Freeze-thaw durability of recycled concrete from construction and demolition wastes

Road engineering is one of the most accepted applications for concrete including recycled aggregates from construction and demolition wastes as a partial replacement of the natural coarse aggregates. Amongst the durability concerns of such application, the deterioration due to freeze-thaw cycles is one of the most important causes decreasing the life span of concrete in countries with a continental climate. Moreover, the use of de-icing salts, which is a common practice to prevent ice formation on roadways and walkways, increases the superficial degradation of concrete due to frost-salt scaling. Thus, this paper aims to assess the resistance to frost salt with de-icing salts of two recycled concrete mixtures containing a 50% replacement of the conventional gravel by recycled aggregates both of mixed and ceramic nature, i.e. containing ceramic percentages of 34% and 100%, in comparison to a conventional concrete made with siliceous gravel. Therefore, the surface scaling was evaluated based on EN 1339 (2004) on 28 days cured cylinders, exposed to 7, 14, 21 and 28 freeze-thaw cycles in the presence of sodium chloride solution. Given that no airentraining admixture was used in any of the mixtures, the scaling of both conventional and recycled concretes exceeded the 1 kg/m2 limit established by the European standard. Nonetheless, for the casting surface, the recycled concrete with low ceramic content exhibited a similar behaviour to the conventional concrete, whereas the performance of the recycled concrete with high ceramic content was better. However, as expected, trowelled surfaces showed a worse performance and both recycled concretes had a lower freeze-thaw durability than the conventional mixture. In any case, the results suggested that the composition of the recycled aggregates could be used as a factor to limit the differences in performance between recycled and conventional mixtures

Failure to Preserve β-Cell Function With Mycophenolate Mofetil and Daclizumab Combined Therapy in Patients With New- Onset Type 1 Diabetes

OBJECTIVE This trial tested whether mycophenolate mofetil (MMF) alone or with daclizumab (DZB) could arrest the loss of insulin-producing β-cells in subjects with new-onset type 1 diabetes. RESEARCH DESIGN AND METHODS A multi-center, randomized, placebo-controlled, double-masked trial was initiated by Type 1 Diabetes TrialNet at 13 sites in North America and Europe. Subjects diagnosed with type 1 diabetes and with sufficient C-peptide within 3 months of diagnosis were randomized to either MMF alone, MMF plus DZB, or placebo, and then followed for 2 years. The primary outcome was the geometric mean area under the curve (AUC) C-peptide from the 2-h mixed meal tolerance test. RESULTS One hundred and twenty-six subjects were randomized and treated during the trial. The geometric mean C-peptide AUC at 2 years was unaffected by MMF alone or MMF plus DZB versus placebo. Adverse events were more frequent in the active therapy groups relative to the control group, but not significantly. CONCLUSIONS Neither MMF alone nor MMF in combination with DZB had an effect on the loss of C-peptide in subjects with new-onset type 1 diabetes. Higher doses or more targeted immunotherapies may be needed to affect the autoimmune process

Discovery of faint double-peak Halpha emission in the halo of low redshift galaxies

Aiming at the detection of cosmological gas being accreted onto galaxies of the local Universe, we examined the Halpha emission in the halo of 164 galaxies in the field of view of the Multi-Unit Spectroscopic Explorer Wide survey (\musew ) with observable Halpha (redshift < 0.42). An exhaustive screening of the corresponding Halpha images led us to select 118 reliable Halpha emitting gas clouds. The signals are faint, with a surface brightness of 10**(-17.3 pm 0.3) erg/s/cm2/arcsec2. Through statistical tests and other arguments, we ruled out that they are created by instrumental artifacts, telluric line residuals, or high redshift interlopers. Around 38% of the time, the Halpha line profile shows a double peak with the drop in intensity at the rest-frame of the central galaxy, and with a typical peak-to-peak separation of the order of pm 200 km/s. Most line emission clumps are spatially unresolved. The mass of emitting gas is estimated to be between one and 10**(-3) times the stellar mass of the central galaxy. The signals are not isotropically distributed; their azimuth tends to be aligned with the major axis of the corresponding galaxy. The distances to the central galaxies are not random either. The counts drop at a distance > 50 galaxy radii, which roughly corresponds to the virial radius of the central galaxy. We explore several physical scenarios to explain this Halpha emission, among which accretion disks around rogue intermediate mass black holes fit the observations best.Comment: pay attention to the last sentence of the abstract! Accepted for publication in Ap

