Universités et universitaires palestiniens d’une intifâda à l’autre

Le soulèvement palestinien de septembre 2000 contre l’occupation et la colonisation israéliennes des Territoires occupés et sa répression convoient médiatiquement l’idée d’une rupture historique avec un ordre social qui serait hérité des négociations intérimaires d’Oslo débutées en 1993. À une période de calme « normalité » succéderait depuis bientôt deux ans une période obscure de crise multiforme et violente. La mise en exergue de cette violence risque de faire oublier que les trois million..

Quelques réflexions à propos des processus coercitifs dans les Territoires occupés

RésuméÀ partir d’une ethnologie d’universitaires palestiniens des Territoires occupés, cet article se propose de rendre compte de certaines dimensions, peu évoquées, de la violence à l’œuvre dans cet espace. Nous pensons qu’aux lieux et moments de violence les plus immédiats correspondent des logiques médiates d’expérience de la violence par les acteurs. Cette mise en relation de l’expérience quotidienne des individus avec les dispositifs de contrainte permet de saisir la portée sociale des phénomènes coercitifs en évitant les registres réducteurs de la victimisation, de l’héroïsme ou bien de l’institutionnalisme dépersonnalisé. L’analyse de l’enfermement spatial renvoie ainsi à une logique d’enfermement chronologique, où différentes temporalités – individuelles et collectives, passées et présentes – s’entrechoquent.AbstractThis ethnological study of Palestinian academics from the Occupied Territories seeks to explain certain seldom mentioned dimensions of violence there. “Mediate logics of the experience of violence by actors” correspond to the immediate places and times of acts of violence. This correlation of individuals’ everyday experiences with coercive measures highlights the social scope of coercive phenomena while avoiding the reductionistic categories of victimization, heroism or even depersonalized institutions. The analysis of spatial confinement turns out to be related to a “logic of chronological confinement”, as various temporalities (individual and collective, past and present) clash

Variação temporal da biomassa do café arábica arborizado e Pleno Sol através de índices de vegetação.

http://www.dsr.inpe.br/sbsr2011/files/p0665.pdfInternational audienceIn recent years, several works have been accomplished in order to analyze the spectral response of coffee crop fields cultivated in full sun. However, the number of papers related to the monitoring of shaded coffee systems is reduced although this kind of cultivation is very important from the perspective of climate change and agriculture. In addition, the biomass of coffee systems can store carbon, which is a mitigation action. In this context, this paper presents the assessment of the meteorological variation joined with the biomass increase in three different coffee plantation systems: full sun, shaded coffee associated with legumes (SAF), and shaded coffee with Macadamia trees. We used Landsat-5 images from 2004 to 2010, and the NDVI and SAVI indexes. LAI index measured in the test area during all 2009 year. The results showed that the shaded coffee systems presented the NDVI and SAVI indexes with higher values than those found with the system of planting in full sun what corroborates the idea of greater amount of biomass in this type of planting. All indexes present the seasonal rain variation. One month after a large period of drought the indexes NDVI, SAVI and LAI decrease. The NDVI and SAVI indexes presented high correlation with the measured LAI. The shaded coffee system and the full sun coffee reached high vegetation indexes what indicate a high concentration of biomass. This factor should be considered in the decision making process since is important to take advantage of cultivation systems acting as carbon sinks

Epidermal Langerhans Cells Rapidly Capture and Present Antigens from C-Type Lectin-Targeting Antibodies Deposited in the Dermis

Antigen-presenting cells can capture antigens that are deposited in the skin, including vaccines given subcutaneously. These include different dendritic cells (DCs) such as epidermal Langerhans cells (LCs), dermal DCs, and dermal langerin+ DCs. To evaluate access of dermal antigens to skin DCs, we used mAb to two C-type lectin endocytic receptors, DEC-205/CD205 and langerin/CD207. When applied to murine and human skin explant cultures, these mAbs were efficiently taken up by epidermal LCs. In addition, anti-DEC-205 targeted langerin+ CD103+ and langerin− CD103− mouse dermal DCs. Unexpectedly, intradermal injection of either mAb, but not isotype control, resulted in strong and rapid labeling of LCs in situ, implying that large molecules can diffuse through the basement membrane into the epidermis. Epidermal LCs targeted in vivo by ovalbumin-coupled anti-DEC-205 potently presented antigen to CD4+ and CD8+ T cells in vitro. However, to our surprise, LCs targeted through langerin were unable to trigger T-cell proliferation. Thus, epidermal LCs have a major function in uptake of lectin-binding antibodies under standard vaccination conditions

Murine Langerin+ dermal dendritic cells prime CD8+ T cells while Langerhans cells induce cross-tolerance.

