La cátedra Diseño Industrial 2 B trabajó sobre dispositivos domésticos para desinfección en contexto de la pandemia del COVID-19

TRABAJOS: PROYECTO: Pul.sa / AUTORES: Pilar Peralta y Bautista Mugnaini PROYECTO: Numo / AUTORES: Tamara Toledo y Ramiro Ríos PROYECTO: Zenely / AUTORES: Sergio Olmedo y Manuel Reartes PROYECTO: Torretas de Ozono / AUTORES: Pedro Juan Delgado Bratti y Daniel Shen PROYECTO: ANCO / AUTORES: Belén Sol Quinteros y Bruno Mediavilla PROYECTO: Fructífero / AUTORES: Romina Escudero y Santiago Bognano PROYECTO: Acom / AUTORES: Ariadna Cevasco y M. Laura Gonzalez PROYECTO: NOZ / AUTORES: Camila Rapaline & Tomás Rodriguez BravoLa cátedra Diseño Industrial 2 B trabajó sobre dispositivos domésticos para desinfección en contexto de la pandemia del COVID-19 Compartimos los proyectos realizados por estudiantes de la cátedra Diseño Industrial 2B, que durante la primera parte del año, trabajaron sobre dispositivos domésticos para desinfección en contexto de la pandemia del COVID-19. Desde la Facultad de Arquitectura, Urbanismo y Diseño (Universidad Nacional de Córdoba) se iniciaron diferentes acciones para adaptar los contenidos de las carreras y atender a las diferentes necesidades sociales en el contexto de emergencia sanitaria. En ese sentido, la cátedra Diseño Industrial 2B se propuso situar la problemática de trabajo en las condiciones generadas por la pandemia del COVID-19, a partir de las cuales se generan cambios en la vida cotidiana, que afectan las actividades y llevan a incorporar nuevos hábitos y formas de relacionarse. La cátedra propuso a sus estudiantes pensar sistemas portátiles para el ámbito doméstico que permitieran la desinfección de elementos y pertenencias en el ingreso al domicilio. El trabajo práctico propuesto, abordó la complejidad de un producto-máquina desde su comprensión como sistema, con piezas intercambiables y/o combinables que posibilitan diferentes instancias de funcionamiento, abarcando la variablidad de escalas, tanto de relación manual como corporal, en cuanto a la observación de actividades, posturas y situaciones de uso.Fil: Oliva, Silvia. Universidad Nacional de Córdoba. Facultad de Arquitectura, Urbanismo y Diseño. Cátedra Diseño Industrial; Argentina.Fil: de la Fuente, Federico. Universidad Nacional de Córdoba. Facultad de Arquitectura, Urbanismo y Diseño. Cátedra Diseño Industrial; Argentina.Fil: Speroni, Diego. Universidad Nacional de Córdoba. Facultad de Arquitectura, Urbanismo y Diseño. Cátedra Diseño Industrial; Argentina.Fil: Franco, Belén. Universidad Nacional de Córdoba. Facultad de Arquitectura, Urbanismo y Diseño. Cátedra Diseño Industrial; Argentina.Fil: Cagliero, Leonardo. Universidad Nacional de Córdoba. Facultad de Arquitectura, Urbanismo y Diseño. Cátedra Diseño Industrial; Argentina.Fil: Parra, Javier. Universidad Nacional de Córdoba. Facultad de Arquitectura, Urbanismo y Diseño. Cátedra Diseño Industrial; Argentina.Fil: Talmon, Gaspar. Universidad Nacional de Córdoba. Facultad de Arquitectura, Urbanismo y Diseño. Cátedra Diseño Industrial; Argentina.Fil: Gili, Agustina. Universidad Nacional de Córdoba. Facultad de Arquitectura, Urbanismo y Diseño. Cátedra Diseño Industrial; Argentina.Fil: Costamagna, Camila. Universidad Nacional de Córdoba. Facultad de Arquitectura, Urbanismo y Diseño. Cátedra Diseño Industrial; Argentina.Fil: Vélez, Simón. Universidad Nacional de Córdoba. Facultad de Arquitectura, Urbanismo y Diseño. Cátedra Diseño Industrial; Argentina.Fil: Giménez, Lucas. Universidad Nacional de Córdoba. Facultad de Arquitectura, Urbanismo y Diseño. Cátedra Diseño Industrial; Argentina