Mechanical properties of geopolymer concretes reinforced with waste steel fibers

The article presents the research that try to determinate the possibilities of utilization the waste came from used tires to create the composites based on geopolymer matrix. The tire is multicomponent construction. It mainly consists of elastomer (rubber), metal and textile fibres such called textile cord. A lot of components causes difficulties in the tire recycling process. The main aim of the research was determinate the possibilities of recycling the waste steel from used tires in geopolymer composites and develop the eco-friendly material for construction industry. The matrix based on fly ash from power station located in city named Skawina (Poland) and fine sand at a ratio of 1:1. The process of activation was made by 10M sodium hydroxide solution combined with the sodium silicate solution. In order to manufacture these composites the addition of 2% and 3.5% of waste steel fibres by mass was applied. Also specimen without steel fiber reinforcement were made to get reference specimens. The waste steel fibres came from recycling company from Argentina - 'Regomax'. The specimens were prepared according to the methodology described in the standard EN 12390-1. The research methods used were: microstructure research, tensile strength and compressive strength tests as well as analysis of breakthroughs.Fil: Gailitis, R. Riga Technical University; LetoniaFil: Korniejenko, K. Cracow University Of Technology; PoloniaFil: Lach, M. Riga Technical University; LetoniaFil: Sliseris, J. Riga Technical University; LetoniaFil: Moran, Juan Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaFil: Rodriguez, Exequiel Santos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaFil: Mikula, J. Cracow University Of Technology; Poloni

The Right to Code and Share Arms

Glycerol is, to date, the most widely used cryoprotectant to freeze stallion spermatozoa at concentrations between 2% and 5%. Cryoprotectant toxicity has been claimed to be the single most limiting factor for the success of cryopreservation. In order to evaluate the toxic effects of the concentrations of glycerol used in practice, stallion spermatozoa were incubated in Biggers Whitten and Whittingham (BWW) media supplemented with 0%, 0.5%, 1.5%, 2.5%, 3.5%, and 5% glycerol. In two additional experiments, a hyposmotic (75 mOsm/kg) and a hyperosmotic (900 mOsm/kg) control media were included. Sperm parameters evaluated included cell volume, membrane integrity, lipid peroxidation, caspase 3, 7, and 8 activation, mitochondrial membrane potential, and integrity of the cytoskeleton. Glycerol exerted toxicity at concentrations 3.5% and the maximal toxicity was observed at 5%. The actin cytoskeleton was especially sensitive to glycerol presence, inducing rapid F actin depolymerization at concentrations over 1.5%. The sperm membrane and the mitochondria were other structures affected. The toxicity of glycerol is apparently related to osmotic and nonosmotic effects. In view of our results the concentration of glycerol in the freezing media for stallion spermatozoa should not surpass 2.5%.Funding Agencies|Ministerio de Ciencia e Innovacion-FEDER Madrid, Spain|AGL 2010 20758 (GAN)|Inia|RZ2008-00018-00-00|Junta de Extremadura FEDER GR|10010

Importance of Magnesium Status in COVID-19

A large amount of published research points to the interesting concept (hypothesis) that magnesium (Mg) status may have relevance for the outcome of COVID-19 and that Mg could be protective during the COVID disease course. As an essential element, Mg plays basic biochemical, cellular, and physiological roles required for cardiovascular, immunological, respiratory, and neurological functions. Both low serum and dietary Mg have been associated with the severity of COVID-19 outcomes, including mortality; both are also associated with COVID-19 risk factors such as older age, obesity, type 2 diabetes, kidney disease, cardiovascular disease, hypertension, and asthma. In addition, populations with high rates of COVID-19 mortality and hospitalization tend to consume diets high in modern processed foods, which are generally low in Mg. In this review, we review the research to describe and consider the possible impact of Mg and Mg status on COVID-19 showing that (1) serum Mg between 2.19 and 2.26 mg/dL and dietary Mg intakes &gt; 329 mg/day could be protective during the disease course and (2) inhaled Mg may improve oxygenation of hypoxic COVID-19 patients. In spite of such promise, oral Mg for COVID-19 has thus far been studied only in combination with other nutrients. Mg deficiency is involved in the occurrence and aggravation of neuropsychiatric complications of COVID-19, including memory loss, cognition, loss of taste and smell, ataxia, confusion, dizziness, and headache. Potential of zinc and/or Mg as useful for increasing drug therapy effectiveness or reducing adverse effect of anti-COVID-19 drugs is reviewed. Oral Mg trials of patients with COVID-19 are warranted

Quality improvement of mixed and ceramic recycled aggregates by biodeposition of calcium carbonate

This research focuses on improving the quality of mixed and ceramic recycled aggregates by microbially induced carbonate precipitation (Bacillus sphaericus). The precipitation contributed to a weight increase and unleashed a waterproofing response. The roughness of the ceramic particles created a more uniform layer compared to natural or concrete particles. For the concrete fraction, which had a higher macroporosity, the consolidation effect was more pronounced. High ceramic content aggregates profited from a greater biodeposition, leading to a remaining amount of precipitates after sonication which was still greater than in cementitious materials. Pore-filling effect was detected by SEM, supporting the waterproofing result. (C) 2017 Elsevier Ltd. All rights reserved

Impact of the dosimetry approach on the resulting 90Y radioembolization planned absorbed doses based on 99mTc-MAA SPEC T-CT: is there agreement between dosimetry methods?

