishing operations alongside other species. Noting recent warnings concerning the high mortality of the species in this ocean region, and the threat of imminent population collapse, this article sets out a number of applicable law of the sea provisions, and carries out an evaluation of relevant measures for target and incidental capture species, discussing their applicability to the mako fishery. It also presents an analysis of regional and global governance actions taken to date by the international community and by individual actors, noting a number of shortfalls, and outlining potential responses

Cryptococcus neoformans phosphoinositide-dependent kinase 1 (PDK1) ortholog is required for stress tolerance and survival in murine phagocytes

Cryptococcus neoformans PKH2-01 and PKH2-02 are orthologous to mammalian PDK1 kinase genes. Although orthologs of these kinases have been extensively studied in S. cerevisiae, little is known about their function in pathogenic fungi. In this study, we show that PKH2-02 but not PKH2-01 is required for C. neoformans to tolerate cell wall, oxidative, nitrosative, and antifungal drug stress. Deletion of PKH2-02 leads to decreased basal levels of Pkc1 activity and, consequently, reduced activation of the cell wall integrity mitogen-activated protein kinase (MAPK) pathway in response to cell wall, oxidative, and nitrosative stress. PKH2-02 function also is required for tolerance of fluconazole and amphotericin B, two important drugs for the treatment of cryptococcosis. Furthermore, OSU-03012, an inhibitor of human PDK1, is synergistic and fungicidal in combination with fluconazole. Using a Galleria mellonella model of low-temperature cryptococcosis, we found that PKH2-02 is also required for virulence in a temperature-independent manner. Consistent with the hypersensitivity of the pkh2-02Δ mutant to oxidative and nitrosative stress, this mutant shows decreased survival in murine phagocytes compared to that of wild-type (WT) cells. In addition, we show that deletion of PKH2-02 affects the interaction between C. neoformans and phagocytes by decreasing its ability to suppress production of tumor necrosis factor alpha (TNF-α) and reactive oxygen species. Taken together, our studies demonstrate that Pkh2-02-mediated signaling in C. neoformans is crucial for stress tolerance, host-pathogen interactions, and both temperature-dependent and -independent virulence

Kurcuma: a kitchen utensil recognition collection for unsupervised domain adaptation

The use of deep learning makes it possible to achieve extraordinary results in all kinds of tasks related to computer vision. However, this performance is strongly related to the availability of training data and its relationship with the distribution in the eventual application scenario. This question is of vital importance in areas such as robotics, where the targeted environment data are barely available in advance. In this context, domain adaptation (DA) techniques are especially important to building models that deal with new data for which the corresponding label is not available. To promote further research in DA techniques applied to robotics, this work presents Kurcuma (Kitchen Utensil Recognition Collection for Unsupervised doMain Adaptation), an assortment of seven datasets for the classification of kitchen utensils—a task of relevance in home-assistance robotics and a suitable showcase for DA. Along with the data, we provide a broad description of the main characteristics of the dataset, as well as a baseline using the well-known domain-adversarial training of neural networks approach. The results show the challenge posed by DA on these types of tasks, pointing to the need for new approaches in future work.Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. This work was supported by the I+D+i project TED2021-132103A-I00 (DOREMI), funded by MCIN/AEI/10.13039/501100011033. Some of the computing resources were provided by the Generalitat Valenciana and the European Union through the FEDER funding program (IDIFEDER/2020/003). The second author is supported by grant APOSTD/2020/256 from “Programa I+D+i de la Generalitat Valenciana”

Integrated test environment for a part of the LHCb calorimeter - TWEPP09

An integrated test environment for the data acquisition electronics of the Scintillator Pad Detector (SPD) from the calorimeter of the LHCb experiment is presented. It allows to test separately every single board or to perform global system tests, while being able to emulate every part of the system and debug it. This environment is foreseen to test the production of spare electronic boards and help the maintenance of the SPD electronics along the life of the detector. The heart of the system is an Altera Stratix II FPGA while the main board can be controlled over USB, Ethernet or WiFi

Using RAW as Control Plane for Wireless Deterministic Networks: Challenges Ahead

This paper provides extensive analysis of RAW (Reliable and Available Wireless) enhancements and solutions needed to manage industrial environments more effectively. Starting from the description of the industrial use case, an analysis of gaps and potential new extensions is performed. Namely, the need to (i) support multi-domain operation, at both technology and administrative levels; (ii) integrate RAW with edge architectures; and, (iii) the support for mobility support in RAW networks, are analysed. The identified gaps are indeed not yet tackled by the relevant standardisation development organisations, mainly the Internet Engineering Task Force, and are thus object of our future wor