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Evolving trends in the management of acute appendicitis during COVID-19 waves. The ACIE appy II study

Background: In 2020, ACIE Appy study showed that COVID-19 pandemic heavily affected the management of patients with acute appendicitis (AA) worldwide, with an increased rate of non-operative management (NOM) strategies and a trend toward open surgery due to concern of virus transmission by laparoscopy and controversial recommendations on this issue. The aim of this study was to survey again the same group of surgeons to assess if any difference in management attitudes of AA had occurred in the later stages of the outbreak. Methods: From August 15 to September 30, 2021, an online questionnaire was sent to all 709 participants of the ACIE Appy study. The questionnaire included questions on personal protective equipment (PPE), local policies and screening for SARS-CoV-2 infection, NOM, surgical approach and disease presentations in 2021. The results were compared with the results from the previous study. Results: A total of 476 answers were collected (response rate 67.1%). Screening policies were significatively improved with most patients screened regardless of symptoms (89.5% vs. 37.4%) with PCR and antigenic test as the preferred test (74.1% vs. 26.3%). More patients tested positive before surgery and commercial systems were the preferred ones to filter smoke plumes during laparoscopy. Laparoscopic appendicectomy was the first option in the treatment of AA, with a declined use of NOM. Conclusion: Management of AA has improved in the last waves of pandemic. Increased evidence regarding SARS-COV-2 infection along with a timely healthcare systems response has been translated into tailored attitudes and a better care for patients with AA worldwide

A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

Meeting abstrac

Evaluation of appendicitis risk prediction models in adults with suspected appendicitis

Background Appendicitis is the most common general surgical emergency worldwide, but its diagnosis remains challenging. The aim of this study was to determine whether existing risk prediction models can reliably identify patients presenting to hospital in the UK with acute right iliac fossa (RIF) pain who are at low risk of appendicitis. Methods A systematic search was completed to identify all existing appendicitis risk prediction models. Models were validated using UK data from an international prospective cohort study that captured consecutive patients aged 16–45 years presenting to hospital with acute RIF in March to June 2017. The main outcome was best achievable model specificity (proportion of patients who did not have appendicitis correctly classified as low risk) whilst maintaining a failure rate below 5 per cent (proportion of patients identified as low risk who actually had appendicitis). Results Some 5345 patients across 154 UK hospitals were identified, of which two‐thirds (3613 of 5345, 67·6 per cent) were women. Women were more than twice as likely to undergo surgery with removal of a histologically normal appendix (272 of 964, 28·2 per cent) than men (120 of 993, 12·1 per cent) (relative risk 2·33, 95 per cent c.i. 1·92 to 2·84; P < 0·001). Of 15 validated risk prediction models, the Adult Appendicitis Score performed best (cut‐off score 8 or less, specificity 63·1 per cent, failure rate 3·7 per cent). The Appendicitis Inflammatory Response Score performed best for men (cut‐off score 2 or less, specificity 24·7 per cent, failure rate 2·4 per cent). Conclusion Women in the UK had a disproportionate risk of admission without surgical intervention and had high rates of normal appendicectomy. Risk prediction models to support shared decision‐making by identifying adults in the UK at low risk of appendicitis were identified

Co 2 Laser Treatment for Vaginal Intraepithelial Neoplasia, Assesment of Recurrence

Objective: To assess the response and evolution of vaginal intraepithelial neoplasia (VAIN) after CO2 laser treatment.&nbsp;Material and Methods: A retrospective study was conducted from a database of 139 women who had VAIN and were referred for treatment with CO2 laser. The lesions were detected following a hysterectomy. Human papillomavirus (HPV) typification was performed in all cases. The diagnosis of the lesions was performed by liquid based cytology and the location was by colposcopic study. Treatment with CO2 laser was performed in continuous mode. In the statistical study were assessed: age, diagnosis before hysterectomy, diagnosis before the laser treatment, the characteristics of the lesions and HPV genomic.&nbsp;Results: 131 patients were evaluated after elimination of 8 cases of incomplete data. The age of patients ranged between 35 and 68 years. 68.70% were female aged 45 years and older. The cause of hysterectomy was myoma in 16.3% and the rest for other cervical pathology. 22 patients were diagnosed with VAIN II and 106 (80.91%) of VAIN III. The risk factors for recurrence were age over 45 years, type of VAIN and HPV 16 infection. The lesion with more recurrence was VAIN III, with 15.26%.&nbsp;Conclusion: Laser vaporization can be considered a safe treatment for VAIN.</p

