Denied and Disparaged: Madisonian Federalism and the Original Meaning of the Ninth Amendment

The Ninth Amendment played an important role in the founding of our nation, but it has long been forgotten and misunderstood. In the last decade, however, scholars have begun to reexamine the history of the Ninth Amendment to determine its original meaning. Ninth Amendment scholarship has primarily been driven by a new debate between Kurt Lash and Randy Barnett. This thesis examines that debate. After concluding that Lash's "federalism" model of the Ninth Amendment is more historically accurate, it explores the "federalism" model's applicability to modern Ninth Amendment jurisprudence, how it relates to the "right to privacy," and the role of originalism in the Ninth Amendment debate.No embarg

The Role of SGK1-NDRG1 Axis in Inflammatory Breast Cancer Stem Cells

https://openworks.mdanderson.org/sumexp23/1005/thumbnail.jp

In-situ measurement of texture development rate in CaIrO₃ post-perovskite

The rate of crystallographic preferred orientation (CPO) development during deformation of post-perovskite is crucial in interpreting seismic anisotropy in the lowermost mantle but the stability field of MgSiO3 post-perovskite prevents high-strain deformation experiments being performed on it. Therefore, to constrain the rate of CPO development in post-perovskite, we deformed CaIrO3, a low-pressure analogue of MgSiO3 post-perovskite, in simple shear at 3.2GPa and 400○C to a shear strain (γ) of 0.81. From X-ray diffraction patterns acquired during deformation, we invert for CPO as a function of strain. By comparing the CPO that develops with visco-plastic self-consistent (VPSC) models we constrain the critical resolved shear stresses (CRSS) of the non-primary slip-systems in CaIrO3 to be of order 6 times stronger than the primary [100](010) slip system. This value is significantly less than has been assumed by previous studies and if applicable to MgSiO3 implies that seismic anisotropy in the D′ layer develops slower than has previously been assumed

New advances in using seismic anisotropy, mineral physics and geodynamics to understand deformation in the lowermost mantle

The D′′ region, which lies in the lowermost few hundred kilometres of the mantle, is a central cog in the Earth's heat engine, influencing convection in the underlying core and overlying mantle. In recent years dense seismic networks have revealed a wealth of information about the seismic properties of this region, which are distinct from those of the mantle above. Here we review observations of seismic anisotropy in this region. In the past it has been assumed that the region exhibits a simple form of transverse isotropy with a vertical symmetry axis (VTI anisotropy). We summarise new methodologies for characterising a more general style of anisotropy using observations from a range of azimuths. The observations can be then used to constrain the mineralogy of the region and its style of deformation by a lattice preferred orientation (LPO) of the constituent minerals. Of specific interest is the recent discovery of the stability of the post-perovskite phase in this region, which might explain many enigmatic properties of D′′. Mantle flow models based on density models derived from global tomographic seismic velocity models can be used to test plausible mineralogies, such as post-perovskite, and their deformation mechanisms. Here we show how linked predictions from mineral physics, geodynamical modelling and seismic observations can be used to better constrain the dynamics, mineralogy and physical properties of the lowermost mantle