Skin dendritic cells (DCs) control the immunogenicity of cutaneously administered vaccines. Antigens targeted to DCs via the C-type lectin Langerin/CD207 are cross-presented to CD8(+) T cells in vivo. We investigated the relative roles of Langerhans cells (LCs) and Langerin(+) dermal DCs (dDCs) in different vaccination settings. Poly(I:C) and anti-CD40 agonist antibody promoted cytotoxic responses upon intradermal immunization with ovalbumin (OVA)-coupled anti-Langerin antibodies (Langerin/OVA). This correlated with CD70 upregulation in Langerin(+) dDCs, but not LCs. In chimeric mice where Langerin targeting was restricted to dDCs, CD8(+) T-cell memory was enhanced. Conversely, providing Langerin/OVA exclusively to LCs failed to prime cytotoxicity, despite initial antigen cross-presentation to CD8(+) T cells. Langerin/OVA combined with imiquimod could not prime CD8(+) T cells and resulted in poor cytotoxicity in subsequent responses. This tolerance induction required targeting and maturation of LCs. Altogether, Langerin(+) dDCs prime long-lasting cytotoxic responses, while cross-presentation by LCs negatively influences CD8(+) T-cell priming. Moreover, this highlights that DCs exposed to TLR agonists can still induce tolerance and supports the existence of qualitatively different DC maturation programs.journal articleresearch support, n.i.h., extramuralresearch support, non-u.s. gov't2014 Sepimporte

Laparoscopy in management of appendicitis in high-, middle-, and low-income countries: a multicenter, prospective, cohort study.

BACKGROUND: Appendicitis is the most common abdominal surgical emergency worldwide. Differences between high- and low-income settings in the availability of laparoscopic appendectomy, alternative management choices, and outcomes are poorly described. The aim was to identify variation in surgical management and outcomes of appendicitis within low-, middle-, and high-Human Development Index (HDI) countries worldwide. METHODS: This is a multicenter, international prospective cohort study. Consecutive sampling of patients undergoing emergency appendectomy over 6 months was conducted. Follow-up lasted 30 days. RESULTS: 4546 patients from 52 countries underwent appendectomy (2499 high-, 1540 middle-, and 507 low-HDI groups). Surgical site infection (SSI) rates were higher in low-HDI (OR 2.57, 95% CI 1.33-4.99, p = 0.005) but not middle-HDI countries (OR 1.38, 95% CI 0.76-2.52, p = 0.291), compared with high-HDI countries after adjustment. A laparoscopic approach was common in high-HDI countries (1693/2499, 67.7%), but infrequent in low-HDI (41/507, 8.1%) and middle-HDI (132/1540, 8.6%) groups. After accounting for case-mix, laparoscopy was still associated with fewer overall complications (OR 0.55, 95% CI 0.42-0.71, p < 0.001) and SSIs (OR 0.22, 95% CI 0.14-0.33, p < 0.001). In propensity-score matched groups within low-/middle-HDI countries, laparoscopy was still associated with fewer overall complications (OR 0.23 95% CI 0.11-0.44) and SSI (OR 0.21 95% CI 0.09-0.45). CONCLUSION: A laparoscopic approach is associated with better outcomes and availability appears to differ by country HDI. Despite the profound clinical, operational, and financial barriers to its widespread introduction, laparoscopy could significantly improve outcomes for patients in low-resource environments. TRIAL REGISTRATION: NCT02179112

SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues

Variability in SARS-CoV-2 susceptibility and COVID-19 disease severity between individuals is partly due to genetic factors. Here, we identify 4 genomic loci with suggestive associations for SARS-CoV-2 susceptibility and 19 for COVID-19 disease severity. Four of these 23 loci likely have an ethnicity-specific component. Genome-wide association study (GWAS) signals in 11 loci colocalize with expression quantitative trait loci (eQTLs) associated with the expression of 20 genes in 62 tissues/cell types (range: 1:43 tissues/gene), including lung, brain, heart, muscle, and skin as well as the digestive system and immune system. We perform genetic fine mapping to compute 99% credible SNP sets, which identify 10 GWAS loci that have eight or fewer SNPs in the credible set, including three loci with one single likely causal SNP. Our study suggests that the diverse symptoms and disease severity of COVID-19 observed between individuals is associated with variants across the genome, affecting gene expression levels in a wide variety of tissue types

Pooled analysis of WHO Surgical Safety Checklist use and mortality after emergency laparotomy

Background The World Health Organization (WHO) Surgical Safety Checklist has fostered safe practice for 10 years, yet its place in emergency surgery has not been assessed on a global scale. The aim of this study was to evaluate reported checklist use in emergency settings and examine the relationship with perioperative mortality in patients who had emergency laparotomy. Methods In two multinational cohort studies, adults undergoing emergency laparotomy were compared with those having elective gastrointestinal surgery. Relationships between reported checklist use and mortality were determined using multivariable logistic regression and bootstrapped simulation. Results Of 12 296 patients included from 76 countries, 4843 underwent emergency laparotomy. After adjusting for patient and disease factors, checklist use before emergency laparotomy was more common in countries with a high Human Development Index (HDI) (2455 of 2741, 89.6 per cent) compared with that in countries with a middle (753 of 1242, 60.6 per cent; odds ratio (OR) 0.17, 95 per cent c.i. 0.14 to 0.21, P <0001) or low (363 of 860, 422 per cent; OR 008, 007 to 010, P <0.001) HDI. Checklist use was less common in elective surgery than for emergency laparotomy in high-HDI countries (risk difference -94 (95 per cent c.i. -11.9 to -6.9) per cent; P <0001), but the relationship was reversed in low-HDI countries (+121 (+7.0 to +173) per cent; P <0001). In multivariable models, checklist use was associated with a lower 30-day perioperative mortality (OR 0.60, 0.50 to 073; P <0.001). The greatest absolute benefit was seen for emergency surgery in low- and middle-HDI countries. Conclusion Checklist use in emergency laparotomy was associated with a significantly lower perioperative mortality rate. Checklist use in low-HDI countries was half that in high-HDI countries.Peer reviewe