Évaluation directe de la compétitivité et de la tolérance à la défoliation des graminées vivaces

Stipa clarazii is a dominant, late-seral perennial grass species under exclosure or lightly grazed rangelands in semiarid Argentina, whereas S. tenuis and S. ambigua are earlier-seral perennial tussock grasses. Recent studies have demonstrated that late-seral species are more competitive and can have either similar or greater herbivory tolerance than earlier-seral species. We hyphothesized that (1) tolerance to defoliation is greater on defoliated plants of S. clarazii than on those of S. tenuis and S. ambigua, (2) competitive ability is greater in S. clarazii than in S. tenuis and S. ambigua when plants remain undefoliated or are exposed to a comparable defoliation intensity, and (3) competitive ability decreases in S. clarazii when this species is selectively defoliated within a non-defoliated, nearby neighbourhood of S. tenuis or S. ambigua. The study objectives included obtaining a direct measure of competitive ability and defoliation tolerance in the three perennial grasses when they grew either in isolation or in different neighbourhoods and were exposed to various defoliation patterns in the field. In 1998, two parallel studies were conducted within a 2-yr-old field exclosure during one growing season. In one study, responses were evaluated on either defoliated or undefoliated plants of all three species without neighbours. In a second experiment, four types of neighborhoods were selected such that a central (target) plant of one species was surrounded by five neighboring plants of a different species. Three different defoliation patterns were imposed on each neighbourhood type. Results led to acceptance of the first and second and rejection of the third hypothesis. When plants grew without nearby neighbours, greater growth rates for height, dry matter production and end-of-season daughter tiller production per parent tiller in S. clarazii relative to S. tenuis and S. ambigua contributed to greater regrowth in S. clarazii. Amounts of 15N atom excess were always greater in S. clarazii than in S. tenuis and S. ambigua independently of neighbourhood type and pattern of defoliation. However, uptake of 15N was similar in S. clarazii to that in S. tenuis or S. ambigua when S. clarazii was selectively defoliated within a non-defoliated, nearby neighbourhood of any of the other two species. Selective herbivory of S. clarazii, rather than factors associated with its competitive ability and defoliation tolerance, were found to be the major determinant driving its replacement by earlier-seral, less desirable perennial grasses in rangelands of central Argentina.Stipa clarazii est une graminée de transition vivace tardive mais dominante dans les exclos ou les grands parcours peu fréquentés des régions semi-arides de l’Argentine, où les vivaces de transition S. tenuis et S. ambigua peuplent plus hâtivement les buttes de tourbe. Des études récentes indiquent que les espèces de transition tardives sont plus compétitives et tolèrent autant ou mieux les herbivores que les espèces de transition plus précoces. Les auteurs ont formulé les hypothèses suivantes : (1) les plants de S. clarazii défoliés tolèrent plus la