Background: Prior radioembolization, a simulation using 99mTc-macroaggregated albumin as 90Y-microspheres surrogate is performed. Gamma scintigraphy images (planar, SPECT, or SPECT-CT) are acquired to evaluate intrahepatic 90Y-microspheres distribution and detect possible extrahepatic and lung shunting. These images may be used for pre-treatment dosimetry evaluation to calculate the 90Y activity that would get an optimal tumor response while sparing healthy tissues. Several dosimetry methods are available, but there is still no consensus on the best methodology to calculate absorbed doses. The goal of this study was to retrospectively evaluate the impact of using different dosimetry approaches on the resulting 90Y-radioembolization pre-treatment absorbed dose evaluation based on 99mTc-MAA images. Methods: Absorbed doses within volumes of interest resulting from partition model (PM) and 3D voxel dosimetry methods (3D-VDM) (dose-point kernel convolution and local deposition method) were evaluated. Additionally, a new “Multi-tumor Partition Model” (MTPM) was developed. The differences among dosimetry approaches were evaluated in terms of mean absorbed dose and dose volume histograms within the volumes of interest. Results: Differences in mean absorbed dose among dosimetry methods are higher in tumor volumes than in non-tumoral ones. The differences between MTPM and both 3D-VDM were substantially lower than those observed between PM and any 3D-VDM. A poor correlation and concordance were found between PM and the other studied dosimetry approaches. DVH obtained from either 3D-VDM are pretty similar in both healthy liver and individual tumors. Although no relevant global differences, in terms of absorbed dose in Gy, between both 3D-VDM were found, important voxel-by-voxel differences have been observed. Conclusions: Significant differences among the studied dosimetry approaches for 90Y-radioembolization treatments exist. Differences do not yield a substantial impact in treatment planning for healthy tissue but they do for tumoral liver. An individual segmentation and evaluation of the tumors is essential. In patients with multiple tumors, the application of PM is not optimal and the 3D-VDM or the new MTPM are suggested instead. If a 3D-VDM method is not available, MTPM is the best option. Furthermore, both 3D-VDM approaches may be indistinctly used

The High-Density Ionized Gas in the Central Parsecs of the Galaxy

We report the results from observations of H30$\alpha$ line emission in Sgr A West with the Submillimeter Array at a resolution of 2\arcsec and a field of view of about 40\arcsec. The H30$\alpha$ line is sensitive to the high-density ionized gas in the minispiral structure. We compare the velocity field obtained from H30$\alpha$ line emission to a Keplerian model, and our results suggest that the supermassive black hole at Sgr A* dominates the dynamics of the ionized gas. However, we also detect significant deviations from the Keplerian motion, which show that the impact of strong stellar winds from the massive stars along the ionized flows and the interaction between Northern and Eastern arms play significant roles in the local gas dynamics.Comment: 4 pages, 2 figure

The XMM-Newton serendipitous survey. VII. The third XMM-Newton serendipitous source catalogue

Thanks to the large collecting area (3 x ~1500 cm$^2$ at 1.5 keV) and wide field of view (30' across in full field mode) of the X-ray cameras on board the European Space Agency X-ray observatory XMM-Newton, each individual pointing can result in the detection of hundreds of X-ray sources, most of which are newly discovered. Recently, many improvements in the XMM-Newton data reduction algorithms have been made. These include enhanced source characterisation and reduced spurious source detections, refined astrometric precision, greater net sensitivity and the extraction of spectra and time series for fainter sources, with better signal-to-noise. Further, almost 50\% more observations are in the public domain compared to 2XMMi-DR3, allowing the XMM-Newton Survey Science Centre (XMM-SSC) to produce a much larger and better quality X-ray source catalogue. The XMM-SSC has developed a pipeline to reduce the XMM-Newton data automatically and using improved calibration a new catalogue version has been produced from XMM-Newton data made public by 2013 Dec. 31 (13 years of data). Manual screening ensures the highest data quality. This catalogue is known as 3XMM. In the latest release, 3XMM-DR5, there are 565962 X-ray detections comprising 396910 unique X-ray sources. For the 133000 brightest sources, spectra and lightcurves are provided. For all detections, the positions on the sky, a measure of the quality of the detection, and an evaluation of the X-ray variability is provided, along with the fluxes and count rates in 7 X-ray energy bands, the total 0.2-12 keV band counts, and four hardness ratios. To identify the detections, a cross correlation with 228 catalogues is also provided for each X-ray detection. 3XMM-DR5 is the largest X-ray source catalogue ever produced. Thanks to the large array of data products, it is an excellent resource in which to find new and extreme objects.Comment: 23 pages, version accepted for publication in A&