défoliation que ceux de S. tenuis et de S. ambigua; (2) S. clarazii est plus compétitive que les deux autres espèces quand ses plants ne sont pas défoliés ou sont exposés à une défoliation analogue; (3) la compétitivité de S. clarazii diminue quand on défolie cette espèce de manière sélective près de peuplements de S. tenuis et de S. amgigua. L’étude devait servir à mesurer directement la compétitivité et la tolérance à la défoliation des trois graminées vivaces, cultivées en isolement ou dans des milieux différents puis exposées à divers modes de défoliation observés sur le terrain. En 1998, les auteurs ont tenu deux études parallèles sur un champ de deux ans exclos durant la période végé- tative. Dans la première, ils ont évalué la réaction des plants défoliés et normaux des trois espèces en l’absence de plantes voisines. Dans la seconde, ils ont sélectionné quatre types d’environnement, de telle sorte que les plantes d’une espèce (cible) était entourée de cinq plants d’une espèce différente. Trois modes de défoliation ont ensuite été appliqués à chaque environnement. Les résultats ont amené les auteurs à retenir les deux premières hypothèses et à rejeter la troisième. Quand les plantes poussent sans voisin immédiat, un meilleur taux de croissance relatif pour la hauteur, une plus forte production de matière sèche et un plus grand nombre de talles filles en fin de saison concourent à une meilleure repousse de S. clarazii, comparativement à S. tenuis et à S. ambigua. La proportion d’atomes 15N en excé- dent était toujours plus élevée chez S. clarazii que chez les deux autres espèces, sans égard au type d’environnement ou au mode de défoliation. L’absorption du 15N chez S. clarazii était néanmoins semblable à celle observée chez S. tenuis ou S. ambigua quand on défolie sélectivement S. clarazii dans un peuplement non défolié d’une des deux autres espèces. On doit surtout la substitution de S. clarazii par des graminées vivaces de transition plus hâtives et moins désirables dans les grands parcours de l’Argentine à un broutage sélectif plutôt qu’à d’autres facteurs comme la compétitivité et la tolérance à la défoliation de l’espèce.Fil: Saint Pierre, Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Centro de Recursos Naturales Renovables de la Zona Semiárida. Universidad Nacional del Sur. Centro de Recursos Naturales Renovables de la Zona Semiárida; ArgentinaFil: Busso, Carlos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Centro de Recursos Naturales Renovables de la Zona Semiárida. Universidad Nacional del Sur. Centro de Recursos Naturales Renovables de la Zona Semiárida; ArgentinaFil: Montenegro, Oscar Alberto. Provincia de Buenos Aires. Ministerio de Asuntos Agrarios. Chacra Experimental de Patagones; ArgentinaFil: Rodriguez, Gustavo Dionisio. Provincia de Buenos Aires. Ministerio de Asuntos Agrarios. Chacra Experimental de Patagones; ArgentinaFil: Giorgetti, Hugo Dosindo. Provincia de Buenos Aires. Ministerio de Asuntos Agrarios. Chacra Experimental de Patagones; ArgentinaFil: Montani, Tomás. Universidad Nacional del Sur. Departamento de Agronomía; ArgentinaFil: Bravo, Oscar Abel. Universidad Nacional del Sur. Departamento de Agronomía; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin

Soil resource acquisition mechanisms, nutrient concentrations and growth in perennial grasses

Species historically heavily grazed may have been selected for grazing-resistance traits associated with improved nutrient use efficiency (Chapin and Slack, 1979). Higher root length density (RLD) and vesicular-arbuscular mycorrhizae (VAM) colonization have been associated with greater nutrient acquisition in perennial grasses, thus contributing to competitive ability (Jackson and Caldwell, 1996). This is especially true in unproductive environments where competition for belowground resources is strong (Jackson and Caldwell, 1996). Mycorrhizal fungi can affect competitive interactions among plants by improving soil nutrient uptake (Marschner and Dell, 1994; Mohammad et al., 1998). However, lack of or even negative responses have been obtained under increased levels of mycorrhizal colonization (Fitter and Hay, 1983).Relationships among soil resource acquisition mechanisms and components of shoot tissue production were studied in the late-seral, grazing tolerant and competitive Stipa clarazii Ball and in the earlier-seral, less grazing tolerant and competitive S. tenuis Phil and S. ambigua Speg. History of grazing and/or fire determines abundance of these C3 perennial tussock grasses in temperate, semiarid rangelands of Argentina. We hypothesized lower values for root length density (RLD) and percentage vesicular-arbuscular mycorrhizal (%VAM) colonization on defoliated than on undefoliated plants, and also greater values for RLD and %VAM colonization on defoliated and undefoliated plants of S. clarazii than on those of the other two species, because of its greater competitive ability and defoliation tolerance. Field study was conducted within a 2-year exclosure to domestic herbivory. One group of plants was defoliated once to 5cm stubble height in early spring, while another group was defoliated twice, in early and mid-spring. A third group remained undefoliated (control). Measurements were conducted 6-10 days after each defoliation, and at the end of the growing season. RLD and %VAM colonization were similar on defoliated plants and on undefoliated controls in all three species. Greater regrowth production in S. clarazii was not associated with higher RLD and %VAM colonization in the more competitive species. The positive relationship between RLD and either dry weight production or tissue N and P concentration in these species suggests that their root activity must be maintained after defoliation to rapidly reestablish a photosynthetic canopy and keep resource supply at equilibrium. All perennial grasses showed consistently high %VAM colonization, suggesting they may function as obligate mycotrophs. The negative correlation between %VAM colonization and RLD or soil available P for S. clarazii could represent a mechanism to avoid shifts from mutualism to parasitism in the plant-mycorrhizae relationship.Estudaram-se as relações entre os mecanismos de aquisição de recursos do solo e os componentes de produção de tecido foliar na espécie de etapas serais tardias, tolerante ao pastoreio e competitiva Stipa clarazii Ball e nas espécies de etapas serais mais prematuras, menos tolerantes ao pastoreio e competitivas S. tenuis Phil. e S. ambigua Speg. A história de pastoreio e/ou fogo determina a abundância destas gramíneas perenes cespitosas C3 nos pastizais temperados semi-áridos da Argentina. A hipótese de trabalho foi de que as plantas desfolhadas teriam menor densidade de longitude de raízes (DLR) e porcentagem de colonização por micorrizas vesiculares-arbusculares (%MAV) que aquelas não desfolhadas, e também que as plantas desfolhadas e não desfolhadas de S. clarazii teríam maiores valores de DLR y %MAV que aquelas das outras espécies, por sua maior capacidade competitiva e tolerância à desfolhação. Se conduziu um estudo sob condições de campo em uma área excluída ao pastoreio por herbívoros domésticos durante 2 anos. Um grupo de plantas foi desfolhado uma vez a 5 cm do solo no início da primavera, enquanto que outro grupo foi desfolhado duas vezes, no início e na metade da primavera. Um terceiro grupo permaneceu não desfolhado. As medições se conduziram 6-10 dias depois de cada desfolhação, e no final da estação de crescimento. DLR y %MAV foram similares em plantas desfolhadas e não desfolhadas nas três espécies. A maior produção de rebrote em S. clarazii não esteve associado com maiores DLR y %MAV na espécie mais competitiva. A relação positiva entre DLR e produção de peso seco, ou a concentração de N e P no tecido nestas espécies, sugere que sua atividade radical deve se manter após a desfolhação para restabelecer uma superficie fotossintética e manter a distribuição de recursos em equilíbrio. Todas as espécies mostraram valores consistentemente altos de % MAV, sugerindo que podem ter uma associação mutualística obrigada com as micorrizas. A correlação negativa entre %MAV e DLR ou P disponível do solo para S. clarazii poderia representar um mecanismo para evitar mudanças de associação mutualística a parasítica na relação planta-micorriza.Fil: Saint Pierre, Carolina. Universidad Nacional del Sur; ArgentinaFil: Busso, Carlos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Centro de Recursos Naturales Renovables de la Zona Semiárida. Universidad Nacional del Sur. Centro de Recursos Naturales Renovables de la Zona Semiárida; ArgentinaFil: Montenegro, Oscar Alberto. Provincia de Buenos Aires. Ministerio de Asuntos Agrarios. Chacra Experimental de Patagones; Argentina. Universidad Nacional del Sur; ArgentinaFil: Rodriguez, Gustavo Dionisio. Provincia de Buenos Aires. Ministerio de Asuntos Agrarios. Chacra Experimental de Patagones; ArgentinaFil: Giorgetti, Hugo Dosindo. Provincia de Buenos Aires. Ministerio de Asuntos Agrarios. Chacra Experimental de Patagones; Argentina. Universidad Nacional del Sur; ArgentinaFil: Montani, Tomás. Universidad Nacional del Sur; ArgentinaFil: Bravo, Oscar Abel. Universidad Nacional del Sur; Argentin